A Inui

Summary

Affiliation: Kobe University
Country: Japan

Publications

  1. ncbi Obesity--a chronic health problem in cloned mice?
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Trends Pharmacol Sci 24:77-80. 2003
  2. ncbi Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 18:439-56. 2004
  3. ncbi Cachexia and obesity: two sides of one coin?
    Akio Inui
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Curr Opin Clin Nutr Metab Care 6:395-9. 2003
  4. ncbi Neuropeptide gene polymorphisms and human behavioural disorders
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Nat Rev Drug Discov 2:986-98. 2003
  5. ncbi Melanocortin signalling, single nucleotide polymorphism, and eating disorders
    Akio Inui
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Int J Psychiatry Med 34:399-403. 2004
  6. ncbi Eating behavior in anorexia nervosa--an excess of both orexigenic and anorexigenic signalling?
    A Inui
    Second Department of Internal Medicine, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Mol Psychiatry 6:620-4. 2001
  7. ncbi Transgenic approach to the study of body weight regulation
    A Inui
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Pharmacol Rev 52:35-61. 2000
  8. ncbi Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?
    A Inui
    Second Dept of Internal Medicine, Kobe University School of Medicine, Japan
    Mol Med Today 5:79-85. 1999
  9. ncbi Cancer anorexia-cachexia syndrome: are neuropeptides the key?
    A Inui
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Cancer Res 59:4493-501. 1999
  10. ncbi A role of ghrelin in neuroendocrine and behavioral responses to stress in mice
    A Asakawa
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Neuroendocrinology 74:143-7. 2001

Detail Information

Publications88

  1. ncbi Obesity--a chronic health problem in cloned mice?
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Trends Pharmacol Sci 24:77-80. 2003
    ....
  2. ncbi Ghrelin, appetite, and gastric motility: the emerging role of the stomach as an endocrine organ
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 18:439-56. 2004
    ..Defective ghrelin signaling from the stomach could contribute to abnormalities in energy balance, growth, and associated gastrointestinal and neuroendocrine functions...
  3. ncbi Cachexia and obesity: two sides of one coin?
    Akio Inui
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Curr Opin Clin Nutr Metab Care 6:395-9. 2003
    ..It is not well known, however, how these feeding-regulatory molecules are affected in cachexia associated with cancer and other critical conditions in which cytokines such as interleukin-1 and interleukin-6 may have a key role...
  4. ncbi Neuropeptide gene polymorphisms and human behavioural disorders
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Nat Rev Drug Discov 2:986-98. 2003
  5. ncbi Melanocortin signalling, single nucleotide polymorphism, and eating disorders
    Akio Inui
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    Int J Psychiatry Med 34:399-403. 2004
  6. ncbi Eating behavior in anorexia nervosa--an excess of both orexigenic and anorexigenic signalling?
    A Inui
    Second Department of Internal Medicine, Kobe University School of Medicine, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Mol Psychiatry 6:620-4. 2001
    ..Therapeutic intervention using such receptor antagonists may lead to more successful and targeted psychopharmacological treatment...
  7. ncbi Transgenic approach to the study of body weight regulation
    A Inui
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Pharmacol Rev 52:35-61. 2000
    ..Advanced gene-targeting strategies aimed at specific alterations (on and off) of a gene product at desired tissues and times could lead to a better understanding of the system...
  8. ncbi Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders?
    A Inui
    Second Dept of Internal Medicine, Kobe University School of Medicine, Japan
    Mol Med Today 5:79-85. 1999
    ..Here, I discuss the evidence for and against a central role for neuropeptide Y and leptin in anorexia and cachexia...
  9. ncbi Cancer anorexia-cachexia syndrome: are neuropeptides the key?
    A Inui
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Cancer Res 59:4493-501. 1999
    ....
  10. ncbi A role of ghrelin in neuroendocrine and behavioral responses to stress in mice
    A Asakawa
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Neuroendocrinology 74:143-7. 2001
    ....
  11. ncbi Antagonism of ghrelin receptor reduces food intake and body weight gain in mice
    A Asakawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Gut 52:947-52. 2003
    ..Gastric peptide ghrelin and GHS-R may be promising therapeutic targets not only for anorexia-cachexia but also for obesity and type 2 diabetes, which are becoming increasingly prevalent worldwide...
  12. ncbi Stomach regulates energy balance via acylated ghrelin and desacyl ghrelin
    A Asakawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Gut 54:18-24. 2005
    ..The effect is mediated via the hypothalamus. Although derived from the same precursor, the inverse effects of these two peptides suggest that the stomach might be involved as an endocrine organ in the regulation of the energy balance...
  13. ncbi Urocortin reduces oxygen consumption in lean and ob/ob mice
    A Asakawa
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Int J Mol Med 7:539-41. 2001
    ..These results suggest that urocortin decreases oxygen consumption, and that the CRF type 2 receptor may influence energy balance in lean and ob/ob mice...
  14. ncbi Cocaine-amphetamine-regulated transcript influences energy metabolism, anxiety and gastric emptying in mice
    A Asakawa
    Second Department of Internal Medicine, Kobe University School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Horm Metab Res 33:554-8. 2001
    ..Furthermore, the i. c. v. injection of CART significantly reduced oxygen consumption and gastric emptying rate. These results suggest that CART modulates feeding, emotion, and autonomic functions in mice...
  15. ncbi Orexin reverses cholecystokinin-induced reduction in feeding
    A Asakawa
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Diabetes Obes Metab 4:399-401. 2002
    ..CONCLUSIONS: Orexin reversed the CCK-induced loss of appetite. Our results indicate that orexin might be a promising target for pharmacological intervention in the treatment of anorexia and cachexia induced by various diseases...
  16. ncbi Endomorphin-1, an endogenous mu-opioid receptor-selective agonist, stimulates oxygen consumption in mice
    A Asakawa
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Horm Metab Res 32:51-2. 2000
    ..These results suggest that endomorphin 1 stimulates oxygen consumption, and that the mu-opioid receptor influences energy balance in mice...
  17. ncbi Modest overexpression of neuropeptide Y in the brain leads to obesity after high-sucrose feeding
    T Kaga
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Diabetes 50:1206-10. 2001
    ....
  18. ncbi Urocortin reduces food intake and gastric emptying in lean and ob/ob obese mice
    A Asakawa
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Gastroenterology 116:1287-92. 1999
    ..Gastric emptying plays an important role in regulating food intake. This study was designed to investigate whether intraperitoneally injected urocortin reduces gastric emptying, feeding, and body weight in lean and ob/ob obese mice...
  19. ncbi Transgenic study of energy homeostasis equation: implications and confounding influences
    A Inui
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    FASEB J 14:2158-70. 2000
    ..Advanced gene targeting strategies in which genes can be turned on or off at desired tissues and times would undoubtedly lead to a better understanding of the highly integrated and redundant systems for energy homeostasis equation...
  20. ncbi Gastric bypass model in the obese rat to study metabolic mechanisms of weight loss
    Y Xu
    Second Department of Internal Medicine, Kobe School of Medicine, Japan
    J Surg Res 107:56-63. 2002
    ..A dependable, reproducible gastric bypass with Roux-en-Y obesity model was developed. This permits the study of biochemical and eventually molecular mechanism(s) of weight loss resulting from the operation...
  21. ncbi Feeding and body-weight regulation by hypothalamic neuropeptides--mediation of the actions of leptin
    A Inui
    Second Dept of Internal Medicine, Kobe University School of Medicine, Japan
    Trends Neurosci 22:62-7. 1999
    ....
  22. ncbi Emerging functions of neuropeptide Y Y(2) receptors in the brain
    T Kaga
    Second Department of Internal Medicine, Kobe University School of Medicine, Kobe, Japan
    Peptides 22:501-6. 2001
    ..Very recently, Y(2) receptor selective antagonist has been developed and Y(2) receptor-deficient animals have been created. These new pharmacological tools will help to clarify the roles of this receptor in brain functions...
  23. ncbi [Ghrelin and gut motility]
    Akihiro Asakawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Nippon Rinsho 62:365-8. 2004
  24. ncbi Characterization of the effects of pancreatic polypeptide in the regulation of energy balance
    Akihiro Asakawa
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Meidicine, Japan
    Gastroenterology 124:1325-36. 2003
    ..Pancreatic polypeptide (PP) belongs to a family of peptides including neuropeptide Y and peptide YY. We examined the role of PP in the regulation of body weight as well as the therapeutic potential of PP...
  25. ncbi Effect of trimebutine maleate on emptying of stomach and gallbladder and release of gut peptide following a solid meal in man
    H Okano
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Dig Dis Sci 38:817-23. 1993
    ..05). The major effect of trimebutine maleate appears to be a shortening of the lag time at the start of gastric emptying probably via its anticholinergic activity...
  26. ncbi Mosapride, a 5HT-4 receptor agonist, improves insulin sensitivity and glycaemic control in patients with Type II diabetes mellitus
    N Ueno
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Diabetologia 45:792-7. 2002
    ..CONCLUSIONS/INTERPRETATION: Mosapride could improve insulin action at muscle and glycaemic control in Type II diabetic patients...
  27. ncbi [Abnormality in feeding and body weight regulation in obesity]
    T Kaga
    Second Department of Internal Medicine, Kobe University School of Medicine
    Nippon Rinsho 59:487-96. 2001
    ..A detailed understanding of the physiology and genetics of the regulatory systems is critical for the development of new approaches for treating obesity and its sequelae...
  28. ncbi A motilin agonist, erythromycin, decreases circulating growth hormone levels in normal subjects but not in diabetic subjects
    Naohiko Ueno
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho Chuo ku, Kobe 650 0017, Japan
    J Diabetes Complications 20:380-3. 2006
    ..We conclude that EM decreases GH levels in normal subjects while not changing SS levels. This effect was not observed in type 2 diabetic subjects...
  29. ncbi Leptin transgene expression in the hypothalamus enforces euglycemia in diabetic, insulin-deficient nonobese Akita mice and leptin-deficient obese ob/ob mice
    Naohiko Ueno
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University, Kobe, Japan
    Peptides 27:2332-42. 2006
    ....
  30. ncbi [Pathogenesis and treatment of cancer anorexia-cachexia, with special emphasis on aged patients]
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Nippon Ronen Igakkai Zasshi 41:460-7. 2004
    ..Because weight loss shortens the survival time of cancer patients and decreases performance status, effective therapy would extend patient survival and improve quality of life...
  31. ncbi [Molecular mechanisms and clinical implications for the regulatory feedback loop of feeding and body adiposity]
    Akio Inui
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine
    Nippon Shokakibyo Gakkai Zasshi 100:298-305. 2003
  32. ncbi Blunted metabolic response to fasting in obese mice
    Naohiko Ueno
    Department of Internal Medicine, Kobe Seaside Hospital, 1 1 28 Isobe dori Chuo ku, Kobe, Hyogo, 651 0084, Japan
    Endocrine 32:192-6. 2007
    ..This data show that obese mice may have decreased sensitivity to fasting-induced increase in circulating ghrelin and their oxygen consumption exhibited a blunted response to fasting...
  33. ncbi Biological actions of peptide YY: effects on endocrine pancreas, pituitary-adrenal axis, and plasma catecholamine concentrations in the dog
    A Inui
    Second Department of Internal Medicine, Kobe University School of Medicine, Hyogo, Japan
    Horm Metab Res 19:353-7. 1987
    ..These results suggest that PYY can affect anterior pituitary hormone secretion, sympathetic nervous outflow and pancreatic endocrine activity in addition to its known actions on gastric and pancreatic secretion in the dog...
  34. ncbi Cancer anorexia-cachexia syndrome: current issues in research and management
    Akio Inui
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Japan
    CA Cancer J Clin 52:72-91. 2002
    ..Because weight loss shortens the survival time of cancer patients and decreases performance status, effective therapy would extend patient survival and improve quality of life...
  35. ncbi Endoscopic treatment of hydrocephalus in children: a controlled study using newly developed Yamadori-type ventriculoscopes
    S Kamikawa
    Department of Neurosurgery, Kobe University School of Medicine, Kobe, Japan
    Minim Invasive Neurosurg 44:25-30. 2001
    ..0001) compared to a control group of 44 patients treated initially by VP shunting. Our data demonstrate that therapeutic ventriculoscopy is safe and clinically effective as the first-line treatment of hydrocephalus in children...
  36. ncbi Leptin treatment ameliorates anxiety in ob/ob obese mice
    Akihiro Asakawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Hyogo, Japan
    J Diabetes Complications 17:105-7. 2003
    ..2% after treatment. Leptin treatment ameliorated not only obesity but also anxiety in ob/ob mice. Our results indicate that the treatment of obesity may lead to the solution of psychological problems...
  37. ncbi Effects of agouti-related protein, orexin and melanin-concentrating hormone on oxygen consumption in mice
    Akihiro Asakawa
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan
    Int J Mol Med 10:523-5. 2002
    ..These results suggest that AGRP, orexin and MCH might have different effects on energy expenditure, thereby regulating appetite and body weight...
  38. ncbi Different effects of ghrelin, des-acyl ghrelin and obestatin on gastroduodenal motility in conscious rats
    Mineko Fujimiya
    Department of Anatomy, Sapporo Medical University, School of Medicine, Chuo Ku, Sapporo 060 8556, Japan
    World J Gastroenterol 14:6318-26. 2008
    ..Vagal afferent pathways might be involved in the action of ghrelin, but not involved in the action of des-acyl ghrelin, whereas vagal afferent pathways might be partially involved in the action of obestatin...
  39. ncbi Ob/ob mice as a model of delayed gastric emptying
    Akihiro Asakawa
    Department of Clinical Molecular Medicine, Division of Diabetes, Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Japan
    J Diabetes Complications 17:27-8. 2003
    ..01). Our results indicate that the ob/ob mice are a useful model not only of glucose intolerance but also of delayed gastric emptying as a diabetic complication...
  40. ncbi Melanin-concentrating hormone enhances sucrose intake
    Ruka Sakamaki
    International Center for Medical Research, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Mol Med 15:1033-9. 2005
    ..These results indicate that MCH may be an important regulator of sugar intake in normal as well as in obese diabetic animals...
  41. ncbi Intracerebroventricularly administered urocortin inhibits gastric emptying in mice
    Toshiaki Nagata
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Int J Mol Med 15:1041-3. 2005
    ..These results suggest that the potent anorectic properties of urocortin may be partly due to the anti-gastroprokinetic activity of the peptide...
  42. ncbi Anticancer drugs that induce cancer-associated cachectic syndromes
    Akiko Tohgo
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan
    Expert Rev Anticancer Ther 2:121-9. 2002
    ..This review outlines what is known about the development of cachectic reactions, especially in tumor-bearing mice, that occur during treatment with anticancer agents and highlights the clinical relevance of the information...
  43. ncbi Gastrointestinal hormones (anorexigenic peptide YY and orexigenic ghrelin) influence neural tube development
    Hideki Yuzuriha
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    FASEB J 21:2108-12. 2007
    ..The present study is the first linking GI hormones to the leading cause of infant mortality and provides a novel insight for neurogenesis in which materno-fetal communication through GI hormones appears to be important...
  44. ncbi Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Cell Metab 3:267-75. 2006
    ..These results thus indicate that IL-6-STAT3 signaling in the liver contributes to insulin action in the brain, leading to the suppression of hepatic glucose production...
  45. ncbi Acute intracerebroventricular administration of either carboxyl-terminal or amino-terminal fragments of agouti-related peptide produces a long-term decrease in energy expenditure in rats
    Kyoko Goto
    Division of Diabetes, Digestive and Kidney Diseases, Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe 6500017, Japan
    Int J Mol Med 12:379-83. 2003
    ..This suggests that the amino-terminal region of AgRP plays a regulatory role in energy metabolism...
  46. ncbi Increased circulating cholecystokinin contributes to anorexia and anxiety behavior in mice overexpressing pancreatic polypeptide
    Naohiko Ueno
    Department of Internal Medicine, Kobe Seaside Hospital, 1 1 28 Isogami dori, Chuo Ku, Kobe, 651 0084, Japan
    Regul Pept 141:8-11. 2007
    ..These results indicated that elevated CCK may contribute to anorexic and anxious phenotype of PP overexpressing mice...
  47. ncbi Ghrelin concentrations and cardiac vagal tone are decreased after pharmacologic and cognitive-behavioral treatment in patients with bulimia nervosa
    Muneki Tanaka
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Horm Behav 50:261-5. 2006
    ....
  48. ncbi [Recent development in research and management of cancer anorexia-cachexia syndrome]
    Akio Inui
    Dept. of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
    Gan To Kagaku Ryoho 32:743-9. 2005
    ..Because weight loss shortens the survival time of cancer patients and decreases performance status, effective therapy would extend patient survival and improve quality of life...
  49. ncbi Branched-chain amino acids: the best compromise to achieve anabolism?
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Curr Opin Clin Nutr Metab Care 8:408-14. 2005
    ..More effective therapies are needed to promote appetite and food intake, to preserve lean body mass, and to ameliorate patients' psychological distress...
  50. ncbi Ghrelin treatment causes increased food intake and retention of lean body mass in a rat model of cancer cachexia
    Mark D DeBoer
    Center for the Study of Weight Regulation, Oregon Health and Science University, 707 SW Gaines Road, Portland, OR 97239, USA
    Endocrinology 148:3004-12. 2007
    ..We conclude that ghrelin and a synthetic ghrelin receptor agonist improve weight gain and lean body mass retention via effects involving orexigenic neuropeptides and antiinflammatory changes...
  51. ncbi Incomplete restoration of the secretion of ghrelin and PYY compared to insulin after food ingestion following weight gain in anorexia nervosa
    Toshihiro Nakahara
    Department of Behavioral Medicine, Kagoshima University, Graduate School of Medical and Dental Sciences, 8 35 1, Sakuragaoka, Kagoshima City 890 8520, Japan
    J Psychiatr Res 41:814-20. 2007
    ..We investigated pre- and postprandial responses of ghrelin and PYY in anorexia nervosa (AN) and the influence of weight gain...
  52. ncbi Therapy insight: Cancer anorexia-cachexia syndrome--when all you can eat is yourself
    Alessandro Laviano
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Nat Clin Pract Oncol 2:158-65. 2005
    ....
  53. ncbi Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats
    Ana Guijarro
    Dept of Surgery, University Hospital, 750 East Adams St, Syracuse, NY 13210, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1474-89. 2007
    ..These events override the compensatory response to the drop in leptin levels aimed at conserving energy...
  54. ncbi [Feeding-related disorders in medicine, with special reference to cancer anorexia-cachexia syndrome]
    Akio Inui
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890-8520
    Rinsho Byori 54:1044-51. 2006
    ..As weight loss shortens the survival time of cancer patients and decreases their performance status, effective therapy would extend patient survival and improve quality of life...
  55. ncbi Leptin and gastric neuroendocrine system
    Akio Inui
    Gastroenterology 123:1751. 2002
  56. ncbi Orexigenic/anorexigenic signals in bulimia nervosa
    Yoshiyuki Takimoto
    Department of Psychosomatic Medicine, Faculty of Medicine, Tokyo University, Tokyo, Japan
    Curr Mol Med 3:349-60. 2003
    ..This report reviews data that point to the hypothesis that dysregulation of monoaminergic and new peptidergic circuitry controlling food intake and energy expenditure play a major role in the eating behavior of BN...
  57. ncbi Anorexia in space and possible etiologies: an overview
    Monica S Da Silva
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, SUNY Upstate Medial University, Syracuse, New York 13210, USA
    Nutrition 18:805-13. 2002
    ....
  58. ncbi Ghrelin induces fasted motor activity of the gastrointestinal tract in conscious fed rats
    Kazunori Fujino
    Department of Surgery, Shiga University of Medical Science, Otsu, Japan
    J Physiol 550:227-40. 2003
    ..The action of ghrelin to induce fasted motor activity is strongly affected by intragastric pH; low pH inhibits the action...
  59. ncbi The role of ghrelin and ghrelin analogues in wasting disease
    Mayra M Kamiji
    Department of Gastroenterology, Faculty of Medicine, University of Sao Paulo, Ribeirao Preto, Brazil
    Curr Opin Clin Nutr Metab Care 11:443-51. 2008
    ..The purpose of this review is to summarize recent studies that investigated the role of ghrelin and ghrelin analogs in wasting conditions...
  60. ncbi Obestatin inhibits motor activity in the antrum and duodenum in the fed state of conscious rats
    Koji Ataka
    Research Institute, Taiko Pharmaceutical Co Ltd, Osaka, Japan
    Am J Physiol Gastrointest Liver Physiol 294:G1210-8. 2008
    ..These results suggest that, in the fed state, obestatin inhibits motor activity in the antrum and duodenum and that CRF type 1 and type 2 receptors in the brain might be involved in these effects of obestatin on gastroduodenal motility...
  61. ncbi Ghrelin treatment of chronic kidney disease: improvements in lean body mass and cytokine profile
    Mark D DeBoer
    Department of Pediatrics, University of Virginia, Charlottesville, VA 22908, USA
    Endocrinology 149:827-35. 2008
    ..We conclude that ghrelin treatment in uremia results in improved lean mass accrual in part due to suppressed muscle proteolysis and possibly related to antiinflammatory effects...
  62. ncbi Plasma obestatin concentrations are negatively correlated with body mass index, insulin resistance index, and plasma leptin concentrations in obesity and anorexia nervosa
    Toshihiro Nakahara
    Department of Psychosomatic Medicine, Respiratory and Stress Care Center, Kagoshima University Hospital, Kagoshima City, Japan
    Biol Psychiatry 64:252-5. 2008
    ..Obestatin is a recently identified ghrelin gene product that was reported to inhibit appetite and gastric motility in contrast to ghrelin. We investigated fasting obestatin and ghrelin levels in patients with obesity and anorexia nervosa...
  63. ncbi Cancer anorexia-cachexia syndrome: cytokines and neuropeptides
    Eduardo J B Ramos
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, Upstate Medical University, Syracuse, NY 13210, USA
    Curr Opin Clin Nutr Metab Care 7:427-34. 2004
    ..Interfering pharmacologically with cytokine expression or neural transduction of cytokine signals can be an effective therapeutic strategy in anorectic patients before they develop cancer anorexia-cachexia syndrome...
  64. ncbi Leptin modulates orexigenic effects of ghrelin and attenuates adiponectin and insulin levels and selectively the dark-phase feeding as revealed by central leptin gene therapy
    Naohiko Ueno
    Department of Neuroscience, McKnight Brain Institute, P O Box 100244, Gainesville, Florida 32610 0244, USA
    Endocrinology 145:4176-84. 2004
    ..Cumulatively, these results identify newer central and peripheral modulatory influences of leptin on hormonal signals of disparate origin implicated in weight homeostasis and metabolic disorders...
  65. ncbi A role for pancreatic polypeptide in feeding and body weight regulation
    Shinya Kojima
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1, Sakuragaoka, Kagoshima City 890 8520, Japan
    Peptides 28:459-63. 2007
    ....
  66. ncbi Olanzapine-induced hyperglycemia in anorexia nervosa
    Daisuke Yasuhara
    Am J Psychiatry 164:528-9. 2007
  67. ncbi Central prostaglandin D(2) stimulates food intake via the neuropeptide Y system in mice
    Kousaku Ohinata
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, Kyoto, Japan
    FEBS Lett 582:679-84. 2008
    ..The orexigenic activity of PGD(2) was also abolished by an antagonist for neuropeptide Y (NPY) Y(1) receptor. Taken together, PGD(2) may stimulate food intake through central DP(1) receptor coupled to the NPY system...
  68. ncbi Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH
    Takakazu Kawamata
    Department of Neurosurgery, Tokyo Women s Medical University, Tokyo, Japan
    Clin Endocrinol (Oxf) 67:140-4. 2007
    ..This study investigated dysregulation of ghrelin secretion in acromegaly and its short-term postoperative recovery...
  69. ncbi Pathogenesis and treatment of eating disorders associated with type 1 diabetes mellitus
    Daisuke Yasuhara
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
    Nat Clin Pract Endocrinol Metab 3:612-3. 2007
  70. ncbi Anorexia in hemodialysis patients: the possible role of des-acyl ghrelin
    Maurizio Muscaritoli
    Department of Clinical Medicine, University La Sapienza, Rome, Italy
    Am J Nephrol 27:360-5. 2007
    ..The aim of this cross-sectional study is to clarify whether anorexia and body weight change in HD patients relate to plasma des-acyl ghrelin levels...
  71. ncbi Obestatin, acyl ghrelin, and des-acyl ghrelin responses to an oral glucose tolerance test in the restricting type of anorexia nervosa
    Toshiro Harada
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Japan
    Biol Psychiatry 63:245-7. 2008
    ..We investigated simultaneously obestatin, acyl ghrelin, and des-acyl ghrelin in the restricting type of anorexia nervosa (AN-R) patients...
  72. ncbi Albutensin A and complement C3a decrease food intake in mice
    Kousaku Ohinata
    Division of Food Bioscience and Biotechnology, Graduate School of Agriculture, Kyoto University, Gokasho Uji, 611-0011, Kyoto, Japan
    Peptides 23:127-33. 2002
    ..In contrast, C5a increased food intake after central injection. Based on these results, we conclude that the inhibitory effect of albutensin A on food intake is mediated through the C3a receptor...
  73. ncbi Is obesity an inflammatory disease?
    Eduardo J B Ramos
    Department of Surgery, Management Information and Decision, Clinical Molecular Medicine, SUNY Upstate Medical University, Syracuse University, Syracuse, NY, USA
    Surgery 134:329-35. 2003
    ..CONCLUSIONS: Gastric bypass reduces biochemical markers of inflammation, suggesting that obesity is an inflammatory condition...
  74. ncbi Anorexia nervosa and hyperthyroidism
    Akio Inui
    Int J Psychiatry Med 33:181-2. 2003
  75. ncbi Effect of amphetamine repeated treatment on the feeding behavior in neuropeptide Y-overexpressing mice
    Dong Yih Kuo
    Department of Physiology, Chung Shan Medical University, Taichung City, 40201, Taiwan
    Neurosci Lett 329:359-61. 2002
    ..Thus, NPY can be considered to play a functional role in the regulation of AMPH-induced anorexia in mice...
  76. ncbi Interleukin-1beta system in anorectic catabolic tumor-bearing rats
    Nicolas P Turrin
    Molecular Endocrinology and Oncology Research Centre, Laval University Hospital Centre, and Department of Anatomy and Physiology, Laval University, Ste-Foy, , G1V 4G2, Canada
    Curr Opin Clin Nutr Metab Care 7:419-26. 2004
    ..In vivo, the characterization of cytokine components in the brain may provide data for potential pharmacological interventions to ameliorate the anorexia of disease...
  77. ncbi Acyl and desacyl ghrelin in anorexia nervosa
    Akio Inui
    Psychoneuroendocrinology 30:115. 2005
  78. ncbi Central mechanisms involved with catabolism
    Jyotirmoy Nandi
    Department of Medicine, Gastroenterology Division, University Hospital, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Curr Opin Clin Nutr Metab Care 5:407-18. 2002
    ..Several studies have demonstrated important progress towards our understanding of the central mechanisms involved in anorexia and weight loss, which we summarize in this review...
  79. ncbi Neurobiologic changes in the hypothalamus associated with weight loss after gastric bypass
    Irina V Romanova
    Surgical Metabolism and Nutrition Laboratory, Neuroscience Program, Department of Surgery, University Hospital, SUNY Upstate Medical University, Syracuse, NY, USA
    J Am Coll Surg 199:887-95. 2004
    ..05). CONCLUSIONS: Obese rats that undergo weight loss after RYGB demonstrate changes in hypothalamic down regulation of NPY and up regulation of alpha-MSH and serotonin...
  80. ncbi Leptin-replacement therapy in lipodystrophy
    Akio Inui
    N Engl J Med 346:2009; author reply 2009-10. 2002
  81. ncbi Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats
    Chih Yen Chen
    Division of Gastroenterology, Taipei Veterans General Hospital, Taiwan
    Gastroenterology 129:8-25. 2005
    ..Although it has been shown that des-acyl ghrelin decreases food intake and gastric emptying, no previous studies have examined the effects of des-acyl ghrelin on physiologic fed and fasted motor activity in the gastrointestinal tract...
  82. ncbi Glucose tolerance predicts short-term refeeding outcome in females with anorexia nervosa
    Daisuke Yasuhara
    Department of Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City, Japan
    Psychosom Med 67:669-76. 2005
    ....
  83. ncbi Paracentral cortical atrophy in patients with eating disorders
    Akio Inui
    Am J Med 112:681-3. 2002
  84. ncbi Inhibitory effect of 5-hydroxytryptamine on hyperphagia in mice with genetic overexpression of neuropeptide Y
    Sheng-Huang Hsiao
    Department of Neurosurgery, Taiepi City Hospital, Taipei City 10601, Taiwan
    Neurosci Lett 394:256-8. 2006
    ..In conclusion, 5-HT reduces hyperphagia in the NPY-overexpressing rat through action on 5-HT2A receptors and this hypophagic effect of 5-HT does not depend on the hyperglycemia...
  85. ncbi [Ghrelin-neuropeptide Y axis in the control of feeding and gastrointestinal motility]
    Akio Inui
    Nippon Yakurigaku Zasshi 127:83-7. 2006
  86. ncbi Anorexia in cancer: role of feeding-regulatory peptides
    Simona Perboni
    Department of Medical Oncology, University of Cagliari, Monserrato, Italy
    Philos Trans R Soc Lond B Biol Sci 361:1281-9. 2006
    ..A better appreciation of the molecular and neuronal mechanisms that control body weight homeostasis may lead to the development of new therapies for improving the survival and quality of life of these patients...
  87. ncbi Role of leucine in regulating food intake
    Alessandro Laviano
    Science 313:1236-8; author reply 1236-8. 2006
  88. ncbi Synergistic effects of Y2 and Y4 receptors on adiposity and bone mass revealed in double knockout mice
    Amanda Sainsbury
    Neurobiology Program, Garvan Institute of Medical Research, St Vincent s Hospital, 384 Victoria Street, Darlinghurst, Sydney, New South Wales 2010, Australia
    Mol Cell Biol 23:5225-33. 2003
    ..However, a synergistic interaction between Y2 and Y4 pathways seems to regulate bone volume and adiposity and could have important implications for possible interventions in obesity and for anabolic treatment of osteoporotic bone loss...