Research Topics
Species | Takemasa TakiiSummaryAffiliation: Nagoya City University Country: Japan Publications
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Detail Information
Publications
Simple fibroblast-based assay for screening of new antimicrobial drugs against Mycobacterium tuberculosisTakemasa Takii
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Antimicrob Agents Chemother 46:2533-9. 2002..Thus, this fibroblast-based method enabled us to evaluate both antibacterial activity of drugs and their cytotoxicity to human cells within a short period of time...
Effectiveness of BCG vaccination to aged miceTsukasa Ito
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe, Mizuho, Nagoya 467 8603, Japan
Immun Ageing 7:12. 2010..Emerging the multidrug resistant Mycobacterium tuberculosis (MDR-TB) make us to see the importance of vaccination against TB in new light. In this study, we evaluated the efficacy of BCG vaccination in aged mice...
Simple fibroblast-based assay to test the pyrazinamide susceptibility of Mycobacterium tuberculosisTakemasa Takii
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya 467 8603, Japan
Antimicrob Agents Chemother 49:804-7. 2005..Forty-five clinical isolates were examined. The MICs of PZA for susceptible strains in an SFA were between 3.13 and 12.5 microg/ml, and the MICs of PZA for resistant strains were more than 100 microg/ml...
Synthesis of new sugar derivatives and evaluation of their antibacterial activities against Mycobacterium tuberculosisYasuhiro Horita
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Bioorg Med Chem Lett 19:6313-6. 2009....
TGF-beta down-regulates IL-1alpha-induced TLR2 expression in murine hepatocytesTakayuki Matsumura
Graduate School of Pharmaceutical Sciences, Nagoya City University, 3-1 Tanabe-dori, Mizuho-ku, Nagoya, Aichi 467-8603, Japan
J Leukoc Biol 75:1056-61. 2004..These results also demonstrate the disparity between IL-1alpha and TGF-beta in regulating TLR2-mediated SAA production in hepatocytes...
Dihydrotestosterone inhibits interleukin-1? or tumor necrosis factor ?-induced proinflammatory cytokine production via androgen receptor-dependent inhibition of nuclear factor-?B activation in rheumatoid fibroblast-like synovial cell lineJian Xu
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Japan
Biol Pharm Bull 34:1724-30. 2011....
Cigarette smoke condensate upregulates the gene and protein expression of proinflammatory cytokines in human fibroblast-like synoviocyte lineMiki Shizu
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, Japan
J Interferon Cytokine Res 28:509-21. 2008..These results support the epidemiological studies indicating a strong association between heavy cigarette smoking and pathogenesis of RA...
Etiological role of cigarette smoking in rheumatoid arthritis: Nasal exposure to cigarette smoke condensate extracts augments the development of collagen-induced arthritis in miceShosuke Okamoto
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho 3 1, Nagoya 467 8603, Japan
Biochem Biophys Res Commun 404:1088-92. 2011..Histological examination confirmed the augmenting effect of CSC. These findings provide experimental bases supporting the etiological role of cigarette smoking in RA...
Synthesis and evaluation of anti-tubercular activity of new dithiocarbamate sugar derivativesYasuhiro Horita
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Bioorg Med Chem Lett 21:899-903. 2011..Overall, this study presents OCT313HK as a novel and potent compound against MTB, particularly promising to overcome drug resistance...
Biochemical characteristics among Mycobacterium bovis BCG substrainsDaisuke Hayashi
Department of Molecular Health Sciences, Nagoya City University, Japan
FEMS Microbiol Lett 306:103-9. 2010..The study also contributes to the re-evaluation of BCG substrains for use as vaccines...
IL-1-induced ERK1/2 activation up-regulates p21(Waf1/Cip1) protein by inhibition of degradation via ubiquitin-independent pathway in human melanoma cells A375Tomohiro Arakawa
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
Biochem Biophys Res Commun 392:369-72. 2010..These results suggest that IL-1-induced ERK1/2 activation leads to the up-regulation of p21 by inhibiting degradation via ubiquitin-independent pathway in human melanoma cells A375...
Cigarette smoke condensate extracts augment collagen-induced arthritis in miceSatomi Chujo
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya 467 8603, Japan
Int Immunopharmacol 10:1194-9. 2010..Peritoneal injected mainstream CSC one day before immunization also exhibited the augmenting effect, suggesting the systemic effect of CSC. These results support the etiological role of cigarette smoking in RA...
Dihydrotestosterone inhibits tumor necrosis factor alpha induced interleukin-1alpha mRNA expression in rheumatoid fibroblast-like synovial cellsYuka Itoh
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Biol Pharm Bull 30:1140-3. 2007..These results suggest that DHT inhibits the TNFalpha-induced IL-1alpha mRNA expression by inhibiting NF-kappaB activation, and contributes to the gender differences of the disease...
Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Guérin (BCG) substrainsDaisuke Hayashi
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
FEMS Immunol Med Microbiol 56:116-28. 2009..Our study provides the basic information for immunological characterization of various BCG strains and may contribute to a re-evaluation of them as a reference strain for vaccination against tuberculosis...
The interaction with Sp1 and reduction in the activity of histone deacetylase 1 are critical for the constitutive gene expression of IL-1 alpha in human melanoma cellsKazuaki Enya
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, 3 1 Tanabe dori, Mizuho ku, Nagoya, Aichi 467 8603, Japan
J Leukoc Biol 83:190-9. 2008..These results indicate that the reduction in the activity and interaction of HDAC1 with Sp1 are critical for the constitutive IL-1 alpha gene expression...
Synthesis of new sugar derivatives from Stachys sieboldi Miq and antibacterial evaluation against Mycobacterium tuberculosis, Mycobacterium avium, and Staphylococcus aureusTaku Chiba
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan
Bioorg Med Chem Lett 17:2487-91. 2007..The allyl group at C-1 and the acetoxy groups of the manninotrioside were requisite for the antibacterial activity...
Polycyclic aromatic hydrocarbon increases mRNA level for interleukin 1 beta in human fibroblast-like synoviocyte line via aryl hydrocarbon receptorAyako Tamaki
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, Japan
Biol Pharm Bull 27:407-10. 2004..As PAHs are much contained in cigarette smoke, these findings provide the possible basis for epidemiological studies indicating a strong association between heavy cigarette smoking and outcome of RA...
TRAF6-NF-kappaB pathway is essential for interleukin-1-induced TLR2 expression and its functional response to TLR2 ligand in murine hepatocytesTakayuki Matsumura
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Japan
Immunology 109:127-36. 2003....
Preservation of hematopoietic properties in transplanted bone marrow cells in the brainKenji Ono
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya, Aichi, Japan
J Neurosci Res 72:503-7. 2003..Thus, BMC that migrate to the brain probably have preserved hematopoietic properties under physiological conditions...
Multiple mechanisms involved in the inhibition of proinflammatory cytokine production from human monocytes by N-(p-coumaroyl)serotonin and its derivativesTakemasa Takii
Department of Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Nagoya City University, Mizuho, Nagoya 467-8623, Japan
Int Immunopharmacol 3:273-7. 2003..S was moderate, and that of Cin.T was quite weak. These results indicate that CS and its derivatives inhibit the production of proinflammatory cytokines through multiple mechanisms...
