T Akihisa

Summary

Affiliation: Nihon University
Country: Japan

Publications

  1. ncbi Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Nat Prod 65:462-5. 2002
  2. ncbi Cucurbitane-type triterpenoids from the fruit of Momordica charantia
    Yumiko Kimura
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Nat Prod 68:807-9. 2005
  3. ncbi Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Life Sci 77:2127-40. 2005
  4. ncbi Acyclic and incompletely cyclized triterpene alcohols in the seed oils of theaceae and gramineae
    T Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Lipids 34:1151-7. 1999
  5. ncbi Cancer chemopreventive effects of polyunsaturated fatty acids
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    Cancer Lett 205:9-13. 2004
  6. ncbi Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugdai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 67:407-10. 2004
  7. ncbi Triacylglycerol and triterpene ester composition of shea nuts from seven African countries
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    J Oleo Sci 60:385-91. 2011
  8. ncbi Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Tokyo 101 8308, Japan
    J Nat Prod 70:1233-9. 2007
  9. ncbi Antitubercular activity of triterpenoids from Asteraceae flowers
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Biol Pharm Bull 28:158-60. 2005
  10. ncbi Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Agric Food Chem 53:562-5. 2005

Collaborators

Detail Information

Publications61

  1. ncbi Inhibition of tumor-promoting effects by poricoic acids G and H and other lanostane-type triterpenes and cytotoxic activity of poricoic acids A and G from Poria cocos
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Nat Prod 65:462-5. 2002
    ..3 nM], although it showed only moderate cytotoxicity to the other cells. Compound 4 exhibited moderate cytotoxicity to all of the cancer cell lines tested...
  2. ncbi Cucurbitane-type triterpenoids from the fruit of Momordica charantia
    Yumiko Kimura
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Nat Prod 68:807-9. 2005
    ..This is the first report of the isolation of tetracyclic triterpenoids possessing a delta23,25-conjugated diene system, viz., 1 and 2, from a natural source...
  3. ncbi Structural analysis of isosteviol and related compounds as DNA polymerase and DNA topoisomerase inhibitors
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science, Kobe Gakuin University, Nishi ku, Kobe, Hyogo 651 2180, Japan
    Life Sci 77:2127-40. 2005
    ..0%). The relationship between the structure of stevioside-based compounds and these activities were discussed...
  4. ncbi Acyclic and incompletely cyclized triterpene alcohols in the seed oils of theaceae and gramineae
    T Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Lipids 34:1151-7. 1999
    ..Two other compounds isolated were characterized as (2Z,6Z,10E,14E)-geranylfarnesol, a sesterterpene alcohol, and phytol, a diterpene alcohol. Graminol A and (2Z,6Z,10E,14E)-geranylfarnesol are considered to be new natural products...
  5. ncbi Cancer chemopreventive effects of polyunsaturated fatty acids
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    Cancer Lett 205:9-13. 2004
    ..Furthermore, DHA methyl ester exhibited remarkable anti-tumor-promoting activity on an in vivo two-stage carcinogenesis test of mouse tumor using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter...
  6. ncbi Microbial transformation of isosteviol and inhibitory effects on Epstein-Barr virus activation of the transformation products
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugdai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 67:407-10. 2004
    ..All the diterpenes tested showed potent inhibitory effects, with the five metabolites 3-7 exhibiting more potent effects...
  7. ncbi Triacylglycerol and triterpene ester composition of shea nuts from seven African countries
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    J Oleo Sci 60:385-91. 2011
    ..No striking regional difference in the composition of the TE fractions was observed...
  8. ncbi Cucurbitane-type triterpenoids from the fruits of Momordica charantia and their cancer chemopreventive effects
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Tokyo 101 8308, Japan
    J Nat Prod 70:1233-9. 2007
    ..Compounds 1 and 2 exhibited marked inhibitory effects in both 7,12-dimethylbenz[a]anthracene (DMBA)- and peroxynitrite (ONOO-; PN)-induced mouse skin carcinogenesis tests...
  9. ncbi Antitubercular activity of triterpenoids from Asteraceae flowers
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Biol Pharm Bull 28:158-60. 2005
    ..Cytotoxicity of compound 17 against Vero cells gave an IC50 value of over 62.5 microg/ml, suggesting some degree of selectivity for M. tuberculosis...
  10. ncbi Azaphilones, furanoisophthalides, and amino acids from the extracts of Monascus pilosus-fermented rice (red-mold rice) and their chemopreventive effects
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Agric Food Chem 53:562-5. 2005
    ..All of the compounds tested showed moderate inhibitory effects on NOR 1 activation...
  11. ncbi Oxygenated lanostane-type triterpenoids from the fungus ganodermalucidum
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 68:559-63. 2005
    ....
  12. ncbi Triterpene acids from Poria cocos and their anti-tumor-promoting effects
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 70:948-53. 2007
    ..Compound 12 and poricoic acid C (13) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter...
  13. ncbi Antitubercular activity and inhibitory effect on Epstein-Barr virus activation of sterols and polyisoprenepolyols from an edible mushroom, Hypsizigus marmoreus
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Biol Pharm Bull 28:1117-9. 2005
    ..Sterols 6 and 7 showed potent inhibitory effects while preserving the high viability of Raji cells...
  14. ncbi Anti-inflammatory and potential cancer chemopreventive constituents of the fruits of Morinda citrifolia (Noni)
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 70:754-7. 2007
    ..In addition, when compounds 1-13 were evaluated against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA, all of the compounds exhibited moderate inhibitory effects (IC50 values of 386-578 mol ratio/32 pmol TPA)...
  15. ncbi Cucurbitane glycosides from the fruits of Siraitia gros venorii and their inhibitory effects on Epstein-Barr virus activation
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 70:783-8. 2007
    ..In addition, compounds 1-8 showed weak inhibitory effects on activation of (+/-)-(E)-methyl-2-[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitric oxide (NO) donor...
  16. ncbi Anti-inflammatory and anti-tumor-promoting effects of triterpene acids and sterols from the fungus Ganoderma lucidum
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Kanda Surugadai, Chiyoda ku, Tokyo, Japan
    Chem Biodivers 4:224-31. 2007
    ..Further, 20-hydroxylucidenic acid N (18) exhibited inhibitory effects on skin-tumor promotion in an in vivo two-stage mouse-skin carcinogenesis test based on 7,12-dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter...
  17. ncbi Chalcones and other compounds from the exudates of Angelica keiskei and their cancer chemopreventive effects
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Tokyo 101 8308, Japan
    J Nat Prod 69:38-42. 2006
    ..Further, isobavachalcone (4) exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter...
  18. ncbi Anti-tumor-initiating effects of monascin, an azaphilonoid pigment from the extract of Monascus pilosus fermented rice (red-mold rice)
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    Chem Biodivers 2:1305-9. 2005
    ..These findings suggest that compound 1 may be valuable as potential cancer chemopreventive agent in chemical and environmental carcinogenesis...
  19. ncbi Biotransformation of cycloartane-type triterpenes by the fungus Glomerella fusarioides
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 69:604-7. 2006
    ..The structures of four new metabolites, 7, 8, 9, and 14, were established by spectroscopic methods...
  20. ncbi Acerogenin M, a cyclic diarylheptanoid, and other phenolic compounds from Acer nikoense and their anti-inflammatory and anti-tumor-promoting effects
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, 101 8308 Tokyo, Japan
    Chem Pharm Bull (Tokyo) 54:735-9. 2006
    ....
  21. ncbi Dehydrotrametenonic acid and dehydroeburiconic acid from Poria cocos and their inhibitory effects on eukaryotic DNA polymerase alpha and beta
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Biosci Biotechnol Biochem 68:448-50. 2004
    ..Compounds 1 and 2 inhibited calf DNA polymerase alpha and rat DNA polymerase beta, with the 50% inhibition values of 45.5 microM (1) and 40.8 microM (2), and 86.5 microM (1) and 30.0 microM (2), respectively...
  22. ncbi Anti-tumor-promoting effects of 25-methoxyporicoic acid A and other triterpene acids from Poria cocos
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 72:1786-92. 2009
    ..Further, 17 compounds, 1-14, 16, 18, and 19, were evaluated for their cytotoxic activity against two human tumor cell lines, HL60 (leukemia) and CRL1579 (melanoma)...
  23. ncbi Triterpene alcohol and sterol ferulates from rice bran and their anti-inflammatory effects
    T Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    J Agric Food Chem 48:2313-9. 2000
    ..On the other hand, whereas two free triterpene alcohols, CAR and 24-MCA, showed strong inhibition (ID(50) 0.2-0.3 mg/ear), eight free sterols examined showed weaker activity (ID(50) 0.7-2.7 mg/ear) than their corresponding ferulates...
  24. ncbi Inhibitory effects of triterpenoids and sterols on human immunodeficiency virus-1 reverse transcriptase
    T Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Lipids 36:507-12. 2001
    ..4 microM), and karounidiol 29-benzoate (2.2 microM) inhibited most effectively. Some of the triterpenoids and sterols may be potential new lead compounds to find still more potent HIV-1 reverse transcriptase inhibitors...
  25. ncbi Anti-tumor promoting effects of multiflorane-type triterpenoids and cytotoxic activity of karounidiol against human cancer cell lines
    T Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    Cancer Lett 173:9-14. 2001
    ..Their structure-activity relationship is discussed. Evaluation of the cytotoxic activity of karounidiol (27) against human cancer cell lines exhibited cytotoxicity especially against a human renal cancer...
  26. ncbi 4-Hydroxyderricin from Angelica keiskei roots induces caspase-dependent apoptotic cell death in HL60 human leukemia cells
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    J Oleo Sci 60:71-7. 2011
    ..4-Hydroxyderricin may therefore hold promise as an effective antitumor agent...
  27. ncbi Eupha-7,9(11),24-trien-3beta-ol ("antiquol C") and other triterpenes from Euphorbia antiquorum latex and their inhibitory effects on Epstein-Barr virus activation
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 65:158-62. 2002
    ....
  28. ncbi Microbial transformations of two lupane-type triterpenes and anti-tumor-promoting effects of the transformation products
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 65:278-82. 2002
    ..All of the triterpenes tested showed potent inhibitory effects, with the four metabolites 3-6 exhibiting the more potent effects...
  29. ncbi The melanogenesis-inhibitory, anti-inflammatory, and chemopreventive effects of limonoids in n-hexane extract of Azadirachta indica A. Juss. (neem) seeds
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    J Oleo Sci 60:53-9. 2011
    ..The triacylglycerol fraction of the n-hexane extract contained oleic acid (50.2%) as the most predominant fatty acid constituent...
  30. ncbi Cancer chemopreventive effects and cytotoxic activities of the triterpene acids from the resin of Boswellia carteri
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    Biol Pharm Bull 29:1976-9. 2006
    ..Further, fifteen compounds, 1-7, 9-11, 13-15, 17, and 18, exhibited potent cytotoxic activities with IC(50) values of 4.1-82.4 muM against all of the three human neuroblastoma cells tested...
  31. ncbi 3-epicabraleahydroxylactone and other triterpenoids from camellia oil and their inhibitory effects on Epstein-Barr virus activation
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    Chem Pharm Bull (Tokyo) 52:153-6. 2004
    ....
  32. ncbi Melanogenesis inhibitory, anti-inflammatory, and chemopreventive effects of limonoids from the seeds of Azadirachta indicia A. Juss. (neem)
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo, Japan
    J Oleo Sci 58:581-94. 2009
    ....
  33. ncbi Melanogenesis inhibitory activities of iridoid-, hemiterpene-, and fatty acid-glycosides from the fruits of Morinda citrifolia (Noni)
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, Tokyo 101 8308, Japan
    J Oleo Sci 59:49-57. 2010
    ....
  34. ncbi Chalcones, coumarins, and flavanones from the exudate of Angelica keiskei and their chemopreventive effects
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    Cancer Lett 201:133-7. 2003
    ....
  35. ncbi Anti-inflammatory and chemopreventive effects of triterpene cinnamates and acetates from shea fat
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 1001 8308, Japan
    J Oleo Sci 59:273-80. 2010
    ....
  36. ncbi Triterpene alcohol and fatty acid composition of shea nuts from seven African countries
    Toshihiro Akihisa
    College of Science and Technology, Nihon University
    J Oleo Sci 59:351-60. 2010
    ..Both stearic acid and total triterpene alcohol contents were significantly correlated to the latitude and elevation of the source population, indicating that higher levels of these compounds are found at higher ambient temperatures...
  37. ncbi Anti-inflammatory and anti-tumor-promoting effects of cucurbitane glycosides from the roots of Bryonia dioica
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 65:179-83. 2002
    ..2-0.6 mg per ear. In addition, all of the compounds tested except for compound 5 showed potent inhibitory effects on EBV-EA induction (100% inhibition at 1 x 10(3) mol ratio/TPA)...
  38. ncbi Constituents of compositae plants. 2. Triterpene diols, triols, and their 3-o-fatty acid esters from edible chrysanthemum flower extract and their anti-inflammatory effects
    M Ukiya
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Agric Food Chem 49:3187-97. 2001
    ..All of the triterpenes examined showed marked inhibitory activity, with a 50% inhibitory dose (ID50) of 0.03-1.0 mg/ear, which was more inhibitive than quercetin (ID50 = 1.6 mg/ear), a known inhibitor of TPA-induced inflammation in mice...
  39. ncbi Anti-inflammatory, anti-tumor-promoting, and cytotoxic activities of constituents of marigold (Calendula officinalis) flowers
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Nat Prod 69:1692-6. 2006
    ....
  40. ncbi Triterpene glycosides from the flower petals of sunflower (Helianthus annuus) and their anti-inflammatory activity
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 70:813-6. 2007
    ..7 nmol/ear) in mice, all of the compounds tested exhibited marked anti-inflammatory activity, with ID50 values in the range 65-262 nmol per ear...
  41. ncbi Constituents of Compositae plants III. Anti-tumor promoting effects and cytotoxic activity against human cancer cell lines of triterpene diols and triols from edible chrysanthemum flowers
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    Cancer Lett 177:7-12. 2002
    ....
  42. ncbi Sunpollenol and five other rearranged 3,4-seco-tirucallane-type triterpenoids from sunflower pollen and their inhibitory effects on Epstein-Barr virus activation
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Nat Prod 66:1476-9. 2003
    ..All of the compounds tested showed potent inhibitory effects on EBV-EA activation (97-100% inhibition at 1 x 10(3) mol ratio/TPA)...
  43. ncbi Three new cyclic diarylheptanoids and other phenolic compounds from the bark of Myrica rubra and their melanogenesis inhibitory and radical scavenging activities
    Hiroyuki Akazawa
    College of Science and Technology, Nihon University, Tokyo, Japan
    J Oleo Sci 59:213-21. 2010
    ..6-7.3 microg/mL)]...
  44. ncbi Inhibitory effects of cucurbitane glycosides and other triterpenoids from the fruit of Momordica grosvenori on epstein-barr virus early antigen induced by tumor promoter 12-O-tetradecanoylphorbol-13-acetate
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Agric Food Chem 50:6710-5. 2002
    ..All of the compounds tested showed potent inhibitory effects on EBV-EA induction (70-100% inhibition at 1 x 10(3) mol ratio/TPA)...
  45. ncbi (+)- and (-)-syn-2-isobutyl-4-methylazetidine-2,4-dicarboxylic acids from the extract of Monascus pilosus-fermented rice (red-mold rice)
    Toshihiro Akihisa
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Nat Prod 67:479-80. 2004
    ....
  46. ncbi Melanogenesis inhibitory and free radical scavenging activities of diarylheptanoids and other phenolic compounds from the bark of Acer nikoense
    Hiroyuki Akazawa
    College of Science and Technology, Nihon University, Kanda Surugadai, Tokyo, Japan
    Biol Pharm Bull 29:1970-2. 2006
    ..0 microgM) followed by compounds 1, 3, 4, and 6 (IC(50) 40.2-44.0 microgM) showed potent scavenging activities...
  47. ncbi Isolation, structural elucidation, and inhibitory effects of terpenoid and lipid constituents from sunflower pollen on Epstein-Barr virus early antigen induced by tumor promoter, TPA
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1-8 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
    J Agric Food Chem 51:2949-57. 2003
    ..Among the 30 compounds tested, 21 compounds possessing a di- or a polycyclic ring system in the molecule (1-4, 6-16, and 19-24) showed potent inhibitory effects on EBV-EA induction (91-100% inhibition at 1 x 10(3) mol ratio/TPA)...
  48. ncbi Antitumor-promoting effects and cytotoxic activities of dammar resin triterpenoids and their derivatives
    Motohiko Ukiya
    College of Science and Technology, Nihon University, 1 8 Kanda Surugadai, Chiyoda ku, Tokyo 101 8308, Japan
    Chem Biodivers 7:1871-84. 2010
    ..e., 21 and 22) or conjugation with L-amino acids (i.e., 23-34) of compound 1 enhanced the cytotoxicity against human melanoma cell line CRL1579...
  49. ncbi Proteomic analysis of apoptosis induced by xanthoangelol, a major constituent of Angelica keiskei, in neuroblastoma
    Kou Motani
    Research Unit of Clinical Medicine, College of Pharmacy, Nihon University, 7 7 1 Narashinodai, Funabashi, Chiba 274 8555, Japan
    Biol Pharm Bull 31:618-26. 2008
    ..These findings suggest that xanthoangelol induces apoptosis by increasing reactive oxygen species and targeting DJ-1, and such mechanism may be an effective therapeutic approach for advanced neuroblastoma...
  50. ncbi Cancer chemopreventive effects of cycloartane-type and related triterpenoids in in vitro and in vivo models
    Takashi Kikuchi
    College of Science and Technology, Nihon University, 1 8 Kanda Surugdai, Chiyoda ku, Tokyo 101 8308, Japan
    J Nat Prod 70:918-22. 2007
    ..Furthermore, compounds 14 and 15 exhibited inhibitory effects on skin tumor promotion in an in vivo two-stage mouse skin carcinogenesis test using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter...
  51. ncbi Isobavachalcone, a chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma
    Reiko Nishimura
    Research Unit of Clinical Medicine, College of Pharmacy, Nihon University, Funabashi, Chiba, Japan
    Biol Pharm Bull 30:1878-83. 2007
    ..Therefore, isobavachalcone may be applicable as an efficacious and safe drug for the treatment of neuroblastoma...
  52. ncbi Xanthoangelol, a major chalcone constituent of Angelica keiskei, induces apoptosis in neuroblastoma and leukemia cells
    Keiichi Tabata
    Clinical Pharmacy Center, College of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi, Chiba 274-8555, Japan
    Biol Pharm Bull 28:1404-7. 2005
    ..Therefore, xanthoangelol may be applicable as an effective drug for treatment of neuroblastoma and leukemia...
  53. ncbi Albanol A from the root bark of Morus alba L. induces apoptotic cell death in HL60 human leukemia cell line
    Takashi Kikuchi
    College of Science and Technology, Nihon University, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 58:568-71. 2010
    ..Therefore, albanol A may be a promising lead compound for developing an effective drug for treatment of leukemia...
  54. ncbi Oxyfunctionalization of unactivated C-H bonds in triterpenoids with tert-butylhydroperoxide catalyzed by meso-5,10,15,20-tetramesitylporphyrinate osmium(II) carbonyl complex
    Shoujiro Ogawa
    Department of Chemistry, College of Humanities and Sciences, Nihon University, Sakurajousui, Setagaya Ku, Tokyo 156 8550, Japan
    Chem Phys Lipids 163:165-71. 2010
    ..Factors governing the regioselectivity and the possible mechanism for the oxyfunctionalization of the unactivated carbons are also discussed...
  55. ncbi A novel DNA topoisomerase inhibitor: dehydroebriconic acid, one of the lanostane-type triterpene acids from Poria cocos
    Yoshiyuki Mizushina
    Laboratory of Food and Nutritional Sciences, Department of Nutritional Science and High Technology Research Center, Kobe Gakuin University, Kobe, Hyogo 651 2180, Japan
    Cancer Sci 95:354-60. 2004
    ..6 and 38.4 microM, respectively. The cells were halted at the G1 phase in the cell cycle. The relation between the structure of triterpene acids and their inhibitory activities is discussed...
  56. ncbi Lucidenic acids P and Q, methyl lucidenate P, and other triterpenoids from the fungus Ganoderma lucidum and their inhibitory effects on Epstein-Barr virus activation
    Kenji Iwatsuki
    K-Laboratories for Intelligent Medical Remote Services, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan
    J Nat Prod 66:1582-5. 2003
    ..All of the compounds tested showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 x 10(3) mol ratio/TPA)...
  57. ncbi Sterol ferulates, sterols, and 5-alk(en)ylresorcinols from wheat, rye, and corn bran oils and their inhibitory effects on Epstein-Barr virus activation
    Kenji Iwatsuki
    K-Laboratories for Intelligent Medical Remote Services, 2266-22 Anagahora, Shimoshidami, Moriyama-ku, Nagoya 463-0003, Japan
    J Agric Food Chem 51:6683-8. 2003
    ..Four compounds, 1, 2, 4, and 11, showed potent inhibitory effects on EBV-EA induction...
  58. ncbi Triterpene acids from the leaves of Perilla frutescens and their anti-inflammatory and antitumor-promoting effects
    Norihiro Banno
    Ichimaru Pharcos Company Ltd, Gifu, Japan
    Biosci Biotechnol Biochem 68:85-90. 2004
    ..Furthermore, compound 5 exhibited strong antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz(a)anthracene (DMBA) as an initiator and TPA as a promoter...
  59. ncbi Anti-inflammatory activities of the triterpene acids from the resin of Boswellia carteri
    Norihiro Banno
    Ichimaru Pharcos Company Ltd, 318-1 Asagi, Motosu, Gifu 501-0475, Japan
    J Ethnopharmacol 107:249-53. 2006
    ..05-0.49 mg/ear...
  60. ncbi Anti-inflammatory and antitumor-promoting effects of the triterpene acids from the leaves of Eriobotrya japonica
    Norihiro Banno
    Ichimaru Pharcos Company Ltd; 318-1 Asaki, Motosu, Gifu 501-0475, Japan
    Biol Pharm Bull 28:1995-9. 2005
    ..Furthermore, euscaphic acid (12) exhibited marked antitumor-promoting activity in an in vivo two-stage carcinogenesis test of mouse tumor by using 7,12-dimethylbenz[a]anthracene (DMBA) as an initiator and TPA as a promoter...
  61. ncbi Selinidin suppresses IgE-mediated mast cell activation by inhibiting multiple steps of Fc epsilonRI signaling
    Sachiko Kishiro
    Division of Molecular Cell Immunology and Allergology, Nihon University Graduate School of Medical Science, 30 1 Oyaguchikami cho, Itabashi ku, Tokyo 173 8610, Japan
    Biol Pharm Bull 31:442-8. 2008
    ..These results suggest that this compound suppresses IgE-mediated mast cell activation by inhibiting multiple steps of FcepsilonRI-dependent signaling pathways and would be beneficial for the prevention of allergic inflammation...