K Miyake

Summary

Affiliation: Nippon Medical School
Country: Japan

Publications

  1. ncbi HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia
    K Miyake
    Department of Biochemistry and Molecular Biology, Division of Gene Therapy Research Center for Advanced Medical Technology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Gene Ther 14:1662-7. 2007
  2. ncbi Development of targeted gene transfer into human primary T lymphocytes and macrophages using high-titer recombinant HIV vectors
    Koichi Miyake
    Department of Biochemistry and Molecular Biology, Division of Gene Therapy Research Center for Advanced Medical Technology, Nippon Medical School, Tokyo 113 8602, Japan
    J Biotechnol 129:532-8. 2007
  3. ncbi Selective killing of human immunodeficiency virus-infected cells by targeted gene transfer and inducible gene expression using a recombinant human immunodeficiency virus vector
    K Miyake
    Department of Biochemistry and Molecular Biology, Division of Gene Therapy Research, Center for Advanced Medical Technology, Nippon Medical School, Tokyo 113 8602, Japan
    Hum Gene Ther 12:227-33. 2001
  4. ncbi Adeno-associated virus vector-mediated anti-angiogenic gene therapy for collagen-induced arthritis in mice
    H Takahashi
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Clin Exp Rheumatol 23:455-61. 2005
  5. ncbi Selective transduction of HIV-1-infected cells by the combination of HIV and MMLV vectors
    N Sakai
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Int J Hematol 73:476-82. 2001
  6. ncbi Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl
    K Miyake
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Gene Ther 12:541-5. 2005
  7. ncbi Inhibition of replication of HIV-1 at both early and late stages of the viral life cycle by single-chain antibody against viral integrase
    Y Kitamura
    Division of Molecular Genetics, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
    J Acquir Immune Defic Syndr Hum Retrovirol 20:105-14. 1999
  8. ncbi Aging increases, and duodenal ulcer reduces the risk for intestinal metaplasia of the gastric corpus in Japanese patients with dyspepsia
    T Tsukui
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    J Gastroenterol Hepatol 16:15-21. 2001
  9. ncbi Effect of acid suppression therapy on development of gastric erosions after cure of Helicobacter pylori infection
    K Miyake
    Third Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
    Aliment Pharmacol Ther 16:210-6. 2002
  10. ncbi Implications of corpus gastritis, atrophy and cyclooxygenase in the development of gastric erosions after curing Helicobacter pylori infection
    K Miyake
    Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Dig Liver Dis 37:394-401. 2005

Collaborators

Detail Information

Publications35

  1. ncbi HIV vector-mediated targeted suicide gene therapy for adult T-cell leukemia
    K Miyake
    Department of Biochemistry and Molecular Biology, Division of Gene Therapy Research Center for Advanced Medical Technology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Gene Ther 14:1662-7. 2007
    ..Taken together, these findings suggest that HIV vectors could be used for in vivo targeted gene transfer into ATL cells and could thus serve as the basis for the development of effective new therapies for the treatment of ATL...
  2. ncbi Development of targeted gene transfer into human primary T lymphocytes and macrophages using high-titer recombinant HIV vectors
    Koichi Miyake
    Department of Biochemistry and Molecular Biology, Division of Gene Therapy Research Center for Advanced Medical Technology, Nippon Medical School, Tokyo 113 8602, Japan
    J Biotechnol 129:532-8. 2007
    ..These results also indicate that these HIV vectors are useful for the manipulation of gene expression in HIV infectable cells and the development of gene therapy targeting lymphocytes and macrophages...
  3. ncbi Selective killing of human immunodeficiency virus-infected cells by targeted gene transfer and inducible gene expression using a recombinant human immunodeficiency virus vector
    K Miyake
    Department of Biochemistry and Molecular Biology, Division of Gene Therapy Research, Center for Advanced Medical Technology, Nippon Medical School, Tokyo 113 8602, Japan
    Hum Gene Ther 12:227-33. 2001
    ..These results are indicative of the potential benefits of using HIV vectors in gene therapies for the treatment of HIV-1 infection...
  4. ncbi Adeno-associated virus vector-mediated anti-angiogenic gene therapy for collagen-induced arthritis in mice
    H Takahashi
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Clin Exp Rheumatol 23:455-61. 2005
    ..Anti-angiogenic gene therapy using AAV vector may provide a new approach for the effective treatment of rheumatoid arthritis...
  5. ncbi Selective transduction of HIV-1-infected cells by the combination of HIV and MMLV vectors
    N Sakai
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Int J Hematol 73:476-82. 2001
    ..More than 70% of HIV-1-infected cells were transduced by this strategy. These findings indicate that this 2-step method can be used for selective and stable gene transfer into HIV-1-infected cells...
  6. ncbi Antiangiogenic gene therapy of myeloproliferative disease developed in transgenic mice expressing P230 bcr/abl
    K Miyake
    Department of Biochemistry and Molecular Biology, Nippon Medical School, Tokyo, Japan
    Gene Ther 12:541-5. 2005
    ..These results demonstrated, for the first time, that antiangiogenic gene therapy is effective to inhibit leukemogenesis caused by expression of the chimeric bcr/abl gene...
  7. ncbi Inhibition of replication of HIV-1 at both early and late stages of the viral life cycle by single-chain antibody against viral integrase
    Y Kitamura
    Division of Molecular Genetics, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan
    J Acquir Immune Defic Syndr Hum Retrovirol 20:105-14. 1999
    ..The single-chain, antigen-binding peptide molecule may prove useful not only for studies of the functions of IN and its role in the viral life cycle but also for developing a gene therapy strategy against AIDS...
  8. ncbi Aging increases, and duodenal ulcer reduces the risk for intestinal metaplasia of the gastric corpus in Japanese patients with dyspepsia
    T Tsukui
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    J Gastroenterol Hepatol 16:15-21. 2001
    ....
  9. ncbi Effect of acid suppression therapy on development of gastric erosions after cure of Helicobacter pylori infection
    K Miyake
    Third Department of Internal Medicine, Nippon Medical School, Bunkyo-ku, Tokyo, Japan
    Aliment Pharmacol Ther 16:210-6. 2002
    ..These results support the idea that recovery of acid secretion may be one of factors for development of gastric mucosal erosions after successful eradication...
  10. ncbi Implications of corpus gastritis, atrophy and cyclooxygenase in the development of gastric erosions after curing Helicobacter pylori infection
    K Miyake
    Third Department of Internal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8603, Japan
    Dig Liver Dis 37:394-401. 2005
    ..Helicobacter pylori eradication decreases recurrence of peptic ulcers with marked improvement in histological inflammation, but gastric mucosal injuries may be developed even after eradication...
  11. ncbi Monocyte chemoattractant protein 1 (MCP-1) released from Helicobacter pylori stimulated gastric epithelial cells induces cyclooxygenase 2 expression and activation in T cells
    S Futagami
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Gut 52:1257-64. 2003
    ..CONCLUSIONS: Cytokines such as MCP-1, released from gastric epithelial cells in response to HPWEP, seem to modulate T cell immune responses, at least in part via COX-2 expression...
  12. ncbi Preventive therapy for non-steroidal anti-inflammatory drug-induced ulcers in Japanese patients with rheumatoid arthritis: the current situation and a prospective controlled-study of the preventive effects of lansoprazole or famotidine
    K Miyake
    Third Department of Internal Medicine, Nippon Medical School, Sendagi, Tokyo, Japan
    Aliment Pharmacol Ther 21:67-72. 2005
    ..There is a lack of evidence for the efficacy of preventive medications for peptic ulcers (PUs) among long-term users of non-steroidal anti-inflammatory drugs (NSAIDs) in Japan...
  13. ncbi Chemopreventive effect of celecoxib in gastric cancer
    S Futagami
    Third Department of Internal Medicine, Nippon Medical School, Bunkyo ku, Tokyo, 113 8602, Japan
    Inflammopharmacology 15:1-4. 2007
    ..Therefore, studies hoping to clarify how selective COX-2 inhibitors modulate gastric cancer must keep in mind that coxibs have also been linked to serious cardiovascular events and disruption of renal physiology...
  14. ncbi Duodenogastric reflux induced by endoscopic submucosal dissection
    K Miyake
    Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School, Tokyo 113 8603, Japan
    Endoscopy 41:934-40. 2009
    ..Endoscopic submucosal dissection (ESD) may cause excessive duodenogastric reflux (DGR) in a similar manner to distal gastrectomy, particularly after antral resections. We aimed to examine the occurrence of DGR after ESD...
  15. ncbi Inhibition of Helicobacter pylori-induced cyclo-oxygenase-2 aggravates NSAID-caused gastric damage in Mongolian gerbils
    S Futagami
    Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Aliment Pharmacol Ther 16:847-55. 2002
    ..Therefore, inhibition of cyclo-oxygenase-2 activity may enhance non-steroidal anti-inflammatory drug-caused gastric damage in H. pylori-infected animals...
  16. ncbi Importance of c-kit mutation detection method sensitivity in prognostic analyses of t(8;21)(q22;q22) acute myeloid leukemia
    S Wakita
    Division of Hematology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Leukemia 25:1423-32. 2011
    ..006). We conclude that sensitivity of c-kit mutation detection method is important to predict prognosis for t(8;21) AML...
  17. ncbi Involvement of TLR4/MD-2 complex in species-specific lipopolysaccharide-mimetic signal transduction by Taxol
    K Kawasaki
    Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan
    J Endotoxin Res 7:232-6. 2001
    ..We also found that mouse MD-2, but not human MD-2, is involved in Taxol signaling, suggesting that MD-2 is responsible for the species-specific responsiveness to Taxol...
  18. ncbi RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family
    K Miyake
    Department of Immunology, Saga Medical School, Japan
    J Immunol 154:3333-40. 1995
    ..These results demonstrate that RP105 is a novel member of the leucine-rich repeat protein family, and the first member that is specifically expressed on B cells...
  19. ncbi Increase of RP105-lacking activated B cells in the peripheral blood and salivary glands in patients with Sjögren's syndrome
    Y Kikuchi
    Department of Internal Medicine, Faculty of Medicine, Saga University, Japan
    Clin Exp Rheumatol 26:5-12. 2008
    ..To quantify the activated B cells in the peripheral blood and salivary glands of patients with Sjögren's syndrome (SS) by analyzing the expression of RP105 molecule on the B cells...
  20. ncbi Cell wound assays
    P L McNeil
    Medical College of Georgia, Augusta, Georgia, USA
    Curr Protoc Cell Biol . 2001
    ..This unit describes methods for identifying "wounded" cells, often present as a minority in culture or tissues. The use of these methods can provide information about the frequency and extent of cellular wounding...
  21. ncbi Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1)
    N Sugiyama
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Rheum Dis 67:1461-7. 2008
    ....
  22. ncbi Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface
    H Hu
    Department of Viral Infection, Institute of Medical Science, University of Tokyo, Minato ku, Japan
    J Virol 70:7462-70. 1996
    ..Thus, the sialylation catalyzed by host cell pathways appeared to reduce the infectivity of human and nonhuman primate lentiviruses. Our results further suggested that desialylation would help increase the titers of HIV-based vectors...
  23. ncbi Novel role of HDAC inhibitors in AML1/ETO AML cells: activation of apoptosis and phagocytosis through induction of annexin A1
    Y Tabe
    Section of Molecular Hematology and Therapy, Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Cell Death Differ 14:1443-56. 2007
    ..These findings identify a novel mechanism of action of HDAC inhibitors, which induce the expression and externalization of ANXA1 in leukemic cells, which in turn mediates the phagocytic clearance of apoptotic cells by macrophages...
  24. ncbi Molecular cloning of a human RP105 homologue and chromosomal localization of the mouse and human RP105 genes (Ly64 and LY64)
    Y Miura
    Department of Immunology, Saga Medical School, Nabeshima, Saga, 849, Japan
    Genomics 38:299-304. 1996
    ..The human LY64 locus was localized to 5q12 by fluorescence in situ hybridization, confirming the syntenic relationship between these regions of the mouse and human chromosomes...
  25. ncbi Physical and functional association between thymic shared antigen-1/stem cell antigen-2 and the T cell receptor complex
    A Kosugi
    School of Allied Health Sciences, Faculty of Medicine, Osaka University, Osaka 565, Japan
    J Biol Chem 273:12301-6. 1998
    ..These results imply that the physical association to CD3zeta underlies a regulatory role of TSA-1/Sca-2 in the TCR-signaling pathway...
  26. ncbi Disruption-induced mucus secretion: repair and protection
    K Miyake
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, United States of America
    PLoS Biol 4:e276. 2006
    ..This mode of mechanotransduction can, we propose, explain how lubrication in the gastrointestinal tract is rapidly and precisely adjusted to widely fluctuating, diet-dependent levels of mechanical stress...
  27. ncbi The molecular mechanism of B cell activation by toll-like receptor protein RP-105
    V W Chan
    Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA
    J Exp Med 188:93-101. 1998
    ..We also find that negative regulation of RP-105-mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor-mediated arrest of RP-105-mediated B cell proliferation...
  28. ncbi Mouse MD-1, a molecule that is physically associated with RP105 and positively regulates its expression
    K Miyake
    Department of Immunology, Saga Medical School, Japan
    J Immunol 161:1348-53. 1998
    ..Thus, MD-1 is physically associated with RP105 and is important for efficient cell surface expression...
  29. ncbi RP105 is associated with MD-1 and transmits an activation signal in human B cells
    Y Miura
    Department of Immunology and the Division of Dermatology in the Department of Internal Medicine, Saga Medical School, Saga, Japan
    Blood 92:2815-22. 1998
    ..Moreover, the anti-RP105 MoAb activates B cells, leading to increases in cell size, expression of a costimulatory molecule CD80, and DNA synthesis. The B-cell activation pathway using RP105 is conserved in humans...
  30. ncbi Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells
    M Ogata
    Department of Oncology, Biomedical Research Center, Osaka University Medical School, Suita, Osaka 565 0871, Japan
    J Biol Chem 274:12905-9. 1999
    ..These results indicate that PTP36 affects cytoskeletons, cell adhesion, and cell growth, thus suggesting that PTP36 is involved in their regulatory processes...
  31. ncbi Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice
    S Shimizu
    Department of Medicine and Biosystemic Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
    Rheumatology (Oxford) 43:1121-8. 2004
    ..CONCLUSION: Anti-MCP-1 gene therapy is specifically effective in the localized inflammatory region. The data presented here indicate that this anti-MCP-1 gene therapy may be effective adjunct in the management of DPLN...
  32. ncbi The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells
    H Ogata
    Department of Immunology, Saga Medical School, Saga 849 8501, Japan
    J Exp Med 192:23-9. 2000
    ..These data suggest the existence of the TLR4-RP105 signaling module in the LPS-induced B cell activation...
  33. ncbi Genetically determined interferon-gamma production influences the histological phenotype of lupus nephritis
    K Miyake
    Department of Medicine and Biosystemic Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Rheumatology (Oxford) 41:518-24. 2002
    ..CONCLUSION: The IFN-gamma gene is associated with the histological phenotype in lupus nephritis...
  34. ncbi Functional association of CD9 with the Fc gamma receptors in macrophages
    K Kaji
    Department of Life Science, Tokyo Institute of Technology, Yokohama, Japan
    J Immunol 166:3256-65. 2001
    ..Our results demonstrate that co-cross-linking of CD9 and Fc gamma Rs activates macrophages; therefore, CD9 may collaborate with FcRs functioning in infection and inflammation on macrophages...
  35. ncbi Involvement of very late activation antigen 4 (VLA-4) and vascular cell adhesion molecule 1 (VCAM-1) in tumor necrosis factor alpha enhancement of experimental metastasis
    H Okahara
    First Department of Surgery, School of Medicine, Juntendo University, Tokyo, Japan
    Cancer Res 54:3233-6. 1994
    ..These results indicate that the interaction between VLA-4 on tumor cells and vascular cell adhesion molecule 1 on activated endothelial cells is critically involved in TNF-alpha enhancement of metastasis...