Nahoko Uchiyama

Summary

Affiliation: National Institute of Health Sciences
Country: Japan

Publications

  1. ncbi [Analysis of designer drugs detected in the products purchased in fiscal year 2006]
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Yakugaku Zasshi 128:1499-505. 2008
  2. ncbi Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi
    Soodabeh Saeidnia
    Department of Pharmacy, Faculty of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran
    Chem Pharm Bull (Tokyo) 52:1249-50. 2004
  3. ncbi Effects of synthetic cannabinoids on electroencephalogram power spectra in rats
    Nahoko Uchiyama
    National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Forensic Sci Int 215:179-83. 2012
  4. ncbi [Analytical data of designated substances (Shitei-Yakubutsu) controlled by the Pharmaceutical Affairs Law in Japan, part II: Color test and TLC]
    Nahoko Uchiyama
    National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Yakugaku Zasshi 128:981-7. 2008
  5. ncbi [Analysis of newly distributed designer drugs detected in the products purchased in fiscal year 2008]
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Yakugaku Zasshi 130:263-70. 2010
  6. ncbi HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Pharm Biomed Anal 46:864-9. 2008
  7. ncbi Iridoid glycosides and cucurbitacin glycoside from Neopicrorhiza scrophulariiflora
    Ik Hwi Kim
    National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Phytochemistry 67:2691-6. 2006
  8. ncbi [Analytical data of designated substances (Shitei-Yakubutsu) controlled by the Pharmaceutical Affairs Law in Japan, part I: GC-MS and LC-MS]
    Ruri Kikura-Hanajiri
    National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Yakugaku Zasshi 128:971-9. 2008
  9. ncbi Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 56:1331-4. 2008
  10. ncbi Identification of a cannabinoid analog as a new type of designer drug in a herbal product
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 57:439-41. 2009

Collaborators

  • Nobuo Kawahara
  • R Kikura
  • Yuji Haishima
  • Kiyoshi Fukuhara
  • Hiroshi Morita
  • Khalijah Awang
  • Yukihiro Goda
  • Ruri Kikura-Hanajiri
  • Ik Hwi Kim
  • Yusuke Hirasawa
  • Fumiyuki Kiuchi
  • Soodabeh Saeidnia
  • Gisho Honda
  • Alfarius E Nugroho
  • Jun Deguchi
  • Motoo Shiro
  • A Hamid A Hadi
  • Takashi Arai
  • Takahiro Hosoya
  • Tomokazu Shoji
  • Kazuhiro Saisho
  • Jun Ogata
  • Maiko Kawamura
  • Hiroyuki Kamakura
  • Noriko Kaneko
  • Ji Ean Lee
  • Koichi Takeya
  • Michiho Ito
  • Ahmad Reza Gohari
  • Takashi Aoki
  • Junko Nakajima-Shimada
  • Akiko Tsubouchi
  • Yoshiaki Itano

Detail Information

Publications18

  1. ncbi [Analysis of designer drugs detected in the products purchased in fiscal year 2006]
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Yakugaku Zasshi 128:1499-505. 2008
    ..5-MeO-EIPT was newly identified in this study...
  2. ncbi Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi
    Soodabeh Saeidnia
    Department of Pharmacy, Faculty of Pharmacy, Medical Sciences University of Mazandaran, Sari, Iran
    Chem Pharm Bull (Tokyo) 52:1249-50. 2004
    ..Compounds 1 (3.1 microM), 2 (3.1 microM), 3 (3.1 microM), 5 (6.2 microM), 6 (6.2 microM), and 8 (6.2 microM) were effective against epimastigotes of Trypanosoma cruzi...
  3. ncbi Effects of synthetic cannabinoids on electroencephalogram power spectra in rats
    Nahoko Uchiyama
    National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Forensic Sci Int 215:179-83. 2012
    ..Among the three compounds, CCH and CP-47,497 exerted a longer duration of the change in the EEG power spectra and suppression of the locomotor activity than JWH-018...
  4. ncbi [Analytical data of designated substances (Shitei-Yakubutsu) controlled by the Pharmaceutical Affairs Law in Japan, part II: Color test and TLC]
    Nahoko Uchiyama
    National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Yakugaku Zasshi 128:981-7. 2008
    ..All substances were detected by UV(254 nm) and an iodoplatinate reagent. These results suggest that color tests and TLC, followed by GC-MS and LC-MS analyses, can be used for preliminary identification of designated substances...
  5. ncbi [Analysis of newly distributed designer drugs detected in the products purchased in fiscal year 2008]
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Yakugaku Zasshi 130:263-70. 2010
    ..N-Me-2-FMP and 5-MeO-EPT were newly identified in this study. Additionally, ALEPH-4 and DON were found as novel illegal drugs distributed in Japan...
  6. ncbi HPLC separation of naringin, neohesperidin and their C-2 epimers in commercial samples and herbal medicines
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Pharm Biomed Anal 46:864-9. 2008
    ....
  7. ncbi Iridoid glycosides and cucurbitacin glycoside from Neopicrorhiza scrophulariiflora
    Ik Hwi Kim
    National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Phytochemistry 67:2691-6. 2006
    ..Their structures were elucidated on the basis of both chemical and spectroscopic data...
  8. ncbi [Analytical data of designated substances (Shitei-Yakubutsu) controlled by the Pharmaceutical Affairs Law in Japan, part I: GC-MS and LC-MS]
    Ruri Kikura-Hanajiri
    National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Yakugaku Zasshi 128:971-9. 2008
    ....
  9. ncbi Determination of a new type of phosphodiesterase-5 inhibitor, thioquinapiperifil, in a dietary supplement promoted for sexual enhancement
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 56:1331-4. 2008
    ..Quantitative analysis showed that the contents of 1 and thiodenafil in the products were about 13-15 mg/tablet (43-48 microg/mg) and about 0.4 mg/tablet (1 microg/mg), respectively...
  10. ncbi Identification of a cannabinoid analog as a new type of designer drug in a herbal product
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 57:439-41. 2009
    ..and reported as a potent cannabinoid analog possessing cannabinoid receptor binding activity and analgesic activity in the 1990 s. This is the first report to identify a cannabinoid analog in an illegal drug...
  11. ncbi [Isomeric analysis of synthetic cannabinoids detected as designer drugs]
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Yakugaku Zasshi 131:1141-7. 2011
    ....
  12. ncbi Identification of a novel cannabimimetic phenylacetylindole, cannabipiperidiethanone, as a designer drug in a herbal product and its affinity for cannabinoid CB? and CB? receptors
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 59:1203-5. 2011
    ..3- and 9.4-fold lower affinities than those of JWH-250. This is the first report to identify cannabimimetic compound (1) as a designer drug and to show its binding affinity to cannabinoid receptors...
  13. ncbi Two phenylpropanoid glycosides from Neopicrorhiza scrophulariiflora
    Ik Hwi Kim
    National Institute of Health Sciences (NIHS, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 54:275-7. 2006
    ..Their structures were elucidated on the basis of both chemical and spectroscopic data...
  14. ncbi Survey of current trends in the abuse of psychotropic substances and plants in Japan
    Ruri Kikura-Hanajiri
    National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya, Tokyo 158 8501, Japan
    Leg Med (Tokyo) 13:109-15. 2011
    ..In this review, we survey current trends in the abuse of psychotropic substances and plants in Japan, focusing especially on synthetic cannabinoids, cathinone derivatives and psychotropic plants...
  15. ncbi Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii
    Yusuke Hirasawa
    Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan
    Bioorg Med Chem Lett 20:2021-4. 2010
    ..The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines...
  16. ncbi Chemical analysis of synthetic cannabinoids as designer drugs in herbal products
    Nahoko Uchiyama
    National Institute of Health Sciences, Setagaya Ku, Tokyo, Japan
    Forensic Sci Int 198:31-8. 2010
    ..6 to 210.9mg/g, respectively, and showed considerable variation. In this study, details of the analysis and identification of these synthetic cannabinoids in herbal products being sold on the Japanese drug market are described...
  17. ncbi HPLC separation of hesperidin and the C-2 epimer in commercial hesperidin samples and herbal medicines
    Nahoko Uchiyama
    National Institute of Health Sciences, Tokyo, Japan
    Chirality 17:373-7. 2005
    ..Because diastereomers differ from each other in physicochemical and biological activities, HPLC to separate hesperidin from the C-2 epimer should be introduced into the letter of approval for herbal medicines...
  18. ncbi Monoterpene hydroperoxides with trypanocidal activity from Chenopodium ambrosioides
    Fumiyuki Kiuchi
    Graduate School of Pharmaceutical Sciences, Kyoto University, 46 29 Yoshida, Sakyo ku, Kyoto, 606 8501, Japan
    J Nat Prod 65:509-12. 2002
    ..8 microM, respectively. Fresh leaves of C. ambrosioides also contained isomeric hydroperoxides 6a and 7a, and the content ratio of 2a-7a suggested that these hydroperoxides were formed through the singlet-oxygen oxidation of limonene...