Research Topics
Genomes and Genes | Takahiro OchiSummaryAffiliation: National Hospital Organization Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Proinflammatory role of amphiregulin, an epidermal growth factor family member whose expression is augmented in rheumatoid arthritis patientsShoji Yamane
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sakuradai 18 1, Sagamihara, Kanagawa 228 8522, Japan
J Inflamm (Lond) 5:5. 2008....- Enhanced expression of mRNA for nuclear factor kappaB1 (p50) in CD34+ cells of the bone marrow in rheumatoid arthritisShunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo 173 8605, Japan
Arthritis Res Ther 8:R54. 2006..These results indicate that the enhanced expression of NFkappaB1 mRNA in bone marrow CD34+ cells plays a pivotal role in their abnormal responses to TNF-alpha and, thus, in the pathogenesis of RA... - Mesenchymal stromal cells. Nurse-like cells reside in the synovial tissue and bone marrow in rheumatoid arthritisTakahiro Ochi
Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
Arthritis Res Ther 9:201. 2007..The present review considers the evidence that supports these possibilities... - The interaction of monocytes with rheumatoid synovial cells is a key step in LIGHT-mediated inflammatory bone destructionSatoru Ishida
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
Immunology 128:e315-24. 2009.... - Regional differences in chondrocyte metabolism in osteoarthritis: a detailed analysis by laser capture microdissectionNaoshi Fukui
National Hospital Organization Sagamihara Hospital, Sagamihara, Japan
Arthritis Rheum 58:154-63. 2008..To determine the change in metabolic activity of chondrocytes in osteoarthritic (OA) cartilage, considering regional difference and degree of cartilage degeneration... - Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulationNaoshi Fukui
Department of Pathomechanisms, Clinical Research Center, National Hospital Organization Sagamihara Hospital, Sagamihara, Kanagawa, and Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, Japan
J Biol Chem 281:27229-41. 2006.... - LIGHT induces cell proliferation and inflammatory responses of rheumatoid arthritis synovial fibroblasts via lymphotoxin beta receptorSatoru Ishida
Clinical Research Center for Allergy and Rheumatology, National Hospital Organization, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
J Rheumatol 35:960-8. 2008.... - A new biotechnology for articular cartilage repair: subchondral implantation of a composite of interconnected porous hydroxyapatite, synthetic polymer (PLA-PEG), and bone morphogenetic protein-2 (rhBMP-2)Noriyuki Tamai
Department of Orthopaedic Surgery, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
Osteoarthritis Cartilage 13:405-17. 2005..Hence, this novel cell-free implant biotechnology could mark a new development in the field of articular cartilage repair... - Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patientsNobuo Nakamura
Center of Arthroplasty, Kyowakai Hospital, Suita, Japan
DNA Res 13:169-83. 2006..We propose that the expression profiling of these AURA genes may improve our understanding of the pathogenesis of RA... - Enhanced generation of endothelial cells from CD34+ cells of the bone marrow in rheumatoid arthritis: possible role in synovial neovascularizationShunsei Hirohata
Teikyo University School of Medicine, Tokyo, Japan
Arthritis Rheum 50:3888-96. 2004..To examine the capacity of bone marrow CD34+ cells to generate endothelial cells, in order to assess the role of bone marrow in neovascularization in the synovium of rheumatoid arthritis (RA)... - VLA-4-dependent and -independent pathways in cell contact-induced proinflammatory cytokine production by synovial nurse-like cells from rheumatoid arthritis patientsEiji Takeuchi
Laboratory of Molecular and Cellular Recognition, Osaka University Graduate School of Medicine, Japan
Arthritis Res 4:R10. 2002..The transmigration process, which is dependent on Rho-GTPase, is not a prerequisite for this phenomenon... - Smad6/Smurf1 overexpression in cartilage delays chondrocyte hypertrophy and causes dwarfism with osteopeniaMitsuru Horiki
Department of Orthopaedics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
J Cell Biol 165:433-45. 2004..Mating Smad6 and Smurf1 transgenic mice produced double-transgenic pups with more delayed endochondral ossification than Smad6 transgenic mice. These results provided evidence that Smurf1 supports Smad6 function in vivo... - Gait analysis system for assessment of dynamic loading axis of the kneeHideo Kawakami
Department of Medical Robotics and Image Sciences, Division of Robotic Therapy, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Gait Posture 21:125-30. 2005..6% of joint width in the lateral direction (JWLD) on the proximal tibia joint. This system can provide clinically useful information for evaluation of the dynamic loading axis on the knee joint surface... - Bone morphogenetic protein signals are required for cartilage formation and differently regulate joint development during skeletogenesisNoriyuki Tsumaki
Department of Orthopaedic Surgery, Osaka Police Hospital, Japan
J Bone Miner Res 17:898-906. 2002..These conclusions may account for the reason why multiple BMPs are coexpressed in cartilage... - Bone marrow CD34+ progenitor cells stimulated with stem cell factor and GM-CSF have the capacity to activate IgD- B cells through direct cellular interactionShunsei Hirohata
Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan
J Leukoc Biol 71:987-95. 2002..Therefore, the data suggest that the accelerated recruitment of MLC from the bone marrow to the synovium might play a role in the local B cell activation in RA... - Characteristics of fracture and related factors in patients with rheumatoid arthritisAkihide Nampei
Department of Orthopaedics, Osaka University Graduate School of Medicine, Suita, Japan
Mod Rheumatol 18:170-6. 2008..Early intervention to prevent secondary osteoporosis is recommended to maintain the quality of life in patients with rheumatoid arthritis, especially those with functional impairment or undergoing glucocorticoid therapy... - Accuracy evaluation of a shape-based registration method for a computer navigation system for total knee arthroplastyShunsaku Nishihara
Dept of Orthopedic Surgery, Osaka University Medical School, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan
J Knee Surg 16:98-105. 2003..8 mm and 0.6 degrees of bias with 0.2 mm and 0.3 degrees of root-mean-square in the femur, and 0.5 mm and 0.4 degrees of bias with 0.2 mm and 0.3 degrees of root-mean-square in the tibia... - The value and limitation of gadopentetate-enhanced magnetic resonance imaging in detecting the condition of anterior cruciate ligament in rheumatoid knee: comparative study with histologyMasakazu Fujii
Department of Orthopaedic Surgery, Garacia Hospital, Aomadani nishi, Mino, 562 0023, Osaka, Japan
Eur Radiol 13:1728-34. 2003..In the clinical setting, the present imaging technique does allow the ligament to be evaluated to a certain degree, and may prove useful in the evaluation of temporal changes in the RA knee... - Adrenocorticotropic hormone and dehydroepiandrosterone sulfate levels of rheumatoid arthritis patients treated with glucocorticoidsMasao Yukioka
Department of Orthopaedic Surgery, Yukioka Hospital, 2 2 3 Ukita, Kita ku, Osaka 530 0021, Japan
Mod Rheumatol 16:30-5. 2006..The measurement of ACTH and DHEAS may be useful for evaluating adrenal function in patients with RA... - Total ankle replacement in rheumatoid arthritisMasataka Nishikawa
Department of Orthopaedics, Osaka University Graduate School of Medicine, 2-2 Yamada-oka, 565-0871 Suita, Osaka, Japan
Int Orthop 28:123-6. 2004..Migration of the tibial component was seen in 13 ankles and collapse of talus in nine. Although clinical results were poor, patient satisfaction was not... - Effect of GDF-5 on ligament healingToshiyuki Tashiro
Department of Orthopaedic Surgery, JR Tokyo General Hospital, Yoyogi 2-1-3, Shibuya-ku, Tokyo 150-0053, Japan
J Orthop Res 24:71-9. 2006..No adverse effects were observed, and the use of GDF-5 was considered a promising approach to facilitate ligament healing... - Nurse-like cells from patients with rheumatoid arthritis support the survival of osteoclast precursors via macrophage colony-stimulating factor productionHideki Tsuboi
Osaka University Graduate School of Medicine, Suita, Japan
Arthritis Rheum 52:3819-28. 2005..To elucidate the role of nurse-like cells (NLCs) obtained from rheumatoid arthritis (RA) patients in bone loss during progressive synovial expansion... - Prostaglandin E2 strongly inhibits human osteoclast formationIkuko Take
Graduate School of Oral Medicine, Matsumoto Dental University, Nagano, Japan
Endocrinology 146:5204-14. 2005..These results suggest that PGE(2) inhibits human osteoclast formation through the production of an inhibitory factor(s) for osteoclastogenesis of osteoclast precursors... - Effects of rotation on measurement of lower limb alignment for knee osteotomyHideo Kawakami
Department of Medical Robotics and Image Sciences, Division of Robotic Therapy, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, 565 0871, Japan
J Orthop Res 22:1248-53. 2004..2 degrees for internal and external 10 degrees rotation errors in reattaching the osteotomy plane. Rotation may affect measurement of lower limb alignment for knee osteotomy, and 3-D methods are preferable for surgical planning... - [Guidelines for RA therapies]Takahiro Ochi
Sagamihara National Hospital
Nippon Rinsho 63:439-43. 2005 - Change in the locus of dynamic loading axis on the knee joint after high tibial osteotomyHideo Kawakami
Department of Medical Robotics and Image Sciences, Division of Robotic Therapy, Osaka University, Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
Gait Posture 21:271-8. 2005..This indicates that HTO shifted the dynamic loading axis. Lateral movement of the dynamic loading axis in the early stance phase of gait was reduced within a year after HTO... - Low-intensity pulsed ultrasound accelerates maturation of callus in patients treated with opening-wedge high tibial osteotomy by hemicallotasisNoriyuki Tsumaki
Department of Orthopaedics, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
J Bone Joint Surg Am 86:2399-405. 2004..The aim of this study was to determine if low-intensity pulsed ultrasound would accelerate callus maturation when applied after distraction to limbs treated with opening-wedge high tibial osteotomy by hemicallotasis... - Expression of extracellular matrix metalloproteinase inducer and enhancement of the production of matrix metalloproteinases in rheumatoid arthritisTetsuya Tomita
Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
Arthritis Rheum 46:373-8. 2002..To investigate the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) at sites of joint destruction in rheumatoid arthritis (RA) and to correlate it with the production of matrix metalloproteinases (MMPs)...