Research Topics
Genomes and Genes
Species | Yoshinao OdaSummaryAffiliation: Kyushu University Country: Japan Publications
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Detail Information
Publications
Metastasis to the gluteus maximus muscle from renal cell carcinoma with special emphasis on MRI featuresAkio Sakamoto
Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
World J Surg Oncol 5:88. 2007..abstract:..
Dedifferentiated liposarcoma with leukocytosis. A case report of G-CSF-producing soft-tissue tumors, possible association with undifferentiated liposarcoma lineageAkio Sakamoto
Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
World J Surg Oncol 5:131. 2007..abstract:..
Mutation analysis of the Gadd45 gene at exon 4 in atypical fibroxanthomaAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
BMC Dermatol 9:1. 2009..Bax and Gadd45 are p53 effector proteins. Bax is a programmed cell death protein and belongs to the Bcl-2 family. Gadd45 is a multifunctional DNA damage-inducible gene associated with the process of DNA damage...
Pigmented villonodular synovitis with chondroid metaplasia, resembling chondroblastoma of the bone: a report of three casesYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 20:545-51. 2007..The correlation between this lesion and synovial chondromatosis remains uncertain...
Low-grade fibromyxoid sarcoma versus low-grade myxofibrosarcoma in the extremities and trunk. A comparison of clinicopathological and immunohistochemical featuresY Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Histopathology 45:29-38. 2004....
Extrarenal rhabdoid tumors of soft tissue: clinicopathological and molecular genetic review and distinction from other soft-tissue sarcomas with rhabdoid featuresYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 56:287-95. 2006..Detailed clinicopathological and immunohistochemical evaluations are necessary to distinguish MRT of soft tissue from proximal-type ES, because these tumors demonstrated a similar morphology and the same gene alteration...
Recent advances in the molecular pathology of soft tissue sarcoma: implications for diagnosis, patient prognosis, and molecular target therapy in the futureYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
Cancer Sci 100:200-8. 2009..In conclusion, further studies are necessary to search for effective and specific molecules for the inhibition of tumor growth in each type of STS, especially in sarcomas without specific translocation...
Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcomaYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Cancer Sci 99:726-32. 2008..Apart from ERMS, frequent P-gp expression in ARMS may be independent from YB-1 regulation. However, YB-1 may be a candidate for a molecular target in rhabdomyosarcoma therapy, especially in ERMS...
Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosisYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pathol 207:410-21. 2005..In MLS/RCLS, reduction of p14 protein expression and p53 mutation were related to poor prognosis. Accordingly, the p14(ARF)/p53 pathway may contribute to the presence of an RC component and malignant progression in this tumour...
CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasisYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
Mod Pathol 19:738-45. 2006..0053). Our results suggested that CXCR4 expression was associated with metastatic progression, and immunohistochemical VEGF expression in the primary site had predictive value for the osteosarcoma patients, who developed lung metastasis...
Chemokine receptor CXCR4 expression is correlated with VEGF expression and poor survival in soft-tissue sarcomaYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Int J Cancer 124:1852-9. 2009..Determination of the CXCR4 expression level as a novel marker can provide useful prognostic information for patients and it could be a candidate for molecular targeting therapy in MNRCTs of soft-tissue sarcomas...
Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expressionYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Cancer Sci 98:1020-6. 2007..These results indicate that YB-1 nuclear expression and CXCR4 expression are important prognostic factors in ovarian carcinoma...
ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcomasYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Int J Cancer 114:854-62. 2005..In addition, the high levels of both MDR1 and MRP3 mRNA expression in MPNST may help to explain the poor response of this tumor to anticancer-drugs...
Altered expression and molecular abnormalities of cell-cycle-regulatory proteins in rhabdomyosarcomaYukiko Takahashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 17:660-9. 2004..Alveolar type had a significantly higher both mitotic rate and E2F-1 labeling indices when compared with the embryonal type. The current study is the first report of the correlation of E2F-1 with alveolar rhabdomyosarcoma...
Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumorKenichi Kohashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 40:349-55. 2009..Analysis of alterations in the SMARCB1/INI1 gene may thus be a useful diagnostic tool to distinguish proximal-type epithelioid sarcoma from malignant rhabdoid tumor...
Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferationAkifumi Hayashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
Hum Pathol 41:1507-15. 2010..Therefore, programmed cell death 4 can be an important biomarker for intraductal papillary mucinous neoplasm...
Malignant transformation of mature cystic teratoma to squamous cell carcinoma involves altered expression of p53- and p16/Rb-dependent cell cycle regulator proteinsAtsuko Iwasa
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 58:757-64. 2008..The results indicate that alterations in both the p53 and p16-Rb pathways are associated with SCC arising in MCT...
Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expressionTeiyu Izumi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
Am J Surg Pathol 31:85-94. 2007..Dysadherin expression is considered to be one of the determinants of histologic subtype in synovial sarcoma. Moreover, dysadherin expression is an excellent and independent prognostic indicator...
Nuclear expression of Y-box-binding protein-1 correlates with P-glycoprotein and topoisomerase II alpha expression, and with poor prognosis in synovial sarcomaYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pathol 199:251-8. 2003....
SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcomaKenichi Kohashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
Am J Surg Pathol 32:1168-74. 2008..The immunohistochemical result of the SMARCB1/INI expression is not an absolute diagnostic criteria for MRT and careful histologic evaluation is required to make a precise diagnosis of MRT...
Aberrant expression of CHFR in malignant peripheral nerve sheath tumorsChikashi Kobayashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
Mod Pathol 19:524-32. 2006..In addition, MPNST with normal karyotype showed a strong (score, =5) expression of CHFR. Our results support the assertion that CHFR functions as an inhibitor of tumor proliferation...
Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumorTeiyu Izumi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 19:820-31. 2006..However, in malignant rhabdoid tumor, cell growth cycle that is regulated by hSNF5/INI1 gene seems to be critical to lethal biological behavior rather than dysadherin...
Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 34:841-9. 2003..Thus, inactivation of hMSH2/hMLH1 of DNA mismatch repair genes seems to have an important role to play in the mutagenesis of the tumor-suppressor genes in ASPS...
DNA hypermethylation status of multiple genes in soft tissue sarcomasKen-ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 19:106-14. 2006..Furthermore, MGMT methylation may be associated with tumor aggressiveness and the inactivation of MGMT gene...
Microsatellite instability and hMLH1 and hMSH2 expression analysis in soft tissue sarcomasKen-ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Oncol Rep 13:241-6. 2005..These findings suggest that the inactivation of MMR gene expression might be the cause of MSI in STS cases...
Coincident expression of beta-catenin and cyclin D1 in endometrial stromal tumors and related high-grade sarcomasShuichi Kurihara
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
Mod Pathol 23:225-34. 2010..This finding raises the possibility that cyclin D1 is upregulated by beta-catenin in these high-grade sarcomas previously called high-grade endometrial stromal sarcoma...
Reduced expression of SMARCB1/INI1 protein in synovial sarcomaKenichi Kohashi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Mod Pathol 23:981-90. 2010..46). Therefore, it was suggested that there is a post-transcriptional SMARCB1/INI1 regulatory mechanism in the tumor cells of synovial sarcoma...
PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Oncol Rep 11:1011-5. 2004..8%), although the mutation status in TSG was not associated with overall survival rate in patients with SS. Secondary genetic alterations in these TSG seem to have a less important prognostic impact on patients with SS...
Highly aggressive behavior of malignant rhabdoid tumor: a special reference to SMARCB1/INI1 gene alterations using molecular genetic analysis including quantitative real-time PCRKenichi Kohashi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
J Cancer Res Clin Oncol 133:817-24. 2007..Moreover, we investigated the status of hyperphosphorylation in RB protein, known as a key cell cycle molecule...
ATP-binding cassette superfamily transporter gene expression in human primary ovarian carcinomaYoshihiro Ohishi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
Clin Cancer Res 8:3767-75. 2002..Furthermore, a higher level of MRP1 mRNA expression can be a candidate for a useful predictor of a shorter period of progression-free survival...
Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumorsHiroshi Matono
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582 Japan
Hum Pathol 39:1802-8. 2008....
S100P is a novel marker to identify intraductal papillary mucinous neoplasmsKohei Nakata
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:824-31. 2010..On the other hand, MUC5AC was expressed in only 23 cases of 32 invasive components (P < .01). These data suggest that the S100P antibody may be a useful marker for detecting all types of intraductal papillary mucinous neoplasms...
Altered expression of cell cycle regulators in myxofibrosarcoma, with special emphasis on their prognostic implicationsYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Information Science, Kyushu University, Fukuoka, Japan
Hum Pathol 34:1035-42. 2003..Our results suggest that reduced expression of p21 could be considered a new parameter to be evaluated, along with classical clinicopathologic prognostic factors, for identifying those at high risk for myxofibrosarcoma...
Cytoplasmic and stromal expression of laminin ? 2 chain correlates with infiltrative invasion in ovarian mucinous neoplasms of gastro-intestinal typeEmi Okuma
Department of Anatomic Pathology, Kyushu University Hospital, Fukuoka, Japan
Oncol Rep 24:1569-76. 2010..The staining pattern of mural nodules was similar to that of infiltrative invasion. The infiltrative invasion of GI-type ovarian mucinous neoplasms may be promoted by cytoplasmic and/or stromal expression of laminin ? 2 chain...
Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomasKen Ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 36:357-63. 2005..Furthermore, although a further detailed analysis of a larger number of cases is still necessary, the present results suggest that PTEN expression may be a useful indicator of cell proliferation in patients with STS...
Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtypeKenichi Kohashi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
J Cancer Res Clin Oncol 134:1097-103. 2008..Therefore, there might be a correlation between the tumorigenesis of RMS and RB1 alteration...
Endometrial stromal sarcomas and related high-grade sarcomas: immunohistochemical and molecular genetic study of 31 casesShuichi Kurihara
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
Am J Surg Pathol 32:1228-38. 2008..Our data suggest that UES-U shares some molecular genetic and immunohistochemical characteristics with ESS-LG, but UES-P considerably differs from ESS-LG...
APC mutations in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pathol 196:445-9. 2002..All three cases with APC mutations available for follow-up data were long survivors. This study provides the first evidence that APC mutations also occur in the field of sarcoma, especially in synovial sarcoma...
Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular studyKohei Fujita
Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
Am J Surg Pathol 35:295-304. 2011..In addition, our histologic observations suggest a possible close association between SSAN and mucinous adenocarcinoma...
Concordance for neuroblastoma in monozygotic twins: case report and review of the literatureTatsuro Tajiri
Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pediatr Surg 45:2312-6. 2010..This study is the first report presenting the possibility of twin-to-twin metastasis in monozygotic twins with neuroblastoma based on an analysis of the clinical features and genetic aberrations...
Mechanisms of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor prognosisKen-ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pathol 201:487-95. 2003..Furthermore, promoter methylation was more frequent than either homozygous deletion or mutation in this tumour, and promoter methylation was also shown to have a strong association with inactivation of the p16INK4a gene...
Involvement of P-glycoprotein and MRP1 in resistance to cyclic tetrapeptide subfamily of histone deacetylase inhibitors in the drug-resistant osteosarcoma and Ewing's sarcoma cellsTakamitsu Okada
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Int J Cancer 118:90-7. 2006..Because HDACIs are potent and promising antitumor drugs and seem to be close to clinical use, it is necessary to pay attention to the resistance mechanisms against HDACIs...
Mitochondrial p32/C1QBP is highly expressed in prostate cancer and is associated with shorter prostate-specific antigen relapse time after radical prostatectomyRie Amamoto
Department of Clinical Chemistry and Laboratory Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Cancer Sci 102:639-47. 2011..These data suggest that p32 is critical for prostate cancer cell proliferation and may be a novel marker of clinical progression in prostate cancer...
Beta-catenin accumulation and gene mutation in exon 3 in dedifferentiated liposarcoma and malignant fibrous histiocytomaAkio Sakamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Arch Pathol Lab Med 126:1071-8. 2002..beta-Catenin accumulation is also thought to be related to cell proliferation in some of the cases...
Different roles of S100P overexpression in intrahepatic cholangiocarcinoma: carcinogenesis of perihilar type and aggressive behavior of peripheral typeShinichi Aishima
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Am J Surg Pathol 35:590-8. 2011..001, P=0.0728, respectively). Our results suggest that S100P-ezrin signaling has different roles of carcinogenesis of perihilar ICC and an aggressive course of peripheral ICC...
E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Oncogene 23:8629-38. 2004..Thus, E-cadherin downregulation is associated with the loss or absence of glandular epithelial differentiation in certain SS...
Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expressionKen Ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 35:1266-71. 2004..Furthermore, although further detailed analyses are necessary, promoter methylation or homozygous deletion status of DAP kinase may present a major alternative mechanism of a loss of or decrease in DAP kinase expression...
Long-term survival after autologous peripheral blood stem cell transplantation in two patients with malignant rhabdoid tumor of the kidneyYuhki Koga
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pediatr Blood Cancer 52:888-90. 2009..Two patients have been alive without any evidence of disease for 30 and 37 months after diagnosis, respectively, and require no medication. Consolidation with SCT should be further studies for selected patients with high-risk MRTK...
The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomasNokitaka Setsu
Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
Cancer 118:1637-48. 2012..Here the authors investigated the significance of activation of the Akt/mTOR pathway in soft tissue leiomyosarcomas...
Expression of activation-induced cytidine deaminase in ulcerative colitis-associated carcinogenesisMasaki Gushima
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Histopathology 59:460-9. 2011..The aim of this study was to investigate the expression of AID and its association with p53 mutation in ulcerative colitis (UC)-associated carcinogenesis...
Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosisKohei Nakata
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pancreas 40:581-7. 2011..The meaning of "minimal invasion" (MI) in IPMC also remains unclear. We investigated the prognosis of intraductal papillary mucinous neoplasm (IPMN) focusing on MI and subtypes...
Molecular analysis of p53, MDM2, and H-ras genes in osteosarcoma and malignant fibrous histiocytoma of bone in patients older than 40 yearsKen-ichi Kawaguchi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 15:878-88. 2002..Although the number of patients in this analysis was small, it would appear that MFH-like OS may have some characteristic biologic aspects when compared with osteoblastic OS and MFH of bone in elderly patients...
Alterations of the RB1 gene in dedifferentiated liposarcomaTomonari Takahira
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 18:1461-70. 2005..These results suggest that retinoblastoma protein has a major role to play in dedifferentiation and that a 'two-hit' mechanism is involved in the altered retinoblastoma protein expression in dedifferentiated liposarcoma...
Significance of dysadherin and E-cadherin expression in differentiated-type gastric carcinoma with submucosal invasionYoshitomo Maehata
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
Hum Pathol 42:558-67. 2011..Combined dysadherin-positive (?50%) expression and E-cadherin-negative (<50%) expression may be valuable information for predicting aggressive tumor behavior...
Prognostic impact of blood vessel invasion in gastrointestinal stromal tumor of the stomachHidetaka Yamamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 41:1422-30. 2010....
Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor developmentNobuhiro Fujita
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:838-47. 2010..The changes of arterial vessel density in moderately differentiated hepatocellular carcinomas were suggested...
Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcomaSuguru Matsuura
Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:343-51. 2010....
Antioxidant therapy alleviates oxidative stress by androgen deprivation and prevents conversion from androgen dependent to castration resistant prostate cancerMasaki Shiota
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Urol 187:707-14. 2012..We elucidated the state and the role of oxidative stress induced by androgen deprivation therapy and the possibility of antioxidant therapy in human prostate cancer...
Foxo3a suppression of urothelial cancer invasiveness through Twist1, Y-box-binding protein 1, and E-cadherin regulationMasaki Shiota
Department of Urology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Clin Cancer Res 16:5654-63. 2010..Foxo3a is a member of the Foxo transcription factor family that modulates the expression of various genes. We aimed to elucidate the role of Foxo3a in UC invasion...
Hobnail-like cells in serous borderline tumor do not represent concomitant incipient clear cell neoplasmsYoshihiro Ohishi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 40:1168-75. 2009..quot;..
Y-box binding protein-1 promotes castration-resistant prostate cancer growth via androgen receptor expressionMasaki Shiota
Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Endocr Relat Cancer 18:505-17. 2011..In conclusion, these findings suggested that YB-1 induces castration resistance in androgen-dependent PCa cells via AR expression. Thus, YB-1 may be a promising therapeutic target for PCa, as well as CRPC...
Histologic classification of microscopic portal venous invasion to predict prognosis in hepatocellular carcinomaNobuhiro Fujita
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 42:1531-8. 2011..0259). We proposed a new definition for classifying microscopic portal venous invasion and documented the necessity of definite histologic evaluation of it...
Immunohistochemical characterization of mullerian mucinous borderline tumors: possible histogenetic link with serous borderline tumors and low-grade endometrioid tumorsMasafumi Yasunaga
Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
Hum Pathol 40:965-74. 2009....
Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberansTomonari Takahira
The Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 20:668-75. 2007..The PDGFB and PDGFRB mRNA expression levels showed a good correlation (r=0.76, P<0.0001). These results indicate that the fusion protein, which is processed by the COL1A1-PDGFB transcripts, can serve as a functional ligand for PDGFRB...
Frequent microsatellite instability in synchronous ovarian and endometrial adenocarcinoma and its usefulness for differential diagnosisEisuke Kaneki
Department of Anatomic Pathology, Graduate School of Medicine, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka, Japan
Hum Pathol 35:1484-93. 2004..The histological criteria are accurate and useful in most cases; however, in some cases where the relationship between the 2 tumors is difficult to determine, high-resolution MSI analysis may be helpful...
Nuclear beta-catenin correlates with cyclin D1 expression in spindle and pleomorphic sarcomas but not in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 37:689-97. 2006..Thus, cyclin D1 could be considered as one of the targets of the nuclear beta-catenin in spindle cell and pleomorphic sarcomas. A possible association between beta-catenin accumulation and spindle cell morphogenesis may exist in SS...
Alterations of the p16INK4a/p14ARF pathway in clear cell sarcomaTomonari Takahira
Department of Anatomic Pathology (Second Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan
Cancer Sci 95:651-5. 2004..3%). All tumors with genetic alterations of the p16INK4a/p14ARF or p53 gene showed a high mitotic rate or tumor necrosis. These alterations were considered to be influential in the poor prognosis of CCS patients...
Expression and localization of E-cadherin and ?-catenin in uterine carcinosarcomaIzumi Nishimura
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
Virchows Arch 458:85-94. 2011..Furthermore, although the precise mechanism is unclear, nuclear ?-catenin expression in sarcomatous components may also be associated with biphasic morphology and heterologous sarcomatous differentiation...
Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22qHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
J Cancer Res Clin Oncol 135:791-8. 2009....
N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherinYooHyun Song
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:214-22. 2010..0175). NDRG1/Cap43 could be a novel marker for malignant progression and poor prognosis in prostate cancer, plausibly in its close association with the down-regulation of E-cadherin expression...
The possible role of EWS-Fli1 in evasion of senescence in Ewing family tumorsTomoya Matsunobu
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan
Cancer Res 66:803-11. 2006....
Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk gradeNorimoto Nakamura
Department of Anatomic Pathology, Graduate School of Medical Sciences of Kyushu University, Fukuoka 812-8582, Japan
Hum Pathol 36:828-37. 2005..Furthermore, alteration of G2-M regulators, such as cyclin A, cyclin B1, and cdc2, is also a useful marker for predicting aggressive behavior and play an important role, at least in part, in the cell proliferation of GIST...
Cyclin-dependent kinase inhibitor, flavopiridol, induces apoptosis and inhibits tumor growth in drug-resistant osteosarcoma and Ewing's family tumor cellsYan Li
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Int J Cancer 121:1212-8. 2007..The treatment with flavopiridol further inhibited the tumor growth in mouse models of the drug-resistant OS and EFTs. These results suggest that flavopiridol might be promising in clinical therapy for the relapsed OS and EFTs...
Chondromyxoid fibroma of the clavicleAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
J Orthop Sci 11:533-6. 2006
Chromosomal aberrations and microsatellite instability of malignant peripheral nerve sheath tumors: a study of 10 tumors from nine patientsChikashi Kobayashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Cancer Genet Cytogenet 165:98-105. 2006..These findings suggest that chromosomal aberration as a consequence of CIN has a greater role in the pathogenesis of MPNST than does that due to MSI...
Low-grade fibrosarcoma of the proximal humerusTsuyoshi Saito
Department of Anatomic Pathology, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
Pathol Int 53:115-20. 2003..The patient demonstrates no evidence of disease 42 months after surgery. It is important to detect the scant atypical cells for the differential diagnosis of low-grade fibrosarcoma and desmoplastic fibroma of bone...
Prognostic factors in the so-called malignant mesenchymoma: a clinicopathological and immunohistochemical analysisToshisada Adachi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan
Oncol Rep 10:803-11. 2003..In conclusion, a patient age under 40 years and the presence of an RMS component appear to be poor prognostic indicators of survival in patients with so-called MM, and to be a useful adjunct for the classification of these tumors...
Expression of beta-tubulin isotypes in human primary ovarian carcinomaYoshihiro Ohishi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Gynecol Oncol 105:586-92. 2007....
Decreased expression of focal adhesion kinase is associated with a poor prognosis in extrahepatic bile duct carcinomaAkifumi Hayashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:859-66. 2010..It is important to notice the role of FAK in tumor progression when treatments targeting FAK are performed...
H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinomaHideki Shiratsuchi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Oncol Rep 11:597-604. 2004....
Mixed tumor of deep soft tissueToshisada Adachi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 53:35-9. 2003..Histological examination confirmed that the recurrent tumor with an extensive chondroid area invaded the osseous tissue of the fibula. At present, 1 year after the second resection surgery, there is no evidence of disease...
Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases-Takahiro Inoue
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 20:267-76. 2007..Clinically, preoperative evaluation of GalNAc-T3 expression is considered to be useful for decisions regarding operative procedures...
KIT-negative gastrointestinal stromal tumor of the abdominal soft tissue: a clinicopathologic and genetic study of 10 casesHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Am J Surg Pathol 35:1287-95. 2011....
Nuclear localization of E-cadherin but not beta-catenin in human ovarian granulosa cell tumours and normal ovarian follicles and ovarian stromaYoshihiro Ohishi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Histopathology 58:423-32. 2011..The aim of this study was to confirm subcellular localization of key molecules of Wnt signalling (beta-catenin and E-cadherin) in human ovarian GCTs...
Inflammatory myofibroblastic tumor of the mediastinum presenting as superior vena cava syndromeMasafumi Yamaguchi
Department of Surgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
J Thorac Cardiovasc Surg 126:870-2. 2003
Primary gastrointestinal stromal tumor of the liver with PDGFRA gene mutationHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:605-9. 2010..Although KIT-negative gastrointestinal stromal tumor occurring outside the gastrointestinal tract is very rare, this entity should be considered as a potential primary hepatic neoplasm...
Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic studyHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Am J Surg Pathol 33:1330-40. 2009..In addition, the evaluation of IgG4+ plasma cells and the ratio of IgG4+/IgG+ plasma cells and the presence of obstructive phlebitis may be useful for the differential diagnosis between IMT and IgG4-related sclerosing disease...
Successful treatment of advanced pancreatoblastoma by a pylorus-preserving pancreatoduodenectomy after radiation and high-dose chemotherapyRyota Souzaki
Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Pediatr Surg Int 26:1045-8. 2010..This report presents the case of a 6-year-old female with advanced PB treated successfully by a pylorus-preserving pancreatoduodenectomy (PPPD) after induction chemotherapy, radiation and stem cell transplantation (SCT)...
Primitive neuroectodermal tumor and extraskeletal Ewing sarcoma arising primarily around the spinal column: report of four cases and a review of the literatureKatsumi Harimaya
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Spine (Phila Pa 1976) 28:E408-12. 2003..Report of four cases and a review of the literature...
Intramuscular diffuse-type giant cell tumor within the hamstring muscleTatsuya Yoshida
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582 Fukuoka, Japan
Skeletal Radiol 36:331-3. 2007..This case demonstrates that PVS/D-TGCT may have a high SUV on PET imaging, and for this reason PET may be useful for detecting both the tumor and any recurrence...
Apparent diffusion coefficients of breast tumors: clinical applicationMasamitsu Hatakenaka
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Magn Reson Med Sci 7:23-9. 2008..To evaluate the usefulness of apparent diffusion coefficient (ADC) for the differential diagnosis of breast tumors and to determine the relation between ADC and tumor cellularity...
Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion geneHidetaka Yamamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 56:584-90. 2006..These results suggest that IMT may be a heterogeneous group in terms of pathogenesis, and EBV and HHV-8 do not play a major role in the pathogenesis of ALK-positive tumor...
Frequent immunoexpression of TGF-beta1, FGF-2 and BMP-2 in fibroblast-like cells in osteofibrous dysplasiaAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
Oncol Rep 17:531-5. 2007....
Intra-articular osteochondroma of the knee joint in a patient with hereditary multiple osteochondromatosisYoshihiro Matsumoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka City, Fukuoka, Japan
Fukuoka Igaku Zasshi 98:425-30. 2007..Thus, other joint disorders, such as osteochondritis dissecans should be ruled out in such cases. We herein report a case with an intra-articular OC in a knee joint cavity in the patient with HMO...
Parotid gland tumors: can addition of diffusion-weighted MR imaging to dynamic contrast-enhanced MR imaging improve diagnostic accuracy in characterization?Hidetake Yabuuchi
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Radiology 249:909-16. 2008..To determine the value of adding diffusion-weighted (DW) magnetic resonance (MR) imaging to dynamic contrast material-enhanced MR imaging when distinguishing between benign and malignant parotid tumors...
A case of pulmonary synovial sarcoma diagnosed with detection of chimera gene: imaging findingsYoshio Matsuo
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka City, Fukuoka Prefecture 812 8582, Japan
Clin Imaging 30:60-2. 2006..In this case, a lung metastasis could be excluded with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET), and the final diagnosis was histopathologically confirmed by the chimeric gene detection...
Aneurysmal bone cyst of the capitate: case report and a review emphasizing local recurrenceAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Fukuoka Igaku Zasshi 97:302-7. 2006..No recurrence has been observed during the 4 years since operation. We also review the literature related to ABCs of the hand with special emphasis on local recurrence...
Desmoplastic fibroblastoma: a case presenting as a protruding nodule in the dermisMasakazu Takahara
Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Cutan Pathol 35:70-3. 2008..We diagnosed this case as desmoplastic fibroblastoma arising in the dermis and superficial subcutaneous tissue...
Anatomical features of periprostatic tissue and its surroundings: a histological analysis of 79 radical retropubic prostatectomy specimensKeijiro Kiyoshima
Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
Jpn J Clin Oncol 34:463-8. 2004..A proper understanding of prostatic and periprostatic anatomy is essential for surgical procedures and pathological diagnosis; however, the detailed features have not been commonly investigated and completely understood...
Hedgehog signaling pathway in neuroblastoma differentiationRyota Souzaki
Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Pediatr Surg 45:2299-304. 2010..The aim of this study is to show the activation of Hh signaling pathway in neuroblastoma (NB), a pediatric malignancy arising from neural crest cells, and to reveal the meaning of the Hh signaling pathway in NB development...
A case of an inflammatory myofibroblastic tumor in the lung which expressed TPM3-ALK gene fusionY Kinoshita
Department of Pediatric Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
Pediatr Surg Int 23:595-9. 2007..In addition to the histological diagnosis, the detection of the tumor specific fusion gene provided objective evidence in making a diagnosis...
