Yuko Muto

Summary

Affiliation: Meiji Seika Kaisha
Country: Japan

Publications

  1. ncbi Carboxypeptidase B inhibitors reduce tissue factor-induced renal microthrombi in rats
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Eur J Pharmacol 461:181-9. 2003
  2. ncbi Pharmacokinetic and pharmacodynamic properties of biapenem, a carbapenem antibiotic, in rat experimental model of severe acute pancreatitis
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Pancreas 36:125-32. 2008
  3. ncbi EF6265, a novel plasma carboxypeptidase B inhibitor, protects against renal dysfunction in rat thrombotic glomerulonephritis through enhancing fibrinolysis
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan
    Nephron Exp Nephrol 106:e113-21. 2007
  4. ncbi EF6265, a novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor, protects against sepsis-induced organ dysfunction in rats
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan
    Crit Care Med 37:1744-9. 2009
  5. ncbi Enhancement of fibrinolysis by EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxyphosphinoyl] methyl]heptanoic acid], a specific inhibitor of plasma carboxypeptidase B
    Kokichi Suzuki
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan
    J Pharmacol Exp Ther 309:607-15. 2004
  6. ncbi Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans
    Seigo Baba
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    Am J Clin Nutr 85:709-17. 2007
  7. ncbi Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans
    Seigo Baba
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama 350 0289, Japan
    Eur J Nutr 44:1-9. 2005
  8. ncbi Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2
    Chan Choo Yap
    Laboratory for Cellular Information Processing, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Mol Cell Neurosci 24:283-95. 2003
  9. ncbi CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase
    Chan Choo Yap
    Laboratories for Cellular Information Processing, Brain Science Institute BSI, RIKEN, Wako, Saitama, Japan
    J Neurochem 85:123-34. 2003
  10. ncbi PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein
    Chan Choo Yap
    Laboratory for Cellular Information Processing, Brain Science Institute, RIKEN, Wako, 351 0198, Saitama, Japan
    Biochem Biophys Res Commun 301:1122-8. 2003

Collaborators

Detail Information

Publications10

  1. ncbi Carboxypeptidase B inhibitors reduce tissue factor-induced renal microthrombi in rats
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Eur J Pharmacol 461:181-9. 2003
    ..These results indicate that carboxypeptidase B inhibitors can enhance endogenous fibrinolysis and reduce thrombi in the TF-induced microthrombosis model after systemic administration even after thrombi formation...
  2. ncbi Pharmacokinetic and pharmacodynamic properties of biapenem, a carbapenem antibiotic, in rat experimental model of severe acute pancreatitis
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Pancreas 36:125-32. 2008
    ..In this study,we modified a rat experimental model of severe acute pancreatitis for antibiotic evaluation, and the effect of biapenem was compared with that of imipenem to determine the usefulness of biapenem...
  3. ncbi EF6265, a novel plasma carboxypeptidase B inhibitor, protects against renal dysfunction in rat thrombotic glomerulonephritis through enhancing fibrinolysis
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan
    Nephron Exp Nephrol 106:e113-21. 2007
    ..In the present study, the effects of EF6265, a novel specific plasma carboxypeptidase B inhibitor, on renal dysfunction in a rat thrombotic glomerulonephritis model were examined...
  4. ncbi EF6265, a novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor, protects against sepsis-induced organ dysfunction in rats
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan
    Crit Care Med 37:1744-9. 2009
    ..We performed the pharmacologic study to assess the effect of EF6265, a specific inhibitor of activated form of TAFI (TAFIa) on sepsis-induced organ dysfunction models...
  5. ncbi Enhancement of fibrinolysis by EF6265 [(S)-7-amino-2-[[[(R)-2-methyl-1-(3-phenylpropanoylamino)propyl]hydroxyphosphinoyl] methyl]heptanoic acid], a specific inhibitor of plasma carboxypeptidase B
    Kokichi Suzuki
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan
    J Pharmacol Exp Ther 309:607-15. 2004
    ....
  6. ncbi Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans
    Seigo Baba
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    Am J Clin Nutr 85:709-17. 2007
    ..Cocoa powder is rich in polyphenols such as catechins and procyanidins and has been shown in various models to inhibit LDL oxidation and atherogenesis...
  7. ncbi Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans
    Seigo Baba
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama 350 0289, Japan
    Eur J Nutr 44:1-9. 2005
    ..Previous studies have shown RA has antioxidative and anti-inflammatory activity. However, little is known on the absorption, metabolism, degradation and excretion of RA...
  8. ncbi Adaptor protein complex-4 (AP-4) is expressed in the central nervous system neurons and interacts with glutamate receptor delta2
    Chan Choo Yap
    Laboratory for Cellular Information Processing, Brain Science Institute, RIKEN, Wako, Saitama 351 0198, Japan
    Mol Cell Neurosci 24:283-95. 2003
    ..In addition, overexpression of mu4 substantially altered the distribution pattern of delta2 in heterologous cells. These results suggest a potential involvement of AP-4 in the trafficking of delta2 in the brain...
  9. ncbi CIP98, a novel PDZ domain protein, is expressed in the central nervous system and interacts with calmodulin-dependent serine kinase
    Chan Choo Yap
    Laboratories for Cellular Information Processing, Brain Science Institute BSI, RIKEN, Wako, Saitama, Japan
    J Neurochem 85:123-34. 2003
    ..In view of its direct association with CASK, CIP98 may be involved in the formation of CASK scaffolding proteins complex to facilitate synaptic transmission in the CNS...
  10. ncbi PKC regulates the delta2 glutamate receptor interaction with S-SCAM/MAGI-2 protein
    Chan Choo Yap
    Laboratory for Cellular Information Processing, Brain Science Institute, RIKEN, Wako, 351 0198, Saitama, Japan
    Biochem Biophys Res Commun 301:1122-8. 2003
    ..These results show a novel regulatory mechanism for the binding of PDZ domain proteins and suggest that the interaction between delta2 receptor and S-SCAM/MAGI-2 may be important for intracellular trafficking of the receptor...