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Genomes and Genes | Akio SakamotoSummaryAffiliation: Kyushu University Country: Japan Publications
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Publications
Current status and perspectives regarding the treatment of osteo-sarcoma: chemotherapyAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Higashi ku, Maidashi, Fukuoka, 812 8582, Japan
Rev Recent Clin Trials 3:228-31. 2008..This article reviews the current status and perspectives regarding the treatment of osteosarcoma in terms of chemotherapy...- Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthomaAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
BMC Dermatol 9:1. 2009..Bax and Gadd45 are p53 effector proteins. Bax is a programmed cell death protein and belongs to the Bcl-2 family. Gadd45 is a multifunctional DNA damage-inducible gene associated with the process of DNA damage... - GNAS haploinsufficiency leads to subcutaneous tumor formation with collagen and elastin deposition and calcificationAkio Sakamoto
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
Endocr Res 34:1-9. 2009..We now describe the development of fibrous tumors in mice with heterozygous disruption of the Gnas gene, which encodes G(s)alpha and other gene products... - Establishment of an animal model of a pasteurized bone graft, with a preliminary analysis of muscle coverage or FGF-2 administration to the graftTatsuya Yoshida
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Orthop Surg Res 4:31. 2009..abstract:.. - Epithelioid sarcoma with muscle metastasis detected by positron emission tomographyAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
World J Surg Oncol 6:84. 2008..Epithelioid sarcoma is an uncommon high-grade sarcoma, mostly involving the extremities... - Nonossifying fibroma accompanied by pathological fracture in a 12-year-old runnerAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Orthop Sports Phys Ther 38:434-8. 2008..Resident's case problem... - Dedifferentiated liposarcoma with leukocytosis. A case report of G-CSF-producing soft-tissue tumors, possible association with undifferentiated liposarcoma lineageAkio Sakamoto
Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
World J Surg Oncol 5:131. 2007..abstract:.. - Metastasis to the gluteus maximus muscle from renal cell carcinoma with special emphasis on MRI featuresAkio Sakamoto
Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
World J Surg Oncol 5:88. 2007..abstract:.. - Bizarre parosteal osteochondromatous proliferation with an inversion of chromosome 7Akio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Skeletal Radiol 40:1487-90. 2011..In addition, an inversion of chromosome 7 [inv (7)(q22q32)] was observed. Therefore, this case suggests that the translocation between chromosomes 1 and 17 reported in other cases may not be the only cause of BPOP... - Aneurysmal bone cyst of the capitate: case report and a review emphasizing local recurrenceAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Fukuoka Igaku Zasshi 97:302-7. 2006..No recurrence has been observed during the 4 years since operation. We also review the literature related to ABCs of the hand with special emphasis on local recurrence... - Frequent immunoexpression of TGF-beta1, FGF-2 and BMP-2 in fibroblast-like cells in osteofibrous dysplasiaAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
Oncol Rep 17:531-5. 2007.... - Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 34:841-9. 2003..Thus, inactivation of hMSH2/hMLH1 of DNA mismatch repair genes seems to have an important role to play in the mutagenesis of the tumor-suppressor genes in ASPS... - PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Oncol Rep 11:1011-5. 2004..8%), although the mutation status in TSG was not associated with overall survival rate in patients with SS. Secondary genetic alterations in these TSG seem to have a less important prognostic impact on patients with SS... - Beta-catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytomaAkio Sakamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Arch Pathol Lab Med 126:1071-8. 2002..beta-Catenin accumulation is also thought to be related to cell proliferation in some of the cases... - Chondromyxoid fibroma of the clavicleAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
J Orthop Sci 11:533-6. 2006 - Deficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical boneAkio Sakamoto
Metabolic Diseases Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
J Biol Chem 280:21369-75. 2005..Osteoblast-specific G(s)alpha deficiency leads to reduced bone turnover... - Five-year evolution of a telangiectatic osteosarcoma initially managed as an aneurysmal bone cystTsuyoshi Saito
Department of Anatomic Pathology (Second Department of Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, 812-8582 Fukuoka, Japan
Skeletal Radiol 34:290-4. 2005..The patient demonstrates no evidence of disease 13 months after the last surgery without adjuvant therapy (he declined chemotherapy)... - Prognostic factors in the so-called malignant mesenchymoma: a clinicopathological and immunohistochemical analysisToshisada Adachi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan
Oncol Rep 10:803-11. 2003..In conclusion, a patient age under 40 years and the presence of an RMS component appear to be poor prognostic indicators of survival in patients with so-called MM, and to be a useful adjunct for the classification of these tumors... - Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 yearsKen-ichi Kawaguchi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 15:878-88. 2002..Although the number of patients in this analysis was small, it would appear that MFH-like OS may have some characteristic biologic aspects when compared with osteoblastic OS and MFH of bone in elderly patients... - Low-grade fibrosarcoma of the proximal humerusTsuyoshi Saito
Department of Anatomic Pathology, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
Pathol Int 53:115-20. 2003..The patient demonstrates no evidence of disease 42 months after surgery. It is important to detect the scant atypical cells for the differential diagnosis of low-grade fibrosarcoma and desmoplastic fibroma of bone... - APC mutations in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pathol 196:445-9. 2002..All three cases with APC mutations available for follow-up data were long survivors. This study provides the first evidence that APC mutations also occur in the field of sarcoma, especially in synovial sarcoma... - Mixed tumor of deep soft tissueToshisada Adachi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 53:35-9. 2003..Histological examination confirmed that the recurrent tumor with an extensive chondroid area invaded the osseous tissue of the fibula. At present, 1 year after the second resection surgery, there is no evidence of disease... - Adventitial cystic disease of the popliteal vein: report of a caseAkio Sakamoto
Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Surg Today 36:1098-100. 2006..Thus, it is important to be aware of ACD as a possible diagnosis when examining patients with a swelling in the leg... - PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocationsTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Int J Cancer 104:175-8. 2003.... - Clinical outcome following surgical intervention for a solitary bone cyst: emphasis on treatment by curettage and steroid injectionAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Fukuoka, Japan
J Orthop Sci 15:553-9. 2010..Solitary bone cysts are benign, fluid-filled, expansive lesions in children. The success rate of bone consolidation in the case of a solitary bone cyst is unpredictable following steroid injection... - Alternative surgical treatment for giant-cell reparative granuloma in the metacarpal, using phenol and ethanol adjuvant therapyTatsuya Yoshida
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Hand Surg Am 32:887-92. 2007..Adjuvant therapy usually is applied to reduce the recurrence of locally aggressive bone tumors. We report 2 cases of GCRG that were treated successfully with curettage, adjuvant phenol and ethanol, and autogenous bone grafting... - Solitary lymphangioma of the femur. A case reportAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
J Orthop Sci 7:501-4. 2002..Radiographs showed an eccentric osteolytic lesion in the distal femur. This is the first reported case of solitary lymphangioma of the bone occurring in the femur... - Intramuscular diffuse-type giant cell tumor within the hamstring muscleTatsuya Yoshida
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582 Fukuoka, Japan
Skeletal Radiol 36:331-3. 2007..This case demonstrates that PVS/D-TGCT may have a high SUV on PET imaging, and for this reason PET may be useful for detecting both the tumor and any recurrence... - High-dose chemotherapy and autologous peripheral blood stem-cell transfusion after conventional chemotherapy for patients with high-risk Ewing's tumorsKazuhiro Tanaka
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
J Orthop Sci 7:477-82. 2002..However, the real impact of the therapy on the clinical outcome of patients with high-risk Ewing's tumors should be evaluated in a prospective, randomized study... - Leiomyosarcoma in the humerus with leukocytosis and elevation of serum G-CSFTakeaki Ishii
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
Skeletal Radiol 41:719-23. 2012..A diagnosis of leiomyosarcoma of the bone with expression of G-CSF was confirmed immunohistochemically. Histological diagnosis of leiomyosarcoma showed it to be differentiated, which is unusual for G-CSF-secreting tumors... - Vascular compression caused by solitary osteochondroma: useful diagnostic methods of magnetic resonance angiography and Doppler ultrasonographyAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
J Orthop Sci 7:439-43. 2002..Doppler ultrasonography could also reveal the blood flow disturbance objectively, even in current osteochondroma cases in which there were no arterial symptoms... - Congenital pseudarthrosis of the tibia: analysis of the histology and the NF1 geneAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, Japan
J Orthop Sci 12:361-5. 2007..Congenital pseudarthrosis of the tibia (CPT) is frequently, but not always, associated with neurofibromatosis type 1 (NF1). Double inactivation of the NF1 gene has been reported to be the pathogenesis of CPT in NF1 cases... - Chondrocyte-specific knockout of the G protein G(s)alpha leads to epiphyseal and growth plate abnormalities and ectopic chondrocyte formationAkio Sakamoto
Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
J Bone Miner Res 20:663-71. 2005..These results show that G(s)alpha negatively regulates chondrocyte differentiation and is the critical signaling mediator of the PTH/PTH-rP receptor in growth plate chondrocytes... - Revascularization of complete and incomplete distal finger amputations in children below 2 years of age: a report of three casesAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Hand Surg Eur Vol 36:677-81. 2011..Survival of an amputated finger can be expected in cases where venous reconstruction is not possible, provided that there is adequate venous drainage... - Tissue-specific imprinting of the G protein Gsalpha is associated with tissue-specific differences in histone methylationAkio Sakamoto
Metabolic Diseases Branch, National Institute of Diabetes, Digestive, and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
Hum Mol Genet 13:819-28. 2004.... - Extradural nodular fasciitis arising in the spinal canalKensuke Kubota
Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Spine (Phila Pa 1976) 37:E133-7. 2012..Case report... - Minireview: GNAS: normal and abnormal functionsLee S Weinstein
Metabolic Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
Endocrinology 145:5459-64. 2004..Mouse knockout models show that G(s)alpha and the alternative G(s)alpha isoform XLalphas that is expressed from the paternal GNAS allele may have opposite effects on energy metabolism in mice... - Vascularized iliac bone graft in cases of ankle tuberculosisTatsuya Yoshida
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Reconstr Microsurg 25:125-31. 2009..Vascularized bone graft offers the benefits of achieving bone defect reconstruction with promotion of bone union, and the infection can be expected to resolve through medication delivered via the circulation... - Increased expression of insulin-like growth factor I and/or its receptor in gastrinomas is associated with low curability, increased growth, and development of metastasesMasayuki Furukawa
Digestive Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, Hematopathology Section, Laboratory of Pathology, National Cancer Institute, NIH, Bethesda, Maryland 20892 1804, USA
Clin Cancer Res 11:3233-42. 2005..Whether this is true of neuroendocrine tumors such as gastrinomas is unclear. The aim of this study was to address this question in gastrinomas... - Role of the VEGF-Flt-1-FAK pathway in the pathogenesis of osteoclastic bone destruction of giant cell tumors of boneYoshihiro Matsumoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
J Orthop Surg Res 5:85. 2010..abstract:.. - Treatment of pelvic defect and infection with endoprosthesis exposure by topical negative pressure and irrigation with myocutaneous flapSei Yoshida
Department of Plastic Surgery, National Hospital Organization, Kyushu Cancer Center, Fukuoka, Japan
Microsurgery 31:655-8. 2011..2011 Wiley Periodicals, Inc. Microsurgery, 2011... - Mutation analysis of human cytokeratin 8 gene in malignant rhabdoid tumor: a possible association with intracytoplasmic inclusion body formationHideki Shiratsuchi
Department of Anatomic Pathology, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
Mod Pathol 15:146-53. 2002..In conclusion, mutated codons of CK8 gene in MRT were located in the important region involved in the conformational change of intermediate filament... - CCAAT/enhancer binding protein beta mediates expression of matrix metalloproteinase 13 in human articular chondrocytes in inflammatory arthritisMitsumasa Hayashida
Kyushu University, Fukuoka, Japan
Arthritis Rheum 60:708-16. 2009..To determine the function of CCAAT/enhancer binding protein beta (C/EBPbeta) in the expression of matrix metalloproteinase 13 (MMP-13) in chondrocytes in inflammatory arthritis... - Insufficiency fractures in the medial tibial condyle with a special emphasis on the radiographic features and differential diagnosisTomonori Nakanishi
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan
J Orthop Sci 12:296-9. 2007 - Helicobacter pylori induces mono-(adenosine 5'-diphosphate)-ribosylation in human gastric adenocarcinomaTakashi Akai
Department of Frontier Surgery, Chiba University Graduate School of Medicine, Chuo-ku, Chiba 260-8670, Japan
Int J Oncol 29:965-72. 2006..pylori itself. The possible roles underlying our observations on carcinogenesis or development of human gastric carcinoma are yet to be elucidated...