Research Topics
Genomes and Genes | Masaaki MiyazawaSummaryAffiliation: Kinki University Country: Japan Publications
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Publications
[Regulation of retroviral replication and pathogenesis by host factors]Masaaki Miyazawa
Department of Immunology, Kinki University School of Medicene, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan
Uirusu 52:69-76. 2002- Roles of endogenous retroviruses and platelets in the development of vascular injury in spontaneous mouse models of autoimmune diseasesM Miyazawa
Department of Immunology, Kinki University School of Medicine, Osaka Sayama, 589 8511, Osaka, Japan
Int J Cardiol 75:S65-73; discussion S75-6. 2000.... - Mouse APOBEC3 restricts friend leukemia virus infection and pathogenesis in vivoEri Takeda
Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
J Virol 82:10998-1008. 2008..These results indicate, for the first time, that mouse APOBEC3 is a physiologically functioning restriction factor to mouse gammaretroviruses... - Host genetic factors that control immune responses to retrovirus infectionsMasaaki Miyazawa
Department of Immunology, Kinki University School of Medicine, Osaka 589 0023, Japan
Vaccine 26:2981-96. 2008..Recent genetic analyses have indicated that a large proportion of such exposed but uninfected individuals may share a common genetic background... - Peptide-induced immune protection of CD8+ T cell-deficient mice against Friend retrovirus-induced diseaseHiroyuki Kawabata
Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
Int Immunol 18:183-98. 2006.... - Premature terminal exhaustion of Friend virus-specific effector CD8+ T cells by rapid induction of multiple inhibitory receptorsShiki Takamura
Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
J Immunol 184:4696-707. 2010..These results highlight FV's unique ability to evade virus-specific CD8(+) T cell responses and the importance of an early prophylactic approach for preventing terminal exhaustion of CD8(+) T cells... - Persistence of viremia and production of neutralizing antibodies differentially regulated by polymorphic APOBEC3 and BAFF-R loci in friend virus-infected miceSachiyo Tsuji-Kawahara
Department of Immunology, Kinki University School of Medicine, 377 2 Ohno Higashi, Osaka Sayama, Osaka 589 8511, Japan
J Virol 84:6082-95. 2010.... - Natural killer cells recognize friend retrovirus-infected erythroid progenitor cells through NKG2D-RAE-1 interactions In VivoTatsuya Ogawa
Department of Immunology, Kinki University School of Medicine, Osaka Sayama, Osaka 589 8511, Japan
J Virol 85:5423-35. 2011..Enhanced retroviral replication due to host gene-targeting resulted in markedly increased RAE-1 expression in the absence of massive erythroid cell proliferation, indicating a direct role of retroviral replication in RAE-1 upregulation... - Identification of a protective CD4+ T-cell epitope in p15gag of Friend murine leukemia virus and role of the MA protein targeting the plasma membrane in immunogenicityDaisuke Sugahara
Department of Immunology, Kinki University School of Medicine, 377-2 Ohno-Higashi, Osaka-Sayama, Osaka 589-8511, Japan
J Virol 78:6322-34. 2004..These data indicate the importance of the properly processible MA molecule for CD4+ T-cell priming and for the resultant induction of an effective immune response against retrovirus infections... - Increased liver temperature efficiently augments human cellular immune response: T-cell activation and possible monocyte translocationYohei Kida
Department of Immunology, Kinki University School of Medicine, Osaka-Sayama, Osaka, Japan
Cancer Immunol Immunother 55:1459-69. 2006..These results suggest that heating of the liver may efficiently induce cellular immune responses to liver cancers... - Genotypes at chromosome 22q12-13 are associated with HIV-1-exposed but uninfected status in ItaliansYasuyoshi Kanari
Department of Immunology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
AIDS 19:1015-24. 2005..We tested if the above HIV-1-exposed but uninfected status was associated with genetic markers other than a homozygous deletion of the CCR5 gene... - In vivo diagnostic imaging using micro-CT: sequential and comparative evaluation of rodent models for hepatic/brain ischemia and strokeNaoto Hayasaka
Department of Anatomy and Neurobiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
PLoS ONE 7:e32342. 2012..However, soft tissue contrast resolution, particularly in the brain, is insufficient for detailed analysis, unlike the current applications of CT in the clinical arena. We address the soft tissue contrast resolution issue in this report... - Both T and non-T cells with proliferating potentials are effective in inducing suppression of allograft responses by alloantigen-specific intravenous presensitization combined with suboptimal doses of 15-deoxyspergualinHideo Tahara
Department of Immunology, Kinki University School of Medicine, Osaka-Sayama, Osaka 589-8511, Japan
Transpl Immunol 13:25-32. 2004.... - Attenuated food anticipatory activity and abnormal circadian locomotor rhythms in Rgs16 knockdown miceNaoto Hayasaka
Department of Anatomy and Neurobiology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
PLoS ONE 6:e17655. 2011..The present study also suggests that liver and/or thalamus regulate the food-entrained circadian behavior through G protein-mediated signal transduction pathway(s)... - Two genetic determinants acquired late in mus evolution regulate the inclusion of exon 5, which alters mouse APOBEC3 translation efficiencyJun Li
Department of Immunology, Kinki University School of Medicine, Osaka, Japan
PLoS Pathog 8:e1002478. 2012..The widespread geographic distribution of this exon 5-including genetic variant suggests that in some Mus populations the cost of maintaining an effective but mutagenic enzyme may outweigh its antiviral function... - [Pathogenesis of granulomatous arteritis]Masaaki Miyazawa
Department of Immunology, Kinki University School of Medicine
Nippon Rinsho 63:217-22. 2005 - Vaccine-based, long-term, stable control of simian/human immunodeficiency virus 89.6PD replication in rhesus macaquesHiroyuki Yamamoto
International Research Center for Infectious Diseases, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
J Gen Virol 88:652-9. 2007..6PD replication can be stably maintained in the presence of multiple functional immune effectors... - Apolipoprotein B mRNA-editing enzyme, catalytic polypeptide-like 3G: a possible role in the resistance to HIV of HIV-exposed seronegative individualsMara Biasin
Department of Immunology, Dipartimento di Scienze Precliniche Laboratorio Interdisciplinare Tecnologie Avanzate Vialba, Milano University Medical School, Milano, Italy
J Infect Dis 195:960-4. 2007..Higher APOBEC3G expression correlated with a reduced susceptibility of PBMCs to in vitro infection with the HIV-1(Ba-L) R5 strain. APOBEC3G could be important in modulating in vivo susceptibility to sexually transmitted HIV infection... - Influence of glycosylation on the efficacy of an Env-based vaccine against simian immunodeficiency virus SIVmac239 in a macaque AIDS modelKazuyasu Mori
AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan
J Virol 79:10386-96. 2005..This study demonstrated that the prime-boost Env vaccine was effective against homologous SIVmac239 challenge. Changes in glycosylation affected both cell-mediated and humoral immune responses and vaccine efficacy... - Role of TNF-alpha and extracellular ATP in THP-1 cell activation following allergen exposureMasaaki Miyazawa
Kao Corporation, Safety Science Research Laboratories, Haga gun, Tochigi, Japan
J Toxicol Sci 33:71-83. 2008..Therefore, we postulate that not only TNF-alpha but also extracellular ATP may contribute to cell activation following allergen stimulation, which might reflect the mechanism by which DCs respond to allergens... - Cytotoxic T lymphocyte-based control of simian immunodeficiency virus replication in a preclinical AIDS vaccine trialTetsuro Matano
Department of Microbiology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
J Exp Med 199:1709-18. 2004..Our results indicate that vaccine induction of highly effective CTLs can result in the containment of replication of a highly pathogenic immunodeficiency virus... - Role of MAPK signaling pathway in the activation of dendritic type cell line, THP-1, induced by DNCB and NiSO4Masaaki Miyazawa
Kao Corporation, Safety Science Research Laboratories, Haga gun, Tochigi, Japan
J Toxicol Sci 33:51-9. 2008..These data indicate that both DNCB and NiSO(4) activate p38 MAPK and ERK, and thereby stimulate TNF-alpha release and phenotypic changes through the different signal transduction pathways... - Phenotypic alterations and cytokine production in THP-1 cells in response to allergensMasaaki Miyazawa
Safety and Microbial Control Research Center, Kao Corporation, 2606 Akabane, Ichikai Maich, Haga Gun Tochigi 321 3497, Japan
Toxicol In Vitro 21:428-37. 2007..It is suggested that THP-1 cells, which could develop several DC-like properties, are suitable for identifying sensitizing potential of chemicals... - Reference strand-mediated conformation analysis-based typing of multiple alleles in the rhesus macaque MHC class I Mamu-A and Mamu-B lociYumiko Tanaka Takahashi
Department of Molecular Pathogenesis, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
Electrophoresis 28:918-24. 2007..By comparing the data from the parents with those from the descendants in the breeding colony, several MHC class I haplotypes consisting of variable numbers of functional Mamu-A and Mamu-B alleles could be assigned...