Masao Hirose

Summary

Affiliation: National Institute of Health Sciences
Country: Japan

Publications

  1. ncbi Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats
    M Hirose
    First Department of Pathology, Nagoya City University, Medical School, Nagoya, Japan
    Toxicol Pathol 27:448-55. 1999
  2. ncbi Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats
    M Hirose
    Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    Cancer Lett 143:173-8. 1999
  3. ncbi Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis
    M Hirose
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Anticancer Res 19:3665-70. 1999
  4. ncbi Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats
    M Hirose
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Cancer Lett 155:79-88. 2000
  5. ncbi Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2'-dihydroxy-di-n-propylnitrosamine in male F344 rats
    M Hirose
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501, Tokyo, Japan
    Cancer Lett 168:23-9. 2001
  6. ncbi Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats
    Masao Hirose
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Environ Mol Mutagen 39:271-8. 2002
  7. ncbi Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses
    Masao Hirose
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501, Tokyo, Japan
    Cancer Lett 188:163-70. 2002
  8. ncbi Enhancing effects of beta-estradiol 3-benzoate but not methoxychlor on the promotion/progression stage of chemically-induced mammary carcinogenesis in ovariectomized rats
    Makoto Ueda
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Jpn J Cancer Res 93:752-9. 2002
  9. ncbi Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model
    Megumi Yamagishi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 191:49-57. 2003
  10. ncbi Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine
    Yasuki Kitamura
    Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, and Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan
    Int J Cancer 118:2399-404. 2006

Collaborators

Detail Information

Publications92

  1. ncbi Sequential morphological and biological changes in the glandular stomach induced by oral administration of catechol to male F344 rats
    M Hirose
    First Department of Pathology, Nagoya City University, Medical School, Nagoya, Japan
    Toxicol Pathol 27:448-55. 1999
    ..These results indicate that regenerative cell proliferation due to toxicity plays an important role in catechol-induced glandular stomach carcinogenesis. Protein binding and free radicals may not be largely responsible for the toxicity...
  2. ncbi Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic compounds in rats
    M Hirose
    Division of Pathology, Biological Safety Research Center, National Institute of Health Sciences, Tokyo, Japan
    Cancer Lett 143:173-8. 1999
    ..It is suggested that depression of metabolic activation rather than antioxidant activity is responsible for the observed effect. However, other mechanisms, including the effects on phase II enzymes cannot be ruled out...
  3. ncbi Modifying effects of phytic acid and gamma-oryzanol on the promotion stage of rat carcinogenesis
    M Hirose
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Anticancer Res 19:3665-70. 1999
    ..The effect of phytic acid itself on urinary bladder carcinogenesis is equivocal. gamma-Oryzanol is a promoter of lung carcinogenesis but its effect is weak and exerted only at a very high dose level...
  4. ncbi Effects of arctiin on PhIP-induced mammary, colon and pancreatic carcinogenesis in female Sprague-Dawley rats and MeIQx-induced hepatocarcinogenesis in male F344 rats
    M Hirose
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Cancer Lett 155:79-88. 2000
    ..On the other hand, it may have a weak co-carcinogenic influence on MeIQx-induced hepatocarcinogenesis. In addition, the results suggested that PhIP is a weak pancreatic carcinogen in female SD rats, targeting acinar cells...
  5. ncbi Green tea catechins enhance tumor development in the colon without effects in the lung or thyroid after pretreatment with 1,2-Dimethylhydrazine or 2,2'-dihydroxy-di-n-propylnitrosamine in male F344 rats
    M Hirose
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501, Tokyo, Japan
    Cancer Lett 168:23-9. 2001
    ..These results indicate that GTCs do not inhibit, but rather may enhance colon carcinogenesis, while not influencing lung and thyroid carcinogenesis under the present experimental conditions...
  6. ncbi Chemoprevention of heterocyclic amine-induced mammary carcinogenesis in rats
    Masao Hirose
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Environ Mol Mutagen 39:271-8. 2002
    ..The present results indicate that a number of compounds may be candidate chemopreventive agents against PhIP-induced mammary carcinogenesis, acting through different mechanisms and depending on the stage of carcinogenesis...
  7. ncbi Lack of inhibitory effects of green tea catechins in 1,2-dimetylhydrazine-induced rat intestinal carcinogenesis model: comparison of the different formulations, administration routes and doses
    Masao Hirose
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501, Tokyo, Japan
    Cancer Lett 188:163-70. 2002
    ..01% MGTC (W) and 0.1% TGTC (W) groups. Thus it can be concluded that GTC does not exert chemopreventive effects on intestinal carcinogenesis irrespective of its formulation, dose or route of administration...
  8. ncbi Enhancing effects of beta-estradiol 3-benzoate but not methoxychlor on the promotion/progression stage of chemically-induced mammary carcinogenesis in ovariectomized rats
    Makoto Ueda
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Jpn J Cancer Res 93:752-9. 2002
    ..The results of our study suggest that MXC has no promotion / progression effect, but rather possesses a weak inhibitory effect, whereas the strongly estrogenic substance EB clearly enhanced DMBA-induced mammary tumorigenesis...
  9. ncbi Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model
    Megumi Yamagishi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 191:49-57. 2003
    ..No significant modification in the small intestine, colon or kidney was evident. These results indicate that CLPr exerts chemopreventive effects in the lung without any promoting influence in other major organs...
  10. ncbi Enhancing effects of simultaneous treatment with sodium nitrite on 2-amino-3-methylimidazo[4,5-f]quinoline-induced rat liver, colon and Zymbal's gland carcinogenesis after initiation with diethylnitrosamine and 1,2-dimethylhydrazine
    Yasuki Kitamura
    Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, and Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan
    Int J Cancer 118:2399-404. 2006
    ..In addition, this experiment showed that IQ can act as a potent lung carcinogen in rats...
  11. ncbi Lack of in vivo mutagenicity and oxidative DNA damage by flumequine in the livers of gpt delta mice
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Arch Toxicol 81:63-9. 2007
    ..These results suggest that genotoxicity, including oxidative DNA damage, is not involved in mouse hepatocarcinogenesis by FLU, which might rather solely exert tumor-promoting effects in the liver...
  12. ncbi A possible role of nrf2 in prevention of renal oxidative damage by ferric nitrilotriacetate
    Keita Kanki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Pathol 36:353-61. 2008
    ..In conclusion, the present study showed that Nrf2 might play an important role in protecting cells from oxidative stress in the kidney through its regulation of antioxidant enzymes...
  13. ncbi Combined ascorbic acid and sodium nitrite treatment induces oxidative DNA damage-associated mutagenicity in vitro, but lacks initiation activity in rat forestomach epithelium
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Sci 104:274-82. 2008
    ....
  14. ncbi A 55-week chronic toxicity study of dietary administered kojic acid (KA) in male F344 rats
    Yoshio Ota
    Division of Pathology, National Institute of Health Sciences, Tokyo
    J Toxicol Sci 34:305-13. 2009
    ..At 2.0%, hypertrophy of cortical cells in zona fasciculata was also increased in the adrenals. In conclusion, no observed adverse effect level of KA was below 0.5%, which is equivalent to 227 mg/kg body weight/day in male rats...
  15. ncbi Impact of maternal dietary exposure to endocrine-acting chemicals on progesterone receptor expression in microdissected hypothalamic medial preoptic areas of rat offspring
    Hironori Takagi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Toxicol Appl Pharmacol 208:127-36. 2005
    ..The results thus suggest that agents causing developmental and/or reproductive abnormalities in later life may affect hypothalamic PR expression during the exposure period in early life...
  16. ncbi Nine-week detection of six genotoxic lung carcinogens using the rasH2/BHT mouse model
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Lett 231:314-8. 2006
    ..The data overall suggest the rasH2/BHT model to be a powerful screening tool for genotoxic lung carcinogens...
  17. ncbi Lack of modifying effects of genistein on disruption of the reproductive system by perinatal dietary exposure to ethinylestradiol in rats
    Hironori Takagi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Reprod Toxicol 18:687-700. 2004
    ..GEN alone also affected estrous cyclicity and the reproductive system in females. However, no combination effects of GEN with EE were evident, suggesting no synergism between the two...
  18. ncbi A crucial role of Nrf2 in in vivo defense against oxidative damage by an environmental pollutant, pentachlorophenol
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Sci 90:111-9. 2006
    ..These data suggest that Nrf2 plays a key role in prevention of PCP-induced oxidative stress and cell proliferation...
  19. ncbi Lung as a new target in rats of 2-amino-3-methylimidazo[4,5-f]quinoline carcinogenesis: results of a two-stage model initiated with N-bis(2-hydroxypropyl)nitrosamine
    Yasuki Kitamura
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Sci 97:368-73. 2006
    ..The overall data clearly indicate that IQ is a potent lung carcinogen in rats, in which oxidative stress may not be involved in lung carcinogenesis...
  20. ncbi Pronounced synergistic promotion of N-bis(2-hydroxypropyl)nitrosamine-initiated thyroid tumorigenesis in rats treated with excess soybean and iodine-deficient diets
    Akiyoshi Nishikawa
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, and Showa Women s University, Tokyo 154 8533, Japan
    Toxicol Sci 86:258-63. 2005
    ..Thus co-exposure to excess soybean and iodine deficiency results in synergistic promotion of DHPN-initiated thyroid tumorigenesis in rats, of which mechanisms appear to primarily involve effects on serum hormone levels...
  21. ncbi Promoting potential of a Jamaica quassia extract in a rat medium-term hepatocarcinogenesis bioassay
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 45:1160-4. 2007
    ..The results thus indicate that JQE at high dose has promoting potential for rat hepatocarcinogenesis...
  22. ncbi Protective effects of benzyl isothiocyanate and sulforaphane but not resveratrol against initiation of pancreatic carcinogenesis in hamsters
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, 1-8-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 241:275-80. 2006
    ..Our data suggest that the naturally occurring isothiocyanates BITC and SFN can block BOP-initiation of hamster pancreatic carcinogenesis...
  23. ncbi In vivo mutagenicity and initiation following oxidative DNA lesion in the kidneys of rats given potassium bromate
    Takashi Umemura
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Cancer Sci 97:829-35. 2006
    ..The two-step experiment shows that cells exposed to the alteration of the intranuclear status by oxidative stress including 8-OHdG formation might be able to form tumors with appropriate promotion...
  24. ncbi Lack of modifying effects of prepubertal exposure to acrylamide (AA) on N-methyl-N-nitrosourea (MNU)-induced multi-organ carcinogenesis in F344 rats
    Shigeaki Takami
    Division of Pathology, National Institute of Health Sciences, Tokyo
    J Toxicol Sci 35:57-68. 2010
    ..In conclusion, no significant modifying actions of AA on MNU-induced multi-organ carcinogenesis were exhibited in any organs of rats when exposed prepubertally under the present experimental conditions...
  25. ncbi Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Science, Setagaya Ku, Tokyo, Japan
    Cancer Sci 100:617-25. 2009
    ..Decrease of thyroglobulin in Ca may reflect dedifferentiation with progression...
  26. ncbi One-year chronic toxicity of madder color in F344 rats--induction of preneoplastic/neoplastic lesions in the kidney and liver
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:3303-10. 2008
    ..0% in both sexes. These results indicate that MC has chronic toxicity targeting kidney, liver and blood cells. Moreover, the results strongly suggest that MC may have the carcinogenic potential in the kidney and the liver...
  27. ncbi A new medium-term rat colorectal bioassay applying neoplastic lesions as end points for detection of carcinogenesis modifiers effects with weak or controversial modifiers
    Young Man Cho
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Toxicol Pathol 36:459-64. 2008
    ..Thus, the system is suitable for detection of colorectal carcinogenesis modifiers with advantages over previous models using ACF alone as end points...
  28. ncbi Detection of oxidative DNA damage, cell proliferation and in vivo mutagenicity induced by dicyclanil, a non-genotoxic carcinogen, using gpt delta mice
    Takashi Umemura
    Divisions of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Mutat Res 633:46-54. 2007
    ....
  29. ncbi Specificity of co-promoting effects of caffeine on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine
    Hwa-Young Son
    Division of Pathology, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan
    Toxicol Pathol 32:338-44. 2004
    ....
  30. ncbi Hypothalamus region-specific global gene expression profiling in early stages of central endocrine disruption in rat neonates injected with estradiol benzoate or flutamide
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Dev Neurobiol 67:253-69. 2007
    ..Moreover, many selected genes common to EB and FA showed down-regulation in females with both drugs, suggesting a common mechanism for endocrine center disruption in females, at least at early stages of post-natal development...
  31. ncbi Enhancement of hepatocarcinogenesis by kojic acid in rat two-stage models after initiation with N-bis(2-hydroxypropyl)nitrosamine or N-diethylnitrosamine
    Tamotsu Takizawa
    Division of Pathology, National Institute of Health Sciences, Tokyo 158-8501, Japan
    Toxicol Sci 81:43-9. 2004
    ..This study also indicated that enhanced replication of hepatocytes related to toxic changes might be involved as an underlying mechanism...
  32. ncbi Development of invasive follicular cell carcinomas in a rat thyroid carcinogenesis model: biological impact of capsular inflammation and reduced cyclooxygenase-2 expression
    Toshio Imai
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Sci 96:31-7. 2005
    ..The present results suggest that capsular inflammation could play a role in development of invasive carcinomas, but COX-2 expression does not make a major contribution...
  33. ncbi Induction of kidney and liver cancers by the natural food additive madder color in a two-year rat carcinogenicity study
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 47:184-91. 2009
    ..These data provide clear evidence that MC exerts unequivocal carcinogenicity against renal tubule cells and hepatocytes in rats...
  34. ncbi Diverse developmental toxicity of di-n-butyl phthalate in both sexes of rat offspring after maternal exposure during the period from late gestation through lactation
    Kyoung-Youl Lee
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Toxicology 203:221-38. 2004
    ..Thus, developmental exposure to DBP affected female sexual development involving pituitary function, while in males testicular toxicity was mostly reversible but mammary gland toxicity was persistent at a dose level as low as 20 ppm...
  35. ncbi Inhibitory effects of aminoguanidine on thyroid follicular carcinoma development in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation
    Toshio Imai
    Division of Pathology, National Institute of Health Sciences, Cabinet Office, Government of Japan, Tokyo, Japan
    Cancer Sci 100:1794-800. 2009
    ..05) their multiplicity. The carcinoma cells were partly positive for iNOS. These results thus suggested that iNOS induction in both inflammatory and tumor cells might play pivotal roles in tumor progression in this DHPN-SDM rat model...
  36. ncbi Lack of preventive effects of dietary fibers or chlorophyllin against acrylamide toxicity in rats
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Tokyo 158 8501, Japan
    Food Chem Toxicol 45:1507-15. 2007
    ....
  37. ncbi Induction of colon tumors in C57BL/6J mice fed MeIQx, IQ, or PhIP followed by dextran sulfate sodium treatment
    Akiyoshi Nishikawa
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Sci 84:243-8. 2005
    ..05 or 0.01) different from the DSS alone value (0%). Thus our results clearly indicate that, in addition to PhIP, MeIQx and IQ can induce colon tumors in mice under an experimental condition promoting colon tumors...
  38. ncbi Synergistic interaction between excess caffeine and deficient iodine on the promotion of thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine
    Hwa Young Son
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Sci 94:334-7. 2003
    ....
  39. ncbi Induction of characteristic hepatocyte proliferative lesion with dietary exposure of Wistar Hannover rats to tocotrienol for 1 year
    Masako Tasaki
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicology 250:143-50. 2008
    ..Based on the present data demonstrating nodular liver lesions only at the high dose of both sexes, we conclude that the no-observed-adverse-effect level (NOAEL) is 0.4% (303 mg/kg/day for males, and 472 mg/kg/day for females)...
  40. ncbi Alteration of pituitary hormone-immunoreactive cell populations in rat offspring after maternal dietary exposure to endocrine-active chemicals
    Naoya Masutomi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, 158-8501 Tokyo, Japan
    Arch Toxicol 78:232-40. 2004
    ..The difference in the pituitary effect between MXC and EE is discussed...
  41. ncbi Increased susceptibility to hepatocarcinogenicity of Nrf2-deficient mice exposed to 2-amino-3-methylimidazo[4,5-f]quinoline
    Yasuki Kitamura
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo, Japan
    Cancer Sci 98:19-24. 2007
    ....
  42. ncbi Pathological assessment of the nervous and male reproductive systems of rat offspring exposed maternally to acrylamide during the gestation and lactation periods - a preliminary study
    Miwa Takahashi
    Division of Pathology, National Institute of Health Sciences, Kamiyoga, Tokyo, Japan
    J Toxicol Sci 33:11-24. 2008
    ..Maternal malnutrition was apparent at >/=100 ppm during the lactation period. Therefore, poor lactational ACR-exposure due to maternal toxicity might account for the lack of ACR-induced offspring toxicity other than retarded body growth...
  43. ncbi Combined treatment with green tea catechins and sodium nitrite selectively promotes rat forestomach carcinogenesis after initiation with N-methyl-N'- nitro-N-nitrosoguanidine
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Cancer Sci 98:949-57. 2007
    ..However, no influence was exerted in the glandular stomach...
  44. ncbi Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats
    Megumi Yamagishi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, 158-8501, Tokyo, Japan
    Cancer Lett 185:123-30. 2002
    ..These results indicate that CLPr inhibit in vitro mutagenicity of PhIP, as well as rat pancreatic carcinogenesis in the initiation stage, but not mammary carcinogenesis induced by PhIP...
  45. ncbi Comparison of enhancing effects of different goitrogen treatments in combination with beta-estradiol-3-benzoate for establishing a rat two-stage thyroid carcinogenesis model to detect modifying effects of estrogenic compounds
    Tamotsu Takizawa
    Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Sci 97:25-31. 2006
    ..m), SDM (100 p.p.m) and PPC (100 p.p.m). The results showed that EB has only a marginal promoting effect on DHPN-induced rat thyroid carcinogenesis and that antithyroidal chemicals, particularly PTU, are effective as co-promoting agents...
  46. ncbi A repeated 28-day oral dose toxicity study of nonylphenol in rats, based on the 'Enhanced OECD Test Guideline 407' for screening of endocrine-disrupting chemicals
    Gye Hyeong Woo
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Arch Toxicol 81:77-88. 2007
    ..The no-observed-adverse-effect level of NP was estimated to be 10 mg/kg per day...
  47. ncbi Dose-threshold for thyroid tumor-promoting effects of xylazine in rats
    Miwa Okamura
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3 5 8 Saiwai cho, Fuchuu city, Tokyo, 183 8509, Japan
    Toxicology 188:275-83. 2003
    ..These results suggest that the threshold dose of rat thyroid tumor-promoting effects of XZ is between 250 and 500 ppm under the present experimental condition...
  48. ncbi Assessment of developmental effects of hypothyroidism in rats from in utero and lactation exposure to anti-thyroid agents
    Makoto Shibutani
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Reprod Toxicol 28:297-307. 2009
    ....
  49. ncbi Sequential analysis of development of invasive thyroid follicular cell carcinomas in inflamed capsular regions of rats treated with sulfadimethoxine after N-bis(2-hydroxypropyl)nitrosamine-initiation
    Toshio Imai
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Pathol 32:229-36. 2004
    ..Whether this is associated with mutations in the beta-catenin gene remains to be clarified...
  50. ncbi A 13-week subchronic toxicity study of madder color in F344 rats
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:241-52. 2008
    ..6% in diet, that is attributable to be the lowest-observed adverse effect level (305.8-309.2mg/kg body weight/day)...
  51. ncbi Enhancement of esophageal carcinogenesis in acid reflux model rats treated with ascorbic acid and sodium nitrite in combination with or without initiation
    Yuichi Kuroiwa
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Sci 99:7-13. 2008
    ..These findings suggest that the risk of excessive intake of a combination of nitrite and antioxidants for esophageal carcinogenesis is appreciable, particularly in patients with reflux esophagitis...
  52. ncbi Hepatocellular tumor induction in heterozygous p53-deficient CBA mice by a 26-week dietary administration of kojic acid
    Tamotsu Takizawa
    Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Toxicol Sci 73:287-93. 2003
    ..The results of the present study indicate tumorigenic potential of KA in the liver, but not thyroid follicular epithelial cells in CBA mice and a contribution of genotoxicity on hepatocellular tumor development cannot be ruled out...
  53. ncbi Impact of dietary exposure to methoxychlor, genistein, or diisononyl phthalate during the perinatal period on the development of the rat endocrine/reproductive systems in later life
    Naoya Masutomi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Toxicology 192:149-70. 2003
    ..The SDN-POA volume remained unchanged with all three chemicals. The results demonstrated that perinatal dietary exposure to EDCs for a limited period causes endocrine disruption in offspring only at high doses...
  54. ncbi Impaired oligodendroglial development by decabromodiphenyl ether in rat offspring after maternal exposure from mid-gestation through lactation
    Hitoshi Fujimoto
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Reprod Toxicol 31:86-94. 2011
    ..The lowest-observed-adverse-effect level of DBDE was determined to be 10 ppm (0.7-2.4 mg/kg-body weight-d)...
  55. ncbi Lack of a significant effect of arctiin on development of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
    Mai Hasumura
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Nutr Cancer 57:201-8. 2007
    ..In conclusion, weak inhibitory effects of arctiin on DMBA-induced mammary tumor development were suggested in OVX rats, but any further assessment is needed to obtain conclusive results...
  56. ncbi Possible contribution of rubiadin, a metabolite of madder color, to renal carcinogenesis in rats
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Food Chem Toxicol 47:752-9. 2009
    ..These results indicate that Rub may be a potent carcinogenic metabolite of MC, targeting proximal tubule cells in the outer medulla, although oxidative stress increased by Alz or LuP might also be involved in renal carcinogenesis by MC...
  57. ncbi Improvement of a two-stage carcinogenesis model to detect modifying effects of endocrine disrupting chemicals on thyroid carcinogenesis in rats
    Hisayoshi Takagi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 178:1-9. 2002
    ..The present modified rat two-stage thyroid carcinogenesis model appears to have advantages over our previous model for screening purposes...
  58. ncbi Enhancement by acrylamide of N-methyl-N-nitrosourea-induced rat mammary tumor development-possible application for a model to detect co-modifiers of carcinogenesis
    Toshio Imai
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Lett 230:25-32. 2005
    ..05) in MNU- but not DMBA+DHPN-treated rats. No thyroid tumors were induced in any case. The results indicate that the MNU model is suitable for detection of modifiers of AA actions...
  59. ncbi Dose-dependent promotion of rat forestomach carcinogenesis by combined treatment with sodium nitrite and ascorbic acid after initiation with N-methyl-N'-nitro-N-nitrosoguanidine: possible contribution of nitric oxide-associated oxidative DNA damage
    Kazushi Okazaki
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Sci 97:175-82. 2006
    ....
  60. ncbi Absence of in vivo genotoxic potential and tumor initiation activity of kojic acid in the rat thyroid
    Toru Tamura
    Division of Pathology, National Institute of Health Sciences, 1-18-1, Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Toxicology 222:213-24. 2006
    ....
  61. ncbi Indomethacin induces small intestinal damage and inhibits amitrole-associated thyroid carcinogenesis in rats initiated with N-bis(2-hydroxypropyl)nitrosamine
    Toshio Imai
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Lett 164:71-80. 2006
    ....
  62. ncbi Depression of T cell-mediated immunity reduces sulfadimethoxine-induced capsular inflammation and inhibits associated development of invasive thyroid follicular cell carcinomas in rats
    Toshio Imai
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Sci 98:294-8. 2007
    ..The results thus suggest that development of invasive carcinomas is enhanced by capsular inflammation mediated by T cells, and inducible nitric oxide synthase induction may play a role in tumor progression...
  63. ncbi Lack of modification of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)-induced hepatocarcinogenesis in rats by fenbendazole--a CYP1A2 inducer
    Shugo Suzuki
    First Department of Pathology, Nagoya City University Medical School, 1 Kawasumi, Mizuho cho, Mizuho ku, 467 8601, Nagoya, Japan
    Cancer Lett 185:39-45. 2002
    ..These results suggest that elevated CYP1A2 expression is not sufficient to enhance MeIQx-induced hepatocarcinogenesis...
  64. ncbi Prolonged effects of beta-estradiol 3-benzoate on thyroid tumorigenesis in gonadectomized rats pretreated with N-bis(2-hydroxypropyl)nitrosamine
    Hwa-Young Son
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 190:21-9. 2003
    ..These results, thus indicate the possible contribution of prolonged EB stimulation at lower doses to thyroid tumorigenesis without additional promotive condition...
  65. ncbi Microdissected region-specific gene expression analysis with methacarn-fixed, paraffin-embedded tissues by real-time RT-PCR
    Hironori Takagi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    J Histochem Cytochem 52:903-13. 2004
    ..These results indicate high performance with methacarn, close to that of unfixed tissues, regarding quantitative expression analysis of mRNAs in microdissected PET-specimens...
  66. ncbi Methacarn fixation for genomic DNA analysis in microdissected, paraffin-embedded tissue specimens
    Chikako Uneyama
    Division of Pathology, National Institute of Health Sciences, Setagaya-ku, Tokyo, Japan
    J Histochem Cytochem 50:1237-45. 2002
    ..The results thus demonstrate the superior performance of methacarn to that reported with formalin in genomic DNA analysis using microdissected PET specimens...
  67. ncbi Lack of enhancing effects of sodium nitrite on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in female Sprague-Dawley rats
    Yasuki Kitamura
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Tokyo 158-8501, Japan
    Cancer Lett 235:69-74. 2006
    ..These results indicate that NaNO(2) does not enhance PhIP-induced rat mammary carcinogenesis, rather possessing some potential for inhibition...
  68. ncbi A cyclooxygenase-2 inhibitor, nimesulide, inhibits postinitiation phase of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters
    Fumio Furukawa
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Int J Cancer 104:269-73. 2003
    ..No neoplastic lesions were detected in animals receiving nimesulide alone. Our results clearly indicate that nimesulide protects against BOP-induced pancreatic tumors in hamsters...
  69. ncbi Chemoprevention of 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine-induced colon carcinogenesis by 1-O-hexyl-2,3,5-trimethylhydroquinone after initiation with 1,2-dimethylhydrazine in F344 rats
    Mitsuru Futakuchi
    First Department of Pathology, Nagoya City University, Medical School, 1 Kawasomi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Carcinogenesis 23:283-7. 2002
    ..The observed inhibition may largely be due to interference with PhIP-DNA adduct formation. In addition, HTHQ has been demonstrated to inhibit duodenal carcinogenesis in the post-initiation stage...
  70. ncbi Lack of prepubertal administration of ethinyl estradiol on susceptibility to multiple organ carcinogenesis in rats exposed to 7,12-dimethylbenz[a]anthracene and N-bis(2-hydroxypropyl)nitrosamine during adolescence
    Young-Man Cho
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 223:37-46. 2005
    ..The present results thus indicate a lack of influence of estrogen early in life on carcinogenic susceptibility, although the possible impact on mammary carcinogenesis requires further examination...
  71. ncbi Lack of significant effects of genistein on the progression of 7,12-dimethylbenz(a)anthracene-induced mammary tumors in ovariectomized Sprague-Dawley rats
    Makoto Ueda
    Division of Pathology, National Institute of Health Sciences, Setagaya-ku, Tokyo 158-8501, Japan
    Nutr Cancer 47:141-7. 2003
    ..The present study indicates that genistein does not exert clear inhibitory effects on mammary carcinogenesis in the promotion/progression stage in female rats under ovarian hormone-free conditions...
  72. ncbi Rapid induction of uterine endometrial proliferative lesions in transgenic mice carrying a human prototype c-Ha-ras gene (rasH2 mice) given a single intraperitoneal injection of N-ethyl-N-nitrosourea
    Takao Watanabe
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, 183-8509, Tokyo, Japan
    Cancer Lett 188:39-46. 2002
    ..The result in the present study suggests that female rasH2 mice are very susceptible to uterine carcinogenesis, providing a useful model for ENU-induced uterine epithelial tumors...
  73. ncbi Lack of modifying effects of atrazine and/or tamoxifen on thyroid carcinogenesis in rats pretreated with N-bis(2-hydroxypropyl)nitrosamine (DHPN)
    Hwa-Young Son
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Food Chem Toxicol 41:1811-6. 2003
    ..These results suggest that neither atrazine nor tamoxifen may promote thyroid carcinogenesis, alone as well as in combination...
  74. ncbi Carcinogenic potential of alizarin and rubiadin, components of madder color, in a rat medium-term multi-organ bioassay
    Kaoru Inoue
    Division of Pathology, National Institute of Health Sciences, Tokyo, Japan
    Cancer Sci 100:2261-7. 2009
    ..Rubiadin may also target the liver and large intestine, suggesting a major role in madder color-induced carcinogenicity...
  75. ncbi Rapid induction of colorectal tumors in rats initiated with 1,2-dimethylhydrazine followed by dextran sodium sulfate treatment
    Jun-Ichi Onose
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 198:145-52. 2003
    ....
  76. ncbi A new medium-term rat colon bioassay applying neoplastic lesions as endpoints for detection of carcinogenesis modifiers-validation with known modifiers
    Jun-Ichi Onose
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 232:272-8. 2006
    ..08) with DCA. It is concluded that this system offers a useful tool for detection of colorectal carcinogenesis modifiers within 10-20 weeks, pending further studies for verification employing other model chemicals...
  77. ncbi Gene expression profile in the livers of rats orally administered ethinylestradiol for 28 days using a microarray technique
    Natsumi Kato
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Toxicology 200:179-92. 2004
    ..0 ppm, up-regulation of genes dose-dependently in females provides a sensitive tool to detect estrogenic effects in the rat liver in the framework of the 28-day toxicity study...
  78. ncbi Promoting effects of combined antioxidant and sodium nitrite treatment on forestomach carcinogenesis in rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine
    Makoto Miyauchi
    Division of Pathology, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan
    Cancer Lett 178:19-24. 2002
    ..Concurrent alpha-Toc, TBHQ or PG treatment with NaNO2 is likely to induce forestomach tumors in the long term...
  79. ncbi Effects of antioxidant 1-O-hexyl-2,3,5-trimethylhydroquinone or ascorbic acid on carcinogenesis induced by administration of aminopyrine and sodium nitrite in a rat multi-organ carcinogenesis model
    Hideaki Yada
    Department of Experimental Oncology and Tumor Biology, Graduate School of Medical Science, Nagoya City University, Mizuho-ku, Nagoya 467-8601, Japan
    Jpn J Cancer Res 93:1299-307. 2002
    ....
  80. ncbi In vivo mutational analysis of liver DNA in gpt delta transgenic rats treated with the hepatocarcinogens N-nitrosopyrrolidine, 2-amino-3-methylimidazo[4,5-f]quinoline, and di(2-ethylhexyl)phthalate
    Keita Kanki
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Mol Carcinog 42:9-17. 2005
    ..Our data also indicate that analysis of specific in vivo mutational responses with transgenic animal models can provide crucial information for understanding the molecular mechanisms underlying chemical carcinogenesis...
  81. ncbi Cigarette smoking, metabolic activation and carcinogenesis
    Akiyoshi Nishikawa
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Curr Drug Metab 5:363-73. 2004
    ..Keeping these data, the aim of this review is to discuss any relevancy of modulated metabolic activation by cigarette smoking to cancer risk in human...
  82. ncbi Enhancement by cigarette smoke exposure of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline-induced rat hepatocarcinogenesis in close association with elevation of hepatic CYP1A2
    Akiyoshi Nishikawa
    Division of Pathology, National Institute of Health Sciences, Setagaya Ku, Tokyo 158 8501, Japan
    Jpn J Cancer Res 93:24-31. 2002
    ....
  83. ncbi Modifying effects of prepubertal exposure to potassium perchlorate and tetrabromobisphenol A on susceptibility to N-bis(2-hydroxypropyl)nitrosamine- and 7,12-dimethylbenz(a)anthracene-induced carcinogenesis in rats
    Toshio Imai
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Toxicol Lett 185:160-7. 2009
    ..Although causes of the effect on thyroid carcinogenesis might be direct and/or indirect hormonal actions, further studies are needed for confirmation...
  84. ncbi Tumor promoting effect of phenolphthalein on development of lung tumors induced by N-ethyl-N-nitrosourea in transgenic mice carrying human prototype c-Ha-ras gene
    Masako Imaoka
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Fuchu, Japan
    J Vet Med Sci 64:489-93. 2002
    ..In addition, the ratio of area of adenomas in the ENU + PhP group was significantly higher than that in the ENU alone group. The result of our study suggests that PhP has a clear tumor promoting effect in the lung of rasH2 mice...
  85. ncbi Mutation and overexpression of the transgene in ethylnitrosourea-induced tumors in mice carrying a human prototype c-Ha-ras gene
    Kaoru Toyosawa
    Safety Research Laboratories, Dainippon Pharmaceutical Co, Ltd, Suita, Osaka 564 0053, Japan
    Toxicol Pathol 31:491-5. 2003
    ..The results obtained in this study suggest that mutations in codon 61 and amplification of the transgene play key roles in the carcinogenesis induced by ENU in rasH2 mice...
  86. ncbi Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 222:11-5. 2005
    ....
  87. ncbi Evaluation of subchronic toxicity of dietary administered Cry1Ab protein from Bacillus thuringiensis var. Kurustaki HD-1 in F344 male rats with chemically induced gastrointestinal impairment
    Jun ichi Onose
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Food Chem Toxicol 46:2184-9. 2008
    ..In conclusion, no significant toxicological effects were detected in this subchronic gastrointestinal impairment rat model...
  88. ncbi Inhibition by ethinylestradiol of N-ethyl-N-nitrosourea-initiated uterine carcinogenesis in transgenic mice carrying a human prototype C-Ha-ras gene (rasH2 mice)
    Takao Watanabe
    Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, 3-5-8, Saiwai-cho, Fuchu, Tokyo 183-8509, Japan
    Toxicol Pathol 31:496-505. 2003
    ..These results suggest that 2.5 ppm EE paradoxically inhibits the uterine carcinogenesis in rasH2 mice initiated with ENU...
  89. ncbi Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline or N-nitrosodiethylamine
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Jpn J Cancer Res 93:1076-82. 2002
    ..These results imply that there is a no-observed effect level for hepatocarcinogenesis by these genotoxic carcinogens...
  90. ncbi Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline
    Shoji Fukushima
    Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Abeno Ku, Osaka 545 8585, Japan
    Cancer Lett 191:35-40. 2003
    ..001-1 ppm. The results imply a no-observed effect level for hepatocarcinogenicity with this genotoxic agent...
  91. ncbi Effects of cigarette smoke and a heterocyclic amine, MeIQx on cytochrome P-450, mutagenic activation of various carcinogens and glucuronidation in rat liver
    Yukio Mori
    Laboratory of Radiochemistry, Gifu Pharmaceutical University, 6 1 Mitahora higashi 5 chome, Gifu 502 8585, Japan
    Mutagenesis 18:87-93. 2003
    ....
  92. ncbi Modifying effects of chitin, chitosan and their related compounds on 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in a rat medium-term hepatocarcinogenesis model, and their post-initiation effects in a female rat 2-stage multi-organ carcinogenesi
    Mayumi Kawabe
    Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Food Chem Toxicol 46:2758-63. 2008
    ....