Research Topics
| Akira ToribaSummaryAffiliation: Kanazawa University Country: Japan Publications
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Detail Information
Publications
Evaluation of estrogenic activities of hydroxylated polycyclic aromatic hydrocarbons in cigarette smoke condensateMakiko Kamiya
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
Food Chem Toxicol 43:1017-27. 2005..This is a first study to identify estrogenic hydroxylated PAHs in cigarette smoke condensate. The present findings points out the necessity for detailed investigation of exposure to aerosols containing apparently estrogenic compounds...- Direct measurement of the glucuronide conjugate of 1-hydroxypyrene in human urine by using liquid chromatography with tandem mass spectrometryKensaku Kakimoto
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
J Chromatogr B Analyt Technol Biomed Life Sci 867:259-63. 2008..13 fmol/injection. Urinary concentrations of 1-OHP-G determined by this method were strongly correlated (r(2)=0.961) with concentrations of 1-hydroxypyrene by conventional HPLC with fluorescence detection... - Identification and quantification of 1-nitropyrene metabolites in human urine as a proposed biomarker for exposure to diesel exhaustAkira Toriba
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
Chem Res Toxicol 20:999-1007. 2007..This method for determining urinary 1-NP metabolites should be useful for the surveillance of exposure to NPAHs and DEP and will facilitate the study of cancer risk associated with these exposures... - Quantification of polycyclic aromatic hydrocarbons (PAHs) in human hair by HPLC with fluorescence detection: a biological monitoring method to evaluate the exposure to PAHsAkira Toriba
Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa, Ishikawa 920 0934, Japan
Biomed Chromatogr 17:126-32. 2003..The analysis of PAHs in human hair should be useful as a new biomarker to evaluate the exposure to PAHs... - Quantification of 2-hydroxyfluorene in human urine by column-switching high performance liquid chromatography with fluorescence detectionAkira Toriba
Graduate School of Natural Science and Technology, Kanazawa University, 13 1, Takara machi, Kanazawa, Ishikawa 920 0934, Japan
Analyst 128:605-10. 2003..01). Thus, the data suggest that urinary 2-OHF might be a sensitive and specific biological marker for the assessment of the exposure to polycyclic aromatic hydrocarbons... - Antiandrogenic activity of extracts of diesel exhaust particles emitted from diesel-engine truck under different engine loads and speedsKazumasa Okamura
Graduate School of Natural Science and Technology, Kanazawa University, 13-1 Takara-machi, Kanazawa, Ishikawa 920-0934, Japan
Toxicology 195:243-54. 2004..In conclusion, the antiandrogenic effects of DEPE samples were enhanced by a higher engine load which resulted in DEPC samples with elevated AhR agonistic and AR antagonistic activities... - Antiandrogenic activities of diesel exhaust particle extracts in PC3/AR human prostate carcinoma cellsRyoichi Kizu
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 0934, Japan
Toxicol Sci 76:299-309. 2003.... - Activation of 5-lipoxygenase and NF-kappa B in the action of acenaphthenequinone by modulation of oxidative stressSang Woon Chung
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
Toxicol Sci 101:152-8. 2008..Thus, based on our findings, we propose that AcQ-induced damage is likely due to increased RS generation and NF-kappa B activity through 5-LO activation... - A new luciferase reporter gene assay for the detection of androgenic and antiandrogenic effects based on a human prostate specific antigen promoter and PC3/AR human prostate cancer cellsRyoichi Kizu
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 0934, Japan
Anal Sci 20:55-9. 2004..We developed the first assay system, in which the expression of luciferase was driven by the promoter of a prostate-specific antigen gene, a typical human androgen-regulated gene... - Long-range transport of fluoride in East Asia monitored at Noto Peninsula, JapanXiao Yang Yang
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
Sci Total Environ 407:4681-6. 2009.... - Determination of 1-hydroxypyrene in human urine by high-performance liquid chromatography with fluorescence detection using a deuterated internal standardThaneeya Chetiyanukornkul
Graduate School of Natural Science and Technology, Kanazawa University, Ishikawa, Japan
J Chromatogr A 961:107-12. 2002..Urine sample treatment involved enzymatic hydrolysis followed by solid-phase extraction using Sep-Pak C18 cartridges. The proposed method was used to determine urinary 1-OHP in smokers and non-smokers... - [Comparison of atmospheric pollution of Kitakyushu and Tieling from the viewpoints of PAH, NPAH, mutagenicity and generation of reactive oxygen species]Kanae Bekki
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
J UOEH 30:39-45. 2008..More studies are needed on the environmental behaviors of compounds other than PAHs and NPAHs, such as quinoid PAHs, and their biological activities... - Atmospheric formation of hydroxynitropyrenes from a photochemical reaction of particle-associated 1-nitropyreneTakayuki Kameda
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
Environ Sci Technol 45:3325-32. 2011..e., photochemical reactions of 1-NP are expected to have a significant effect on the occurrence of OHNPs in the atmosphere... - Determination of 1-nitropyrene in low volume ambient air samples by high-performance liquid chromatography with fluorescence detectionTakanori Ohno
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa, Japan
J Chromatogr A 1216:4625-8. 2009..1-NP was detected in all samples at concentrations in the low fmol/m(3) range. The proposed method has enough sensitivity and precision to determine 1-NP in the limited air volume of the portable sampler... - Determination of 1-nitropyrene metabolites by high-performance liquid chromatography with chemiluminescence detectionKazuichi Hayakawa
Graduate School of Natural Science and Technology, Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
J Chromatogr A 1107:286-9. 2006..To demonstrate the proposed method, it was used to determine three compounds in the incubation mixture of 1-nitropyrene and rat S9 mix... - Method for determining monohydroxybenzo[a]pyrene isomers using column-switching high-performance liquid chromatographyAkira Toriba
Graduate School of Natural Science and Technology, Kanazawa University, 13-1, Takara-machi, Kanazawa City, Ishikawa 920-0934, Japan
Anal Biochem 312:14-22. 2003..2% for 1-OHP, respectively. In 11 kinds of isomers, only 3-OHBaP was detected in the human urine. Urinary concentration of 3-OHBaP was quantified at 0.5 ng/g creatinine concentration and the 3-OHBaP/1-OHP ratio was approximately 1/130... - Improvement of an automatic HPLC system for nitropolycyclic aromatic hydrocarbons: removal of an interfering peak and increase in the number of analytesNing Tang
Graduate School of Natural Science and Technology, Kanazawa University, 13-1, Takara-machi, Kanazawa 920-0934, Japan
Anal Sci 19:249-53. 2003..3 to 1.8 mL/min... - Identification of estrogenic/anti-estrogenic compounds in diesel exhaust particulate extractKeiko Noguchi
Graduate School of Natural Science and Technology Faculty of Pharmaceutical Sciences, Kanazawa University, Kakuma machi, Kanazawa, Japan
Biomed Chromatogr 21:1135-42. 2007..This is the first study to identify 2,6-dimethyl-4-nitrophenol in DEPE and the first study to show that it is an estrogenic compound. In the N fraction, 1-hydroxypyrene was also identified by LC-MS/MS as an anti-estrogenic compound... - Hair analysis of nicotine and cotinine for evaluating tobacco smoke exposure by liquid chromatography-mass spectrometryThaneeya Chetiyanukornkul
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan
Biomed Chromatogr 18:655-61. 2004..In both cases, the method provided good selectivity, accuracy and precision... - Determination of airborne particle-associated benz[a]anthracene-7,12-quinone using high-performance liquid chromatography with in-line reduction and fluorescence detectionTakayuki Kameda
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
J Chromatogr A 1216:6758-61. 2009.... - Direct-acting mutagenicity of extracts of coal burning-derived particulates and contribution of nitropolycyclic aromatic hydrocarbonsRina Taga
Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
Mutat Res 581:91-5. 2005..3. Among the NPAHs examined, 3-nitrobenzanthrone made the largest mutagenic contribution. This is the first report of detection of 3-nitrobenzanthrone in coal burning-derived particulates... - An environmental quinoid polycyclic aromatic hydrocarbon, acenaphthenequinone, modulates cyclooxygenase-2 expression through reactive oxygen species generation and nuclear factor kappa B activation in A549 cellsSang Woon Chung
Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
Toxicol Sci 95:348-55. 2007..These results provide that AcQ might play an important role in human lung inflammatory diseases as an air pollutant... - [How do transport and metabolism affect on the biological effects of polycyclic aromatic hydrocarbons?]Kanae Bekki
Division of Environmental Science and Engineering, Graduate School of Natural Science and Technology, Kanazawa University, Ishikawa, Japan
Yakugaku Zasshi 132:325-9. 2012..In this review, our recent results on the generation of PAH derivatives by atmospheric transport and metabolism are reported. Also, the existing condition of PAHs as atmospheric pollutants is considered... - On-line concentration and fluorescence determination HPLC for polycyclic aromatic hydrocarbons in seawater samples and its application to Japan SeaYing Li
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma machi, Kanazawa, Ishikawa, Japan
Chem Pharm Bull (Tokyo) 60:531-5. 2012.... - Analysis of 8-hydroxy-2'-deoxyguanosine in human urine using hydrophilic interaction chromatography with tandem mass spectrometryChiemi Hosozumi
Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
J Chromatogr B Analyt Technol Biomed Life Sci 893:173-6. 2012..0 and 26.0fmol/injection, respectively. The proposed method makes it possible to monitor the basal level of urinary 8-OHdG from non-exposed healthy subjects and can be used for large-scale human studies... - A role of aryl hydrocarbon receptor in the antiandrogenic effects of polycyclic aromatic hydrocarbons in LNCaP human prostate carcinoma cellsRyoichi Kizu
Graduate School of Natural Science and Technology, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
Arch Toxicol 77:335-43. 2003..These results suggest that AhR can stimulate AP-1 expression resulting in inhibition of the binding of AR to ARE in the transcription regulatory region of target genes such as PSA... - Damage to and recovery of coastlines polluted with C-heavy oil spilled from the NakhodkaKazuichi Hayakawa
Graduate School of Natural Science and Technology, Kanazawa University, Kakama machi, Kanazawa 920 1192, Japan
Water Res 40:981-9. 2006..These results suggest that the coastlines in Ishikawa and Fukui Prefectures that were polluted with C-heavy oil recovered in 3 years... - Simultaneous determination of urinary hydroxylated metabolites of naphthalene, fluorene, phenanthrene, fluoranthene and pyrene as multiple biomarkers of exposure to polycyclic aromatic hydrocarbonsThaneeya Chetiyanukornkul
Environmental Science Program, Faculty of Science, Chiang Mai University, Chiang Mai, 50200, Thailand
Anal Bioanal Chem 386:712-8. 2006..The results showed higher urinary concentrations of OHPAHs in rural villagers, consistent with higher respiratory exposure to PAHs... - Homologue and isomer distribution of dioxins observed in water samples collected from Kahokugata Lagoon and inflowing rivers, JapanHitoshi Kakimoto
Ishikawa Prefectural Institute of Public Health and Environmental Science, 1 11 Taiyogaoka, Kanazawa 920 1154, Japan
Water Res 40:1929-40. 2006..The dyeing discharge was found to make a contribution only in the water samples collected near the plant and the seasonal variation of the contribution might depend on the flow rate of the river... - Analysis of 1-nitropyrene in air particulate matter standard reference materials by using two-dimensional high performance liquid chromatography with online reduction and tandem mass spectrometry detectionJustin P Miller Schulze
Department of Chemistry, University of Washington, Seattle, WA 98195, USA
J Chromatogr A 1167:154-60. 2007..This method is an approximately 10-fold improvement in sensitivity over HPLC methods utilizing fluorescence and/or chemiluminescence detection... - Rapid and sensitive determination of tryptophan, serotonin and psychoactive tryptamines by thin-layer chromatography/fluorescence detectionNoriyuki Kato
Scientific Crime Laboratory, Kanagawa Prefectural Police Headquarters, 155 1 Yamashita cho, Naka ku, Yokohama, Kanagawa 231 0023, Japan
J Chromatogr A 1145:229-33. 2007..The detection limits of Trp, 5-HT and PATs were in the range from 0.01 microg to 0.06 microg. This method was effectively applied to the detection of confiscated PAT powder and PAT in abusers' urine samples... - Simultaneous detection of monohydroxybenzo[a]pyrene positional isomers by reversed-phase liquid chromatography coupled to electrospray ionization mass spectrometryHideki Sasaki
Nihon Waters K K, 3 12, Kitashingawa 1 chome, Shinagawa ku, Tokyo 140 0001, Japan
Biomed Chromatogr 16:432-6. 2002..This method identified 1-, 3- and 9-OH BaPs as the major metabolites, and 2- (and/or 8-) and 12-OH BaPs as the minor metabolites in the incubation mixture... - An automated fluorescence protein sequencer using 7-methylthio-4-(2,1,3-benzoxadiazolyl) isothiocyanate (MTBD-NCS) as an Edman reagentNatsuko Okiyama
Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
Biomed Chromatogr 16:183-6. 2002..Finally, the sequence of a synthetic peptide (25 pmol), leucine-enkephalin-Thr-amide, was determined and up to six residues were successively analyzed...