H Tanahashi

Summary

Affiliation: National Institute of Neuroscience
Country: Japan

Publications

  1. ncbi X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Tokyo, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 255:663-7. 1999
  2. ncbi Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Neurosci Lett 261:143-6. 1999
  3. ncbi Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neuroreport 10:2575-8. 1999
  4. ncbi Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 258:385-9. 1999
  5. ncbi Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 9:2281-9. 2000
  6. ncbi Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 307:9-12. 2001
  7. ncbi Cloning of the cDNA encoding rat presenilin-2
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Biochim Biophys Acta 1396:259-62. 1998
  8. ncbi Isolation of human delta-catenin and its binding specificity with presenilin 1
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neuroreport 10:563-8. 1999
  9. ncbi A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus
    M Hattori
    Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
    Nucleic Acids Res 25:1802-8. 1997

Collaborators

Detail Information

Publications9

  1. ncbi X11L2, a new member of the X11 protein family, interacts with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Tokyo, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 255:663-7. 1999
    ..Unlike other members of the X11 protein family, X11L2 mRNA was expressed in various tissues...
  2. ncbi Molecular cloning of human Fe65L2 and its interaction with the Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Neurosci Lett 261:143-6. 1999
    ..We also confirmed that the carboxyl-terminal region of PID/PTB of the Fe65L2 interacted with the intracellular domain of the Alzheimer's beta-amyloid precursor protein (APP) and APP-like proteins...
  3. ncbi Genomic organization of the human X11L2 gene (APBA3), a third member of the X11 protein family interacting with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neuroreport 10:2575-8. 1999
    ..The APBA3 was localized by the radiation hybrid mapping to chromosome 19. Determination of the APBA3 genome structure will facilitate the linkage analysis and search for mutations in the APBA3 in patients with Alzheimer's disease...
  4. ncbi Genome structure and chromosomal mapping of the gene for Fe65L2 interacting with Alzheimer's beta-amyloid precursor protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, 187 8502, Japan
    Biochem Biophys Res Commun 258:385-9. 1999
    ..Characterization of the Fe65L2 gene structure will be useful in the linkage analysis and search for mutations in the Fe65L2 gene in patients with Alzheimer's disease...
  5. ncbi Alzheimer's disease-associated presenilin 2 interacts with DRAL, an LIM-domain protein
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Hum Mol Genet 9:2281-9. 2000
    ..The potential role of DRAL in the cellular signaling suggests that DRAL functions as an adaptor protein that links PS2 to an intracellular signaling...
  6. ncbi Three novel alternatively spliced isoforms of the human beta-site amyloid precursor protein cleaving enzyme (BACE) and their effect on amyloid beta-peptide production
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 307:9-12. 2001
    ..Moreover, the beta-secretase activity of BACE-I-457 and BACE-I-476 was significantly weaker than that of BACE-501. Thus, these isoforms may contribute to a physiological function of BACE...
  7. ncbi Cloning of the cDNA encoding rat presenilin-2
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Tokyo, Japan
    Biochim Biophys Acta 1396:259-62. 1998
    ..9%), mouse (96.4%) and Xenopus (70.8%). A minor splicing variant lacking a single glutamate was detected, while the product corresponding to the exon 9 deleted splicing variant observed in human was not detected...
  8. ncbi Isolation of human delta-catenin and its binding specificity with presenilin 1
    H Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, Kodaira, Tokyo, Japan
    Neuroreport 10:563-8. 1999
    ..These results suggest that PS1 and PS2 partly differ in function. PS1 loop fragment containing the pathogenic mutation retained the binding ability. We also found another armadillo-protein, p0071, interacted with PS1...
  9. ncbi A novel method for making nested deletions and its application for sequencing of a 300 kb region of human APP locus
    M Hattori
    Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo 108, Japan
    Nucleic Acids Res 25:1802-8. 1997
    ..8, reasonably low cost and very few gaps remaining to be closed. Development of some new instruments and software is also described which makes this method more applicable for large-scale sequencing...