Research Topics
Genomes and GenesSpecies | Hiroshi MurakamiSummaryAffiliation: Nagoya City University Country: Japan Publications
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Detail Information
Publications
Maintenance of replication forks and the S-phase checkpoint by Cdc18p and Orp1pHiroshi Murakami
Cell Cycle Laboratory, Cancer Research UK London Research Institute, Lincoln s Inn Fields Laboratories, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Nat Cell Biol 4:384-8. 2002..We propose that the presence of unresolved replication forks, together with Orp1p and Cdc18p, are necessary to activate the Cds1p-dependent S-phase checkpoint...- Regulation of yeast forkhead transcription factors and FoxM1 by cyclin-dependent and polo-like kinasesHiroshi Murakami
Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, Nagoya, Japan
Cell Cycle 9:3233-42. 2010.... - Regulation of premeiotic S phase and recombination-related double-strand DNA breaks during meiosis in fission yeastH Murakami
Cell Cycle Laboratory, Imperial Cancer Research Fund, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Nat Genet 28:290-3. 2001.... - Regulation of Cdc2p and Cdc13p is required for cell cycle arrest induced by defective RNA splicing in fission yeastMidori Shimada
Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
J Biol Chem 280:32640-8. 2005..The abundance of Cdc13p was reduced, and the phosphorylation of Cdc2p on tyrosine 15 was maintained in splicing-defective cells. These results suggest that regulation of Cdc13p and Cdc2p is required for G2 arrest in splicing mutants... - Casein kinase II is required for the spindle assembly checkpoint by regulating Mad2p in fission yeastMidori Shimada
Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
Biochem Biophys Res Commun 388:529-32. 2009..The level of Mad2p is low in the CK2 mutants. These results suggest that CK2 has a role in the spindle checkpoint by regulating Mad2p... - Cdc2p controls the forkhead transcription factor Fkh2p by phosphorylation during sexual differentiation in fission yeastMidori Shimada
Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, Mizuho ku, Nagoya, Japan
EMBO J 27:132-42. 2008..We propose that functional interaction between Cdks and forkhead transcription factors may link the mitotic cell cycle and sexual differentiation... - A checkpoint control linking meiotic S phase and recombination initiation in fission yeastYuko Tonami
Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan
Proc Natl Acad Sci U S A 102:5797-801. 2005..In addition, Cdc2p is apparently not involved in this process. We propose that the sequence of meiotic S phase and initiation of recombination is coordinated by DNA-replication-checkpoint proteins... - DNA damage responses in skin biology--implications in tumor prevention and aging accelerationMakoto Nakanishi
Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
J Dermatol Sci 56:76-81. 2009..In this review, changes in chromatin modification in response to UV and the molecular mechanisms accelerating aging phenotypes are discussed... - DNA replication checkpoint control mediated by the spindle checkpoint protein Mad2p in fission yeastIzumi Sugimoto
Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
J Biol Chem 279:47372-8. 2004..These results suggested that Mad2p and Slp1p act downstream of Rad3p in the DNA replication checkpoint and that Mad2p is required for the DNA replication checkpoint when Cds1p is compromised... - Mei4p coordinates the onset of meiosis I by regulating cdc25+ in fission yeastYuko Murakami-Tonami
Department of Biochemistry and Cell Biology, Graduate School of Medicine, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
Proc Natl Acad Sci U S A 104:14688-93. 2007..We propose that Mei4p acts as a rate-limiting regulator of meiosis I by activating cdc25(+) transcription in coordination with other meiotic events... - Chk1-cyclin A/Cdk1 axis regulates origin firing programs in mammalsMakoto Nakanishi
Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya, 467 8601, Japan
Chromosome Res 18:103-13. 2010..Here, we discuss recent advances in the understanding of how S phase programs are regulated in mammals at the correct regions and at the appropriate times... - Ecl1, a regulator of the chronological lifespan of Schizosaccharomyces pombe, is induced upon nitrogen starvationYukiko Miwa
Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan
Biosci Biotechnol Biochem 75:279-83. 2011..Though the nitrogen starvation-induced expression of Ecl1 did not change in the atf1? mutant, induction in both the ste11? mutant and the tor1? mutant showed a delay. Based on these observations, the regulation of Ecl1 is discussed... - The G1/S cyclin Cig2p during meiosis in fission yeastAnnie Borgne
Cell Cycle Laboratory, Imperial Cancer Research Fund, London, WC2A 3PX, United Kingdom
Mol Biol Cell 13:2080-90. 2002..Furthermore, analysis of cig2 transcripts revealed a meiosis-specific regulation of cig2 expression during MI/MII dependent upon the Mei4p transcription factor leading to a different transcription start site at this stage of meiosis... - Mechanisms of dNTP supply that play an essential role in maintaining genome integrity in eukaryotic cellsHiroyuki Niida
Department of Cell Biology, Graduate School of Medical Sciences, Nagoya City University, Mizuho ku, Nagoya, Japan
Cancer Sci 101:2505-9. 2010..In this review, we focus on recent findings related to RNR regulation in eukaryotes of the dNTPs supplied for DNA synthesis. We also discuss the effect of this regulation on mutagenesis and tumorigenesis... - Negative regulation of Chk2 expression by p53 is dependent on the CCAAT-binding transcription factor NF-YTaido Matsui
Department of Biochemistry and Cell Biology, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
J Biol Chem 279:25093-100. 2004..These results suggest that p53 negatively regulates Chk2 gene transcription through modulation of NF-Y function and that this regulation may be important for reentry of cells into the cell cycle after DNA damage is repaired... - Fission yeast Eso1p is required for establishing sister chromatid cohesion during S phaseK Tanaka
Department of Biochemistry and Molecular Biology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
Mol Cell Biol 20:3459-69. 2000..The C-terminal region acts to establish sister chromatid cohesion, and the N-terminal region presumably catalyzes translesion DNA synthesis when template DNA contains lesions that block regular DNA replication... - DNA replication and damage checkpoints and meiotic cell cycle controls in the fission and budding yeastsH Murakami
Imperial Cancer Research Fund, Cell Cycle Laboratory, 44 Lincoln s Inn Fields, London WC2A 3PX, UK
Biochem J 349:1-12. 2000..We have made comparisons with the controls in fission yeast and other organisms, mainly the distantly related budding yeast... - Meiotic DNA replication checkpoint control in fission yeastH Murakami
Cell Cycle Laboratory, Imperial Cancer Research Fund, London WC2A 3PX, UK
Genes Dev 13:2581-93. 1999..This second checkpoint is meiosis specific and may reflect processes occurring only during meiosis such as increased recombination rates, an extended duration of nuclear division, or homolog chromosome pairing... - Genetic studies with the fission yeast Schizosaccharomyces pombe suggest involvement of wee1, ppa2, and rad24 in induction of cell cycle arrest by human immunodeficiency virus type 1 VprM Masuda
Department of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
J Virol 74:2636-46. 2000..The results supported the previously suggested possibility that Vpr affects the cell cycle and cell proliferation through different pathways... - hsf1 (+) extends chronological lifespan through Ecl1 family genes in fission yeastHokuto Ohtsuka
Laboratory of Molecular Microbiology, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
Mol Genet Genomics 285:67-77. 2011..From these results, we suggest that HSF is a conserved regulator of lifespan, at least in yeast and nematode, and Ecl1 family genes such as YGR146C and ecl2 (+) are the direct targets of Hsf1 and mediate lifespan extension by Hsf1... - A double-strand break repair component is essential for S phase completion in fission yeast cell cyclingK Suto
Department of Biochemistry and Molecular Biology, The University of Tokyo, Graduate School of Medicine, Tokyo 113 0033, Japan
Mol Biol Cell 10:3331-43. 1999..Thus, in fission yeast a double-strand break repair component is required for a certain step of chromosome replication unlinked to repair, partly via interacting with replication protein A... - Structural basis of specific tRNA aminoacylation by a small in vitro selected ribozymeHong Xiao
Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, Seattle, Washington 98109 1024, USA
Nature 454:358-61. 2008..Such a mechanism would be reminiscent of the mutually induced fit of tRNA and protein employed by some aminoacyl-tRNA synthetases to increase specificity... - Aminoacyl-tRNA synthesis by a resin-immobilized ribozymeHiroshi Murakami
Department of Chemistry, University at Buffalo, State University of New York, Buffalo, New York 14260-3000
J Am Chem Soc 124:6834-5. 2002..Thus, our ribozyme-based aminoacylation system has significant potential to be a powerful and practical technique for supplying various nonnatural aminoacyl-tRNAs for a highly efficient in vitro translation system... - The evaluation of oxidative DNA damage in children with brain damage using 8-hydroxydeoxyguanosine levelsMiho Fukuda
Department of Pediatrics, St Marianna University School of Medicine, Kawasaki, Japan
Brain Dev 30:131-6. 2008..Therefore, repeated measurements of urinary 8-OHdG may be helpful in estimating the extent of brain damage... - [Expansion and reprogramming of genetic code by Flexizyme]Hiroshi Murakami
Tanpakushitsu Kakusan Koso 51:2496-501. 2006 - A versatile tRNA aminoacylation catalyst based on RNAHiroshi Murakami
Department of Chemistry, State University of New York, Buffalo, Buffalo, NY 14260, USA
Chem Biol 10:655-62. 2003..Thus, it provides a useful and flexible tool for the custom synthesis of mischarged tRNAs with natural and nonnatural amino acids... - Designer ribozymes: programming the tRNA specificity into flexizymeKrishna Ramaswamy
Departments of Chemistry and Biological Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260-3000, USA
J Am Chem Soc 126:11454-5. 2004..Because the tRNA specificity can be easily programmed into Fx10, it is a custom-made catalyst to generate nonnatural aminoacyl-tRNAs...