M Yokoyama

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi Effects of eicosapentaenoic acid on cardiovascular events in Japanese patients with hypercholesterolemia: rationale, design, and baseline characteristics of the Japan EPA Lipid Intervention Study (JELIS)
    Mitsuhiro Yokoyama
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Am Heart J 146:613-20. 2003
  2. ncbi Role of the vascular NADH/NADPH oxidase system in atherosclerosis
    M Yokoyama
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Ann N Y Acad Sci 902:241-7; discussion 247-8. 2000
  3. ncbi Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    Mitsuhiro Yokoyama
    Kobe University, Kobe, Japan
    Lancet 369:1090-8. 2007
  4. ncbi Lysophosphatidylcholine increases the secretion of matrix metalloproteinase 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells
    N Inoue
    First Department of Internal Medicine, School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan
    Atherosclerosis 155:45-52. 2001
  5. ncbi Reduced hypoxic pulmonary vascular remodeling by nitric oxide from the endothelium
    M Ozaki
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Hypertension 37:322-7. 2001
  6. ncbi Endothelial NO synthase overexpression inhibits lesion formation in mouse model of vascular remodeling
    S Kawashima
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 21:201-7. 2001
  7. ncbi A calcium channel blocker, benidipine, inhibits intimal thickening in the carotid artery of mice by increasing nitric oxide production
    T Yamashita
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    J Hypertens 19:451-8. 2001
  8. ncbi Role of endogenous nitric oxide generation in the regulation of vascular tone and reactivity in small vessels as investigated in transgenic mice using synchrotron radiation microangiography
    T Yamashita
    Division of Cardiovascular and Respiratory Medicine, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Nitric Oxide 5:494-503. 2001
  9. ncbi TNF-alpha induces protein synthesis through PI3-kinase-Akt/PKB pathway in cardiac myocytes
    E Hiraoka
    First Department of Internal Medicine, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan
    Am J Physiol Heart Circ Physiol 280:H1861-8. 2001
  10. ncbi Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms
    T Hirase
    First Department of Internal Medicine, Kobe University School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:10423-31. 2001

Collaborators

Detail Information

Publications123 found, 100 shown here

  1. ncbi Effects of eicosapentaenoic acid on cardiovascular events in Japanese patients with hypercholesterolemia: rationale, design, and baseline characteristics of the Japan EPA Lipid Intervention Study (JELIS)
    Mitsuhiro Yokoyama
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Am Heart J 146:613-20. 2003
    ....
  2. ncbi Role of the vascular NADH/NADPH oxidase system in atherosclerosis
    M Yokoyama
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Ann N Y Acad Sci 902:241-7; discussion 247-8. 2000
    ..These observations suggest that oxidative stress, mainly via the NADH/NADPH oxidase system in the vasculature, may play an important role in the pathogenesis of atherosclerosis...
  3. ncbi Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis
    Mitsuhiro Yokoyama
    Kobe University, Kobe, Japan
    Lancet 369:1090-8. 2007
    ..We aimed to test the hypothesis that long-term use of eicosapentaenoic acid (EPA) is effective for prevention of major coronary events in hypercholesterolaemic patients in Japan who consume a large amount of fish...
  4. ncbi Lysophosphatidylcholine increases the secretion of matrix metalloproteinase 2 through the activation of NADH/NADPH oxidase in cultured aortic endothelial cells
    N Inoue
    First Department of Internal Medicine, School of Medicine, Kobe University, 7-5-2 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan
    Atherosclerosis 155:45-52. 2001
    ..Our findings suggest that LPC might activate the endothelial NADH/NADPH oxidase to enhance superoxide production, and it might, in turn, enhance MMP-2 induction...
  5. ncbi Reduced hypoxic pulmonary vascular remodeling by nitric oxide from the endothelium
    M Ozaki
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Hypertension 37:322-7. 2001
    ....
  6. ncbi Endothelial NO synthase overexpression inhibits lesion formation in mouse model of vascular remodeling
    S Kawashima
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 21:201-7. 2001
    ..Our data provide the evidence for the regulatory role of NO from the endothelium on vascular structure integrity...
  7. ncbi A calcium channel blocker, benidipine, inhibits intimal thickening in the carotid artery of mice by increasing nitric oxide production
    T Yamashita
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    J Hypertens 19:451-8. 2001
    ..These results show the possibility of benidipine as a protective tool against vascular remodeling independent of its effect on blood pressure...
  8. ncbi Role of endogenous nitric oxide generation in the regulation of vascular tone and reactivity in small vessels as investigated in transgenic mice using synchrotron radiation microangiography
    T Yamashita
    Division of Cardiovascular and Respiratory Medicine, Department of Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Nitric Oxide 5:494-503. 2001
    ..SR microangiography allows us to evaluate the reactivity in small-sized vessels and appears to be a powerful tool for assessing the microvascular circulation in vivo...
  9. ncbi TNF-alpha induces protein synthesis through PI3-kinase-Akt/PKB pathway in cardiac myocytes
    E Hiraoka
    First Department of Internal Medicine, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan
    Am J Physiol Heart Circ Physiol 280:H1861-8. 2001
    ..These results indicate that activation of the PI3-kinase-Akt/PKB pathway plays an essential role in protein synthesis induced by TNF-alpha in cardiac myocytes...
  10. ncbi Regulation of tight junction permeability and occludin phosphorylation by Rhoa-p160ROCK-dependent and -independent mechanisms
    T Hirase
    First Department of Internal Medicine, Kobe University School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 276:10423-31. 2001
    ..Thus, occludin is a target for receptor-initiated signaling events regulating its phosphorylation, and this phosphorylation may be a key regulator of tight junction permeability...
  11. ncbi Anti-oxidative properties of fluvastatin, an HMG-CoA reductase inhibitor, contribute to prevention of atherosclerosis in cholesterol-fed rabbits
    Y Rikitake
    The First Department of Internal Medicine, Kobe University School of Medicine, Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan
    Atherosclerosis 154:87-96. 2001
    ..In conclusion, the potent anti-oxidative properties of fluvastatin in addition to its cholesterol-lowering activity appear to contribute to its anti-atherosclerotic effect in vivo...
  12. ncbi Signaling mechanism underlying COX-2 induction by lysophosphatidylcholine
    Y Rikitake
    First Department of Internal Medicine, Kobe University School of Medicine, 7 5 1, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Biochem Biophys Res Commun 281:1291-7. 2001
    ..These results suggest that both p38 and ERK may function as upstream signaling pathways capable of activating CREB and ATF-1 with subsequent induction of cyclooxygenase-2 expression by lysophosphatidylcholine...
  13. ncbi Effect of posture on bronchial reactivity to inhaled methacholine in patients with mitral valve stenosis
    Y Nishimura
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Chest 106:1391-5. 1994
    ..We conclude that the bronchial hyperreactivity in MS is enhanced after the supine position for 2 h and that the supine posture may play an important role in the pathogenesis of cardiac asthma...
  14. ncbi Expression of glutaredoxin in human coronary arteries: its potential role in antioxidant protection against atherosclerosis
    M Okuda
    Division of Cardiovascular and Respiratory Medicine, Departments of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 21:1483-7. 2001
    ..These results suggest the possible involvement of thiol-disulfide oxidoreductases in antioxidant protection in human coronary arteries...
  15. ncbi Dysfunction of endothelial nitric oxide synthase and atherosclerosis
    Seinosuke Kawashima
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho Chuo ku Kobe, 650 0017, Japan
    Arterioscler Thromb Vasc Biol 24:998-1005. 2004
    ..An improved understanding of tissue BH4 metabolisms in atherosclerotic vessels is needed, which would help in developing new strategies for the inhibition and treatment of atherosclerosis...
  16. ncbi An anti-proliferative gene BTG1 regulates angiogenesis in vitro
    Kenji Iwai
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 316:628-35. 2004
    ..BTG1-overexpressing endothelial cells displayed increased cell migration. These findings suggest that BTG1 may play an important role in the process of angiogenesis...
  17. ncbi Beta2-adrenergic receptor polymorphisms affect airway responsiveness to salbutamol in asthmatics
    Y Kotani
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    J Asthma 36:583-90. 1999
    ..These results suggest that beta2AR polymorphisms play an important role in the airway responsiveness to inhaled beta2-agonist and the initial asthma onset...
  18. ncbi [Nitric oxide spares myocardial oxygen consumption through attenuation of contractile response to beta-adrenergic stimulation in patients with idiopathic dilated cardiomyopathy]
    T Shinke
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe
    J Cardiol 37:119-20. 2001
    ....
  19. ncbi Propagermanium reduces atherosclerosis in apolipoprotein E knockout mice via inhibition of macrophage infiltration
    Tomoya Yamashita
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:969-74. 2002
    ..Inhibition of macrophage infiltration by propagermanium prevented the formation of atherosclerotic lesions in apoE-KO mice. This drug may serve as a therapeutic tool for the treatment of atherosclerosis...
  20. ncbi Frequency and clinical characteristics of dilated cardiomyopathy caused by desmin gene mutation in a Japanese population
    Y Miyamoto
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Eur Heart J 22:2284-9. 2001
    ..The ages at diagnosis were younger and the cardiac function had deteriorated further than general cases of sporadic dilated cardiomyopathy...
  21. ncbi Effects of eicosapentaenoic acid on blood pressure, cell membrane fatty acids, and intracellular sodium concentration in essential hypertension
    T Miyajima
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Hypertens Res 24:537-42. 2001
    ..Based on the association between the increase in membrane EPA content and the decrease in intracellular sodium concentration, EPA may lower blood pressure by altering the activities of the membrane sodium transport systems...
  22. ncbi Unsaturated free fatty acids inhibit Ca2+ mobilization and NO release in endothelial cells
    R Kuroda
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine 7-5-1 Kobe, 650-0017, Japan
    Kobe J Med Sci 47:211-9. 2001
    ..From these results, elevated UFFA may contribute to impaired NO production through inhibition of receptor-mediated Ca2+ mobilization and Ca2+ influx in pathological conditions such as multiple risk factor syndrome and insulin resistance...
  23. ncbi A 3-hydroxy-3-methylglutaryl co-enzyme A reductase inhibitor reduces hypertensive nephrosclerosis in stroke-prone spontaneously hypertensive rats
    Tomoya Yamashita
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    J Hypertens 20:2465-73. 2002
    ..These results show the potential of statins as protective tools against proteinuric renal diseases, independent of their cholesterol-decreasing effects...
  24. ncbi Overexpression of endothelial nitric oxide synthase accelerates atherosclerotic lesion formation in apoE-deficient mice
    Masanori Ozaki
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 110:331-40. 2002
    ....
  25. ncbi Elevated pulmonary arterial pressure in pulmonary lymphangiomyomatosis
    Y Kawahara
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Jpn J Med 28:520-2. 1989
    ..She was found to have moderate pulmonary hypertension. Possible mechanisms for the development of pulmonary hypertension are discussed...
  26. ncbi Involvement of NADH/NADPH oxidase in human platelet ROS production
    T Seno
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Thromb Res 103:399-409. 2001
    ..Thus, human platelets have the enzymatic activity of p22(phox)-based NADH/NADPH oxidase, and this oxidase is likely one of the important sources of ROS in platelets...
  27. ncbi Elevated parasympathetic nerve tone in isoproterenol-induced neurally mediated syncope during head-up tilt testing
    A Takei
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Jpn Circ J 65:320-4. 2001
    ..The early and persistent increase in parasympathetic nerve tone provoked by isoproterenol plays an important role in enhancing the vasovagal reaction during head-up tilt testing...
  28. ncbi Expression of Fos-like immunoreactivity by yohimbine and clonidine in the rat brain
    T Tsujino
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Eur J Pharmacol 226:69-78. 1992
    ..Thus, the alpha 2-adrenoceptor is involved in transcriptional control via Fos expression in neurons related to autonomic and other functions...
  29. ncbi Transplantation of cardiotrophin-1-expressing myoblasts to the left ventricular wall alleviates the transition from compensatory hypertrophy to congestive heart failure in Dahl salt-sensitive hypertensive rats
    Ryuji Toh
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Am Coll Cardiol 43:2337-47. 2004
    ..CONCLUSIONS: Transplantation of skeletal myoblasts combined with CT-1-gene transfer could be a useful therapeutic strategy for HF...
  30. ncbi Angiotensin II type 1 receptor blocker telmisartan suppresses superoxide production and reduces atherosclerotic lesion formation in apolipoprotein E-deficient mice
    Tomofumi Takaya
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Atherosclerosis 186:402-10. 2006
    ..Telmisartan reduced atherosclerosis in apolipoprotein E-deficient mice at least partly via the suppression of oxidative stress...
  31. ncbi A specific role for eNOS-derived reactive oxygen species in atherosclerosis progression
    Tomofumi Takaya
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 27:1632-7. 2007
    ..In this study, we addressed the specific importance of uncoupled eNOS in atherosclerosis, and the potential mechanistic role for specific versus nonspecific antioxidant strategies in restoring eNOS coupling...
  32. ncbi Endothelial lipase is increased by inflammation and promotes LDL uptake in macrophages
    Tomoyuki Yasuda
    Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Japan
    J Atheroscler Thromb 14:192-201. 2007
    ..EL is known to act as a bridging molecule for monocytes or lipoproteins in vascular endothelial cells. We investigated the role and regulatory mechanisms of EL expression in macrophages...
  33. ncbi The great Hanshin-Awaji earthquake aggravates blood pressure control in treated hypertensive patients
    K Saito
    First Department of Internal Medicine, Kobe University, School of Medicine, Japan
    Am J Hypertens 10:217-21. 1997
    ....
  34. ncbi Relationship between bronchial hyperreactivity and symptoms of cardiac asthma in patients with non-valvular left ventricular failure
    Y Nishimura
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Jpn Circ J 60:933-9. 1996
    ..710, p < 0.01). We conclude that bronchial hyperreactivity is responsible for cardiac asthma and that it might be related to pulmonary interstitial changes in stable patients with non-valvular LVF...
  35. ncbi Usefulness of beat-to-beat QT dispersion fluctuation for identifying patients with coronary heart disease at risk for ventricular arrhythmias
    E J Figueredo
    Division of Cardiovascular and Respiratory Medicine, Kobe University, Graduate School of Medicine, Kobe, Japan
    Am J Cardiol 88:1235-9. 2001
    ..Thus, QTd has a dynamic behavior with significant beat-to-beat fluctuations even in normal subjects and is more marked in patients with coronary heart disease at risk for ventricular arrhythmias...
  36. ncbi Alpha 2-adrenoceptors and platelet function in patients with variant angina
    A Kusui
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Thromb Res 56:453-63. 1989
    ..These results suggest that increased capacity of platelet alpha-adrenoceptor may explain enhanced reactivity to epinephrine in patients with variant angina...
  37. ncbi Bronchial hyperresponsiveness and exhaled nitric oxide in patients with cardiac disease
    Y Nishimura
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Respiration 68:41-5. 2001
    ..In various cardiac diseases, bronchial hyperresponsiveness is observed, as is bronchial asthma. However, there have been few studies on the relationship between exhaled NO and bronchial responsiveness in cardiac diseases...
  38. ncbi Persistent malapposition after implantation of sirolimus-eluting stent into intramural coronary hematoma: optical coherence tomography observations
    Takahiro Sawada
    Department of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
    Circ J 70:1515-9. 2006
    ..OCT is useful in showing the precise condition of the stent struts...
  39. ncbi Expression of G2A, a receptor for lysophosphatidylcholine, by macrophages in murine, rabbit, and human atherosclerotic plaques
    Yoshiyuki Rikitake
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:2049-53. 2002
    ..Although it has been demonstrated that G2A is expressed predominantly in lymphoid tissues and lymphocytes, there are no reports to determine whether G2A is expressed in atherosclerotic lesions and cardiovascular cells...
  40. ncbi Local overexpression of monocyte chemoattractant protein-1 at vessel wall induces infiltration of macrophages and formation of atherosclerotic lesion: synergism with hypercholesterolemia
    Masayuki Namiki
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:115-20. 2002
    ..To initiate atherosclerotic changes, local MCP-1 overexpression at the vessel is not sufficient, and activation of other factors induced by hypercholesterolemia is required...
  41. ncbi Alterations of circadian expressions of clock genes in Dahl salt-sensitive rats fed a high-salt diet
    Takao Mohri
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki, Chuo, Kobe, 650-0017, Japan
    Hypertension 42:189-94. 2003
    ..Detailed analyses of the relation between circadian expression of clock genes and blood pressure regulation might reveal a role for chronologic therapy of cardiovascular disease...
  42. ncbi Regulation of tyrosine phosphorylation of PYK2 in vascular endothelial cells by lysophosphatidylcholine
    Y Rikitake
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe 650 0017, Japan
    Am J Physiol Heart Circ Physiol 281:H266-74. 2001
    ....
  43. ncbi Clinical significance of junctional pacemaker automaticity in patients with sick sinus syndrome
    H Ogawa
    First Department of Internal Medicine, Kobe University, School of Medicine, Japan
    Jpn Circ J 55:1165-73. 1991
    ..Organic impairment should affect conductivity as well as automaticity in the AV junction...
  44. ncbi Analysis of 7-ketocholesterol in low density lipoprotein and fatty acid composition in erythrocyte membranes of patients on maintenance hemodialysis and healthy controls
    D Tsuzuki
    Department of Public Health, Kobe University, School of Medicine, 7 5 1 Kusunoki cho Chuo ku Kobe, Hyogo, Japan
    Clin Chim Acta 295:155-68. 2000
    ..We believe that the method to quantify 7-KC in this study is concise and reliable and may be used to investigate various diseases...
  45. ncbi Effects of alcohol moderation on blood pressure and intracellular cations in mild essential hypertension
    S T Hsieh
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Am J Hypertens 8:696-703. 1995
    ..abstract truncated at 250 words)..
  46. ncbi Ambulatory blood pressure and heart rate during once-daily, randomized, crossover administration of carteolol and atenolol
    K Saito
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Clin Ther 16:181-90. 1994
    ..001, respectively). These results suggest that the different effects of the two beta-blockers on heart rate and nighttime blood pressure may be attributed to the presence or absence of intrinsic sympathomimetic activity...
  47. ncbi Plasma brain natriuretic peptide as a novel therapeutic indicator in idiopathic dilated cardiomyopathy during beta-blocker therapy: a potential of hormone-guided treatment
    K Kawai
    First Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Am Heart J 141:925-32. 2001
    ..5 and 69 pg/mL, respectively. CONCLUSION: Plasma BNP levels may accurately reflect alteration in LV function and structure and can be used as a therapeutic indicator for risk stratification in patients with IDC during BB therapy...
  48. ncbi High glucose accelerates MCP-1 production via p38 MAPK in vascular endothelial cells
    Hiroshi Takaishi
    Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Biochem Biophys Res Commun 305:122-8. 2003
    ..These results indicate that hyperglycemia can accelerate MCP-1 production through the mechanism involving p38 MAPK, ROS-sensitive signaling pathway, in vascular endothelial cells...
  49. ncbi HMG-CoA reductase inhibitor has protective effects against stroke events in stroke-prone spontaneously hypertensive rats
    Seinosuke Kawashima
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Stroke 34:157-63. 2003
    ..The purpose of this study is to clarify the effect of a statin on stroke in stroke-prone spontaneously hypertensive rats (SHR-SP), in which both cerebral hemorrhage and infarction occur...
  50. ncbi An X-Ray diffraction study on mouse cardiac cross-bridge function in vivo: effects of adrenergic {beta}-stimulation
    Ryuji Toh
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
    Biophys J 90:1723-8. 2006
    ....
  51. ncbi Intramuscular gene transfer of interleukin-10 cDNA reduces atherosclerosis in apolipoprotein E-knockout mice
    Masayuki Namiki
    Department of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, 650-0017, Kobe, Japan
    Atherosclerosis 172:21-9. 2004
    ..Therefore, IL-10 gene transfer changed the Th1 response and suppressed atherosclerotic lesion formation in apoE-KO mice. IL-10 could be a new target as a therapeutic tool for the treatment of atherosclerosis...
  52. ncbi Neointimal coverage of sirolimus-eluting stents at 6-month follow-up: evaluated by optical coherence tomography
    Daisuke Matsumoto
    Department of Internal Medicine, Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Hyogo 650 0017, Japan
    Eur Heart J 28:961-7. 2007
    ..However, optical coherence tomography (OCT) with excellent resolution may be able to detect thinner neointima...
  53. ncbi Sirolimus-eluting stent fracture with thrombus, visualization by optical coherence tomography
    Junya Shite
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Hyogo, Japan
    Eur Heart J 27:1389. 2006
  54. ncbi Dual ECE/NEP inhibition on cardiac and neurohumoral function during the transition from hypertrophy to heart failure in rats
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1, Kusunoki, Chuo, Kobe, 650 0017, Japan
    Hypertension 45:1145-52. 2005
    ..The beneficial effects of CGS 26303 are likely caused in part by the greater reduction of plasma ET-1. Dual ECE/NEP inhibitor may provide a new strategy for the treatment of human heart failure...
  55. ncbi Impact of increasing diabetes on coronary artery disease in the past decade
    Hiroshi Takaishi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan
    J Atheroscler Thromb 11:271-7. 2004
    ..38). In conclusion, the prevalence rate of DM among CAD patients significantly increased in this decade, and the consequent increase in the prevalence of MVD should be recognized as the most important problem clinically...
  56. ncbi Xenogenic macrophage immunization reduces atherosclerosis in apolipoprotein E knockout mice
    Tomoya Yamashita
    Division of Cardiovascular Medicine, Dept of Internal Medicine, Kobe Univ Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Am J Physiol Cell Physiol 293:C865-73. 2007
    ..This method is a novel and potentially useful cell-mediated immune therapeutic technique against atherosclerosis...
  57. ncbi Effect of continuous positive airway pressure on soluble CD40 ligand in patients with obstructive sleep apnea syndrome
    Kazuyuki Kobayashi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Chest 129:632-7. 2006
    ..The present study examines whether CD40 ligation contributes to outcomes in patients with OSAS...
  58. ncbi Oxidant stress and atherosclerosis
    Mitsuhiro Yokoyama
    Cardiovascular Division, Department of Medicine, Kobe University Graduate School of Medicine, 5 1 7 Chome, Kusunoki cho, Chuo Ku, Kobe, 650 0017, Japan
    Curr Opin Pharmacol 4:110-5. 2004
    ....
  59. ncbi Vitamin C restores the contractile response to dobutamine and improves myocardial efficiency in patients with heart failure after anterior myocardial infarction
    Toshiro Shinke
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Am Heart J 154:645.e1-8. 2007
    ..We hypothesized that the antioxidant vitamin C may help reverse hyporesponsiveness to beta-adrenergic stimulation and improve myocardial efficiency in patients with heart failure (HF) after myocardial infarction (MI)...
  60. ncbi Endocardial substrate mapping for monomorphic ventricular tachycardia ablation in ischemic and non-ischemic cardiomyopathy
    Koji Fukuzawa
    Department of Internal Medicine, Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 54:E122-35. 2008
    ..VT recurrence rate subsequent to endocardial ablation was higher in NICM than in ICM patients...
  61. ncbi Decreased mAKAP, ryanodine receptor, and SERCA2a gene expression in mdx hearts
    Mohammad Saifur Rohman
    Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 6500017, Japan
    Biochem Biophys Res Commun 310:228-35. 2003
    ..Therefore, dystrophin deficiency may cause an impairment of SR Ca(2+) homeostasis and E-C coupling in mdx hearts, in part, by decreased gene expression of molecules involved in SR Ca(2+) handling...
  62. ncbi Heterogeneous loss of connexin43 protein in nonischemic dilated cardiomyopathy with ventricular tachycardia
    Hidetsuna Kitamura
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    J Cardiovasc Electrophysiol 13:865-70. 2002
    ..03). Furthermore, Cx43 protein was distributed heterogeneously in the VT groups (P < 0.0001). CONCLUSION: Heterogeneous reduction of Cx43 protein may result in development of malignant ventricular arrhythmia in DCM...
  63. ncbi Clinical significance of T-wave alternans in hypertrophic cardiomyopathy
    Nami Kuroda
    Department of Internal Medicine, Kobe University Graduate School of Medicine, Chuoku, Japan
    Circ J 66:457-62. 2002
    ..9+/-1.1 vs 0.7+/-0.5; p<0.05). TWA in HCM correlates with histopathological changes, especially disarray and ventricular tachyarrhythmia, and measuring it may be a noninvasive means of detecting high-risk patients with HCM...
  64. ncbi Involvement of endothelial nitric oxide in sphingosine-1-phosphate-induced angiogenesis
    Yoshiyuki Rikitake
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:108-14. 2002
    ..Thus, our results demonstrate the crucial role of NO in S1P-induced angiogenesis in vivo and in vitro and suggest the divergent roles of NO in the S1P-induced angiogenic response...
  65. ncbi Papillary fibroelastoma of the left atrial appendage: echocardiographic findings
    T Tsukube
    Department of Surgery, Kobe University, School of Medicine, Japan
    Ann Thorac Surg 70:1416-7. 2000
    ..The roles of transesophageal echocardiography and surgical intervention are discussed...
  66. ncbi Taurine prevents the decrease in expression and secretion of extracellular superoxide dismutase induced by homocysteine: amelioration of homocysteine-induced endoplasmic reticulum stress by taurine
    H Nonaka
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circulation 104:1165-70. 2001
    ..Taurine restores the secretion and expression of EC-SOD by ameliorating ER stress induced by homocysteine...
  67. ncbi Alternative splicing regulates the endoplasmic reticulum localization or secretion of soluble secreted endopeptidase
    S B Raharjo
    Division of Molecular Medicine, International Center for Medical Research, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki, Chuo, Kobe 6500017, Japan
    J Biol Chem 276:25612-20. 2001
    ..Our results suggest that the unique subcellular localization and secretion of SEP proteins provide a novel model of protein trafficking within the secretory pathway...
  68. ncbi Monophasic action potentials of the right atrium in patients with paroxysmal atrial fibrillation
    J Sekiya
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Jpn Circ J 65:893-6. 2001
    ..3, p<0.05; 3.2+/-0.4 vs 3.7+/-0.3, p<0.02). A shortened and widened dispersion of atrial refractoriness may play an important role in the genesis of AF. Furthermore, smaller wavelengths may form in the atrium of patients with PAF...
  69. ncbi QT and JT dispersion in patients with monomorphic or polymorphic ventricular tachycardia/ventricular fibrillation
    H Shimizu
    Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    J Electrocardiol 34:119-25. 2001
    ..005 vs. the MVT group). Patients with PMVT/VF have a greater dispersion of ventricular repolarization time. Repolarization abnormalities are important for ventricular arrhythmogenesis and detectable on the surface ECG...
  70. ncbi Angiotensin II induces circadian gene expression of clock genes in cultured vascular smooth muscle cells
    H Nonaka
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circulation 104:1746-8. 2001
    ..Our in vitro system will provide a useful tool to further analyze the physiological significance of the peripheral clock in cardiovascular function...
  71. ncbi Superoxide generation in directional coronary atherectomy specimens of patients with angina pectoris: important role of NAD(P)H oxidase
    Hiroshi Azumi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Arterioscler Thromb Vasc Biol 22:1838-44. 2002
    ..CONCLUSIONS: ROS generated by p22(phox)-based NADH/NADPH oxidase likely mediate the oxidative modification of LDL and might play a major role in pathogenesis of atherosclerotic coronary artery disease...
  72. ncbi [Inhibitory effect of nitric oxide on oxidation of low-density lipoprotein]
    Yoshio Fujioka
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    Nippon Rinsho 62:493-5. 2004
  73. ncbi Increased expression of endothelial lipase in rat models of hypertension
    Yasushi Shimokawa
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Chuo Ku, Japan
    Cardiovasc Res 66:594-600. 2005
    ..To gain a better understanding of the involvement of endothelial lipase (EL) in vascular disease, we examined whether the EL expression is regulated in animal models of hypertension...
  74. ncbi Obesity-induced upregulation of myocardial endothelin-1 expression is mediated by leptin
    Suko Adiarto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Biochem Biophys Res Commun 353:623-7. 2007
    ..In contrast, in leptin-deficient obese (ob/ob) mice, both serum and myocardial ET-1 levels were not higher than in wild type mice. These findings suggest that upregulation of myocardial ET-1 by obesity is mediated by leptin...
  75. ncbi Molecular isolation and characterization of novel four subisoforms of ECE-2
    Shoko Ikeda
    Division of Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki, Chuo, Kobe 6500017, Japan
    Biochem Biophys Res Commun 293:421-6. 2002
    ..Detailed analysis of ECE-2 subisoforms will provide crucial information to clarify the physiological function of ECE-2...
  76. ncbi Possible role of brain-derived neurotrophic factor in the pathogenesis of coronary artery disease
    Junya Ejiri
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Circulation 112:2114-20. 2005
    ..NTs and their receptors are expressed in atherosclerotic lesions; however, their significance in cardiovascular disease remains unclear...
  77. ncbi Clinical characteristics of induced nonclinical ventricular tachycardia in nonischemic cardiomyopathy
    Katsunori Okajima
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, Hyogo, Japan
    Jpn Heart J 43:643-54. 2002
    ..In conclusion, induced NCVT and CVT are refractory to pharmacological therapy and both have an important characteristic value in DCM...
  78. ncbi Oxidative stress in the pathogenesis of thoracic aortic aneurysm: protective role of statin and angiotensin II type 1 receptor blocker
    Junya Ejiri
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Cardiovasc Res 59:988-96. 2003
    ..Statin and ARB might have inhibitory effects on the formation of aneurysms via the suppression of NADH/NADPH oxidase...
  79. ncbi Images in cardiovascular medicine. Mouse coronary angiograph using synchrotron radiation microangiography
    Tomoya Yamashita
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circulation 105:E3-4. 2002
  80. ncbi Endothelial urocortin has potent antioxidative properties and is upregulated by inflammatory cytokines and pitavastatin
    Tomoyuki Honjo
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Vasc Res 43:131-8. 2006
    ..Urocortin exerts potent cardioprotective effects under various pathological conditions including ischemia/reperfusion. However, the regulation and function of vascular urocortin are unknown...
  81. ncbi Overexpression of endothelial nitric oxide synthase in endothelial cells is protective against ischemia-reperfusion injury in mouse skeletal muscle
    Masanori Ozaki
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School ofMedicine, Kobe, Japan
    Am J Pathol 160:1335-44. 2002
    ..NOS inhibition completely reversed these protective effects of eNOS overexpression in I/R injury. Thus, eNOS overexpression appears to prevent the I/R injury in skeletal muscle by maintaining vascular integrity...
  82. ncbi Interaction of oxidative stress and inflammatory response in coronary plaque instability: important role of C-reactive protein
    Seiichi Kobayashi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Japan
    Arterioscler Thromb Vasc Biol 23:1398-404. 2003
    ....
  83. ncbi Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels
    Masakatsu Shimizu
    Division of General Medical Science, Department of General Therapeutics, Kobe University Graduate School of Medicine, 7 5 2 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Circ J 71:842-6. 2007
    ..The EL gene has a common 584C/T polymorphism, but it is unclear whether this polymorphism is associated with HDL-C levels or acute myocardial infarction (AMI)...
  84. ncbi Bezafibrate improves hypertension and insulin sensitivity in humans
    Jong Il Kim
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Hyogo, Kobe, Japan
    Hypertens Res 26:307-13. 2003
    ..Abnormalities in membrane lipid composition may play an important role in these metabolic disorders...
  85. ncbi Endothelial lipase modulates monocyte adhesion to the vessel wall. A potential role in inflammation
    Yoko Kojma
    Division of Cardiovascular and Respiratory Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Biol Chem 279:54032-8. 2004
    ..Thus, the up-regulation of EL by inflammatory stimuli may be involved in the progression of inflammation...
  86. ncbi Comparative effects of monatepil, a novel calcium antagonist with alpha 1-adrenergic-blocking activity, and nitrendipine on lipoprotein and carbohydrate metabolism in patients with hypertension
    J Sasaki
    Department of Internal Medicine, Fukuoka University Medical School, Japan
    Am J Hypertens 7:161S-166S. 1994
    ....
  87. ncbi Calcium supplementation inhibits the expression of parathyroid hypertensive factor in DOCA-salt hypertensive rats
    C M Lin
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    Am J Hypertens 7:201-4. 1994
    ....
  88. ncbi Effect of L-arginine administration on myocardial thallium-201 perfusion during exercise in patients with angina pectoris and normal coronary angiograms
    H Fujita
    First Department of Internal Medicine, Kobe University School of Medicine, Japan
    J Nucl Cardiol 7:97-102. 2000
    ..We tested the hypothesis that an exogenous supplement of L-arginine could alleviate coronary perfusion abnormality during exercise in patients with angina pectoris and normal coronary arteries...
  89. ncbi Leptin stimulates rat aortic smooth muscle cell proliferation and migration
    A Oda
    First Division, Department of Internal Medicine, Kobe University School of Medicine
    Kobe J Med Sci 47:141-50. 2001
    ..These results demonstrate that leptin is a proliferative and migratory factor for VSMC, implying that leptin may play a role in the formation and development of vascular lesions...
  90. ncbi Relationship between regional and global left ventricular systolic and diastolic function in patients with coronary artery disease assessed by strain rate imaging
    Hidekazu Tanaka
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Circ J 71:517-23. 2007
    ..The present study aimed to assess whether regional myocardial contraction and relaxation reflect global left ventricular systolic and early diastolic function, respectively...
  91. ncbi Serum beta2-microglobulin concentration as a novel marker to distinguish levels of risk in acute heart failure patients
    Keisuke Kawai
    Department of Internal Medicine, Kasai City Hospital, 1 13, Yoko o, Hojo cho, Kasai, Hyogo 675 2311, Japan
    J Cardiol 55:99-107. 2010
    ..However, the prognostic role of beta2-microglobulin in heart failure has not been elucidated...
  92. ncbi The effect of overexpression of endothelial nitric oxide synthase on eosinophilic lung inflammation in a murine model
    Kazuyuki Kobayashi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Int Immunopharmacol 6:1040-52. 2006
    ....
  93. ncbi [Genetically altered rodent models in the endothelin-related genes]
    Noriaki Emoto
    Division of Cardiovascular and Respiratory Medicine, Department of Inter nal Medicine, Kobe University Graduate School of Medicine
    Nippon Rinsho 64:311-5. 2006
  94. ncbi Trichostatin A, an inhibitor of histone deacetylase, inhibits smooth muscle cell proliferation via induction of p21(WAF1)
    Hiroshi Okamoto
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Atheroscler Thromb 13:183-91. 2006
    ..In conclusion, TSA inhibits VSMC proliferation via the induction of p21(WAF1) expression and subsequent cell-cycle arrest with reduction of the phosphorylation of Rb protein at the G1-S phase...
  95. ncbi Atherosclerotic plaque imaging using phase-contrast X-ray computed tomography
    Masakazu Shinohara
    Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Am J Physiol Heart Circ Physiol 294:H1094-100. 2008
    ..It can be a promising noninvasive technique for the investigation of plaque components and detection of unstable coronary plaques...
  96. ncbi [Relationship between high sensitive C-reactive protein and coronary plaque component in patients with acute coronary syndrome: Virtual Histology study]
    Takahiro Sawada
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine
    J Cardiol 48:141-50. 2006
    ..CONCLUSIONS: IVUS spectral analysis revealed that elevated plasma high sensitve CRP level was correlated with necrotic core volume in patients with ACS, both in culprit and non-culprit lesions, suggesting enhanced vascular inflammation...
  97. ncbi Toll-like receptor 4 expressions on peripheral blood monocytes were enhanced in coronary artery disease even in patients with low C-reactive protein
    Rio Shiraki
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-2, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Life Sci 80:59-66. 2006
    ..The combined measurement of serum hsCRP and the TLR4 expression on peripheral blood monocytes, especially among low-hsCRP subjects, may become a new coronary risk marker...
  98. ncbi Pathophysiological characteristics and responsiveness to neurohormonal antagonism in idiopathic dilated cardiomyopathy patients with antihepatitis C virus antibody
    Keisuke Kawai
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int Heart J 46:407-17. 2005
    ..Nevertheless, the advanced ventricular remodeling with HCV was adequately reversed by neurohormonal antagonism, and did not lead to an unfavorable outcome...
  99. ncbi Sphingosine 1-phosphate induces alpha-smooth muscle actin expression in lung fibroblasts via Rho-kinase
    Yoshiko Urata
    Division of Cardiovascular and Respiratory Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Kobe J Med Sci 51:17-27. 2005
    ..These processes were inhibited by Y-27632, but not by pertussis toxin. These results suggest that S1P induces a phenotypic change of lung fibroblasts via Rho-kinase that may lead to airway remodeling...
  100. ncbi Decreased ornithine decarboxylase activity in the kidneys of Dahl salt-sensitive rats
    Takeshi Hayashi
    Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Hypertens Res 25:787-95. 2002
    ..ODC protein was suggested to increase in compensation for the inhibition of its activity. Impaired ODC activity and polyamine production in the kidney may exaggerate salt-sensitive hypertension in SS rats...
  101. ncbi Decreased expression of arginase II in the kidneys of Dahl salt-sensitive rats
    Sachiyo Iwata
    Department of Internal Medicine, Kobe University Graduate School of Medical Science, Japan
    Hypertens Res 25:411-8. 2002
    ..These findings suggest that decreased arginase expression in the kidney may be at least partially responsible for the salt-sensitive hypertension in SS rats...