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Genomes and Genes | Masaru InataniSummaryAffiliation: Kumamoto University Country: Japan Publications
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Publications
Molecular mechanisms of optic axon guidanceMasaru Inatani
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Naturwissenschaften 92:549-61. 2005..Recent discoveries about the molecular mechanisms underlying optic nerve guidance will facilitate progress in CNS developmental biology and axon-regeneration therapy...- Intraocular pressure elevation after injection of triamcinolone acetonide: a multicenter retrospective case-control studyMasaru Inatani
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
Am J Ophthalmol 145:676-681. 2008..To determine the risk factors for intraocular pressure (IOP) elevation after the injection of triamcinolone acetonide (TA)... - Long-term relationship between intraocular pressure and visual field loss in primary open-angle glaucomaMasaru Inatani
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Japan
J Glaucoma 17:275-9. 2008..To investigate the dependence upon intraocular pressure (IOP) of the progression of visual field defects in eyes with primary open-angle glaucoma (POAG), in which the mean IOP was maintained at < or =21 mm Hg... - Heparan sulfate regulates intraretinal axon pathfinding by retinal ganglion cellsMinako Ogata-Iwao
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Japan
Invest Ophthalmol Vis Sci 52:6671-9. 2011.... - Trabeculectomy with mitomycin for open-angle glaucoma in phakic vs pseudophakic eyes after phacoemulsificationYuji Takihara
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto City, Japan
Arch Ophthalmol 129:152-7. 2011..To determine whether previous phacoemulsification adversely affects surgical prognosis of trabeculectomy with mitomycin for open-angle glaucoma... - Combined intravitreal bevacizumab and trabeculectomy with mitomycin C versus trabeculectomy with mitomycin C alone for neovascular glaucomaYuji Takihara
Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto, Japan
J Glaucoma 20:196-201. 2011..To evaluate the effects of intravitreal bevacizumab (IVB) before mitomycin C trabeculectomy (MMCT) for neovascular glaucoma (NVG)... - Y-27632, a Rho-associated protein kinase inhibitor, attenuates neuronal cell death after transient retinal ischemiaAkira Hirata
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto, 860 8556, Japan
Graefes Arch Clin Exp Ophthalmol 246:51-9. 2008..The current study aimed to investigate whether this damage was attenuated by the inhibition of Rho/ROCK (Rho kinases) signaling, recently shown to play a critical role in the transendothelial migration of leukocytes... - Pitavastatin: protection against neuronal retinal damage induced by ischemia-reperfusion injury in ratsTakahiro Kawaji
Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, Honjo, Kumamoto, Japan
Curr Eye Res 32:991-7. 2007..To evaluate the neuroprotective effects of pitavastatin against neuronal retinal damage induced by ischemia-reperfusion injury in rats... - Heparan sulfate deficiency in periocular mesenchyme causes microphthalmia and ciliary body dysgenesisKeiichiro Iwao
Department of Ophthalmology and Visual Science, Kumamoto University, Graduate School of Medical Sciences, 1 1 1, Honjo, 860 8556 Kumamoto City, Japan
Exp Eye Res 90:81-8. 2010..These findings demonstrate that HS in the periocular mesenchyme plays a critical role in normal ocular morphogenesis, indicating reciprocal interactions between the periocular mesenchyme and the neural ectoderm... - Trabeculectomy with mitomycin C for neovascular glaucoma: prognostic factors for surgical failureYuji Takihara
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto City, Japan
Am J Ophthalmol 147:912-8, 918.e1. 2009..To evaluate the prognostic factors for surgical outcomes of trabeculectomy with mitomycin C (MMC) for neovascular glaucoma (NVG)... - Heparan sulfate deficiency leads to Peters anomaly in mice by disturbing neural crest TGF-beta2 signalingKeiichiro Iwao
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
J Clin Invest 119:1997-2008. 2009..These findings suggest that HS is necessary for neural crest cells to form the anterior chamber via TGF-beta2 signaling. Disturbances of HS synthesis might therefore contribute to the pathology of developmental glaucoma... - Expression of a chondroitin sulfate proteoglycan, versican (PG-M), during development of rat corneaTakahisa Koga
Departments of Ophthalmology and Visual Science and Molecular Genetics, Kumamoto University Graduate School of Medical Sciences, Honjo 2 2 1, Kumamoto 860 0811, Japan
Curr Eye Res 30:455-63. 2005..To understand the role of chondroitin sulfate proteoglycans during the development of rat cornea, expression of chondroitin sulfate and versican (PG-M) was studied... - Frequency and risk factors for intraocular pressure elevation after posterior sub-Tenon capsule triamcinolone acetonide injectionKeiichiro Iwao
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
J Glaucoma 16:251-6. 2007..This study investigated the effects of posterior sub-Tenon capsule (PST) injection of triamcinolone acetonide (TA) on intraocular pressure (IOP) in the human eye... - Success rates of trabeculotomy for steroid-induced glaucoma: a comparative, multicenter, retrospective cohort studyKeiichiro Iwao
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjo, Kumamoto, Japan
Am J Ophthalmol 151:1047-1056.e1. 2011..To evaluate the surgical outcomes of trabeculotomy for steroid-induced glaucoma... - Dynamic imaging of axonal transport in living retinal ganglion cells in vitroYuji Takihara
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Honjo, Kumamoto City, Japan
Invest Ophthalmol Vis Sci 52:3039-45. 2011..Live-cell imaging in vitro was used in this study, to visualize and evaluate the axonal transport of brain-derived neurotrophic factor (BDNF) in both living and axon-damaged RGCs... - Suppression of choroidal neovascularization by N-acetyl-cysteine in miceRyuhei Hara
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
Curr Eye Res 35:1012-20. 2010..N-acetyl-cysteine (NAC) is a potent antioxidant known to be a precursor of glutathione. The purpose of this study was to investigate the role of NAC in the development of choroidal neovascularization (CNV)... - Restricted post-trabeculectomy bleb formation by conjunctival scarringKeiichiro Iwao
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1 1 1, Honjo, 860 8556, Kumamoto, Japan
Graefes Arch Clin Exp Ophthalmol 247:1095-101. 2009..To evaluate the effects of radial conjunctival incision during fornix-based trabeculectomy, and conjunctival scarring associated with previous ocular surgeries, for the restriction of bleb formation... - Stability of the central visual field after modern trabeculectomy techniques in eyes with advanced glaucomaMaiko Awai
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
Jpn J Ophthalmol 51:116-20. 2007..To review the surgical results and complications of trabeculectomy techniques in patients with advanced glaucoma and threatened fixation... - Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteersHidenobu Tanihara
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
Arch Ophthalmol 126:309-15. 2008..To investigate the effects and safety of topical administration of an ophthalmic solution of a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor, SNJ-1656, 0.003% to 0.1%, in healthy male adult volunteers... - Impact of phacoemulsification on failure of trabeculectomy with mitomycin-CNanako Awai-Kasaoka
Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan
J Cataract Refract Surg 38:419-24. 2012..To evaluate whether phacoemulsification after trabeculectomy affects postoperative intraocular pressure (IOP)... - Effect of pitavastatin on experimental choroidal neovascularization in ratsNina Sagara
Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, 1 1 1 Honjo, Kumamoto 860 8556, Japan
Exp Eye Res 84:1074-80. 2007..Thus, we demonstrated that the therapeutic dose of pitavastatin for human hypocholesterolemia effectively suppressed experimental CNV in rats. The use of pitavastatin may be helpful in preventing CNV development in AMD patients... - Fate mapping of neural crest cells during eye development using a protein 0 promoter-driven transgenic techniqueKeiichiro Iwao
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, 1 1 1, Honjo, 860 8556, Kumamoto, Japan
Graefes Arch Clin Exp Ophthalmol 246:1117-22. 2008..To map neural crest cell fate during eye development... - [Exploration of the molecular mechanism of ocular development and the creation of animal models for ocular diseases]Masaru Inatani
Department of Ophthalmology and Visual Science, Kumamoto University Graduate School of Medical Sciences, Japan
Nihon Ganka Gakkai Zasshi 114:280-96; discussion 297. 2010..These developmental animal models revealed that heparan sulfate proteoglycans have an essential role in regulation of heparin-binding molecules in vivo... - Expression of glycosaminoglycans during development of the rat retinaTakahisa Koga
Department of Ophthalmology, Kumamoto University School of Medicine, Kumamoto, Japan
Curr Eye Res 27:75-83. 2003..To investigate the spatiotemporal expression of glycosaminoglycans during development of the rat retina... - Proteoglycans in retinaMasaru Inatani
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
Prog Retin Eye Res 21:429-47. 2002.... - Proteoglycans in the eyeHidenobu Tanihara
Cornea 21:S62-9. 2002..Various proteoglycans are expressed in ocular tissues. We investigated and reviewed the distribution and the potential roles of proteoglycans in cornea, trabecular meshwork, and retinal tissues... - Gene expression of EXT1 and EXT2 during mouse brain developmentMasaru Inatani
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Brain Res Dev Brain Res 141:129-36. 2003..Our results demonstrate that EXT1 and EXT2 are highly expressed in the developing brain, and that their expression is developmentally regulated, suggesting that HS is involved in various neurodevelopmental processes... - Mammalian brain morphogenesis and midline axon guidance require heparan sulfateMasaru Inatani
The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA
Science 302:1044-6. 2003..Furthermore, the EXT1-null brain displayed severe guidance errors in major commissural tracts, revealing a pivotal role of HS in midline axon guidance. These findings demonstrate that HS is essential for mammalian brain development... - Spatiotemporal expression patterns of N-syndecan, a transmembrane heparan sulfate proteoglycan, in developing retinaMasaru Inatani
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
Invest Ophthalmol Vis Sci 43:1616-21. 2002..CONCLUSIONS: The data show that N-syndecan is transiently expressed, primarily in retinal neural fibers, during retinal development, indicating that it may be involved in formation of the retinal neural network... - [Heparan sulfate, an essential of CNS development]Masaru Inatani
Tanpakushitsu Kakusan Koso 49:2369-75. 2004 - Netrin-1/DCC signaling in commissural axon guidance requires cell-autonomous expression of heparan sulfateYoshihiro Matsumoto
Developmental Neurobiology Program, Burnham Institute for Medical Research, La Jolla, California 92037, USA
J Neurosci 27:4342-50. 2007..These results demonstrate that the expression of HS by commissural neurons is essential for these neurons to transduce netrin-1 signals, thus providing evidence for a cell-autonomous role of HS in netrin-1/DCC-mediated axon guidance... - Semaphorin 5A is a bifunctional axon guidance cue regulated by heparan and chondroitin sulfate proteoglycansDavid B Kantor
Department of Neuroscience, Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, Maryland 21205, USA
Neuron 44:961-75. 2004..Thus, neuronal responses to Sema5A are proteoglycan dependent and interpreted according to the biological context in which this membrane bound guidance cue is presented... - Cerebral hypoplasia and craniofacial defects in mice lacking heparan sulfate Ndst1 gene functionKay Grobe
Department of Cellular and Molecular Medicine, Glycobiology Research and Training Center, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0687, USA
Development 132:3777-86. 2005..Most importantly, the data suggest the possibility that defects in heparan sulfate synthesis could give rise to or contribute to a number of developmental brain and facial defects in humans... - Expression of NG2 proteoglycan during endochondral and intramembranous ossificationJun ichi Fukushi
The Burnham Institute, La Jolla, California 92037, USA
Dev Dyn 228:143-8. 2003..Our results indicate that NG2 expression is up-regulated during both endochondral and intramembranous ossification, but is down-regulated as ossification is completed... - Association of Toll-like receptor 4 gene polymorphisms with normal tension glaucomaEtsuko Shibuya
Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan
Invest Ophthalmol Vis Sci 49:4453-7. 2008..This study was undertaken to investigate whether TLR4 polymorphisms are associated with NTG... - Elevated neprilysin activity in vitreous of patients with proliferative diabetic retinopathyHideaki Hara
Department of Biofunctional Molecules, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu, Japan
Mol Vis 12:977-82. 2006..In this study, we measured both the enzymatic activity of neprilysin and the concentration of Abeta in patients with proliferative DR (as compared to their levels in patients with macular hole), and we analyzed their association... - A myosin light chain kinase inhibitor, ML-9, lowers the intraocular pressure in rabbit eyesMegumi Honjo
Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
Exp Eye Res 75:135-42. 2002..The IOP-lowering effects may be related to alterations in TM cell shapes. Inhibitors of MLCK may potentially be developed into novel medications for glaucoma... - Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeysHideki Tokushige
Research Laboratories, Senju Pharmaceutical Co Ltd, Kobe, Osaka, Japan
Invest Ophthalmol Vis Sci 48:3216-22. 2007..To elucidate the intraocular pressure (IOP)-lowering effects and associated characteristics of Y-39983, a selective Rho-associated coiled coil-forming protein kinase (ROCK) inhibitor derived from Y-27632, in animal eyes...