Research Topics
| Kosuke HashimotoSummaryAffiliation: Kyoto University Country: Japan Publications
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Publications
KEGG as a glycome informatics resourceKosuke Hashimoto
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan
Glycobiology 16:63R-70R. 2006..In all the KEGG resources, various objects including KEGG pathways, chemical compounds, as well as carbohydrate structures are commonly represented as graphs, which are widely studied and utilized in the computer science field...- A global representation of the carbohydrate structures: a tool for the analysis of glycanKosuke Hashimoto
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
Genome Inform 16:214-22. 2005..These resources are available at http://www.genome.jp/kegg/glycan/... - The repertoire of desaturases for unsaturated fatty acid synthesis in 397 genomesKosuke Hashimoto
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
Genome Inform 17:173-83. 2006..In this study, we performed a systematic analysis of fatty acid desaturases found in the genomic data of 397 organisms. We obtained a set of desaturases clustered by regioselectivity using a hierarchal clustering analysis... - The repertoire of desaturases and elongases reveals fatty acid variations in 56 eukaryotic genomesKosuke Hashimoto
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
J Lipid Res 49:183-91. 2008..This study provides an example of a potent strategy to bridge the gap from genomic knowledge to chemical knowledge... - Comprehensive analysis of glycosyltransferases in eukaryotic genomes for structural and functional characterization of glycansKosuke Hashimoto
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611 0011, Japan
Carbohydr Res 344:881-7. 2009..Our findings suggest that universality and diversity of glycans originate from two types of evolution of glycosyltransferase families, namely conserved families with few paralogs and diverged families with many paralogs... - An improved scoring scheme for predicting glycan structures from gene expression dataAkitsugu Suga
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
Genome Inform 18:237-46. 2007.... - Prediction of glycan structures from gene expression data based on glycosyltransferase reactionsShin Kawano
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Uji, Kyoto 611-0011, Japan
Bioinformatics 21:3976-82. 2005..Using expression profiles from the human carcinoma cell, glycan structures with sialic acid and sialyl Lewis X epitope were predicted, which corresponded well with experimental results... - Mining significant tree patterns in carbohydrate sugar chainsKosuke Hashimoto
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji 611 0011, Japan
Bioinformatics 24:i167-73. 2008..Finding these glycan tree motifs is an important issue, but there have been no computational methods to capture these motifs efficiently... - Extraction of species-specific glycan substructuresYoshiyuki Hizukuri
Bioinformatics Center, Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto 611 0011, Japan
Genome Inform 15:69-81. 2004..We confirmed that the characteristic substructures extracted by our method correspond to the substructures which are known as the species-specific sugar chain of gamma-glutamyltranspeptidases in the kidney...