Mikiko C Siomi

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi How selfish retrotransposons are silenced in Drosophila germline and somatic cells
    Mikiko C Siomi
    Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    FEBS Lett 582:2473-8. 2008
  2. ncbi PIWI-interacting small RNAs: the vanguard of genome defence
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Nat Rev Mol Cell Biol 12:246-58. 2011
  3. ncbi Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila
    Kuniaki Saito
    Keio University School of Medicine, Tokyo, Japan
    Genes Dev 24:2493-8. 2010
  4. ncbi How does the royal family of Tudor rule the PIWI-interacting RNA pathway?
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Genes Dev 24:636-46. 2010
  5. ncbi piRNA-mediated silencing in Drosophila germlines
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Semin Cell Dev Biol 21:754-9. 2010
  6. ncbi RNA silencing in germlines--exquisite collaboration of Argonaute proteins with small RNAs for germline survival
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Curr Opin Cell Biol 21:426-34. 2009
  7. ncbi A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila
    Kuniaki Saito
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Nature 461:1296-9. 2009
  8. ncbi Chapter 16. How to define targets for small guide RNAs in RNA silencing: a biochemical approach
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo, Japan JST, CREST, Saitama, Japan
    Methods Enzymol 449:345-55. 2008
  9. ncbi Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila
    Keita Miyoshi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    RNA 16:506-15. 2010
  10. ncbi Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis
    Akihiro Nagao
    Department of Molecular Biology, Keio University School of Medicine, Tokyo 160 8582, Japan
    RNA 16:2503-15. 2010

Collaborators

Detail Information

Publications19

  1. ncbi How selfish retrotransposons are silenced in Drosophila germline and somatic cells
    Mikiko C Siomi
    Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    FEBS Lett 582:2473-8. 2008
    ..In this review, we address RNA silencing mechanisms that silence retrotransposons, a subset of TEs, and discuss how germline and somatic cells are equipped with different retrotransposon silencing mechanisms...
  2. ncbi PIWI-interacting small RNAs: the vanguard of genome defence
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Nat Rev Mol Cell Biol 12:246-58. 2011
    ..Now, much progress is being made into our understanding of their biogenesis and molecular functions, including the specific subcellular compartmentalization of the piRNA pathway in granular cytoplasmic bodies...
  3. ncbi Roles for the Yb body components Armitage and Yb in primary piRNA biogenesis in Drosophila
    Kuniaki Saito
    Keio University School of Medicine, Tokyo, Japan
    Genes Dev 24:2493-8. 2010
    ..Thus, piRNA loading is required for Piwi nuclear entry. We propose that a functional Piwi-piRNA complex is formed and inspected in Yb bodies before its nuclear entry to exert transposon silencing...
  4. ncbi How does the royal family of Tudor rule the PIWI-interacting RNA pathway?
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Genes Dev 24:636-46. 2010
    ..Although Tud domains in Tud family members are known to be sDMA-binding modules, involvement of the Tudor family at the molecular level in the piRNA pathway has only recently come into focus...
  5. ncbi piRNA-mediated silencing in Drosophila germlines
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Semin Cell Dev Biol 21:754-9. 2010
    ....
  6. ncbi RNA silencing in germlines--exquisite collaboration of Argonaute proteins with small RNAs for germline survival
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Curr Opin Cell Biol 21:426-34. 2009
    ..This chapter summarizes the exquisite collaboration of Argonaute proteins with small RNAs in the RNA silencing mechanisms necessary for germline survival in Drosophila and mice...
  7. ncbi A regulatory circuit for piwi by the large Maf gene traffic jam in Drosophila
    Kuniaki Saito
    Keio University School of Medicine, Tokyo 160 8582, Japan
    Nature 461:1296-9. 2009
    ..Thus, in gonadal somatic cells, tj gives rise simultaneously to two different molecules: the TJ protein, which activates Piwi expression, and piRNAs, which define the Piwi targets for silencing...
  8. ncbi Chapter 16. How to define targets for small guide RNAs in RNA silencing: a biochemical approach
    Mikiko C Siomi
    Keio University School of Medicine, Tokyo, Japan JST, CREST, Saitama, Japan
    Methods Enzymol 449:345-55. 2008
    ..The method discussed is useful for defining targets for the small RNAs that function in RNA silencing...
  9. ncbi Molecular mechanisms that funnel RNA precursors into endogenous small-interfering RNA and microRNA biogenesis pathways in Drosophila
    Keita Miyoshi
    Keio University School of Medicine, Tokyo 160 8582, Japan
    RNA 16:506-15. 2010
    ..These results suggest that the precursor RNA structure determines the biogenesis mechanism of esiRNAs and miRNAs, thereby implicating hairpin structures with long stems as intermediates in the evolution of Drosophila miRNA...
  10. ncbi Biogenesis pathways of piRNAs loaded onto AGO3 in the Drosophila testis
    Akihiro Nagao
    Department of Molecular Biology, Keio University School of Medicine, Tokyo 160 8582, Japan
    RNA 16:2503-15. 2010
    ..These findings suggest that the impacts of armi mutants on the operation of the piRNA pathway are variable in germ cells of fly testes...
  11. ncbi Functional involvement of Tudor and dPRMT5 in the piRNA processing pathway in Drosophila germlines
    Kazumichi M Nishida
    Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan
    EMBO J 28:3820-31. 2009
    ..Thus, in germline cells, piRNAs are quality-controlled by dPRMT5 that modifies PIWI proteins, in tight association with Tud...
  12. ncbi A direct role for Hsp90 in pre-RISC formation in Drosophila
    Tomohiro Miyoshi
    Keio University School of Medicine, Tokyo, Japan
    Nat Struct Mol Biol 17:1024-6. 2010
    ....
  13. ncbi Small RNA-mediated quiescence of transposable elements in animals
    Kuniaki Saito
    Department of Molecular Biology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Dev Cell 19:687-97. 2010
    ....
  14. ncbi Biochemical analyzes of endogenous argonaute complexes immunopurified with anti-Argonaute monoclonal antibodies
    Keita Miyoshi
    Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan
    Methods Mol Biol 725:29-43. 2011
    ..Furthermore, we will also explain how various parameters, such as antibody properties and buffer conditions, can alter the production and interpretation of experimental data...
  15. ncbi Maelstrom coordinates microtubule organization during Drosophila oogenesis through interaction with components of the MTOC
    Kaoru Sato
    Department of Molecular Biology, Keio University School of Medicine, Tokyo, Japan
    Genes Dev 25:2361-73. 2011
    ..These findings suggest a model in which Mael serves as a platform that nucleates other MTOC components to form a functional MTOC in early oocyte development, which is independent of Chk2 activation and DNA damage signaling...
  16. ncbi Posttranscriptional regulation of microRNA biogenesis in animals
    Haruhiko Siomi
    Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mol Cell 38:323-32. 2010
    ..Here, we discuss recent studies that shed light on how multiple steps in the miRNA biogenesis pathway are regulated to modulate miRNA function in animals...
  17. ncbi On the road to reading the RNA-interference code
    Haruhiko Siomi
    Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 457:396-404. 2009
    ....
  18. ncbi Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway
    Keita Miyoshi
    School of Medicine, Keio University, Tokyo 160 8582, Japan
    RNA 15:1282-91. 2009
    ..The AGO1-PIWI mutant showed no Slicer activity but associates with mature miRNA. These results indicate that these domains are required differently for miRLC and miRISC formation in the miRNA pathway...
  19. ncbi Stress signaling etches heritable marks on chromatin
    Haruhiko Siomi
    Department of Molecular Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell 145:1005-7. 2011
    ..Seong et al. (2011) now reveal how stress-induced signaling through dATF-2 disrupts heterochromatin and leaves heritable marks that influence patterns of gene expression in subsequent generations...