Research Topics
Genomes and Genes
| Ushio KikkawaSummaryAffiliation: Kobe University Country: Japan Publications
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Detail Information
Publications
Protein kinase C delta (PKC delta): activation mechanisms and functionsUshio Kikkawa
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
J Biochem 132:831-9. 2002..This article briefly summarizes the regulatory mechanisms of PKC delta activity and its functions in cell signaling...- AMP-activated protein kinase phosphorylates glutamine : fructose-6-phosphate amidotransferase 1 at Ser243 to modulate its enzymatic activitySatoshi Eguchi
Biosignal Research Center, Kobe University, Japan
Genes Cells 14:179-89. 2009..These results indicate that the phosphorylation of GFAT1 at Ser243 by AMPK has an important role in the regulation of the GFAT1 enzymatic activity... - The proline-rich Akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1Noriko Oshiro
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
J Biol Chem 282:20329-39. 2007..Moreover, they indicate that the ability of raptor to bind endogenous substrates is limiting for the activity of mTORC1 in vivo and is therefore a potential locus of regulation... - Identification of TBC7 having TBC domain as a novel binding protein to TSC1-TSC2 complexAkio Nakashima
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Biochem Biophys Res Commun 361:218-23. 2007..These results indicate TBC7 could take a part in the negative regulation of the tumor suppressor complex through facilitating the downregulation of TSC1... - AMP-activated protein kinase phosphorylates Golgi-specific brefeldin A resistance factor 1 at Thr1337 to induce disassembly of Golgi apparatusTakafumi Miyamoto
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
J Biol Chem 283:4430-8. 2008.... - Different roles for the TOS and RAIP motifs of the translational regulator protein 4E-BP1 in the association with raptor and phosphorylation by mTOR in the regulation of cell sizeSatoshi Eguchi
Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
Genes Cells 11:757-66. 2006.... - Epidermal growth factor receptor phosphorylates protein kinase C {delta} at Tyr332 to form a trimeric complex with p66Shc in the H2O2-stimulated cellsMasakatsu Morita
Biosignal Research Center and Research Center for Environmental Genomics, Kobe University, Kobe 657 8501, Japan
J Biochem 143:31-8. 2008.... - Ceramide-induced apoptosis by translocation, phosphorylation, and activation of protein kinase Cdelta in the Golgi complexTaketoshi Kajimoto
Laboratories of Molecular Pharmacology and Biochemistry, Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
J Biol Chem 279:12668-76. 2004..We demonstrate here that the targeting mechanism of PKCdelta, dual regulation of both its activation and translocation to the Golgi complex, is critical for the ceramide-induced apoptotic event... - The complex formation of PKCdelta through its C1- and C2-like regions in H2O2-stimulated cellsSayaka Umada-Kajimoto
Biosignal Research Center, Kobe University, Japan
Biochem Biophys Res Commun 341:101-7. 2006.... - Contribution of caspase(s) to the cell cycle regulation at mitotic phaseToshiaki Hashimoto
Biosignal Research Center, Kobe University, Nada Ku, Kobe, Japan
PLoS ONE 6:e18449. 2011..These results indicate that caspase(s) contribute to the cell cycle regulation at mitotic phase... - Tyrosine phosphorylation of protein kinase CToshiyoshi Yamamoto
Biosignal Research Center, Kobe University, Japan
Methods Mol Biol 233:207-16. 2003 - Distinct activation mechanisms of protein kinase B by growth-factor stimulation and heat-shock treatmentHidenori Matsuzaki
Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
Biochemistry 43:4284-93. 2004.... - Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO familyHidenori Matsuzaki
Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
J Biochem 138:485-91. 2005..These properties are similar to those of FOXO1 and FOXO3, and thus FOXO transcription factors seem to be regulated through a common mechanism by PKB in the growth factor signaling pathway... - Biochemical assays for multiple activation states of protein kinase CToshiyoshi Yamamoto
Biosignal Research Center, Kobe University, 1-1 Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan
Nat Protoc 1:2791-5. 2006..The combination of these procedures is useful to evaluate the activation states of the PKC family in cells. This protocol can be completed in 3-5 d... - Possible involvement of caspase-7 in cell cycle progression at mitosisToshiaki Hashimoto
Biosignal Research Center, Kobe University, 1 1 Rokkodai cho, Nada Ku, Kobe 657 8501, Japan
Genes Cells 13:609-21. 2008..These results revealed that caspase-7 has a novel role during cell cycle progression at mitosis... - Nuclear transportation of diacylglycerol kinase gamma and its possible function in the nucleusTakehiro Matsubara
Laboratory of Molecular Pharmacology and Laboratory of Biochemistry, Biosignal Research Center, Rokkodai cho 1 1, Nada Ku, Kobe 657 8501
J Biol Chem 281:6152-64. 2006..The cells expressing the kinase-negative mutant of DGKgamma were larger in size and showed slower growth rate, and the S phase of the cells was extended. These findings implicate that nuclear DGKgamma regulates cell cycle... - Early studies of protein kinase C: a historical perspectiveYasutomi Nishizuka
Biosignal Research Center, Kobe University, Japan
Methods Mol Biol 233:9-18. 2003 - Signal transducer and activator of transcription 3 upregulates interleukin-8 expression at the level of transcription in human melanoma cellsMasahiro Oka
Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, Kobe, Japan
Exp Dermatol 19:e50-5. 2010..These results indicate that the upregulation of IL-8 production is caused by constitutive STAT3 activation at the level of gene transcription in melanoma cells... - Protein kinase C-betaII represses hepatocyte growth factor-induced invasion by preventing the association of adapter protein Gab1 and phosphatidylinositol 3-kinase in melanoma cellsMasahiro Oka
Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
J Invest Dermatol 128:188-95. 2008..These results indicate that the HGF signaling process from Gab1 to PI3K is negatively regulated by PKC-betaII, and its loss is critical for melanoma cells to gain invasive potential... - Nuclear translocation of caspase-3 is dependent on its proteolytic activation and recognition of a substrate-like protein(s)Shinji Kamada
Molecular and Cell Biology Laboratory, The Salk Institute, La Jolla, California 92037, USA
J Biol Chem 280:857-60. 2005..These results suggest that active caspase-3 is translocated in association with a substrate-like protein(s) from the cytoplasm into the nucleus during progression through apoptosis... - A-kinase-anchoring protein 95 functions as a potential carrier for the nuclear translocation of active caspase 3 through an enzyme-substrate-like associationShinji Kamada
Molecular and Cell Biology Laboratory, The Salk Institute, La Jolla, CA, USA
Mol Cell Biol 25:9469-77. 2005..These results indicate that AKAP95 is a potential carrier protein for active caspase 3 from the cytoplasm into the nuclei in apoptotic cells... - PKCdelta inhibits PKCalpha-mediated activation of phospholipase D1 in a manner independent of its protein kinase activityMasahiro Oka
Department of Dermatology, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
FEBS Lett 554:179-83. 2003..These results indicate that PKCdelta inhibits TPA-induced PLD1 activation mediated by PKCalpha through the association with PLD1... - Protein kinase C in melanomaMasahiro Oka
Division of Dermatology, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, 650 0017, Japan
Cancer Metastasis Rev 24:287-300. 2005..Here, we summarize current knowledge of the expression and possible roles of the PKC family in melanoma in comparison with those of normal melanocytes... - The yeast Tor signaling pathway is involved in G2/M transition via polo-kinaseAkio Nakashima
Biosignal Research Center, Kobe University, Kobe, Japan
PLoS ONE 3:e2223. 2008..The C-terminal polo-box domain of Cdc5 has an inhibitory role in nuclear translocation. Taken together, our results indicate a novel function of Tor in the regulation of cell cycle and proliferation... - The family of protein kinase C and membrane lipid mediatorsNaoaki Saito
Biosignal Research Center, Kobe University, 1-1, Rokkodai-cho, Nada-ku, 657-8501, Kobe, Japan
J Diabetes Complications 16:4-8. 2002 - Suppression of the mTOR-raptor signaling pathway by the inhibitor of heat shock protein 90 geldanamycinGoh Ohji
Biosignal Research Center, Kobe University, Kobe 657 8501
J Biochem 139:129-35. 2006.... - Activation of AtMEK1, an Arabidopsis mitogen-activated protein kinase kinase, in vitro and in vivo: analysis of active mutants expressed in E. coli and generation of the active form in stress response in seedlingsDaisuke Matsuoka
Graduate School of Science and Technology, Department of Biological and Environmental Science, Faculty of Agriculture, Kobe University, Rokkodai-cho, Nada-ku, Kobe 657-8501, Japan
Plant J 29:637-47. 2002..These data indicate that the AtMEK1 becomes an active form through phosphorylation and activates its downstream target ATMPK4 in stress response in Arabidopsis... - Dual regulation of phospholipase D1 by protein kinase C alpha in vivoMasahiro Oka
Department of Dermatology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
Biochem Biophys Res Commun 294:1109-13. 2002..These results indicate that PLD1 is dually regulated through phosphorylation as well as through the protein-protein interaction by PKCalpha, and probably by PKCbetaII, in vivo... - Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivityKazuhiro Irie
Laboratory of Organic Chemistry in Life Science, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Sakyo ku, 606 8502, Kyoto, Japan
Pharmacol Ther 93:271-81. 2002..Moreover, we recently have found that a new lactone analogue of benzolactams (6) shows significant selectivity in PKCeta-C1B binding... - PP2B-mediated dephosphorylation of c-Jun C terminus regulates phorbol ester-induced c-Jun/Sp1 interaction in A431 cellsBen Kuen Chen
Department of Pharmacology, College of Medicine, Center for Gene Regulation and Signal Transduction Research, National Cheng Kung University, Tainan 701, Taiwan
Mol Biol Cell 18:1118-27. 2007..These findings indicate the dephosphorylation of c-Jun C terminus is required for the c-Jun/Sp1 interaction and reveal that PP2B plays an important role in regulating c-Jun/Sp1 interaction in PMA-induced gene expression...