Yoshiyuki Kojima

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..These advantages can apply to laparoscopic orchiectomy for a testicular nubbin...

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..We examined infertile adults for the presence of spermatozoa in the testes, serum FSH level and testicular volume to predict paternity potential in pubertal boys who had undergone bilateral orchiopexy in childhood...

..We examined the long-term outcome and compared the usefulness of nephroureterectomy with that of bacillus Calmette-Guérin (BCG) therapy for the management of upper urinary tract carcinoma in situ (CIS)...

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..He remains free from the disease after a 30-month follow-up period. S-1/cisplatin combination chemotherapy is suggested to be a potent tool for controlling advanced urachal carcinoma...

..Laparoscopic management of urachal disease can be performed safely, with minimal postoperative pain, excellent cosmetic results and early ambulation. We advocate the use of laparoscopic treatment of urachal anomalies in children...

..However, in XX males, these genes must be up-regulated in the absence of SRY, but the aetiology of SRY-negative XX maleness remains unclear...

..To investigate the risk of germ-line transmission of vector sequences after in vivo adenovirus-mediated gene transfer to mouse testes and to discuss whether an adenovirus vector could be used in the future to treat male factor infertility...

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..Laparoscopic nephrectomy is a feasible and safe method with good indications especially for children with a horseshoe kidney disease...

..Further genomic studies will refine our knowledge of the functions of alpha(1)-AR subtypes, lead to new strategies for the clinical management of BPH and, perhaps, enable personalized treatment of BPH in the future...

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..We established a new strategy for nonpalpable testis, including intra-abdominal testis, testicular nubbins, and intracanalicular testis, to correct these conditions by laparoscopic procedures...

..We compare the technical details and surgical outcomes of adult and pediatric laparoscopic pyeloplasty, and discuss the lessons learned from these comparisons...

..We investigated the long-term physical, hormonal, and sexual outcomes of males with disorders of sex development (DSD) and discussed the necessity of long-term follow-up for these patients after surgery...

..We examined the change in ?(1)-adrenoceptor subtype expression in the prostate due to chronic tamsulosin administration in a benign prostatic hyperplasia rat model and in patients...

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..We examined the role of alpha(1d)-AR in prostate growth and the effect of subtype-selective alpha(1)-AR antagonist, naftopidil, which has relatively higher affinity for alpha(1d)-AR, on prostate growth in vitro and in vivo...

..In this review, we discuss the potential approaches including epidermal growth facter therapy, gene therapy and stem-cell therapy for cryptorchid patients in the future...

..We discuss the possibility of individualizing drug therapy in patients with benign prostatic hyperplasia...

..We then analyzed the transfection efficiency, immunological problems and effects of gene transfer on spermatogenesis and the next generation. In this study we discuss the potential of gene therapy for male infertility...

..Information regarding the usefulness and effectiveness of this procedure is required...

..Urethrocutaneous fistula is a common complication of urethroplasty for hypospadias even when a microsurgical technique is applied...

..We predicted testicular function in prepubertal boys with a history of cryptorchidism and/or hypospadias by measuring serum hormone levels...

..To present our initial experience with laparoscopic pyeloplasty and to evaluate the safety and short-term outcome of this technique in children...

..However, its indication should be restricted to small exophytic renal tumors due to the expected collateral damage causing renal impairment...

..EGF administered in combination with orchiopexy was more effective for spermatogenesis than orchiopexy alone. This may be applicable in patients with cryptorchidism...

..To investigate the accuracy of contralateral testicular hypertrophy in Japanese boys with a nonpalpable testis and to determine the optimal cutoff value of the contralateral testicular size to predict the absence of the testis...

..33 ± 8.31 days, respectively (P = 0.038). Herein, we report the first on silodosin in the management of ureteral lithiasis. Our findings suggest that silodosin might have potential as a medical expulsive therapy for ureteral stones...

..We performed histological analyses of undescended testes to evaluate the influence of orchiopexy timing in an experimental cryptorchid rat model. Furthermore, we extrapolated the timing of orchiopexy in humans from our results...

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..1 +/- 2.3; group 2, 12.3 +/- 2.0; and group 3, 11.3 +/- 3.0). CONCLUSIONS: The spermatogenesis, fertility, and paternity of mature mice were unaffected by testicular biopsy in childhood...

..as the transverse preputial onlay island urethroplasty is excellent for repairing anterior hypospadias with no chordee, and a slit-like normal meatus cannot be constructed in many patients who had the original onlay island-flap repair..

..To elucidate the mechanism of infertility caused by cryptorchidism we focused on early stage spermatogenesis and spermatogonial stem cell activity in undifferentiated spermatogonia in cryptorchid testes...

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..To assess the correlation between intratesticular pressure (ITP) after testicular torsion and subsequent testicular function using a rat model and to show that ITP at surgery is a useful predictor of future spermatogenesis...

..After the foreskin reconstruction, the glans, which was concealed by the reconstructed foreskin, was easily exposed by retracting the foreskin...

..Clarification of the mechanism of alpha1-AR subtypes in the prostate will provide more effective therapy for BPH patients...

..We employed two kinds of meatal based flip-flap urethroplasty procedures for those with an unsuccessful primary hypospadias repair...

..Urethrocutaneous fistula is a common complication of urethroplasty for severe hypospadias, even when a microsurgical technique is applied...

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..Endoscopic ureterolithotripsy was conducted via Lithoclast in the other two patients. The calculi were struvite in the four patients...

..To evaluate the relationship between treatment-related changes in Overactive Bladder Symptom Scores (OABSS) and health-related quality of life (HRQOL) questionnaires...

..Such crystal-removing ability of macrophages through phagocytosis and digestion might become a new target for the prevention of stone formation...

..We consider that not only various genetic mutations but also single-nucleotide polymorphisms or other epigenetic factors might be involved in the development of Wilms tumor...

..If penile curvature is severe or the penis is small in hypospadiac patients, lengthening the ventral aspect using a tunica vaginalis flap is likely to expand instead of dorsal plication or ventral graft...

..The segment of the UPJ area containing the polyp was completely removed, followed by laparoscopic dismembered pyeloplasty. Pathologic findings demonstrated a benign fibroepithelial polyp...

..However, the mechanisms of apoptosis in the germ cells are multifactorial and have not been completely elucidated. NF-kappaB is a transcription factor considered to play an important role in the apoptosis of various cells...

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..Testicular morphology in the patients with KS is more varied than expected, and further investigation is required to elucidate hormonal effects on normal testicular development...

..In the future, the promise of genetic-based prescriptions and therapeutic plans as a useful strategy to improve clinical outcomes of BPH medical therapy may become credible and warrants further investigation...

..To evaluate the validity of 1-stage Fowler-Stephens orchiopexy, we performed this procedure for intra-abdominal testes in an experimental cryptorchid rat model and assessed postoperative spermatogenesis...

..CONCLUSIONS: We recommend switching to onlay-tube-onlay urethroplasty when the attempt to repair moderately severe hypospadias by the simple onlay procedure has to be abandoned, and the urethral plate needs to be divided...

..To investigate influence for the testicular development and to assess the usefulness as an animal model, cryptorchid rats were induced by exposure to flutamide during the fetal period and their testes examined histologically...

..To assess the involvement of estrogen in spermatogenesis, we evaluated the expression of estrogen receptors (ERs) alpha (ERalpha) and beta (ERbeta) in the cryptorchid testes in model rats exposed to flutamide during the fetal stage...

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..We measured the testis volume of patients with unilateral cryptorchidism preoperatively and compared with a unilateral hydrocele testis to assess testicular development in these patients...

..To evaluate the magnetic resonance imaging (MRI) findings, diagnostic accuracy and clinical usefulness of fat-suppressed T2-weighted and diffusion-weighted imaging (DWI) in the management of non-palpable testes...

..Although the tubularized incised plate (TIP) repair has become the most popular surgical procedure for distal hypospadias, some authors suggest that this is not suitable for hypospadias with a narrow plate or shallow groove...

..We believe that laparoscopic nephrectomy should be offered as a management option to the families of children with unilateral MCDK...

..To determine whether the SRY gene is present in the gonads of patients with mixed gonadal dysgenesis (MGD)...

..CONCLUSIONS: Penile curvature due to corporeal disproportion could be repaired by dorsal plication with incisions of the tunica at the 12-o'clock position, irrespective of the presence or absence of hypospadias...

..We recommend US as the first step after clinical examination, and MRI could be performed when the US findings are negative preoperatively for a non-palpable testis...

..This study was carried out to characterize the alpha 1 adrenoceptors (AR) subtype gene and protein expression in the proximal, medial, and distal regions of the human ureter with the aim of facilitating stone expulsion...

..There are many different views worldwide on circumcision; we are presenting a Japanese view on the management of pediatric foreskin...

..Efforts have been made in this decade to improve cosmetic appearance, constructing a slit-like meatus or performing foreskin reconstruction, and to prevent onerous complications...

..CONCLUSIONS: These results suggest that spermatogenesis, sperm motility and fertilization in vitro were unaffected in hypospadiac mice but sexual motivation and arousal were deficient...

..Taken together, TRPM8-expressing sensory neurons with dichotomizing axons projecting to the skin and bladder may be responsible for the urinary urgency evoked by cold sensation...

..These molecular findings suggest that tyrosine kinase receptors may be potential therapeutic targets for CCSK in the future...

..In both cases, CIC had not provided adequate voiding control and incontinence persisted. According to the Mitrofanoff Principle, we used the appendix as a catheterizable conduit, which was constructed to the umbilicus...

..We investigated the effects of bladder outlet obstruction (BOO) on the distribution of interstitial cells (ICs) in the guinea-pig bladder...

..The goal of this review is to evaluate the treatment of VUR using antibiotic prophylaxis, and its advantages and disadvantages based on appropriate descriptions and studies in the literature...

..Paraphimosis is a condition in which the foreskin is left retracted. When manipulation is not effective, a dorsal slit should be done, which is usually followed by circumcision...

..Moreover, significant levels of K(Ca)3.1 expression were observed in human BPH samples. K(Ca)3.1 blockers may be a novel treatment option for patients suffering from BPH...

..To characterize the contractile functions of the ?(1)-adrenoceptor (AR) subtypes present in the human ureter...

..CONCLUSIONS: This hypospadiac rat model is considered valuable for further studying penile growth and differentiation, and the molecular mechanisms in external genitalia formation in hypospadias...

..This malignancy grade-dependent K(+)-channel expression pattern may provide a convenient marker to understand PCa progression level...

..According to Stephens' classification, the sinus appears to be a variant of dorsal urethral duplication of Stephens type 3...

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..3%) with a unilateral nonpalpable and a contralateral scrotal testis. Our strategy of initial inguinal exploration followed by transinguinal laparoscopy for nonpalpable testis may become a reasonable alternative...

..These molecular studies will refine our knowledge of the genetic mechanism involved in external genitalia formation, and lead to new strategies for the clinical management of hypospadias...

..The present study examines the effects of the microgravity (muG) environment on steroidogenesis of Leydig cells...

..CONCLUSIONS: The Snodgrass procedure is suitable for correcting hypospadias in patients with a healthy urethral plate. It is also suitable in patients with proximal hypospadias...

..On the possibility of reproduction in space, there are some problems such as the cosmic radiation besides gravity. It is necessary to carry out further experiments in outer space...

..Here we describe the first case of MURCS in a male in whom testicular sperm extraction was carried out...

..In addition, we showed the effects of Glivec, a c-Kit tyrosine kinase inhibitor, reduced spontaneous action potential in detrusor smooth muscle. Glivec may prove useful for the treatment of OAB in the future...

..These findings suggest a possible relationship between glucose metabolism and germ-cell development...