Jun Ichi Kira

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I
    J Kira
    Department of Neurology, Kyushu University, Fukuoka, Japan
    J Acquir Immune Defic Syndr Hum Retrovirol 16:380-92. 1997
  2. ncbi Atopic myelitis with focal amyotrophy: a possible link to Hopkins syndrome
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 269:143-51. 2008
  3. ncbi Neural damage associated with atopic diathesis: a nationwide survey in Japan
    N Isobe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Neurology 73:790-7. 2009
  4. ncbi MS: prevention of neural damage by early intervention
    Jun-ichi Kira
    Department of Neurology, Kyushu University, Fukuoka 812-8582, Japan
    Lancet Neurol 7:3-5. 2008
  5. ncbi Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status
    Takuya Matsushita
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurol Sci 291:37-43. 2010
  6. ncbi Multiple sclerosis in the Japanese population
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lancet Neurol 2:117-27. 2003
  7. ncbi History of allergic disorders in common neurologic diseases in Japanese patients
    J Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Acta Neurol Scand 105:215-20. 2002
  8. ncbi Neuromyelitis optica and asian phenotype of multiple sclerosis
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann N Y Acad Sci 1142:58-71. 2008
  9. ncbi Changes in the clinical phenotypes of multiple sclerosis during the past 50 years in Japan
    J Kira
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurol Sci 166:53-7. 1999
  10. ncbi Astrocytopathy in Balo's disease
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mult Scler 17:771-9. 2011

Collaborators

Detail Information

Publications119 found, 100 shown here

  1. ncbi Induction of chronic inflammatory arthropathy and mesenchymal tumors in rats infected with HTLV-I
    J Kira
    Department of Neurology, Kyushu University, Fukuoka, Japan
    J Acquir Immune Defic Syndr Hum Retrovirol 16:380-92. 1997
    ....
  2. ncbi Atopic myelitis with focal amyotrophy: a possible link to Hopkins syndrome
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 269:143-51. 2008
    ..This suggests a possible link between atopic myelitis and Hopkins syndrome (asthmatic amyotrophy)...
  3. ncbi Neural damage associated with atopic diathesis: a nationwide survey in Japan
    N Isobe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Neurology 73:790-7. 2009
    ....
  4. ncbi MS: prevention of neural damage by early intervention
    Jun-ichi Kira
    Department of Neurology, Kyushu University, Fukuoka 812-8582, Japan
    Lancet Neurol 7:3-5. 2008
  5. ncbi Reappraisal of brain MRI features in patients with multiple sclerosis and neuromyelitis optica according to anti-aquaporin-4 antibody status
    Takuya Matsushita
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurol Sci 291:37-43. 2010
    ..017) and higher frequency of anti-AQP4 antibody (P(corr)<0.0001) than typical NMO patients without brain lesions, suggesting that development of brain lesions in NMO may reflect high disease activity and thus be a warning sign...
  6. ncbi Multiple sclerosis in the Japanese population
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lancet Neurol 2:117-27. 2003
    ..Opticospinal MS is likely to have a distinct immune-mediated mechanism, which is not operative in conventional MS...
  7. ncbi History of allergic disorders in common neurologic diseases in Japanese patients
    J Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Acta Neurol Scand 105:215-20. 2002
    ..To clarify the association between past and present history of allergic disorders and neurologic diseases...
  8. ncbi Neuromyelitis optica and asian phenotype of multiple sclerosis
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann N Y Acad Sci 1142:58-71. 2008
    ..This review discusses possible mechanisms for OSMS and anti-AQP4 autoimmune syndrome of the CNS...
  9. ncbi Changes in the clinical phenotypes of multiple sclerosis during the past 50 years in Japan
    J Kira
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurol Sci 166:53-7. 1999
    ....
  10. ncbi Astrocytopathy in Balo's disease
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mult Scler 17:771-9. 2011
    ..I propose that AQP4 astrocytopathy, in the absence of anti-AQP4 antibody, is characteristic of Baló's disease. This hypothesis should be tested in future experimental studies...
  11. ncbi [Central nervous system damage associated with allergy]
    Jun-ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Arerugi 55:1504-8. 2006
  12. ncbi Juvenile muscular atrophy of the distal upper limb (Hirayama disease) associated with atopy
    J Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Neurosurg Psychiatry 70:798-801. 2001
    ..005). These findings suggest that atopy may be one of the contributing factors for Hirayama disease...
  13. ncbi Autoimmunity in neuromyelitis optica and opticospinal multiple sclerosis: astrocytopathy as a common denominator in demyelinating disorders
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 311:69-77. 2011
    ..The latter may be mediated by T cells and other cell-mediated mechanisms, and should be tested in future experimental studies...
  14. ncbi Association of anti-Helicobacter pylori neutrophil-activating protein antibody response with anti-aquaporin-4 autoimmunity in Japanese patients with multiple sclerosis and neuromyelitis optica
    Wei Li
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mult Scler 15:1411-21. 2009
    ..Therefore, HP-NAP may be associated with the pathology of anti-AQP4 antibody-related neural damage in MS/NMO patients...
  15. ncbi Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis
    Manabu Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 150:150-6. 2004
    ....
  16. ncbi Multiple system degeneration with basophilic inclusions in Japanese ALS patients with FUS mutation
    Takahisa Tateishi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Acta Neuropathol 119:355-64. 2010
    ..The FUS R521C mutation in this Japanese family caused familial ALS with pathological features of multiple system degeneration and neuronal basophilic inclusions...
  17. ncbi Restoration of microglial function by granulocyte-colony stimulating factor in ALS model mice
    Ryo Yamasaki
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Neuroimmunol 229:51-62. 2010
    ..Impaired migration of cultured mSOD1-Tg microglia to MCP-1 was recovered following G-CSF treatment. Restoration of microglial responses by G-CSF may contribute to its neuroprotective effects...
  18. ncbi Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese
    Takeshi Matsuoka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Brain 130:1206-23. 2007
    ..This indicated that the mechanisms producing LESCLs are also heterogeneous in cases with optic-spinal presentation, namely AQP4 autoimmunity-related and -unrelated...
  19. ncbi Induction of paranodal myelin detachment and sodium channel loss in vivo by Campylobacter jejuni DNA-binding protein from starved cells (C-Dps) in myelinated nerve fibers
    Hua Piao
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 288:54-62. 2010
    ..Thus, we consider that C-Dps damages myelinated nerve fibers, possibly through interference with paranodal sulfatide function, and may contribute to the axonal pathology seen in C. jejuni-related GBS...
  20. ncbi Increase in p53 protein levels by presenilin 1 gene mutations and its inhibition by secretase inhibitors
    Linqing Ma
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Alzheimers Dis 16:565-75. 2009
    ..Taken together, p53-dependent apoptosis upregulated by the I143T/G384A mutant PS1 gene may be associated, at least in part, with intracellular Abeta and proteasome impairment...
  21. ncbi Reappraisal of the motor role of basal ganglia: a functional magnetic resonance image study
    Takayuki Taniwaki
    Department of Clinical Neurophysiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 23:3432-8. 2003
    ..fMRI provides evidence that the basal ganglia-thalamo-motor loop plays a key role in controlling the rate of sequential finger movements in SI movement but not in ET movement...
  22. ncbi Increased IL-13 but not IL-5 production by CD4-positive T cells and CD8-positive T cells in multiple sclerosis during relapse phase
    Hirofumi Ochi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 812 8582, Fukuoka, Japan
    J Neurol Sci 201:45-51. 2002
    ..A distinct profile of IL-13 and IL-5 production by disease and by phase of MS suggests an active involvement of these type 2 cytokines in central nervous system (CNS) inflammation...
  23. ncbi Apomorphine treatment in Alzheimer mice promoting amyloid-? degradation
    Eri Himeno
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Neurol 69:248-56. 2011
    ..Apomorphine (APO) is a dopamine receptor agonist for Parkinson disease and also protects against oxidative stress. Efficacy of APO for an AD mouse model and effects of APO on cell cultures are studied...
  24. ncbi Genetic polymorphisms involved in dopaminergic neurotransmission and risk for Parkinson's disease in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    BMC Neurol 11:89. 2011
    ..Parkinson's disease (PD) is characterized by alterations in dopaminergic neurotransmission. Genetic polymorphisms involved in dopaminergic neurotransmission may influence susceptibility to PD...
  25. ncbi Increased IL-13-producing T cells in ALS: positive correlations with disease severity and progression rate
    Nan Shi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neuroimmunol 182:232-5. 2007
    ....
  26. ncbi Intrathecal upregulation of granulocyte colony stimulating factor and its neuroprotective actions on motor neurons in amyotrophic lateral sclerosis
    Masahito Tanaka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neuropathol Exp Neurol 65:816-25. 2006
    ..On the other hand, MCP-1 correlated with disease severity, which may aggravate motor neuron damage...
  27. ncbi Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model
    Mami Fukunaga Kawamura
    Department Neurology, Neurological Institute, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Exp Neurol 234:437-45. 2012
    ....
  28. ncbi Activation of glutathione peroxidase and inhibition of p53-related apoptosis by apomorphine
    Linqing Ma
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Alzheimers Dis 27:225-37. 2011
    ..In addition, treatment with dopamine D1, D2, D3 and D4 receptor antagonists did not counteract the protective action of APO. Thus, APO may enhance GPx activity through dopamine receptor-independent pathways...
  29. ncbi Heterogeneity and continuum of multiple sclerosis in Japanese according to magnetic resonance imaging findings
    Takeshi Matsuoka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 266:115-25. 2008
    ..These findings suggest that LESCLs are heterogeneous between OSMS and CMS patients, and that there are distinct subtypes of MS in Japanese, according to clinical and MRI findings...
  30. ncbi Anterior periventricular linear lesions in optic-spinal multiple sclerosis: a combined neuroimaging and neuropathological study
    Takuya Matsushita
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 8128582, Japan
    Mult Scler 14:343-53. 2008
    ..Thus, we suggested that anterior periventricular linear lesions without ovoid ones are characteristic of OSMS...
  31. ncbi Functional network of the basal ganglia and cerebellar motor loops in vivo: different activation patterns between self-initiated and externally triggered movements
    Takayuki Taniwaki
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Fukuoka, Japan
    Neuroimage 31:745-53. 2006
    ..Therefore, our modeling approach enabled identification of different contributions of the motor loops of basal ganglia and cerebellum to SI and ET tasks during motor execution...
  32. ncbi Dietary intake of metals and risk of Parkinson's disease: a case-control study in Japan
    Yoshihiro Miyake
    Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan
    J Neurol Sci 306:98-102. 2011
    ..50 (95% CI: 0.26-0.95, P for trend=0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD...
  33. ncbi Increased expression of manganese superoxide dismutase is associated with that of nitrotyrosine in myopathies with rimmed vacuoles
    Yuko Tsuruta
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Acta Neuropathol 103:59-65. 2002
    ..The two SODs may have different roles for cell protection, and the expression of Mn-SOD is associated with nitric oxide-induced oxidative damage in myopathies with rimmed vacuoles...
  34. ncbi A distinct subgroup of chronic inflammatory demyelinating polyneuropathy with CNS demyelination and a favorable response to immunotherapy
    Arnold Angelo M Pineda
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 255:1-6. 2007
    ....
  35. ncbi Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    FASEB J 19:255-7. 2005
    ....
  36. ncbi Tissue binding patterns and in vitro effects of Campylobacter jejuni DNA-binding protein from starved cells
    Hua Piao
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neurochem Res 36:58-66. 2011
    ..However, its binding to the surfaces of cultured NSC34 cells, S16 cells, or dorsal root ganglion cells, did not induce cytotoxicity. These findings suggest a possible involvement of C-Dps in C. jejuni-related GBS...
  37. ncbi A novel mutation (L250V) in the presenilin 1 gene in a Japanese familial Alzheimer's disease with myoclonus and generalized convulsion
    Hirokazu Furuya
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Neurol Sci 209:75-7. 2003
    ..This mutation was found in both patients, but not in a normal family member or normal Japanese control subjects. Thus, L250V is a novel PS1 gene mutation responsible for familial AD (FAD) in Japan...
  38. ncbi CSF chemokine alterations related to the clinical course of amyotrophic lateral sclerosis
    Takahisa Tateishi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neuroimmunol 222:76-81. 2010
    ..CCL4 and CXCL10 showed negative correlations with disease progression rate. These chemokine alterations are assumed to somehow correlate with the clinical course of ALS...
  39. ncbi Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia
    Kei ichiro Takase
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epilepsia 49:997-1010. 2008
    ..However, its epileptogenicity remains unclear. Therefore, we created a novel rat model by freeze lesioning during the late embryonic stage to verify whether FCD influences seizure activities...
  40. ncbi Intraneuronal amyloid beta42 enhanced by heating but counteracted by formic acid
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Neurosci Methods 159:134-8. 2007
    ..Moreover, formic acid treatment counteracted such effects of autoclaving. Thus, intraneuronal Abeta42 accumulation may have been underestimated by conventional methods using formic acid only...
  41. ncbi Involvement of cathepsin B in the motor neuron degeneration of amyotrophic lateral sclerosis
    Hitoshi Kikuchi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
    Acta Neuropathol 105:462-8. 2003
    ..Western blot analysis showed that the 25-kDa activated form of cathepsin B was down-regulated in ALS. Our results suggest that cathepsin B is involved in the motor neuron degeneration in ALS...
  42. ncbi Altered soleus responses to magnetic stimulation in pure cerebellar ataxia
    Tomomi Kurokawa-Kuroda
    Department of Clinical Neurophysiology, Neurological Institute, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, Japan
    Clin Neurophysiol 118:1198-203. 2007
    ..We evaluated the influence of the cerebellofugal pathway on the SPR and SLR in patients with 'pure' cerebellar ataxia...
  43. ncbi Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinson's disease: A case-control study in Japan
    Y Miyake
    Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, 814 0180, Japan
    Parkinsonism Relat Disord 17:112-6. 2011
    ..Our results suggest that intake of dairy products, calcium, and vitamin D was not related to PD, regardless of sex. However, such null relationships might be a consequence of PD...
  44. ncbi Reappraisal of aquaporin-4 astrocytopathy in Asian neuromyelitis optica and multiple sclerosis patients
    Takeshi Matsuoka
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Brain Pathol 21:516-32. 2011
    ..Our present and previous findings suggest that antibody-independent AQP4 loss can occur in heterogeneous demyelinating conditions, including NMO, Baló's disease and MS...
  45. ncbi Platelet-activating factor receptor gene polymorphism in Japanese patients with multiple sclerosis
    Manabu Osoegawa
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 161:195-8. 2005
    ..7%) was also significantly higher than those in healthy controls (6.9%) (p=0.019; OR, 1.78; 95% CI, 1.10-2.89). These findings suggest that the PAFR gene missense mutation has a relation to the susceptibility for MS...
  46. ncbi Dysferlin expression in tubular aggregates: their possible relationship to endoplasmic reticulum stress
    Koji Ikezoe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University 60, 812 8582, Fukuoka, Japan
    Acta Neuropathol 105:603-9. 2003
    ..Strong expression of dysferlin in TAs suggests the possibility that it is located not only at the sarcolemma but also in the SR, at least in the pathological conditions...
  47. ncbi Aquaporin-4 astrocytopathy in Baló's disease
    Takeshi Matsuoka
    Department of Neuropathology, Kyushu University, Higashi ku, Fukuoka, Japan
    Acta Neuropathol 120:651-60. 2010
    ..Furthermore, acute BCS lesions are characterized by extensive AQP4 loss without vasculocentric deposition of complement or immunoglobulin...
  48. ncbi Slowly progressive distal muscular atrophy of the bilateral upper limbs (O'Sullivan-McLeod syndrome) partially alleviated by intravenous immunoglobulin therapy
    Yuji Kawano
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Intern Med 46:515-8. 2007
    ..These effects lasted for a few months. These observations suggest that immune-mediated neural damage partially contributes to O'Sullivan-McLeod syndrome...
  49. ncbi Demyelinating and axonal features of Charcot-Marie-Tooth disease with mutations of myelin-related proteins (PMP22, MPZ and Cx32): a clinicopathological study of 205 Japanese patients
    Naoki Hattori
    Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Brain 126:134-51. 2003
    ....
  50. ncbi Campylobacter jejuni DNA-binding protein from starved cells in Guillain-Barré syndrome patients
    Nobutoshi Kawamura
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neuroimmunol 240:74-8. 2011
    ..jejuni-related GBS patients (5/27, 14.8% and 15/24, 62.5%; respectively). These findings suggest that C-Dps invades the host and may potentially contribute to the peripheral nerve damage in C. jejuni-related GBS...
  51. ncbi [Inhibition of neuronal death by promoting degradation of intracellular amyloid beta-protein]
    Yasumasa Ohyagi
    Department School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:57-62. 2007
    ..Apomorphine hydrochloride is now used as a dopamine agonist for Parkinson's disease or an anti-ED drug in western countries, but also may be one of the candidate drugs to inhibit neuronal death in AD...
  52. ncbi Altered production of brain-derived neurotrophic factor by peripheral blood immune cells in multiple sclerosis
    Satoshi Yoshimura
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mult Scler 16:1178-88. 2010
    ..Within multiple sclerosis lesions, brain-derived neurotrophic factor is detected in neurons and immunocytes...
  53. ncbi Helicobacter pylori infection is a potential protective factor against conventional multiple sclerosis in the Japanese population
    Wei Li
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 184:227-31. 2007
    ..61, p=0.0344 and OR=0.11, p=0.0297). These findings suggest that H. pylori infection is a protective factor against CMS in Japanese...
  54. ncbi [Two cases of familial amyotrophic lateral sclerosis with a SOD1L126S mutation showing high age at onset and slow progression]
    Tomo Iwashima
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 50:163-7. 2010
    ..It is important to consider the possibility of this type of familial ALS in a case of spinal progressive muscular atrophy with late-onset and mild progression, if family history is positive...
  55. ncbi GST polymorphisms, interaction with smoking and pesticide use, and risk for Parkinson's disease in a Japanese population
    C Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Parkinsonism Relat Disord 16:447-52. 2010
    ..Future studies involving larger control and case populations and better pesticide exposure histories will undoubtedly lead to a more thorough understanding of the role of the GST polymorphisms in PD development...
  56. ncbi EEG findings in early-stage corticobasal degeneration and progressive supranuclear palsy: a retrospective study and literature review
    Kenshi Tashiro
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Clin Neurophysiol 117:2236-42. 2006
    ..We assessed the value of EEG for differentiating CBD from PSP...
  57. ncbi Multimodality-evoked potential study of anti-aquaporin-4 antibody-positive and -negative multiple sclerosis patients
    Akihiro Watanabe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan
    J Neurol Sci 281:34-40. 2009
    ..These findings suggest a distinctive nature of optic nerve lesions between anti-AQP4 antibody-positive and -negative patients; lesions are supposed to be more necrotic in the former group and more demyelinating in the latter...
  58. ncbi Oscillatory gamma synchronization binds the primary and secondary somatosensory areas in humans
    Koichi Hagiwara
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuroimage 51:412-20. 2010
    ..Our study first demonstrates the gamma-band synchrony in the early-stage human somatosensory processing...
  59. ncbi Simultaneous arterial spin labeling cerebral blood flow and morphological assessments for detection of Alzheimer's disease
    Tuvshinjargal Dashjamts
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Acad Radiol 18:1492-9. 2011
    ....
  60. ncbi Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis
    Arnold Angelo M Pineda
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 306:115-20. 2011
    ....
  61. ncbi Heterogeneity and continuum of multiple sclerosis phenotypes in Japanese according to the results of the fourth nationwide survey
    Takaaki Ishizu
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 280:22-8. 2009
    ..These findings suggest that demographic features not only vary based on CMS or OSMS phenotype, but also with the presence or absence of LESCLs, and that nonetheless, these four phenotypes constitute a continuum...
  62. ncbi Frequency of chronic headaches in Japanese patients with multiple sclerosis: with special reference to opticospinal and common forms of multiple sclerosis
    Hikaru Doi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Headache 49:1513-20. 2009
    ..In Asians, the opticospinal form of MS, showing similar characteristics to relapsing neuromyelitis optica in Westerners, is regarded as a different subtype from conventional MS...
  63. ncbi [Case of eosinophilic myositis in continuum from localized nodular myositis]
    Dai Matsuse
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 48:36-42. 2008
    ..As discussed, the involvement of eosinophils in three inflammatory myopathies was indicated...
  64. ncbi Left hemisphere specialization for rapid temporal processing: a study with auditory 40 Hz steady-state responses
    Takao Yamasaki
    Department of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Neurophysiol 116:393-400. 2005
    ..To investigate rapid temporal processing in the auditory cortex by using auditory 40 Hz steady-state responses (SSRs)...
  65. ncbi A case of dermato-fasciitis: amyopathic dermatomyositis associated with fasciitis
    Yuko Tsuruta
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, 812 8582, Fukuoka, Japan
    Clin Rheumatol 23:160-2. 2004
    ..With steroid therapy, her symptoms and MRI abnormality disappeared within 2 months. This case is therefore considered to be a variant of ADM, presenting as dermato-fasciitis...
  66. ncbi Wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) syndrome in a patient with neuromyelitis optica spectrum disorder and anti-aquaporin-4 antibody
    Koji Shinoda
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan
    Mult Scler 17:885-7. 2011
    ..Although WEBINO syndrome is occasionally reported in multiple sclerosis patients, diagnosis of NMO should not be excluded in patients with WEBINO syndrome, because AQP4 is expressed abundantly around the periaqueductal region...
  67. ncbi Endoplasmic reticulum stress in myotonic dystrophy type 1 muscle
    Koji Ikezoe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Acta Neuropathol 114:527-35. 2007
    ..Taken together, ER stress is involved in muscle wasting in DM1. However, it seems to be evoked not only by disrupted intracellular Ca2+ homeostasis...
  68. ncbi Differential contributions of spinal and cortical motoneurons to input-output properties of human small hand muscle
    Ayame Oishi
    Department of Neurology, Faculty of Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neurol Res 30:1106-13. 2008
    ..To understand these response functions, we studied patients with amyotrophic lateral sclerosis (ALS) whose upper but not lower motor neurons were affected...
  69. ncbi Age-related alterations of the functional interactions within the basal ganglia and cerebellar motor loops in vivo
    Takayuki Taniwaki
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Fukuoka, Japan
    Neuroimage 36:1263-76. 2007
    ..Aging effects on SI and ET movements are probably caused by functional alterations within BGTM and CC loops...
  70. ncbi Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors
    Katsue Miyoshi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Alzheimers Dis 16:551-64. 2009
    ..Our present data suggest that these PS1 mutants accelerate the activation of initiator caspases and promote apoptosis, which may be associated, at least in part, with amyloid-beta production...
  71. ncbi Accumulation of stress-related proteins within the glomeruli of the rat olfactory bulb following damage to olfactory receptor neurons
    Kazuho Hirata
    Department of Anatomy and Cell Biology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Arch Histol Cytol 71:265-77. 2008
    ..The present study suggests that reactive astrocytes may be involved in axonal regeneration and synaptic remodeling in the olfactory system, through the recapitulation of developmentally regulated proteins, such as nestin and HSP27...
  72. ncbi Myeloradiculitis caused by Cryptococcus neoformans infection in a patient with ulcerative colitis: a neuropathological study
    Hiroyuki Murai
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Neurol Sci 247:236-8. 2006
    ..Cryptococcal infection should be considered while managing myeloradiculopathy of unknown etiology, especially in immunocompromised patients...
  73. ncbi Long-term effects of infrasternal mediastinoscopic thymectomy in myasthenia gravis
    Hiroyuki Murai
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 287:185-7. 2009
    ..Endoscopic thymectomy is commonly used for treatment of myasthenia gravis (MG) patients due to its relatively low invasiveness. However, the long-term effects of endoscopic thymectomy have not been fully evaluated...
  74. ncbi A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene
    Hirokazu Furuya
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Clin Neurol Neurosurg 108:784-6. 2006
    ..0+/-9.2 pmol/ml) in patients with HPD/DRD). The relatively conserved GCH1 activity that is expressed in stimulated peripheral blood mononuclear cells may be related to the late clinical symptoms in this patient...
  75. ncbi Efficacy of mediodorsal thalamic nucleus stimulation in a rat model of cortical seizure
    Kei ichiro Takase
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 100:274-80. 2009
    ..The aim of this study was to determine whether the mediodorsal thalamic nucleus influences seizure induction by electrical stimulation in the rat frontal cortex...
  76. ncbi Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant
    Hirokazu Furuya
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Pharmacol 69:503-16. 2005
    ..This system makes it easy to evaluate the toxic effects of expanded CTG repeats and therefore should be useful for screening other DM1 treatments for their efficacies...
  77. ncbi Deterioration of abstract reasoning ability in mild cognitive impairment and Alzheimer's disease: correlation with regional grey matter volume loss revealed by diffeomorphic anatomical registration through exponentiated lie algebra analysis
    Takashi Yoshiura
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Eur Radiol 21:419-25. 2011
    ..To determine which brain regions are relevant to deterioration in abstract reasoning as measured by Raven's Colored Progressive Matrices (CPM) in the context of dementia...
  78. ncbi Characteristics of myasthenia gravis according to onset-age: Japanese nationwide survey
    Hiroyuki Murai
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurol Sci 305:97-102. 2011
    ..To clarify the prevalence and clinical characteristics of myasthenia gravis (MG) in Japan...
  79. ncbi High frequency of allergic conjunctivitis in myasthenia gravis without thymoma
    Hiroyuki Murai
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 225:27-31. 2004
    ..To investigate the frequency of allergic disorders in myasthenia gravis (MG) patients and characterize the features of MG associated with allergic disorders...
  80. ncbi APOE and CYP2E1 polymorphisms, alcohol consumption, and Parkinson's disease in a Japanese population
    Chikako Kiyohara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neural Transm 118:1335-44. 2011
    ....
  81. ncbi Ultrastructural detection of DNA fragmentation in myonuclei of fatal reducing body myopathy
    Koji Ikezoe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University 60, 812 8582 Fukuoka, Japan
    Acta Neuropathol 107:439-42. 2004
    ..These results suggest that apoptosis takes part in muscle fiber degeneration in fatal reducing body myopathy, although the precise relationship between reducing bodies and apoptosis is uncertain...
  82. ncbi Amyloid-beta accumulation caused by chloroquine injections precedes ER stress and autophagosome formation in rat skeletal muscle
    Koji Ikezoe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Acta Neuropathol 117:575-82. 2009
    ..Chloroquine-treated rats could be useful for investigating the pathogenesis of diseases related to Abeta accumulation...
  83. ncbi Electrophysiological correlates of associative visual agnosia lesioned in the ventral pathway
    Takao Yamasaki
    Department of Neurology, Graduate School of Medical Sciences, Neurological Institute, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 221:53-60. 2004
    ..Therefore, CS-VEPs and ERPs with color and motion discrimination tasks are useful methods for assessing the functional changes of visual recognition such as visual agnosia...
  84. ncbi Repetitive transcranial magnetic stimulation alters optic flow perception
    Kenshi Tashiro
    Department of Clinical Neurophysiology, Graduate School of Medical Sciences, Faculty of Medicine, Kyushu University, and Department of Medical Information Science, Kyushu University Hospital, Higashi ku, Japan
    Neuroreport 18:229-33. 2007
    ..Low-frequency repetitive transcranial magnetic stimulation is a useful tool for exploring visuospatial cognition...
  85. ncbi [Search for the pathogenesis of multiple sclerosis from the bedside]
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 48:931-3. 2008
    ..Future research on both T cells and humoral immunity is expected to disclose the pathophysiology of MS...
  86. ncbi Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants
    Nobutaka Sakae
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 3 2 2 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Hum Mol Genet 17:3191-203. 2008
    ..These observations implicate impairment of FEZ1 function in the pathogenesis of schizophrenia...
  87. ncbi Middle latency auditory-evoked potentials in myotonic dystrophy: relation to the size of the CTG trinucleotide repeat and intelligent quotient
    Kenji Arakawa
    Department of Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Neurol Sci 207:31-6. 2003
    ..To validate usefulness of middle latency auditory-evoked potentials (MLAEPs) in evaluating the central nervous system (CNS) involvement of myotonic dystrophy (MyD)...
  88. ncbi Intrathecal upregulation of IFN-gamma and MIP-1beta in juvenile muscular atrophy of the distal upper extremity
    Masahito Tanaka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 275:74-7. 2008
    ..The intrathecal upregulation of proinflammatory Th1 cytokines/chemokines, such as IFN-gamma and MIP-1beta (CCL3), in the CSF of JMADUE patients indicates the possible involvement of intrathecal immunological processes in this condition...
  89. ncbi A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H)
    Hirokazu Furuya
    Department of Neurology, Neuro Muscular Center, National Omuta Hospital, Fukuoka, Japan
    Am J Med Genet A 146:459-63. 2008
    ..5-Mb region spanning ACVR1 and its neighbor genes suggested that 1067G > A is a de novo mutation. These results give a clue to better understanding of FOP as well as of the mild clinical symptoms in the patient...
  90. ncbi [Case of Borrelia brainstem encephalitis presenting with severe dysphagia]
    Yuji Kawano
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 50:265-7. 2010
    ..Because the clinical symptoms of Borrelia infection are widely variable, neuroborreliosis should be considered in patients with brainstem encephalitis refractory to conventional immunotherapies...
  91. ncbi Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan
    Yoshihiro Miyake
    Department of Public Health, Faculty of Medicine, Fukuoka University, Jonan ku, Fukuoka, Japan
    J Neurol Sci 293:82-6. 2010
    ..Further well-designed investigations of the association of vascular risk factors with the risk of PD are needed, particularly large-scale prospective studies in Asia...
  92. ncbi Cortical kindling in a focal freeze lesion rat model
    Kei ichiro Takase
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Clin Neurosci 16:94-8. 2009
    ..These results suggest that FCD might not influence vulnerability to epileptogenicity, at least in some patients with mild FCD...
  93. ncbi [Treatment strategy for POEMS syndrome]
    Nobutoshi Kawamura
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Brain Nerve 60:621-6. 2008
    ..Finally, we emphasized that the efficacy of these therapies largely depends on the appropriate early diagnosis of POEMS syndrome...
  94. ncbi Atopy and neural damage
    Jun-ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Intern Med 41:169-74. 2002
    ..The former is typically associated with atopic dermatitis while the latter, with airway allergy...
  95. ncbi [Epidemiology of multiple sclerosis: environmental factors versus genetic factors]
    Jun-ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Nippon Rinsho 61:1300-10. 2003
    ..The ratio of conventional to opticospinal MS has increased rapidly in Japanese born after 1960s, suggesting that the modernization occurred after 1960s in Japan has modifying effects on MS susceptibility and phenotypes...
  96. ncbi [An adulthood progressive case of congenital nemaline myopathy showing rimmed vacuoles in muscle biopsy and diffuse neurogenic changes on electromyography]
    Koji Ikezoe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 44:450-3. 2004
    ..Moreover, the presence of both nemaline rods and rimmed vacuoles may have contributed to the development of diffuse neurogenic changes seen in electromyography...
  97. ncbi [A family with autosomal dominant temporal lobe epilepsy accompanied by motor and sensory neuropathy]
    Takeshi Matsuoka
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 44:43-9. 2004
    ..Based on these data, we consider that this family to be a new phenotype of autosomal dominant TLE accompanied by motor and sensory neuropathy...
  98. ncbi [Acute myelitis in a patient with ulcerative colitis]
    Koichi Hagiwara
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Nippon Naika Gakkai Zasshi 96:1703-5. 2007
  99. ncbi Novel missense mutations in the human lysosomal sialidase gene in sialidosis patients and prediction of structural alterations of mutant enzymes
    Kohji Itoh
    Department of Clinical Genetics, The Tokyo Metropolitan Institute of Medical Science, Tokyo Metropolitan Organization for Medical Research, Japan
    J Hum Genet 47:29-37. 2002
    ..The W240R substitution was deduced to influence the molecular surface structure of a limited region of the constructed models, which was also influenced by previously identified V217M and G243R transversions...
  100. ncbi [Neural damage associated with allergic diseases: pathomechanism and therapy]
    Jun-ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 43:756-60. 2003
    ..In children, poliomyelitis-like illness after acute asthma attacks is well known as Hopkins syndrome. These findings strongly suggest a link between atopic diathesis and spinal cord damage...
  101. ncbi Juvenile muscular atrophy of distal upper extremity associated with airway allergy: two cases successfully treated by plasma exchange
    Hirofumi Ochi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    J Neurol Sci 206:109-14. 2003
    ....