Research Topics
| Toshiaki TakahashiSummaryAffiliation: Kochi Medical School Country: Japan Publications
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Detail Information
Publications
Metabolic effects of X-ray irradiation on adult human articular chondrocytesToshiaki Takahashi
Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, Japan
Int J Mol Med 11:631-4. 2003..This suggests that it is important to consider whether there is an osteoarthritic joint in the area that is to receive radiation therapy during tumor surgery...- Posture of the trunk in the sagittal plane is associated with gait in community-dwelling elderly populationDaisuke Hirose
Department of Orthopaedics, Kochi Medical School, Nankoku Kochi, Kochi 783 8505, Japan
Clin Biomech (Bristol, Avon) 19:57-63. 2004..The purpose of this study was to evaluate whether abnormal posture of the trunk in the sagittal plane would affect gait and functional performance in the elderly... - Novel technique for suspension culture of autologous chondrocytes improves cell proliferation and tissue architectureToshiaki Takahashi
Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, Kochi 783 8505, Japan
Cell Transplant 12:667-76. 2003.... - Trunk deformity is associated with a reduction in outdoor activities of daily living and life satisfaction in community-dwelling older peopleToshiaki Takahashi
Department of Orthopaedics, Kochi Medical School, Oko cho, 783 8505 Nankoku, Kochi, Japan
Osteoporos Int 16:273-9. 2005.... - A new computer-assisted method for measuring the tibio-femoral angle in patients with osteoarthritis of the kneeT Takahashi
Department of Orthopaedics, Kochi Medical School, Oko cho, Nankoku, Kochi, 783 8505, Japan
Osteoarthritis Cartilage 12:256-9. 2004..The purpose of this study was to evaluate the inter- and intraobserver variability in measuring the tibio-femoral angle using our new computer-assisted method, and to compare it with a conventional manual method... - Knee pain in people aged 80 years and older is not associated with gait parameter and functional performanceYasunori Nagano
Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, Kochi 783 8505, Japan
Int J Rehabil Res 26:131-6. 2003..However, in the group aged 80 years and over, there was no significant difference between participants with and without knee pain for these parameters... - Anatomical reconstruction of chronic lateral ligament injury of the ankle using pedicle tendon of the extensor digitorum longusToshiaki Takahashi
Department of Orthopaedic Surgery, Kochi Medical School, 783 8505, Kochi, Japan
Arch Orthop Trauma Surg 123:175-9. 2003..Since 1989, we have performed ligament reconstruction using the extensor digitorum longus tendon as a pedicle graft for patients with chronic lateral instability of the ankle... - Vertical ground reaction force shape is associated with gait parameters, timed up and go, and functional reach in elderly femalesToshiaki Takahashi
Department of Orthopaedic Surgery, Kochi Medical School, Kochi, Japan
J Rehabil Med 36:42-5. 2004.... - Cross talk between COX-2 inhibitor and hyaluronic acid in osteoarthritic chondrocytesToshiaki Takahashi
Department of Orthopaedics, Kochi Medical School, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
Int J Mol Med 14:139-44. 2004..Administration of COX-2 inhibitors plus HA could be used as a new alternative way of treating osteoarthritis... - Role of apoptosis inhibition in various chondrocyte culture systemsToshiaki Takahashi
Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, Kochi 783 8505, Japan
Int J Mol Med 11:299-303. 2003..These data suggest that suspension culture with autologous serum is useful in simultaneously maintaining cell proliferation and minimizing apoptosis in cultured human articular chondrocytes... - Mechanoreceptors and length of the patellar ligament after Ho-YAG laser treatment: a long-term follow-up in rabbitsToshiaki Takahashi
Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, Kochi, Japan, 783 8505
Acta Orthop Scand 73:653-7. 2002..Fewer Pacinian and Ruffini corpuscles were found in the irradiated ligaments than in the intact ones at 2 weeks after treatment, but we found no difference between irradiated and intact ligaments at 18 months after treatment... - Pain in arthroscopic knee surgery under local anesthesiaToshiaki Takahashi
Department of Orthopaedics, Kochi Medical School, Oko cho, Nankoku, Kochi 783 8505, Japan
Acta Orthop Scand 75:580-3. 2004..We evaluated pain during arthroscopic knee surgery performed under local anesthesia, with respect to various types of lesions and specific procedures used... - The role of apoptotic resistance in irradiated adult articular chondrocytesMichio Toda
Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, Kochi 783 8505, Japan
Int J Mol Med 9:349-52. 2002..These results demonstrated that the non-degenerated chondrocytes of X-ray irradiation were highly resistant for apoptosis, and this knowledge could be applied to allogenic chondrocytes implantation... - Mechanism of combined injuries of the posterior cruciate ligament and the posterolateral ligament while wake boardingToshiaki Takahashi
Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, 783 8505 Kochi, Japan
Arch Orthop Trauma Surg 124:639-41. 2004..Subsequently, tearing of the PCL in the midsubstance occurred due to increased flexion of the knee... - A combination of selective COX-2 inhibitors and hydrogen peroxide increase the reactive oxygen species formation in osteosarcoma cells after X-ray irradiationToshiaki Takahashi
Department of Orthopaedics, Kochi Medical School, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
Int J Mol Med 14:405-8. 2004..Therefore, low doses of COX-2 inhibitor and hydrogen peroxide together, in combination with irradiation, is a potentially useful alternative form of radiotherapy for apoptotic-resistant neoplasms such as osteosarcoma... - Lysosomal dysfunction on hydrogen peroxide-induced apoptosis of osteoarthritic chondrocytesToshiaki Takahashi
Department of Orthopaedics, Medical School, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
Int J Mol Med 14:197-200. 2004..Anti-oxidants may have a therapeutic application in the prevention of lysosomal dysfunction to inhibit chondrocyte apoptosis and degradation of the cartilage matrix... - Selective COX-2 inhibitor regulates the MAP kinase signaling pathway in human osteoarthritic chondrocytes after induction of nitric oxideToshiaki Takahashi
Department of Orthopaedic Surgery, Ehime University School of Medicine, Shigenobu cho, Onsen gun, Ehime 791 0295, Japan
Int J Mol Med 15:213-9. 2005..NO-induced OA chondrocytes were associated with the p38 and the p44/42 MAPK signaling pathways, in a pathway that is distinct from PGE2-mediated apoptosis... - Mechanism of hydrogen peroxide-induced apoptosis of the human osteosarcoma cell line HS-Os-1Yasuhiro Ogawa
Department of Radiology, Kochi Medical School, Oko cho, Nankoku Shi, Kochi Prefecture 783 8505, Japan
Int J Mol Med 12:459-63. 2003..We therefore concluded that intracellular ROS formation is involved in the hydrogen peroxide-induced apoptosis of HS-Os-1 cells... - Mechanism of apoptotic resistance of human osteosarcoma cell line, HS-Os-1, against irradiationYasuhiro Ogawa
Department of Radiology, Kochi Medical School, Oko cho, Nankoku Shi, Kochi Prefecture 783 8505, Japan
Int J Mol Med 12:453-8. 2003.... - Apoptotic-resistance of the human osteosarcoma cell line HS-Os-1 to irradiation is converted to apoptotic-susceptibility by hydrogen peroxide: a potent role of hydrogen peroxide as a new radiosensitizerYasuhiro Ogawa
Department of Radiology, Kochi Medical School, Oko cho, Nankoku Shi, Kochi Prefecture 783 8505, Japan
Int J Mol Med 12:845-50. 2003..1 mM) is potentially applicable in clinical radiotherapy for many kinds of apoptotic-resistant neoplasms in terms of achieving both local control and improving survival benefit of patients... - Immunocytochemical characteristics of human osteosarcoma cell line HS-Os-1: possible implication in apoptotic resistance against irradiationYasuhiro Ogawa
Department of Radiology, Medical School, Kochi University, Oko cho, Nankoku Shi, Kochi Prefecture 783 8505, Japan
Int J Mol Med 14:397-403. 2004.... - The role of selective COX-2 inhibitors in reactive oxygen species formation in osteosarcoma cells after X-ray irradiationToshiaki Takahashi
Department of Orthopaedics, Medical School, Kochi University, Oko cho, Nankoku, Kochi 783 8505, Japan
Int J Mol Med 13:661-4. 2004..Thus, radiotherapy with selective COX-2 inhibitions has limitations in the treatment of radioresistant osteosarcoma to obtain the effective achievement, it is indispensable to combine another agent in future studies... - Comparison of radiation-induced reactive oxygen species formation in adult articular chondrocytes and that in human peripheral T cells: possible implication in radiosensitivityYasuhiro Ogawa
Department of Radiology, Kochi Medical School, Oko cho, Nankoku Shi, Kochi Prefecture 783 8505, Japan
Int J Mol Med 11:455-9. 2003.... - Treatment for HTLV-I associated arthropathy: a case study and synovial tissue culture analysisToshiaki Takahashi
Department of Orthopaedics, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
Rheumatol Int 26:74-9. 2005..This is a case study describing the treatment of a patient diagnosed with HAAP. We also analyzed the effects of various agents on cultured synovial tissue explants from the patient... - Localized synovial hypertrophy in the anteromedial compartment of the osteoarthritic kneeMasahiko Ikeuchi
Department of Orthopaedics, Kochi Medical School, Kochi University, Toon, Japan
Arthroscopy 21:1457-61. 2005.... - Simultaneous live video presentation during knee arthroscopyMasanobu Tanaka
Department of Orthopaedic Surgery, Kochi Medical School, Oko-cho, Nankoku, 783-8505, Japan
J Orthop Sci 8:518-21. 2003..Live video-presented outpatient arthroscopic knee surgery could be considered a method for improving patient understanding of knee pathology... - Modification of the functional reach test: analysis of lateral and anterior functional reach in community-dwelling older peopleToshiaki Takahashi
Department of Orthopaedics, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
Arch Gerontol Geriatr 42:167-73. 2006..Lateral FR should be considered as a new, alternative means of assessing geriatric social activity and mental status in the elderly... - Posterior-anterior weight-bearing radiograph in 15 degree knee flexion in medial osteoarthritisNorio Yamanaka
Department of Orthopaedic Surgery, Kochi Medical School, Nankoku, Japan
Skeletal Radiol 32:28-34. 2003.... - Recovery of muscle strength after high tibial osteotomyTateo Kawazoe
Department of Orthopaedic Surgery, Kochi Medical School, Oko-cho, Nankoku 783-8505, Japan
J Orthop Sci 8:160-5. 2003.... - Malignant phyllodes tumor of the breast with expression of osteonectin and vinculinN Kuroda
First Department of Pathology, Kochi Medical School, Kochi, Japan
Pathol Int 51:277-82. 2001..Further studies will be necessary to elucidate the significance of vinculin and osteonectin expression in malignant phyllodes tumor... - Salivary duct carcinoma: cytologic characteristics and application of androgen receptor immunostaining for diagnosisT Moriki
Department of Clinical Laboratory, Kochi Medical School Hospital, Nankoku, Kochi, Japan
Cancer 93:344-50. 2001..The authors investigated the cytologic characteristics and utility of AR immunostaining on cytologic smears for the diagnosis of patients with SDC... - Analysis of the shape of the tibial tray in total knee arthroplasty using a three dimension finite element modelShinya Miyoshi
Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, Kochi 783 8505, Japan
Clin Biomech (Bristol, Avon) 17:521-5. 2002..The purpose of this study was to evaluate whether the stress and displacement change with differing shapes of the tibial component in total knee arthroplasty... - Flexion of the knee increases the distance between the popliteal artery and the proximal tibia: MRI measurements in 15 volunteersJ Shiomi
Department of Orthopaedic Surgery, Kochi Medical School, Nankoku, Japan
Acta Orthop Scand 72:626-8. 2001..More distally, no significant difference was noted with increasing flexion. Flexion of the knee may minimize injury to the popliteal artery in procedures between the level of the joint and 15 mm distal to the joint... - Ultrasonographic evaluation of congenital dislocation of the kneeN Kamata
Department of Orthopedic Surgery, Kochi Medical School, Oko-cho Nankoku, Kochi, Japan 783-8505
Skeletal Radiol 31:539-42. 2002..Further, we were able to serially evaluate the abnormal findings and provide advice regarding daily activity to the parents of the patient with CDK... - Expression profiling with progression of dystrophic change in dysferlin-deficient mice (SJL)Naoki Suzuki
Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Sendai 980 8574, Japan
Neurosci Res 52:47-60. 2005..We must reveal some other molecules which may work with dysferlin in order to clarify the pathological network of dysferlinopathy. This process may lead to future improvements in the therapy for human dysferlinopathy... - The influence of Celecoxib on matrix synthesis by chondrocytes under mechanical stress in vitroSeiji Iimoto
Department of Orthopedic Surgery, Ehime University School of Medicine, Toon City, Ehime, Japan
Int J Mol Med 16:1083-8. 2005..These findings show that excessive mechanical stress decreases synthesis of matrix components in chondrocytes through a NO-regulated pathway, and suggest that Celecoxib has a protective effect on matrix metabolism... - Response to Dr. Cooke's question re. Takahashi T et al. A new computer-assisted method for measuring the tibio-femoral angle in patients w/osteoarthritis of the knee. Osteoarthritis Cartilage 2004:256-9Toshiaki Takahashi
Osteoarthritis Cartilage 13:180. 2005 - Combination therapy with telmisartan and spironolactone alleviates L-NAME exacerbated nephrosclerosis with an increase in PPAR-gamma and decrease in TGF-beta(1)Toshiaki Takahashi
Department of Hypertension and Cardiorenal Disease, Dokkyo Medical University, Tochigi, Japan
Int Heart J 48:637-47. 2007..The anti-inflammatory and antifibrotic effects due to PPAR-gamma activation and TGF-beta(1) inhibition may participate in the renoprotection of this combination therapy... - Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritisToshihiko Ishimitsu
Department of Hypertension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
Hypertens Res 30:621-6. 2007..A further large-scale clinical trial will be needed in order to apply the findings of this study to the treatment of patients with renal disease... - Polyglutamine represses cAMP-responsive-element-mediated transcription without aggregate formationToshiaki Takahashi
Department of Neurology, Resource Branch for Brain Disease Research, Center for Bioresource-Based Research, Brain Research Institute, Niigata University, Japan
Neuroreport 16:295-9. 2005..The results demonstrated that the repression of cAMP-responsive-element-mediated transcription is an early event caused by a soluble form of polyglutamine stretch... - [Mutational and clinical features of Japanese patients with dysferlinopathy (Miyoshi myopathy and limb girdle muscular dystrophy type 2B)]Masashi Aoki
Department of Neurology, Tohoku University School of Medicine
Rinsho Shinkeigaku 45:938-42. 2005..The G3370T mutation may be associated with a milder form of MM and LGMD2B. By contrast, the G3510A mutation appears to be associated with a severe form of MM... - Bone morphogenetic protein-2 and -9 regulate the interaction of insulin-like growth factor-I with growth plate chondrocytesToshiaki Takahashi
Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Ehime, Japan
Int J Mol Med 20:53-7. 2007..Taken together, these data suggest that the BMPs may modulate the action of IGF-I via the type 1 IGF receptor and/or IGF binding proteins... - Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive ratsToshihiko Ishimitsu
Department of Hypetension and Cardiorenal Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan
Am J Hypertens 19:1233-40. 2006..The objective of this study was to evaluate the effect of year-long antihypertensive therapy with a calcium channel blocker and an angiotensin-converting enzyme (ACE) inhibitor on cardiac and renal injury... - A case of dysferlinopathy presenting choreic movementsToshiaki Takahashi
Department of Neurology and Division of Clinical Research, Nishitaga National Hospital, Sendai, Japan
Mov Disord 21:1513-5. 2006..The patient had no evidence of other causes of chorea. It is suggested that the chorea may be associated with the altered expression of the brain isoform of dysferlin... - Late-onset distal myopathy with rimmed vacuoles without mutation in the GNE or dysferlin genesNaoki Suzuki
Department of Neurology, Tohoku University School of Medicine, Seiryo-machi, Sendai 980-8574, Japan
Muscle Nerve 32:812-4. 2005..We speculate that dysferlin is involved in the pathogenesis of the myopathy in these patients, which may represent a new disease entity presenting as a distal myopathy... - Dysferlinopathy associated with rigid spine syndromeToshiko Nagashima
Department of Neurology, Seiwa Memorial Hospital, Sapporo, Japan
Neuropathology 24:341-6. 2004..This study might propose some clues to resolve the combination of musular dystrophies and rigid spine syndrome... - [A patient with distal muscular dystrophy without mutations in dysferlin gene but with abnormal dysferlin localization in muscle fibers]Isao Hozumi
Department of Neurology and Geriatrics, Gifu Graduate School of Medicine
Rinsho Shinkeigaku 44:699-702. 2004..The mechanism of dysferlin expression should be elucidated to obtain a conclusive pathogenetic mechanism underlying this disorder... - Characteristics of the increase in plasma brain natriuretic peptide level in left ventricular systolic dysfunction, associated with muscular dystrophy in comparison with idiopathic dilated cardiomyopathyJun Demachi
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Neuromuscul Disord 14:732-9. 2004..Differences in the left ventricular distension and in the physical activity might explain at least partially the different plasma brain natriuretic peptide levels... - [A patient with limb girdle muscular dystrophy type 2B (LGMD2B) manifesting cardiomyopathy]Satoshi Kuru
Department of Neurology, Suzuka National Hospital
Rinsho Shinkeigaku 44:375-8. 2004..Moreover echocardiogram revealed ventricular enlargement and diffuse hypokinesia suggesting secondary cardiomyopathy atributable to muscular dystrophy. Careful cardiac monitoring should be carried out in dysferlinopathy patients... - Novel dysferlin mutations and characteristic muscle atrophy in late-onset Miyoshi myopathyNaoki Suzuki
Department of Neurology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Sendai 980-8574, Japan
Muscle Nerve 29:721-3. 2004..Even older patients with atrophy in the posterior compartment of the distal lower extremities and a relatively high serum creatine kinase level should be examined for the dysferlin gene... - Aprataxin, the causative protein for EAOH is a nuclear protein with a potential role as a DNA repair proteinYasuteru Sano
Department of Neurology, Brain Research Institute, Niigata University, Niigata, Japan
Ann Neurol 55:241-9. 2004.... - Miyoshi myopathy patients with novel 5' splicing donor site mutations showed different dysferlin immunostaining at the sarcolemmaAkiko Saito
Third Department of Internal Medicine, Faculty of Medicine, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Acta Neuropathol 104:615-20. 2002..These results suggest that a splicing mutation of the dysferlin gene may have the potential to cause decreased dysferlin expression but may not be related to the milder clinical phenotype...