Research Topics
| Naoto AshizawaSummaryAffiliation: Nagasaki University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
A 15-year longitudinal follow-up study of heart rate and heart rate variability in healthy elderly personsH Tasaki
The Third Department of Internal Medicine, Nagasaki University School of Medicine, Japan
J Gerontol A Biol Sci Med Sci 55:M744-9. 2000..The objective of this study was to evaluate long-term changes in HR and heart rate variability (HRV) with aging in healthy elderly persons by means of comparison between two Holter monitor recordings obtained at an interval of 15 years...- Sisters with atypical Fabry's disease with complete atrioventricular blockY Doi
Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Heart 89:e2. 2003..In conclusion, two sisters were encountered displaying interesting cases of atypical Fabry's disease. Symptoms began with complete atrioventricular block and histological myocardial findings were specific for Fabry's disease... - A rare case of aortic tube graft occlusion 35 years after coarctectomyNaoto Ashizawa
Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki City, Nagasaki, Japan
Ann Thorac Surg 75:1961-3. 2003..The patient was rescued by an emergency axillofemoral bypass, and residual hypertension in upper limbs was improved by elective ascending aorta-descending aorta bypass grafting... - Disappearance of the Brugada-type electrocardiogram after surgical castration: a role for testosterone and an explanation for the male preponderanceKiyotaka Matsuo
Department of Clinical Studies, Radiation Effects Research Foundation, Nagasaki University School of Medicine, Nagasaki, Japan
Pacing Clin Electrophysiol 26:1551-3. 2003..These facts suggest a possible association between manifestation of the Brugada-type ECG pattern and testosterone... - Fibrotic response to angiotensin II is blunted in the kidney, but not in the heart, in insulin-sensitive long-lived transgenic dwarf ratsOsami Sato
Division of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Int J Mol Med 19:23-7. 2007.... - GH suppresses TGF-beta-mediated fibrosis and retains cardiac diastolic functionRyo Imanishi
Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki 852-8501, Japan
Mol Cell Endocrinol 218:137-46. 2004..These results demonstrated that a chronic excess of GH have an anti-fibrotic effect on cardiac remodeling, probably through a down-regulation of TGF-beta signaling via de-phosphorylation of p38 MAPK... - administration of nifedipine CR immediately after awakening prevents a morning surge in hypertensive patients. Case report of three casesHiroaki Kawano
Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Blood Press 12:44-8. 2003..Administration of nifedipine CR immediately after awakening is one option that can be used to prevent morning surge as well as to control blood pressure throughout the day... - Sotalol-induced coronary spasm in a patient with dilated cardiomyopathy associated with sustained ventricular tachycardiaShigenori Muto
Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki
Intern Med 43:1051-5. 2004..ST elevation with chest discomfort disappeared since he began taking long-acting diltiazem. Coronary vasospasm may be induced by the non-selective beta-blocking properties of sotalol... - Administration of nifedipine CR immediately after awakening prevents a morning surge in hypertensive patients. Case report of three casesHiroaki Kawano
Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Japan
Blood Press Suppl 1:44-8. 2003..Administration of nifedipine CR immediately after awakening is one option that can be used to prevent morning surge as well as to control blood pressure throughout the day... - Bedtime administration of cilnidipine controls morning hypertensionNaoto Ashizawa
Division of Cardiovascular Medicine, Nagasaki University, Nagasaki, Japan
Int Heart J 48:597-603. 2007..The microalbuminuria decreased from 39.6 +/- 13.2 to 27.3 +/- 8.4 mg/g Cr. In conclusion, L-/N-type CCB cilnidipine may be useful for patients with uncontrollable morning hypertension by reducing both ME average and ME difference... - Aldosterone induces circadian gene expression of clock genes in H9c2 cardiomyoblastsKyoe Tanaka
Division of Cardiovascular Medicine, Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
Heart Vessels 22:254-60. 2007..Second, an acute increase in Per1 mRNA after aldosterone treatment is mediated through MR. Third, clock genes are not related to PAI-1 expression in H9c2 cardiomyoblasts... - Risk of development of abdominal aortic aneurysm and dissection of thoracic aorta in a postpartum woman with Marfan's syndromeAki Tomihara
Department of Pathology, Nagasaki University Hospital, Nagasaki, Japan
Intern Med 45:1285-9. 2006..Moreover, the patient subsequently developed a Stanford type B thoracic aortic dissection, even after more than four months of beta-blockade... - Segmental mediolytic arteriopathy involving celiac to splenic and left renal arteriesChisa Takagi
Division of Cardiovascular Medicine, Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Nagasaki University, Sakamoto, Nagasaki
Intern Med 42:818-23. 2003..The patient was also found to have an adrenocortical adenoma, gastrointestinal stromal tumor, hepatocellular carcinoma and schizophrenia. The relationship between SMA and other accompanying diseases was discussed... - [Fungal pericarditis]Naoto Ashizawa
Division of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Nippon Rinsho . 2007 - [Prognosis of elderly hypertension]Naoto Ashizawa
Division of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Nippon Rinsho 64:338-41. 2006 - Hypercalcemia due to vitamin D intoxication with clinical features mimicking acute myocardial infarctionNaoto Ashizawa
Division of Cardiovascular Medicine, Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki
Intern Med 42:340-4. 2003..We introduce the use of QaTc interval shortening in differentiating ST-T changes of hypercalcemia from those of true myocardial ischemia... - Serum adiponectin and leptin in a patient with Cushing's syndrome before and after adrenalectomyNaoto Ashizawa
Division of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Intern Med 46:383-5. 2007..8 ng/ml) before the operation and decreased to within the normal range (6.0 ng/ml) 6 months after adrenalectomy, concomitant with weight reduction and normalization of the serum cortisol level... - [Bacterial pericarditis]Naoto Ashizawa
Division of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Nippon Rinsho . 2007 - A case of mixed connective tissue disease complicated with hypertrophic obstructive cardiomyopathyHideki Nakamura
First Department of Internal Medicine, Graduate School of Biomedical Sciences, Nagasaki University, 1 7 1 Sakamoto, Nagasaki City, Nagasaki 852 8501, Japan
Rheumatol Int 28:1273-5. 2008..She was treated with prednisolone, resulting in improvement of swollen hand, elevated muscle enzymes and interstitial pneumonia. A rare complication of HOCM with MCTD was described... - [Plasma B-type natriuretic peptide (BNP) measuring]Naoto Ashizawa
Division of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Nippon Rinsho 64:861-4. 2006..Measurement of plasma BNP is proved to be not only an efficient but also a cost effective screening tool for identifying patients with acute dyspnea of unknown etiology... - Norepinephrine enhances fibrosis mediated by TGF-beta in cardiac fibroblastsYuri Akiyama-Uchida
Department of Cardiovascular Medicine, Atomic Bomb Disease Institute, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan
Hypertension 40:148-54. 2002..Furthermore, this synergistic effect was attenuated by a specific inhibitor of p38, SB203680. These data indicate that NE enhances cardiac fibrosis through TGF-beta1 post-receptor signaling, predominantly via the p38 MAP kinase pathway... - [Digitalis: characteristics, mechanisms of action, pharmacokinetics, indication, contraindication, clinical data, and side effects]Naoto Ashizawa
Division of Cardiovascular Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Nippon Rinsho 65:14-8. 2007 - Structural analysis of obscurin gene in hypertrophic cardiomyopathyTakuro Arimura
Department of Molecular Pathogenesis, Medical Research Institute and Laboratory of Genome Diversity, School of Biomedical Science, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
Biochem Biophys Res Commun 362:281-7. 2007..Myc-tagged obscurin showed that Arg4344Gln impaired obscurin localization to Z-band. These observations suggest that the obscurin abnormality may be involved in the pathogenesis of HCM...