Hirofumi Tachibana

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor
    Ju Hye Lee
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki, Japan
    PLoS ONE 5:e11051. 2010
  2. ncbi Green tea polyphenol sensing
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 87:66-80. 2011
  3. ncbi Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Dept of Bioscience and Biotechnology, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka, 812 8581, Japan
    Eur J Nutr 46:257-63. 2007
  4. ncbi Light chain shifting: identification of a human plasma cell line actively undergoing light chain replacement
    H Tachibana
    Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Blood 93:198-207. 1999
  5. ncbi A receptor for green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Nat Struct Mol Biol 11:380-1. 2004
  6. ncbi Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: lipid rafts mediate anti-allergic action of the catechin
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biofactors 21:383-5. 2004
  7. ncbi Molecular basis for cancer chemoprevention by green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, Japan
    Forum Nutr 61:156-69. 2009
  8. ncbi Green tea polyphenol EGCG signaling pathway through the 67-kDa laminin receptor
    Hirofumi Tachibana
    Nippon Yakurigaku Zasshi 132:145-9. 2008
  9. ncbi Induction of light chain replacement in human plasma cells by caffeine is independent from both the upregulation of RAG protein expression and germ line transcription
    H Tachibana
    Division of Bioresources, Graduate School, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka, 812 8581, Japan
    J Biol Chem 275:5927-33. 2000
  10. ncbi Identification of a methylated tea catechin as an inhibitor of degranulation in human basophilic KU812 cells
    H Tachibana
    Division of Bioresources and Bioenvironmental Science, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 64:452-4. 2000

Collaborators

Detail Information

Publications68

  1. ncbi Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor
    Ju Hye Lee
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki, Japan
    PLoS ONE 5:e11051. 2010
    ....
  2. ncbi Green tea polyphenol sensing
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 87:66-80. 2011
    ..Here, we review some of the reported mechanisms for the cancer chemopreventive action of EGCG and provide an overview of several molecules that sense and manage the physiological functions of EGCG...
  3. ncbi Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Dept of Bioscience and Biotechnology, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka, 812 8581, Japan
    Eur J Nutr 46:257-63. 2007
    ..We also demonstrated that dietary apigenin decreased IgE level in C57BL/6N mice sera...
  4. ncbi Light chain shifting: identification of a human plasma cell line actively undergoing light chain replacement
    H Tachibana
    Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Blood 93:198-207. 1999
    ..These results suggest that human plasma cells have the potential to actively undergo light chain replacement...
  5. ncbi A receptor for green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Nat Struct Mol Biol 11:380-1. 2004
    ..Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value...
  6. ncbi Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: lipid rafts mediate anti-allergic action of the catechin
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biofactors 21:383-5. 2004
    ..These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcepsilonRI expression...
  7. ncbi Molecular basis for cancer chemoprevention by green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Kyushu University, Fukuoka, Japan
    Forum Nutr 61:156-69. 2009
    ..Our data shed new light on the molecular basis for the cancer-preventive activity of EGCG in vivo and helps in the design of new strategies to prevent cancer...
  8. ncbi Green tea polyphenol EGCG signaling pathway through the 67-kDa laminin receptor
    Hirofumi Tachibana
    Nippon Yakurigaku Zasshi 132:145-9. 2008
  9. ncbi Induction of light chain replacement in human plasma cells by caffeine is independent from both the upregulation of RAG protein expression and germ line transcription
    H Tachibana
    Division of Bioresources, Graduate School, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka, 812 8581, Japan
    J Biol Chem 275:5927-33. 2000
    ..Therefore, although phosphatase inhibition might act, in part, on a mechanism by which V(D)J recombinase activity is regulated within the human plasma cells, other factor(s) are probably also involved in the process...
  10. ncbi Identification of a methylated tea catechin as an inhibitor of degranulation in human basophilic KU812 cells
    H Tachibana
    Division of Bioresources and Bioenvironmental Science, Graduate School, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 64:452-4. 2000
    ..This result indicates that methylation of (-)-epigallocatechin gallate may be an effective modification for the catechin to inhibit degranulation from human basophils...
  11. ncbi Identification of an inhibitor for interleukin 4-induced epsilon germline transcription and antigen-specific IgE production in vivo
    H Tachibana
    Graduate School of Bioresources and Bioenvironmental Science, Kyushu University, Hakozaki 6 10 1, Higashi ku, Fukuoka, 812 8581, Japan
    Biochem Biophys Res Commun 280:53-60. 2001
    ..Taken together, these results suggest that strictinin can inhibit IgE production through the inhibition of IL-4-mediated signaling in B cells...
  12. ncbi Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Agric Food Chem 54:5203-7. 2006
    ..These results suggest that a diet containing apigenin can reduce serum IgE and inflammatory cytokines such as RANTES and sTNFRI in mice...
  13. ncbi Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo
    Yuhei Hiura
    Faculty of Agriculture, Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812 8581, Japan
    J Nutr Biochem 20:607-13. 2009
    ..These results, to our knowledge, are the first demonstration of specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3 accumulation is critical for the antitumor activities of T3...
  14. ncbi Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan
    Nutrition 22:54-9. 2006
    ..We evaluated the effects of dietary pomegranate seed oil (PSO), which contains high levels of punicic acid (9c, 11t, 13c-octadecatrienoic acid), on immune function and lipid metabolism in C57BL/6N mice...
  15. ncbi Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo
    Masao Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:505-11. 2002
    ..5 wt.% enhances the growth of transplanted dRLh-84 cells in vivo. It is believed that growth promotion of dRLh-84 cells in vivo by CLA cannot be clarified by the PG synthesis dependent mechanism...
  16. ncbi The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 364:79-85. 2007
    ..These results suggest that anti-allergic effects of EGCG3"Me may be triggered by the inhibition of MRLC or ERK1/2 phosphorylation mediated through the cell-surface 67LR...
  17. ncbi Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain
    Shuya Yamashita
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    FEBS Lett 584:775-9. 2010
    ..Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling...
  18. ncbi The involvement of the 67 kDa laminin receptor-mediated modulation of cytoskeleton in the degranulation inhibition induced by epigallocatechin-3-O-gallate
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 348:524-31. 2006
    ..These findings suggest that EGCG-induced inhibition of the degranulation includes the primary binding of EGCG to the cell surface 67LR and subsequent modulation of cytoskeleton...
  19. ncbi Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    J Biol Chem 283:3050-8. 2008
    ..Additionally, we found that eEF1A is up-regulated by EGCG through 67LR. Overall, these findings implicate both eEF1A and MYPT1 in EGCG signaling for cancer prevention through 67LR...
  20. ncbi Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats
    Akira Hirao
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:9-12. 2004
    ..In conclusion, the data suggests that dietary CLA inhibits DNA synthesis after PH, which results in hepatocyte proliferation inhibition...
  21. ncbi Relationship between the biological activities of methylated derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) and their cell surface binding activities
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka, Japan
    J Agric Food Chem 55:7144-8. 2007
    ....
  22. ncbi Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Division of Bioresources and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Biochem Biophys Res Commun 297:193-201. 2002
    ..These results suggest that the suppression of Fc epsilon RI expression by PPARs may be due to the down-regulation of Fc epsilon RI alpha or gamma mRNA...
  23. ncbi IgM production of lymphocytes from C57BL/6N mice was stimulated by estrogen treated splenic adherent cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Immunol Lett 98:225-31. 2005
    ....
  24. ncbi Cytotoxity of the trans10,cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, 1 1 Gakuenkibanadai nishi, Miyazaki 889 2192, Japan
    In Vitro Cell Dev Biol Anim 41:239-44. 2005
    ..When cells were treated with 10 microM 10t,12c-CLA for more than 48 h, treatment with additional CLA or alpha-toc could not prevent cell death...
  25. ncbi Isoflavone genistein and daidzein up-regulate LPS-induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Pharmacol 71:108-14. 2005
    ..7 cells, while an ERbeta agonist could not. In conclusion, our results suggest E2, genistein and daidzein activate iNOS, and then up-regulate NO production. This enhancing effect is aroused through ERalpha pathway in RAW264.7 cells...
  26. ncbi The impact of the 67kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Arch Biochem Biophys 476:133-8. 2008
    ..These results suggest that both the galloyl moiety and the B-ring hydroxylation pattern contribute to the exertion of biological activities of tea catechins and their 67LR-dependencies...
  27. ncbi Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells
    Midori Sakai
    Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Nutr Biochem 17:672-6. 2006
    ..These data indicate that gamma-T3 induced apoptosis in Hep3B cells and that caspase-8 and caspase-9 were involved in apoptosis induction. Moreover, these results suggest that Bax and Bid regulated apoptosis induction by gamma-T3...
  28. ncbi Lipid raft-associated catechin suppresses the FcepsilonRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Japan
    FEBS Lett 556:204-10. 2004
    ..Thus, these results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcepsilonRI expression, and ERK1/2 may be involved in this suppression signal...
  29. ncbi TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor
    Eui Hong Byun
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    J Immunol 185:33-45. 2010
    ....
  30. ncbi Flavones suppress the expression of the high-affinity IgE receptor FcepsilonRI in human basophilic KU812 cells
    Satomi Yano
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Agric Food Chem 53:1812-7. 2005
    ..These results suggested that chrysin and apigenin have the ability to downregulate FcepsilonRI expression and this suppressive effect may be due to the reduction of ERK1/2 phosphorylation...
  31. ncbi Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor
    Eui Hong Byun
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    FEBS Lett 585:814-20. 2011
    ..Silencing of Toll-interacting protein (Tollip), a negative regulator of TLR signaling impaired the TLR2 signaling inhibitory activity of EGCG, suggesting that TLR2 response could be inhibited by EGCG via 67LR and Tollip...
  32. ncbi Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid
    Masao Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka 812 8581, Japan
    J Nutr 133:784-8. 2003
    ..These results suggest that 9c,11t and 10t,12c-CLA can stimulate different immunological effects and that the simultaneous intake of the two isomers can change the T cell population...
  33. ncbi Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells
    Yumi Miyamoto-Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka 812 8581, Japan
    Cell Biol Int 31:1501-6. 2007
    ..Our data show that basic JNK activity plays an important role in the progression of the cell cycle at G2/M cell phase...
  34. ncbi H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Eur J Pharmacol 590:61-6. 2008
    ..These results suggest that H89-induced reduction of the MRLC phosphorylation results from inhibition of Rho-kinase and that H89-induced cell growth inhibition is independent of reduction of the MRLC phosphorylation...
  35. ncbi Induction of apoptosis by tocotrienol in rat hepatoma dRLh-84 cells
    Midori Sakai
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Anticancer Res 24:1683-8. 2004
    ..The difference in terms of apoptosis induction by vitamin E homologues seems to be related to their different rates of cellular incorporation...
  36. ncbi Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 371:172-6. 2008
    ..These results suggest that through 67LR, EGCG at a physiological concentration can activate myosin phosphatase by reducing MYPT1 phosphorylation and that may be involved in EGCG-induced cell growth inhibition...
  37. ncbi Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    J Nutr Biochem 20:876-81. 2009
    ..These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-gamma expression in NC/Nga mice...
  38. ncbi Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67 kDa laminin receptor
    Daisuke Umeda
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 333:628-35. 2005
    ..These results suggest that EGCG inhibits the cell growth by reducing the MRLC phosphorylation and this effect is mediated by the 67LR...
  39. ncbi Modulation of proliferation and differentiation of C2C12 skeletal muscle cells by fatty acids
    Ju Hye Lee
    Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Life Sci 84:415-20. 2009
    ..This study was performed to elucidate whether mitogen-activated protein kinases (MAPKs) are involved in the modulation of the proliferation and differentiation of skeletal muscle cells by fatty acids...
  40. ncbi Effect of conjugated linoleic acid isomers on growth factor-induced proliferation of human breast cancer cells
    Hitomi Chujo
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Cancer Lett 202:81-7. 2003
    ..In conclusion, although both c9, t11 and t10, c12-CLA can inhibit the proliferation of MCF-7 cells, our results suggested that they have separate mechanisms and different targets of actions...
  41. ncbi Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Agric Food Chem 50:5729-34. 2002
    ..EGCG' '3Me treatment inhibited the FcepsilonRI cross-linking-induced histamine release. These results suggested that EGCG' '3Me can negatively regulate basophil activation through the suppression of FcepsilonRI expression...
  42. ncbi Effect of estrogens on the interferon-gamma producing cell population of mouse splenocytes
    Mako Nakaya
    Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 70:47-53. 2006
    ..The ligand specific to plasma membrane-associated ER (mER) enhanced the IFN-gamma production. In conclusion, our results indicated that E2 up-regulated the IFN-gamma production by mediating ERalpha, ERbeta and mERs...
  43. ncbi Trans10, cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilization in rat hepatoma cells
    Masao Yamasaki
    Division of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University, Miyazaki 889 2192, Japan
    Biochim Biophys Acta 1735:176-84. 2005
    ..10t, 12c-CLA directly degraded the isolated lysosomes from the rat liver. Our observations indicate that 10t, 12c-CLA induces mitochondria-related apoptosis accompanied by lysosomal destabilization in rat hepatoma cells...
  44. ncbi Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Japan
    Biosci Biotechnol Biochem 71:253-5. 2007
    ..Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the proliferation of cells in the absence of BPA. In addition, this inhibiting effect of royal jelly was heat-stable...
  45. ncbi A lipid raft-associated 67kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcepsilonRI expression
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 336:674-81. 2005
    ..Thus, these results suggest that the lipid raft-associated 67LR plays an important role in mediating the FcepsilonRI-suppressive action of EGCG...
  46. ncbi Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, 1 1 Gakuenkibanadai nishi, Miyazaki 889 2192, Japan
    In Vitro Cell Dev Biol Anim 44:290-4. 2008
    ..However, oleic acid completely inhibited this effect. These observations indicated the involvement of blockade of a p38 MAPK pathway in the ameliorative effect of oleic acid on apoptosis induced by t10, c12-conjugated linoleic acid...
  47. ncbi Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells
    Yumi Yamasaki-Miyamoto
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Agric Food Chem 57:8677-82. 2009
    ..However, caspase-9-specific inhibitor exerted a moderate inhibitory effect on the cytotoxicity of fucoidan. These data indicated that fucoidan could induce apoptotic cell death through a caspase-8-dependent pathway in MCF-7 cells...
  48. ncbi Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars
    Yoshinori Fujimura
    Innovation Center for Medical Redox Navigation, Kyushu University, Higashi ku, Fukuoka, Japan
    PLoS ONE 6:e23426. 2011
    ..Here, we performed metabolomic analyses to explore the relationship between the metabolome and health-promoting attributes (bioactivity) of diverse Japanese green tea cultivars...
  49. ncbi Comparisons of uptake and cell surface binding among pyridoxal, pyridoxine, and pyridoxamine in RAW264.7 cells
    Hiroaki Kanouchi
    Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
    Nutrition 26:648-52. 2010
    ..However, it has not been elucidated why PL has the strongest effect. We compared the uptakes and cell surface interactions among PL, PM, PN, and PLP in RAW264.7 cells...
  50. ncbi A difference between epigallocatechin-3-gallate and epicatechin-3-gallate on anti-allergic effect is dependent on their distinct distribution to lipid rafts
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan
    Biofactors 21:133-5. 2004
    ..On the other hand, the level of ECG in rafts was lower than that of EGCG, suggesting that the association with lipid rafts may have an important role in the FcepsilonRI-suppressive effect of catechins...
  51. ncbi Effect of dietary fiber on the lipid metabolism and immune function of aged Sprague-Dawley rats
    Koji Yamada
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biosci Biotechnol Biochem 67:429-33. 2003
    ..These results suggest that enhancement of the immune function by dietary fiber is mainly expressed in the gut immune system...
  52. ncbi Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    In Vitro Cell Dev Biol Anim 39:383-7. 2003
    ..In addition, E2 conjugated with bovine serum albumin inhibited IFN-gamma production as well as E2. This result suggests that the plasma membrane-associated estrogen receptor plays a prominent role in this suppression mechanism...
  53. ncbi Tea catechin, epigallocatechin-3-gallate suppresses myosin II regulatory light chain phosphorylation
    Daisuke Umeda
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Biofactors 21:387-9. 2004
    ..None of the inhibitors mimic the activity of EGCG. These results suggest that EGCG is a compound that can suppress MRLC phosphorylation...
  54. ncbi Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1
    Shinjiro Maruyama
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka, Japan
    Biomed Pharmacother 63:409-12. 2009
    ..These results show that there is a possibility that PSK directly acts on B cells and simultaneously enhances both humoral immunity and cellular immunity...
  55. ncbi Recombinant perchloric acid-soluble protein suppresses the immunoglobulin production of human-human hybridoma HB4C5 cells
    Hiroaki Kanouchi
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    In Vitro Cell Dev Biol Anim 39:263-5. 2003
    ..These results suggest that the Ig production suppressed by PSP, which has been previously reported to inhibit protein synthesis, contributed to the incorporation of PSP into the HB4C5 cells...
  56. ncbi Increase of immunoglobulin productivity of human-human hybridoma HB4C5 cells by histone
    Takeaki Okamoto
    Department of Bioscience and Biotechnology, Graduate School of Kyushu University, Hakozaki, Fukuoka, Japan
    Biosci Biotechnol Biochem 66:1241-5. 2002
    ..These facts strongly suggest that histone acts as an immunoglobulin production-stimulating factor (IPSF) after internalization into the human B cell lines and the native structure of histone is required for the IPSF activity...
  57. ncbi Simultaneous determination of isoflavones and bisphenol A in rat serum by high-performance liquid chromatography coupled with coulometric array detection
    Shin Yasuda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 68:51-8. 2004
    ..Compound 7 in the serum was not detected until after enzymatic hydrolysis (72 ng/ml). These results suggest that this analytical method would be useful for metabolic and pharmacokinetic studies on isoflavones and bisphenol A...
  58. ncbi Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets
    Masao Yamasaki
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Nutrition 19:30-5. 2003
    ..CONCLUSION: In conclusion, dietary CLA, especially the low-fat diet, reduced body fat without hepatic injury to Sprague-Dawley rats...
  59. ncbi Physiological difference between free and triglyceride-type conjugated linoleic acid on the immune function of C57BL/6N mice
    Masao Yamasaki
    Research and Development Division, Omu Milk Products Company, Ltd, 1 38 1 Shin katsudachi Omuta, Fukuoka 836 0895, Japan
    J Agric Food Chem 52:3644-8. 2004
    ..In addition, seven cytokines were 2-fold down-regulated by TG-CLA. These data show that there is a slight but significant difference between the functionalities of FFA- and TG-CLA...
  60. ncbi Potent cytotoxic effect of the trans10, cis12 isomer of conjugated linoleic acid on rat hepatoma dRLh-84 cells
    Masao Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Japan
    Cancer Lett 188:171-80. 2002
    ..Cytotoxic effect of trans10, cis12-CLA on normal hepatocytes was weaker than on dRLh-84 cells. These data indicate trans10, cis12-CLA has a potent cytotoxic effect on dRLh-84 cells through at least in part by an apoptotic pathway...
  61. ncbi Ultrahighly sensitive in situ metabolomic imaging for visualizing spatiotemporal metabolic behaviors
    Daisuke Miura
    Innovation Center for Medical Redox Navigation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Anal Chem 82:9789-96. 2010
    ....
  62. ncbi Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39
    Yoshiyuki Miyazaki
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Laboratory of Food Chemistry, Faculty of Agriculture, Kyushu University, 46-09, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Biochem Biophys Res Commun 295:547-52. 2002
    ..These results suggest that PPAR gamma ligands inhibit IL-4-induced IgE class switching in B lymphocytes...
  63. ncbi Highly sensitive matrix-assisted laser desorption ionization-mass spectrometry for high-throughput metabolic profiling
    Daisuke Miura
    Innovation Center for Medical Redox Navigation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Anal Chem 82:498-504. 2010
    ..These data suggest that the high-throughput MALDI-MS-based metabolomic technique proposed in the present study can be utilized for drug screening and validation of drug efficacy and safety...
  64. ncbi Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes
    Dalho Han
    Department of Environmental Toxicology, University of California, Davis 95616 8588, USA
    Biol Pharm Bull 25:1263-7. 2002
    ..These results suggest that environmental estrogens affect Ig production of mouse Splenocytes in a complex and class-specific manner...
  65. ncbi O-methylated catechins from tea leaves inhibit multiple protein kinases in mast cells
    Mari Maeda-Yamamoto
    National Institute of Vegetable and Tea Science, National Agriculture Research Organization, and School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Immunol 172:4486-92. 2004
    ..These observations for the first time have revealed the molecular mechanisms of antiallergic effects of tea-derived catechins...
  66. ncbi Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids
    Dal Ho Han
    Department of Environmental Toxicology, University of California, Davis 95616 8588, USA
    Biosci Biotechnol Biochem 66:1479-87. 2002
    ..The suppressive effect of flavonoids suggests that these compounds have anti-estrogenic and anti-cancer activities...
  67. ncbi Alleviation of the cytotoxic activity induced by trans10, cis12-conjugated linoleic acid in rat hepatoma dRLh-84 cells by oleic or palmitoleic acid
    Masao Yamasaki
    R and D division of Omu Milk Products Co Ltd, 1 38 1 Shin katsudachi Omuta, Fukuoka 836 0895, Japan
    Cancer Lett 196:187-96. 2003
    ..Results also suggest that 10t, 12c-CLA induced apoptosis can be inhibited by treatment with OA or POA...
  68. ncbi Aggregated ursolic acid, a natural triterpenoid, induces IL-1beta release from murine peritoneal macrophages: role of CD36
    Yasutaka Ikeda
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan
    J Immunol 178:4854-64. 2007
    ....