Hiroaki Takimoto

Summary

Affiliation: Kitasato University
Country: Japan

Publications

  1. ncbi Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts
    Hiroaki Takimoto
    Department of Biosciences, School of Science and Graduate School of Science, Kitasato University, Sagamihara, Kanagawa, Japan
    Immunopharmacol Immunotoxicol 30:747-60. 2008
  2. ncbi Potentiation of murine innate immunity by alpha-galacturonosyl-type glycosphingolipids isolated from Sphingomonas yanoikuyae and S. terrae
    Masahiro Kubota
    Department of Biosciences, School and Graduate School of Science, Kitasato University, Kitasato, Sagamihara, Japan
    Immunopharmacol Immunotoxicol 31:363-9. 2009
  3. ncbi Involvement of mannose receptor in glycopeptidolipid-mediated inhibition of phagosome-lysosome fusion
    Ken-ichi Shimada
    Department of Bioscience, School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan
    Microbiol Immunol 50:243-51. 2006
  4. ncbi Suppressive effects of the flavonoids quercetin and luteolin on the accumulation of lipid rafts after signal transduction via receptors
    Masahiro Kaneko
    Department of Biosciences, School of Science and Graduate School of Fundamental Life Science, Kitasato University, Sagamihara, Kanagawa, Japan
    Immunopharmacol Immunotoxicol 30:867-82. 2008
  5. ncbi Mechanism of up-regulation of immunoglobulin A production in the intestine of mice unresponsive to lipopolysaccharide
    Masahiro Kaneko
    Department of Biosciences, School of Science and Graduate School for Fundamental Life Science, Kitasato University, Kanagawa, Japan
    Immunology 116:64-70. 2005
  6. ncbi Potentiation of cytotoxic activity in naïve and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies
    Hiroaki Takimoto
    Department of Biosciences, School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa, Japan
    Biol Pharm Bull 27:404-6. 2004
  7. ncbi Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha
    Yoshio Kumazawa
    Department of Biosciences, School of Science and Graduate School of Fundamental Life Science, Kitasato University, 1 15 1 Kitasato, Sagamihara 228 8555, Japan
    Curr Pharm Des 12:4271-9. 2006
  8. ncbi Development of TCR alpha beta CD8 alpha alpha intestinal intraepithelial lymphocytes is promoted by interleukin-15-producing epithelial cells constitutively stimulated by gram-negative bacteria via TLR4
    Masahiro Kaneko
    Department of Biosciences, School of Science, Kitasato University, Sagamihara, Kanagawa, Japan
    Biol Pharm Bull 27:883-9. 2004
  9. ncbi Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice
    Takeo Kitamoto
    Laboratory of Molecular Embryology, Department of Bioscience, Kitasato University School of Science, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Biochem Biophys Res Commun 331:1154-62. 2005
  10. ncbi Serotype-specific modulation of human monocyte functions by glycopeptidolipid (GPL) isolated from Mycobacterium avium complex
    Hideyuki Kano
    Department of Bioscience, School of Science and Graduate School of Fundamental Life Science, Kitasato University, Sagamihara 228-8555, Japan
    Biol Pharm Bull 28:335-9. 2005

Collaborators

Detail Information

Publications11

  1. ncbi Amelioration of skewed Th1/Th2 balance in tumor-bearing and asthma-induced mice by oral administration of Agaricus blazei extracts
    Hiroaki Takimoto
    Department of Biosciences, School of Science and Graduate School of Science, Kitasato University, Sagamihara, Kanagawa, Japan
    Immunopharmacol Immunotoxicol 30:747-60. 2008
    ..Our results strongly suggest that oral administration of Agaricus extracts ameliorates the Th1/Th2 balance from the Th2-skewed conditions...
  2. ncbi Potentiation of murine innate immunity by alpha-galacturonosyl-type glycosphingolipids isolated from Sphingomonas yanoikuyae and S. terrae
    Masahiro Kubota
    Department of Biosciences, School and Graduate School of Science, Kitasato University, Kitasato, Sagamihara, Japan
    Immunopharmacol Immunotoxicol 31:363-9. 2009
    ..The results show that a higher ratio of C21cyclopropane to C20:1 in the dihydrosphingosine molecule allows a more optimal activation of iNKT cells and other cell types...
  3. ncbi Involvement of mannose receptor in glycopeptidolipid-mediated inhibition of phagosome-lysosome fusion
    Ken-ichi Shimada
    Department of Bioscience, School of Science, Kitasato University, Sagamihara, Kanagawa 228-8555, Japan
    Microbiol Immunol 50:243-51. 2006
    ..Recruitment of early endosome antigen 1 and Ca2+/calmodulin kinase II in human macrophage-like THP-1 cells were significantly suppressed by GPL, indicating that GPL inhibits steps for leading to the P-L fusion...
  4. ncbi Suppressive effects of the flavonoids quercetin and luteolin on the accumulation of lipid rafts after signal transduction via receptors
    Masahiro Kaneko
    Department of Biosciences, School of Science and Graduate School of Fundamental Life Science, Kitasato University, Sagamihara, Kanagawa, Japan
    Immunopharmacol Immunotoxicol 30:867-82. 2008
    ..Our observations suggest that QUER and LUTE interact with receptors on the cell surface and suppress the accumulation of lipid rafts that occurs downstream of the activation of the receptors...
  5. ncbi Mechanism of up-regulation of immunoglobulin A production in the intestine of mice unresponsive to lipopolysaccharide
    Masahiro Kaneko
    Department of Biosciences, School of Science and Graduate School for Fundamental Life Science, Kitasato University, Kanagawa, Japan
    Immunology 116:64-70. 2005
    ..These results indicate that high IgA levels in the intestine of TLR4-mutated mice are due to up-regulation of TGF-beta and IL-10 and the lack of regulation by SOCS-1...
  6. ncbi Potentiation of cytotoxic activity in naïve and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies
    Hiroaki Takimoto
    Department of Biosciences, School of Science, Kitasato University, Kitasato, Sagamihara, Kanagawa, Japan
    Biol Pharm Bull 27:404-6. 2004
    ....
  7. ncbi Immunomodulating effects of flavonoids on acute and chronic inflammatory responses caused by tumor necrosis factor alpha
    Yoshio Kumazawa
    Department of Biosciences, School of Science and Graduate School of Fundamental Life Science, Kitasato University, 1 15 1 Kitasato, Sagamihara 228 8555, Japan
    Curr Pharm Des 12:4271-9. 2006
    ..The intake of dietary flavonoids reduces acute and chronic inflammation due to blocking receptor accumulation and signaling cascades, and would assist individuals at high-risk from life-style related diseases...
  8. ncbi Development of TCR alpha beta CD8 alpha alpha intestinal intraepithelial lymphocytes is promoted by interleukin-15-producing epithelial cells constitutively stimulated by gram-negative bacteria via TLR4
    Masahiro Kaneko
    Department of Biosciences, School of Science, Kitasato University, Sagamihara, Kanagawa, Japan
    Biol Pharm Bull 27:883-9. 2004
    ..Our findings suggest that LPS induces IL-15 production by i-EC, resulting in the development of TCR alpha beta CD8 alpha alpha i-IEL...
  9. ncbi Functional redundancy of the Notch gene family during mouse embryogenesis: analysis of Notch gene expression in Notch3-deficient mice
    Takeo Kitamoto
    Laboratory of Molecular Embryology, Department of Bioscience, Kitasato University School of Science, 1 15 1, Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    Biochem Biophys Res Commun 331:1154-62. 2005
    ..We also surveyed the adult tissues of Notch3-/- mice and found significantly fewer thymocytes in 10-week-old mice. Therefore, the thymus might be a target tissue affected by Notch3 deficiency...
  10. ncbi Serotype-specific modulation of human monocyte functions by glycopeptidolipid (GPL) isolated from Mycobacterium avium complex
    Hideyuki Kano
    Department of Bioscience, School of Science and Graduate School of Fundamental Life Science, Kitasato University, Sagamihara 228-8555, Japan
    Biol Pharm Bull 28:335-9. 2005
    ..These results indicated that the immunomodulating activity of GPL on macrophage functions is serovar-dependent...
  11. ncbi Does high mobility group 1 protein function as a late mediator for LPS- or TNF-induced shock in galactosamine-sensitized mice?
    Ryoichi Hasunuma
    Department of Biosciences, School of Science, Kitasato University, Sagamihara, Japan
    J Endotoxin Res 8:391-8. 2002
    ..Taken together with the late appearance of HMG-1 in moribund mice, these data suggest that HMG-1 does not decisively contribute to lethality in the GalN sensitization model...