Masaya Higuchi

Summary

Affiliation: Niigata University
Country: Japan

Publications

  1. ncbi Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Virol 81:11900-7. 2007
  2. ncbi Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:117. 2009
  3. ncbi Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Retrovirology 2:29. 2005
  4. ncbi Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2
    Toshiyuki Shoji
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:83. 2009
  5. ncbi Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus
    Akiko Niinuma
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
    J Virol 79:11925-34. 2005
  6. ncbi Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line
    Rie Kondo
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 3:88. 2006
  7. ncbi Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction
    Masaaki Okajima
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Virus Genes 37:231-40. 2008
  8. ncbi Knockdown of synapse-associated protein Dlg1 reduces syncytium formation induced by human T-cell leukemia virus type 1
    Sakiko Yoshida
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Virus Genes 37:9-15. 2008
  9. ncbi Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3
    Minako Ohashi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
    Virology 320:52-62. 2004
  10. ncbi Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein
    Kojiro Ishioka
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Retrovirology 3:71. 2006

Collaborators

Detail Information

Publications27

  1. ncbi Cooperation of NF-kappaB2/p100 activation and the PDZ domain binding motif signal in human T-cell leukemia virus type 1 (HTLV-1) Tax1 but not HTLV-2 Tax2 is crucial for interleukin-2-independent growth transformation of a T-cell line
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    J Virol 81:11900-7. 2007
    ....
  2. ncbi Distinct functions of HTLV-1 Tax1 from HTLV-2 Tax2 contribute key roles to viral pathogenesis
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:117. 2009
    ..In this review, we summarize the functions of Tax1 associated with cell survival, cell proliferation, persistent infection as well as pathogenesis. We emphasize special attention to distinctions between Tax1 and Tax2...
  3. ncbi Elevated expression of CD30 in adult T-cell leukemia cell lines: possible role in constitutive NF-kappaB activation
    Masaya Higuchi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951 8510, Japan
    Retrovirology 2:29. 2005
    ..The aim of this study was to identify the molecules responsible for the constitutive activation of NF-kappaB in ATL cells using a retroviral functional cloning strategy...
  4. ncbi Identification of a novel motif responsible for the distinctive transforming activity of human T-cell leukemia virus (HTLV) type 1 Tax1 protein from HTLV-2 Tax2
    Toshiyuki Shoji
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 6:83. 2009
    ..This distinction was mediated by at least two Tax1 specific functions, an interaction with host cellular factors through the PDZ domain binding motif (PBM) and the activation of NF-kappa B2 (NF-kappa B2)/p100...
  5. ncbi Aberrant activation of the interleukin-2 autocrine loop through the nuclear factor of activated T cells by nonleukemogenic human T-cell leukemia virus type 2 but not by leukemogenic type 1 virus
    Akiko Niinuma
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
    J Virol 79:11925-34. 2005
    ..The results also suggest that differences in long-term cytokine production between HTLV-1 and HTLV-2 infection are another factor for the differences in pathogenesis...
  6. ncbi Human T-cell leukemia virus type 2 Tax protein induces interleukin 2-independent growth in a T-cell line
    Rie Kondo
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 3:88. 2006
    ..We herein examined whether Tax2 by itself has a growth promoting activity in a mouse T-cell line CTLL-2, and compared the activity with that of Tax1...
  7. ncbi Human T-cell leukemia virus type 1 Tax induces an aberrant clustering of the tumor suppressor Scribble through the PDZ domain-binding motif dependent and independent interaction
    Masaaki Okajima
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Virus Genes 37:231-40. 2008
    ..These results suggest that Tax1 through two binding sites induce aberrant clustering of Scribble, thereby altering the functions in HTLV-1-infected cells, which may thus play a role in persistent HTLV-1 infection and the pathogenesis...
  8. ncbi Knockdown of synapse-associated protein Dlg1 reduces syncytium formation induced by human T-cell leukemia virus type 1
    Sakiko Yoshida
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Virus Genes 37:9-15. 2008
    ..These results suggest that Dlg1, through the interaction with GLUT1 as well as Env, plays a positive role in the syncytium formation induced by HTLV-1...
  9. ncbi Human T-cell leukemia virus type 1 Tax oncoprotein induces and interacts with a multi-PDZ domain protein, MAGI-3
    Minako Ohashi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
    Virology 320:52-62. 2004
    ..Our results suggest that the interaction of Tax1 and MAGI-3 alters their respective biological activities, which may play a role in transformation by Tax1 as well as in the pathogenesis of HTLV-1-associated diseases...
  10. ncbi Inactivation of tumor suppressor Dlg1 augments transformation of a T-cell line induced by human T-cell leukemia virus type 1 Tax protein
    Kojiro Ishioka
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, Japan
    Retrovirology 3:71. 2006
    ..The interaction of human T-cell leukemia virus type 1 (HTLV-1) Tax1 protein with the tumor suppressor Dlg1 is correlated with cellular transformation...
  11. ncbi A novel KRAB-Zinc finger protein interacts with latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus and activates transcription via terminal repeat sequences
    Akiko Watanabe
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata, 951 8510, Japan
    Virus Genes 34:127-36. 2007
    ..Our results suggest that KZLP and LANA regulate gene expression through TRs in the KSHV viral genome, including the K1 gene in latent KSHV-infected cells...
  12. ncbi The PDZ domain binding motif (PBM) of human T-cell leukemia virus type 1 Tax can be substituted by heterologous PBMs from viral oncoproteins during T-cell transformation
    Tomoya Aoyagi
    Division of Virology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Virus Genes 40:193-9. 2010
    ..The present results suggest that PBMs of high-risk oncoviruses have a common function(s) required for these three tumor viruses to transform cells, which is likely associated with the subtype-specific oncogenesis of these tumor viruses...
  13. ncbi PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein augments the transforming activity in a rat fibroblast cell line
    Akira Hirata
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan
    Virology 318:327-36. 2004
    ....
  14. ncbi PDZ domain-binding motif of human T-cell leukemia virus type 1 Tax oncoprotein is essential for the interleukin 2 independent growth induction of a T-cell line
    Chikako Tsubata
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Retrovirology 2:46. 2005
    ..HTLV-1 encodes the transforming gene tax1, whose expression in an interleukin (IL)-2-dependent T-cell line (CTLL-2) induces IL-2-independent growth...
  15. ncbi Visualization of a functional KSHV episome-maintenance protein LANA in living cells
    Takafumi Tetsuka
    Divisions of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
    Virus Genes 29:175-82. 2004
    ..Thus, GFP-LANA is a useful tool for the analyses of the functions and dynamics of LANA in living cells...
  16. ncbi Latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus interacts with human myeloid cell nuclear differentiation antigen induced by interferon alpha
    Masaya Fukushi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757, Asahimachi Dori, Niigata, 951 8510, Japan
    Virus Genes 27:237-47. 2003
    ..Our results suggest that LANA interacts with MNDA in KSHV-infected cells exposed to IFNalpha. Such interaction may modulate IFN-mediated host defense activities...
  17. ncbi Rearranged NF-kappa B2 gene in an adult T-cell leukemia cell line
    Masato Isogawa
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1 757 Asahimachi dori, Niigata 951 8510, Japan
    Cancer Sci 99:792-8. 2008
    ..These results suggest that such NF-kappa B2 gene rearrangement may therefore be a factor in the constitutive activation of NF-kappaB in ATL, and thereby playing a role in the ATL pathogenesis...
  18. ncbi [HTLV-1, 2]
    Masahiro Fujii
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences
    Nippon Rinsho 61:503-7. 2003
  19. ncbi Homotypic cell-cell adhesion induced by human T cell leukemia virus type 1 tax protein in T cell lines
    Toshiyuki Takahashi
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan
    Virology 302:132-43. 2002
    ..Taken together, our results suggest that Tax induces cell-cell adhesion and morphologic changes in HTLV-1-infected cells. Tax may thus play a role in persistent HTLV-1 infection and the pathogenesis of associated disease...
  20. ncbi Activation of mTOR by human T-cell leukemia virus type 1 Tax is important for the transformation of mouse T cells to interleukin-2-independent growth
    Manami Yoshita
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Cancer Sci 103:369-74. 2012
    ..These results suggest that Tax activates the mTOR pathway in T cells, and that this activation plays a crucial role in the growth of HTLV-1-infected T cells when a limited amount of IL-2 is available...
  21. ncbi Nucleotide sequences and functions of the Epstein-Barr virus latent membrane protein 1 genes isolated from salivary gland lymphoepithelial carcinomas
    Kai Yu Jen
    Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan
    Virus Genes 30:223-35. 2005
    ....
  22. ncbi [HTLV-1: multistep leukemogenesis of adult T-cell leukemia]
    Masahiro Fujii
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences
    Uirusu 52:103-8. 2002
  23. ncbi Human T-cell leukemia virus type 2 (HTLV-2) Tax protein transforms a rat fibroblast cell line but less efficiently than HTLV-1 Tax
    Keiichi Endo
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
    J Virol 76:2648-53. 2002
    ..Our results showed that Tax2 has a lower transforming activity than Tax1 and suggest that the high transforming activity of Tax1 is involved in the leukemogenic property of HTLV-1...
  24. ncbi Isolation and characterization of novel human parechovirus from clinical samples
    Kanako Watanabe
    Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
    Emerg Infect Dis 13:889-95. 2007
    ..Clinical symptoms of the persons infected with the NII561-2000-related viruses were infectious gastroenteritis, rash, upper respiratory tract infection, and paralysis, in addition to Reye syndrome in the 1-year-old girl...
  25. ncbi [Human herpesvirus 8/Kaposi's sarcoma-associated herpesvirus]
    Masahiro Fujii
    Division of Virology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata-shi, Niigata 951-8510, Japan
    Uirusu 52:281-5. 2002
  26. ncbi Chromosome binding site of latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus is essential for persistent episome maintenance and is functionally replaced by histone H1
    Hirohiko Shinohara
    Divisions of Virology. Thoracic and Cardiovascular Surgery, Graduate School of Medical and Dental Sciences, Niigata University, 1-757 Asahimachi-dori, Niigata 951-8510, Japan
    J Virol 76:12917-24. 2002
    ..Our results suggest that tethering of KSHV episomes to mitotic chromosomes by LANA1 is crucial in mediating the long-term maintenance of viral episomes in dividing cells...
  27. ncbi The Epstein-Barr virus latent membrane protein 1 putative Janus kinase 3 (JAK3) binding domain does not mediate JAK3 association or activation in B-lymphoma or lymphoblastoid cell lines
    Masaya Higuchi
    Channing Laboratory and Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115-5804, USA
    J Virol 76:455-9. 2002
    ....