Keiji Suzuki

Summary

Affiliation: Nagasaki University
Country: Japan

Publications

  1. ncbi Epigenetic gene silencing is a novel mechanism involved in delayed manifestation of radiation-induced genomic instability in mammalian cells
    Keiji Suzuki
    Division of Radiation and Life Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8523, Japan
    Radiat Res 175:416-23. 2011
  2. ncbi ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome
    K Suzuki
    Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Radiat Prot Dosimetry 143:279-83. 2011
  3. ncbi Creating localized DNA double-strand breaks with microirradiation
    Keiji Suzuki
    Atomic Bomb Disease Institute, Course of Life Sciences and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Nat Protoc 6:134-9. 2011
  4. ncbi Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases
    Keiji Suzuki
    Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Genome Integr 1:4. 2010
  5. ncbi Dynamics of ionizing radiation-induced DNA damage response in reconstituted three-dimensional human skin tissue
    Keiji Suzuki
    Atomic Bomb Disease Institute, Course of Life Sciences and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Radiat Res 174:415-23. 2010
  6. ncbi Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation
    Aya Ishikawa
    Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Genome Integr 1:10. 2010
  7. ncbi Long-term persistence of X-ray-induced genomic instability in quiescent normal human diploid cells
    Keiji Suzuki
    Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Mutat Res 671:33-9. 2009
  8. ncbi Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation
    Keiji Suzuki
    Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan
    Mutat Res 683:29-34. 2010
  9. ncbi [Low-dose radiation effects and intracellular signaling pathways]
    Keiji Suzuki
    Division of Radiation Biology, Graduate School of Biomedical Sciences, Nagasaki University, Japan
    Yakugaku Zasshi 126:859-67. 2006
  10. ncbi Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling
    Motohiro Yamauchi
    Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    DNA Repair (Amst) 7:405-17. 2008

Collaborators

Detail Information

Publications58

  1. ncbi Epigenetic gene silencing is a novel mechanism involved in delayed manifestation of radiation-induced genomic instability in mammalian cells
    Keiji Suzuki
    Division of Radiation and Life Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8523, Japan
    Radiat Res 175:416-23. 2011
    ..These results indicate that epigenetic gene silencing, in addition to elevated recombination, is involved in delayed mutagenesis, which is a novel mechanism underlying delayed manifestations of radiation-induced genomic instability...
  2. ncbi ATM-dependent cellular response to DNA double strand breaks plays a pivotal role in the maintenance of the integrity of the genome
    K Suzuki
    Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Radiat Prot Dosimetry 143:279-83. 2011
    ..Especially, a proper DNA damage response of cells to lower doses of ionising radiation required amplification of the ATM-dependent damage signal by recruiting the DNA damage checkpoint factors to the site of chromatin...
  3. ncbi Creating localized DNA double-strand breaks with microirradiation
    Keiji Suzuki
    Atomic Bomb Disease Institute, Course of Life Sciences and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Nat Protoc 6:134-9. 2011
    ..The quality is the same as that obtained by laser microirradiation or by any other focal irradiation. DSBs become visible within 30 min of UVC irradiation...
  4. ncbi Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases
    Keiji Suzuki
    Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Genome Integr 1:4. 2010
    ....
  5. ncbi Dynamics of ionizing radiation-induced DNA damage response in reconstituted three-dimensional human skin tissue
    Keiji Suzuki
    Atomic Bomb Disease Institute, Course of Life Sciences and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Radiat Res 174:415-23. 2010
    ..These results confirmed a dynamic DNA damage response in three-dimensional tissue, which provides a practical model for studying DNA damage response in vivo...
  6. ncbi Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation
    Aya Ishikawa
    Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Genome Integr 1:10. 2010
    ..Therefore, we have developed a novel parameter for DNA damage signal based on the image analysis of the foci and quantified the amount of the signal sufficient for G2 arrest...
  7. ncbi Long-term persistence of X-ray-induced genomic instability in quiescent normal human diploid cells
    Keiji Suzuki
    Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Mutat Res 671:33-9. 2009
    ..These results suggest that there are ROS-independent mechanism(s) induced by radiation, which can generate persistent delayed effects in quiescent cells, and could ultimately contribute to carcinogenesis...
  8. ncbi Role of Ku80-dependent end-joining in delayed genomic instability in mammalian cells surviving ionizing radiation
    Keiji Suzuki
    Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Sakamoto, Nagasaki, Japan
    Mutat Res 683:29-34. 2010
    ..Since DNA-PKcs-defective cells showed delayed phenotypes, Ku80-dependent illegitimate rejoining is involved in delayed impairment of the integrity of the genome in radiation-survived cells...
  9. ncbi [Low-dose radiation effects and intracellular signaling pathways]
    Keiji Suzuki
    Division of Radiation Biology, Graduate School of Biomedical Sciences, Nagasaki University, Japan
    Yakugaku Zasshi 126:859-67. 2006
    ..From these results, it can be concluded that low-dose radiation is sensed both in the membrane and in the nucleus, and activation of multiple signal transduction pathways could be involved in manifestations of low-dose effects...
  10. ncbi Growth of persistent foci of DNA damage checkpoint factors is essential for amplification of G1 checkpoint signaling
    Motohiro Yamauchi
    Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    DNA Repair (Amst) 7:405-17. 2008
    ....
  11. ncbi Qualitative and quantitative analysis of phosphorylated ATM foci induced by low-dose ionizing radiation
    Keiji Suzuki
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8521, Japan
    Radiat Res 165:499-504. 2006
    ....
  12. ncbi X-ray-induced telomeric instability in Atm-deficient mouse cells
    Barkhaa Undarmaa
    Laboratory of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki 852 8521, Japan
    Biochem Biophys Res Commun 315:51-8. 2004
    ....
  13. ncbi Delayed induction of telomere instability in normal human fibroblast cells by ionizing radiation
    Mitsuaki Ojima
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Japan
    J Radiat Res (Tokyo) 45:105-10. 2004
    ..Because no induction of telomere abnormality was observed in cells 24 hours after irradiation, X-irradiation might not affect telomeres directly, but it specifically induces delayed telomere instability in normal human fibroblast cells...
  14. ncbi Interstitial chromatin alteration causes persistent p53 activation involved in the radiation-induced senescence-like growth arrest
    Masatoshi Suzuki
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Biochem Biophys Res Commun 340:145-50. 2006
    ..Our results indicate that chromatin alteration in interstitial chromosomal regions is the most likely cause of continuous activation of p53, which results in the induction of SLGA by ionizing radiation...
  15. ncbi Exogenous expression of exonuclease domain-deleted WRN interferes with the repair of radiation-induced DNA damages
    Genro Kashino
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Japan
    J Radiat Res (Tokyo) 46:407-14. 2005
    ..These results suggested a function of WRN exonuclease activity that is separable from helicase activity and is essential for the repair of radiation-induced DNA damages...
  16. ncbi Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation
    Masatoshi Suzuki
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Nagasaki University, Nagasaki, Japan
    Radiat Res 165:269-76. 2006
    ..It is suggested that "residual" foci indicate an aberrant chromatin structure by illegitimate rejoining but not a DNA double-strand break itself...
  17. ncbi Involvement of telomere dysfunction in the induction of genomic instability by radiation in scid mouse cells
    Ayumi Urushibara
    Division of Radiation Biology, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Biochem Biophys Res Commun 313:1037-43. 2004
    ..Thus, the present study suggests that a cause of genomic instability is telomere dysfunction induced by radiation and that a defect in DNA-PKcs enhances the telomeric destabilization...
  18. ncbi Alteration of p53-binding protein 1 expression during skin carcinogenesis: association with genomic instability
    Yuki Naruke
    Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki Unviersity Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Cancer Sci 99:946-51. 2008
    ..The detection of 53BP1 expression by immunofluorescence can be a useful histological marker to estimate the malignant potential of human skin tumors...
  19. ncbi Mode of ATM-dependent suppression of chromosome translocation
    Motohiro Yamauchi
    Graduate School of Biomedical Sciences, Nagasaki University, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Biochem Biophys Res Commun 416:111-8. 2011
    ..From the results in the present study, we conclude that ATM minimizes translocation frequency through its commitment to G1 checkpoint and DNA double-strand break repair pathway that requires kinase activity of DNA-PKcs...
  20. ncbi Delayed reactivation of p53 in the progeny of cells surviving ionizing radiation
    Keiji Suzuki
    Laboratory of Radiation and Life Science, School of Pharmaceutical Sciences, Nagasaki University, Nagasaki 852 8521, Japan
    Cancer Res 63:936-41. 2003
    ..e., the breaks lead to delayed chromosome rearrangements, delayed cell death, and so forth, many generations after irradiation and that activation of p53 function may eliminate cells that have potentially accumulated genomic alterations...
  21. ncbi Involvement of reactive oxygen species (ROS) in the induction of genetic instability by radiation
    Hideyuki Tominaga
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Graduate School of Biomedical Science, Nagasaki University, Japan
    J Radiat Res (Tokyo) 45:181-8. 2004
    ..The APM treatment kept the ROS production at a lower level than an untreated control. These results suggest that the cause of genetic instability might be fixed by ROS during a 2-week postirradiation period...
  22. ncbi Persistence and dynamics of DNA damage signal amplification determined by microcolony formation and live-cell imaging
    Yasuyoshi Oka
    Atomic Bomb Disease Institute, Graduate School of Biochemical Sciences, Nagasaki University, Nagasaki 852 8523, Japan
    J Radiat Res 52:766-74. 2011
    ..Thus, our results indicate that amplified DNA damage signal could be ignored, which may be explained in part by the dynamic nature of the amplification process...
  23. ncbi Genomic instability in the epidermis induced by atomic bomb (A-bomb) radiation: a long-lasting health effect in A-bomb survivors
    Yuki Naruke
    Department of Tumor and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Cancer 115:3782-90. 2009
    ..In this study, the authors evaluated the presence of GIN in the epidermis of survivors as a late effect of A-bomb radiation...
  24. ncbi Activation of ATM and phosphorylation of p53 by heat shock
    Mana Miyakoda
    Laboratory of Radiation and Life Science, School of Pharmaceutical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Oncogene 21:1090-6. 2002
    ..These results indicate that heat shock induces phosphorylation of p53, especially at Ser15, and its phosphorylation is mediated by ATM kinase...
  25. ncbi Dedifferentiation of human primary thyrocytes into multilineage progenitor cells without gene introduction
    Keiji Suzuki
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Nagasaki, Japan
    PLoS ONE 6:e19354. 2011
    ..The presently described culture system may be useful for regenerative medicine, but the primary importance will be as a tool to elucidate the mechanisms of thyroid diseases...
  26. ncbi Mutation analysis of RAP1 gene in papillary thyroid carcinomas
    Michiko Matsuse
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Endocr J 56:161-4. 2009
    ..No mutations in either RAP1A or RAP1B genes were found. These results suggest that RAP1 mutation does not play an important role in PTC pathogenesis...
  27. ncbi A novel and simple micro-irradiation technique for creating localized DNA double-strand breaks
    Keiji Suzuki
    Atomic Bomb Disease Institute, Course of Life Sciences and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Nucleic Acids Res 38:e129. 2010
    ..The present technique should accelerate research in the fields of DNA damage response, DNA repair and DNA recombination, as it provides more chances to perform micro-irradiation experiments without any specific equipment...
  28. ncbi Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis
    Katsuya Matsuda
    Department of Tumour and Diagnostic Pathology, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Histopathology 59:441-51. 2011
    ..Our aim was to analyse the presence of DSBs by immunofluorescence for 53BP1 expression in a series of cervical lesions, to evaluate the significance of GIN during carcinogenesis...
  29. ncbi Reciprocal paracrine interactions between normal human epithelial and mesenchymal cells protect cellular DNA from radiation-induced damage
    Yuka Nakazawa
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Radiat Oncol Biol Phys 71:567-77. 2008
    ..To explore whether interactions between normal epithelial and mesenchymal cells can modulate the extent of radiation-induced DNA damage in one or both types of cells...
  30. ncbi Relief of oxidative stress by ascorbic acid delays cellular senescence of normal human and Werner syndrome fibroblast cells
    Genro Kashino
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Free Radic Biol Med 35:438-43. 2003
    ....
  31. ncbi Delayed activation of DNA damage checkpoint and radiation-induced genomic instability
    Keiji Suzuki
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Japan
    Mutat Res 597:73-7. 2006
    ..The possible involvement of delayed activation of a DNA damage checkpoint in the delayed induction of genomic instability in bystander cells is also discussed...
  32. ncbi Different involvement of radical species in irradiated and bystander cells
    Tadayuki Harada
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
    Int J Radiat Biol 84:809-14. 2008
    ..To examine whether nitric oxide (NO) and other radical species are involved in radiation-induced bystander effects in normal human fibroblasts...
  33. ncbi miR-195, miR-455-3p and miR-10a( *) are implicated in acquired temozolomide resistance in glioblastoma multiforme cells
    Kenta Ujifuku
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Japan
    Cancer Lett 296:241-8. 2010
    ..In conclusion, our findings suggest that those miRNAs may play a role in acquired TMZ resistance and could be a novel target for recurrent GBM treatment...
  34. ncbi Stabilization of alanine substituted p53 protein at Ser15, Thr18, and Ser20 in response to ionizing radiation
    Motohiro Yamauchi
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Biochem Biophys Res Commun 323:906-11. 2004
    ..These results indicate that the phosphorylation of p53 at Ser15, Thr18, and Ser20 is not necessarily needed for p53 stabilization in response to ionizing radiation...
  35. ncbi Recruitment of the cohesin loading factor NIPBL to DNA double-strand breaks depends on MDC1, RNF168 and HP1? in human cells
    Yasuyoshi Oka
    Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University, Graduate School of Biomedical Sciences, Japan
    Biochem Biophys Res Commun 411:762-7. 2011
    ..Taken together, our study reveals that human NIPBL is a novel protein recruited to DSB sites, and the recruitment is controlled by MDC1, RNF168 and HP1?...
  36. ncbi Abnormal stability of wild-type p53 protein in a human lung carcinoma cell line
    Motohiro Yamauchi
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Biochem Biophys Res Commun 330:483-8. 2005
    ..These results provide a novel mechanism, by which p53 is stabilized in tumor cells, and they suggest that a mediator should exist between ubiquitinated p53 and proteasome, which may be defective in H1299 cells...
  37. ncbi The FOXE1 and NKX2-1 loci are associated with susceptibility to papillary thyroid carcinoma in the Japanese population
    Michiko Matsuse
    Department of Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Med Genet 48:645-8. 2011
    ..FOXE1 and NKX2-1 are two known genetic risk factors for the predisposition to sporadic papillary thyroid carcinoma (PTC) in Europeans, but their association in other ethnicities is still unknown...
  38. ncbi Radiation-induced DNA damage and delayed induced genomic instability
    Keiji Suzuki
    Department of Radiology and Radiation Biology, Course of Life Sciences and Radiation Research, Graduate School of Biomedical Sciences, Nagasaki University, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Oncogene 22:6988-93. 2003
    ..In particular, the mechanism(s) involved in the initiation and perpetuation of radiation-induced genomic instability, and a role of delayed activation of p53 protein are discussed...
  39. ncbi p53 status-dependent sensitization of human tumour cells to hyperthermia by plant flavonol
    Tomoyuki Hamamoto
    Department of Hospital Pharmacy, Nagasaki University School of Medicine, Nagasaki, Japan
    Int J Hyperthermia 24:415-24. 2008
    ..This study was conducted to examine the effects of QCT on the heat sensitivities of human tumour cell lines with different p53 statuses...
  40. ncbi Ionizing radiation accelerates Drp1-dependent mitochondrial fission, which involves delayed mitochondrial reactive oxygen species production in normal human fibroblast-like cells
    Shinko Kobashigawa
    Atomic Bomb Disease Institute, Course of Life Sciences and Radiation Research, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Biochem Biophys Res Commun 414:795-800. 2011
    ....
  41. ncbi Low dose of wortmannin reduces radiosensitivity of human glioblastoma cells through the p53 pathway
    Kumio Okaichi
    Department of Radiation Biophysics, Radiation Effect Research Unit, Atomic Bomb Disease Institute, Nagasaki University School of Medicine, Sakamoto, Nagasaki 852 8523, Japan
    Oncol Rep 9:859-62. 2002
    ..A low dose of wortmannin did not affect the accumulation of p53 and the phosphorylation of p53 at ser-15, but reduced the induction of WAF1 and enhanced the induction of GADD45...
  42. ncbi Foci formation of P53-binding protein 1 in thyroid tumors: activation of genomic instability during thyroid carcinogenesis
    Masahiro Nakashima
    Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Int J Cancer 122:1082-8. 2008
    ..We propose that immunofluorescence analysis of 53BP1 expression can be a useful tool to estimate the level of GIN and, simultaneously, the malignant potency of human thyroid tumors...
  43. ncbi Gap junctional intercellular communication and cellular response to heat stress
    Nobuyuki Hamada
    Division of Radiation Biology, Department of Radiology and Radiation Biology, Graduate School of Biomedical Sciences, Nagasaki University, 1-14 Bunkyo-machi, Nagasaki 852-8521, Japan
    Carcinogenesis 24:1723-8. 2003
    ..Our present results imply that GJIC contributes to protection against heat stress and that loss of GJIC function during carcinogenesis exacerbates hyperthermic lethality...
  44. ncbi Acceleration of astrocytic differentiation in neural stem cells surviving X-irradiation
    Ayumi Ozeki
    Department of Radiation Medical Sciences, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    Neuroreport 23:290-3. 2012
    ....
  45. ncbi [Molecular mechanism of cell death by radiation]
    Masami Watanabe
    Division of Radiation Biology, Graduate School of Biomedical Sciences, Nagasaki University
    Nippon Igaku Hoshasen Gakkai Zasshi 62:540-4. 2002
    ..SLGA can be utilized as an index of cancer therapy, because it is induced not only by radiation but also by anticancer drugs and is easy to examine by vital staining, thereby making the induction of SA-beta-gal an index...
  46. ncbi Non-specific detection of the centrosomes by antibodies recognizing phosphorylated ATM at serine 1981
    Keiji Suzuki
    Cell Cycle 5:1008-9; author reply 1010. 2006
  47. ncbi Current topics in DNA double-strand break repair
    Junya Kobayashi
    Department of Genome Repair Dynamics, Radiation Biology Center, Kyoto University, Kyoto, Japan
    J Radiat Res 49:93-103. 2008
    ..In addition to the function of these proteins in DSB repair, the biological function of nuclear foci formation following DSB induction is discussed...
  48. ncbi Effective suppression of bystander effects by DMSO treatment of irradiated CHO cells
    Genro Kashino
    Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University
    J Radiat Res 48:327-33. 2007
    ..It is suggested that increased ROS in irradiated cells is not a substantial trigger of a bystander signal...
  49. ncbi Transmission of genomic instability from a single irradiated human chromosome to the progeny of unirradiated cells
    Naoki Mukaida
    Division of Radiation Life Science, Department of Radiation Life Science and Radiation Medical Science, Kyoto University Research Reactor Institute, Osaka, Japan
    Radiat Res 167:675-81. 2007
    ....
  50. ncbi Histone H2AX phosphorylation in normal human cells irradiated with focused ultrasoft X rays: evidence for chromatin movement during repair
    Nobuyuki Hamada
    Cell and Molecular Radiation Biology Group, Gray Cancer Institute, PO Box 100, Mount Vernon Hospital, Northwood, Middlesex, HA6 2JR, United Kingdom
    Radiat Res 166:31-8. 2006
    ..4-fold longer in AlK-irradiated cells than that in cells exposed to conventional X rays. For conventional X rays, we also report significant accumulation of larger-sized foci at longer times after irradiation...
  51. ncbi Orally administrated aluminum-maltolate complex enhances oxidative stress in the organs of mice
    Noritsugu Kaneko
    Department of Analytical and Bioinorganic Chemistry, Kyoto Pharmaceutical University, 5 Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto 607-8414, Japan
    J Inorg Biochem 98:2022-31. 2004
    ..The level of Al in the organs can then be determined by subtraction of the radioactivity due to 28Al originated in 31P from the total radioactivity of the samples...
  52. ncbi Differences in effects of oncogenes on sensitivity to anticancer drugs
    Tomoyuki Hamamoto
    Department of Hospital Pharmacy, Nagasaki University School of Medicine, Japan
    J Radiat Res (Tokyo) 46:197-203. 2005
    ..These results suggest that the expression of each oncogene would differently affect sensitivity to the four anticancer drugs used in this study, and this property could be a possible marker to predict chemosensitivity...
  53. ncbi Pulmonary function and structure following mild preterm birth in lambs
    Megan Cock
    Fetal and Neonatal Research Group, Department of Physiology, Monash University, Melbourne, Victoria, Australia
    Pediatr Pulmonol 40:336-48. 2005
    ..Persistent increases in lung protein content and in the thickness of the airway epithelium, and a greater number of smaller alveolar, may alter later lung function...
  54. ncbi Radiation induced bystander signals are independent of DNA damage and DNA repair capacity of the irradiated cells
    Genro Kashino
    Gray Cancer Institute, P O Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Mutat Res 619:134-8. 2007
    ..Overall the work presented here adds to the understanding that it is the repair phenotype of the cells receiving bystander signals, which determines overall response rather than that of the cell producing the bystander signal...
  55. ncbi Increased chromosome instability and accumulation of DNA double-strand breaks in Werner syndrome cells
    Kentaro Ariyoshi
    Laboratory of Radiation Biology, Research Reactor Institute, Kyoto University
    J Radiat Res (Tokyo) 48:219-31. 2007
    ..These results indicate that WS cells are prone to accumulate DSBs spontaneously due to a defect of WRN, which leads to increased chromosome instability that could activate checkpoints, resulting in accelerated senescence...
  56. ncbi Fetal growth restriction has long-term effects on postnatal lung structure in sheep
    Gert S Maritz
    Department of Physiology, University of the West Cape, Bellville, South Africa
    Pediatr Res 55:287-95. 2004
    ....
  57. ncbi Changes of heavy metal, metallothionein and heat shock proteins in Sertoli cells induced by cadmium exposure
    Takahiko Kusakabe
    School of Health Sciences, Faculty of Medicine, Gunma University, 3 39 15 Shouwa machi, Maebashi, Gunma, Japan
    Toxicol In Vitro 22:1469-75. 2008
    ..As a result, Cd-induced MT was protected Sertoli cells against apoptosis, and Cd-induced HO-1 was involved in protection against oxidative stress. Incidentally, MT, Hsp70 and HO-1 showed similar responses to Cd exposure...
  58. ncbi Evidence for induction of DNA double strand breaks in the bystander response to targeted soft X-rays in CHO cells
    Genro Kashino
    Gray Cancer Institute, P.O. Box 100, Mount Vernon Hospital, Northwood, Middlesex HA6 2JR, UK
    Mutat Res 556:209-15. 2004
    ..These results suggest that DNA double strand breaks rather than base damage are caused by factors secreted in the medium from irradiated cells...