M Kawai

Summary

Affiliation: Nagoya Institute of Technology
Country: Japan

Publications

  1. ncbi Cytotoxic activity of physalins and related compounds against HeLa cells
    M Kawai
    Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan
    Pharmazie 57:348-50. 2002
  2. ncbi The structure of physalin T from Physalis alkekengi var. franchetti
    M Kawai
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Asian Nat Prod Res 3:199-205. 2001
  3. ncbi Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column
    Y Deng
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Chromatogr B Biomed Appl 670:47-54. 1995
  4. ncbi Assay for the (R)- and (S)-enantiomers of salsolinols in biological samples and foods with ion-pair high-performance liquid chromatography using beta-cyclodextrin as a chiral mobile phase additive
    Y Deng
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Chromatogr B Biomed Sci Appl 689:313-20. 1997
  5. ncbi Cytotoxic activity of physalins possessing modified skeletal structures against HeLa cells
    B Makino
    Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan
    Pharmazie 58:70-1. 2003
  6. ncbi Preparation of (R)-N-methylsalsolinol via reversed-phase high-performance liquid chromatography using beta-cyclodextrin as a mobile-phase additive
    C Minami
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Chromatogr B Biomed Sci Appl 702:245-8. 1997
  7. ncbi Generation of reactive oxygen species accounts for cytotoxicity of an endogenous dopaminergic neurotoxin, (R)-N-methylsalsolinol, to differentiated dopaminergic SH-SY5Y cells
    C Minami
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Neural Transm 105:397-405. 1998
  8. ncbi Tautomerism between exomethylene type physalins and oxymethylene-bridged physalins
    B Makino
    Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan
    Pharmazie 57:215-6. 2002
  9. ncbi Capillary zone electrophoretic chiral discrimination using a cationic cyclodextrin derivative: determination of velocity and association constants of each enantiomer of the amino acid derivative with 6-trimethylammonio-deoxy-beta-cyclodextrin
    H Yamamura
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    Electrophoresis 22:478-83. 2001
  10. ncbi Proline residue-modified polycationic analogs of gramicidin S with high antibacterial activity against both Gram-positive and Gram-negative bacteria and low hemolytic activity
    M Kawai
    Graduate School of Engineering, Nagoya Institute of Technology, Nagoya 466 8555, Japan
    J Pept Res 65:98-104. 2005

Detail Information

Publications13

  1. ncbi Cytotoxic activity of physalins and related compounds against HeLa cells
    M Kawai
    Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan
    Pharmazie 57:348-50. 2002
  2. ncbi The structure of physalin T from Physalis alkekengi var. franchetti
    M Kawai
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Asian Nat Prod Res 3:199-205. 2001
    ..The structure was confirmed by the chemical transformation from the known physalin D (2) to physalin T...
  3. ncbi Determination of the (R)- and (S)-enantiomers of salsolinol and N-methylsalsolinol by use of a chiral high-performance liquid chromatographic column
    Y Deng
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Chromatogr B Biomed Appl 670:47-54. 1995
    ..Preliminary results indicate that the (R)-enantiomer of both isoquinoline derivatives predominate in the human brain...
  4. ncbi Assay for the (R)- and (S)-enantiomers of salsolinols in biological samples and foods with ion-pair high-performance liquid chromatography using beta-cyclodextrin as a chiral mobile phase additive
    Y Deng
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Chromatogr B Biomed Sci Appl 689:313-20. 1997
    ..On the other hand, the (R)-enantiomers of both salsolinol and N-methylsalsolinol were found to predominate in the human brain...
  5. ncbi Cytotoxic activity of physalins possessing modified skeletal structures against HeLa cells
    B Makino
    Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan
    Pharmazie 58:70-1. 2003
  6. ncbi Preparation of (R)-N-methylsalsolinol via reversed-phase high-performance liquid chromatography using beta-cyclodextrin as a mobile-phase additive
    C Minami
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Chromatogr B Biomed Sci Appl 702:245-8. 1997
    ..Beta-cyclodextrin was removed completely in good yield by acid extraction and solid-phase extraction. By a slight modification, this method will be applicable to the isolation of various types of biologically important enantiomers...
  7. ncbi Generation of reactive oxygen species accounts for cytotoxicity of an endogenous dopaminergic neurotoxin, (R)-N-methylsalsolinol, to differentiated dopaminergic SH-SY5Y cells
    C Minami
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    J Neural Transm 105:397-405. 1998
    ..The results suggest that oxidative stress induced by hydroxyl radical may be involved in the cell death of dopaminergic neurons by N-methylsalsolinol...
  8. ncbi Tautomerism between exomethylene type physalins and oxymethylene-bridged physalins
    B Makino
    Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan
    Pharmazie 57:215-6. 2002
  9. ncbi Capillary zone electrophoretic chiral discrimination using a cationic cyclodextrin derivative: determination of velocity and association constants of each enantiomer of the amino acid derivative with 6-trimethylammonio-deoxy-beta-cyclodextrin
    H Yamamura
    Department of Applied Chemistry, Nagoya Institute of Technology, Japan
    Electrophoresis 22:478-83. 2001
    ....
  10. ncbi Proline residue-modified polycationic analogs of gramicidin S with high antibacterial activity against both Gram-positive and Gram-negative bacteria and low hemolytic activity
    M Kawai
    Graduate School of Engineering, Nagoya Institute of Technology, Nagoya 466 8555, Japan
    J Pept Res 65:98-104. 2005
    ..All of these additional amino group-containing analogs showed substantially reduced toxicity against human blood cells...
  11. ncbi Increases in body mass index, even within non-obese levels, raise the risk for Type 2 diabetes mellitus: a follow-up study in a Japanese population
    T Nagaya
    Department of Health Promotion and Preventive Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan
    Diabet Med 22:1107-11. 2005
    ..We investigated the effects of body mass index (BMI, kg/m(2)) on the incidence of diabetes mellitus in a Japanese population...
  12. ncbi Enantio-selective occurrence of (S)-tetrahydropapaveroline in human brain
    K Sango
    Department of Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan
    Neurosci Lett 283:224-6. 2000
    ..The results suggest that (S)-tetrahydropapaveroline may be enantio-selectively synthesized in human brain and it may be an intermediate of the de novo synthesis of morphine analogues...
  13. ncbi RNA polymerase mutants of Escherichia coli. III. A temperature-sensitive rifampicin-resistant mutant
    M Kawai
    Mol Gen Genet 143:233-41. 1976
    ..The hypothetical beta subunit mutation seems to modify quantitatively the rifampicin resistance caused by the beta subunit mutation...