Takuji Tanaka

Summary

Affiliation: Kanazawa Medical University
Country: Japan

Publications

  1. ncbi Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    BMC Cancer 11:281. 2011
  2. ncbi Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Life Sci 69:1935-45. 2001
  3. ncbi Citrus compounds inhibit inflammation- and obesity-related colon carcinogenesis in mice
    Takuji Tanaka
    Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, Japan
    Nutr Cancer 60:70-80. 2008
  4. ncbi Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats by mandarin juices rich in beta-cryptoxanthin and hesperidin
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 88:146-50. 2000
  5. ncbi Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin
    T Tanaka
    Department of Pathology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 22:193-8. 2001
  6. ncbi Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Biofactors 13:213-8. 2000
  7. ncbi Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Cancer Res 61:2424-8. 2001
  8. ncbi Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:129-37. 2004
  9. ncbi Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
    Takuji Tanaka
    The Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 26:229-38. 2005
  10. ncbi A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293
    Cancer Sci 94:965-73. 2003

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice
    Masahito Shimizu
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, Japan
    BMC Cancer 11:281. 2011
    ..In the present study, we examined the effects of pitavastatin - a drug used for the treatment of hyperlipidemia - on the development of diethylnitrosamine (DEN)-induced liver preneoplastic lesions in C57BL/KsJ-db/db (db/db) obese mice...
  2. ncbi Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Life Sci 69:1935-45. 2001
    ....
  3. ncbi Citrus compounds inhibit inflammation- and obesity-related colon carcinogenesis in mice
    Takuji Tanaka
    Kanazawa Medical University, Daigaku, Uchinada, Ishikawa, Japan
    Nutr Cancer 60:70-80. 2008
    ..1% CUSM, and 59% inhibition by 0.5% CUSM. CUSM treatment also decreased serum level of triglycerides. Our findings suggest that certain citrus materials are capable of inhibiting clitis- and obesity-related colon carcinogenesis...
  4. ncbi Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats by mandarin juices rich in beta-cryptoxanthin and hesperidin
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 88:146-50. 2000
    ..In addition, treatment with MJ, MJ2, or MJ5 significantly increased apoptotic index in colonic adenocarcinoma. These findings might suggest effective chemopreventive ability of MJs, especially MJ5, in colon tumorigenesis...
  5. ncbi Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin
    T Tanaka
    Department of Pathology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 22:193-8. 2001
    ..0002). Our results suggest that the citrus limonoids obacunone and limonin might be useful for the prevention of human colon cancers...
  6. ncbi Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Biofactors 13:213-8. 2000
    ..Thus, citrus bitter limonoids obacunone and limonin possess chemopreventive effects on chemically induced rat colon carcinogenesis...
  7. ncbi Ligands for peroxisome proliferator-activated receptors alpha and gamma inhibit chemically induced colitis and formation of aberrant crypt foci in rats
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Cancer Res 61:2424-8. 2001
    ..Our results suggest that synthetic PPARs ligands (PPARalpha and PPARgamma) can inhibit the early stages of colon tumorigenesis with or without colitis...
  8. ncbi Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:129-37. 2004
    ..These results might suggest dietary feeding of a EDC atrazine did not affect DMBA-induced rat ovarian carcinogenesis...
  9. ncbi Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
    Takuji Tanaka
    The Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 26:229-38. 2005
    ..The findings suggest that DSS exerts powerful tumor-promoting effects on PhIP-initiated colon carcinogenesis in mice and this mouse model is useful for investigating environment-related colon carcinogenesis within a short-term period...
  10. ncbi A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293
    Cancer Sci 94:965-73. 2003
    ....
  11. ncbi A novel geranylated derivative, ethyl 3-(4'-geranyloxy-3'-methoxyphenyl)-2-propenoate, synthesized from ferulic acid suppresses carcinogenesis and inducible nitric oxide synthase in rat tongue
    Takuji Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Oncology 64:166-75. 2003
    ....
  12. ncbi Inhibitory effects of estrogenic compounds, 4-nonylphenol and genistein, on 7,12-dimethylbenz[a]anthracene-induced ovarian carcinogenesis in rats
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Ecotoxicol Environ Saf 52:38-45. 2002
    ..These results might suggest that dietary feeding of estrogenic compounds either synthetic (4-NP) or natural (GS) could act as an inhibitor of DMBA-induced rat ovarian carcinogenesis...
  13. ncbi Modifying effects of dietary capsaicin and rotenone on 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
    Takuji Tanaka
    Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Carcinogenesis 23:1361-7. 2002
    ..Neurosci., 3, 1301-1306, 2000), suggesting that additional studies to confirm the safety of rotenone are warranted...
  14. ncbi Suppressing effects of dietary supplementation of the organoselenium 1,4-phenylenebis(methylene)selenocyanate and the Citrus antioxidant auraptene on lung metastasis of melanoma cells in mice
    T Tanaka
    Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Cancer Res 60:3713-6. 2000
    ..We suggest that these agents, especially p-XSC, may be valuable in preventing metastatic diseases in future studies in the clinic...
  15. ncbi Prevention of colonic aberrant crypt foci by dietary feeding of garcinol in male F344 rats
    T Tanaka
    Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 21:1183-9. 2000
    ..These findings might suggest possible chemopreventive ability of garcinol, through induction of liver GST and QR, inhibition of O(2)(-) and NO generation and/or suppression of iNOS and COX-2 expression, on colon tumorigenesis...
  16. ncbi Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice
    T Tanaka
    First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 20:1471-6. 1999
    ..These findings might suggest that oral administration of citrus auraptene effectively enhanced macrophage and lymphocyte functions in mice...
  17. ncbi Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats
    T Tanaka
    Department of Pathology, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa
    Jpn J Cancer Res 91:25-33. 2000
    ....
  18. ncbi Colorectal cancer chemoprevention by 2 beta-cyclodextrin inclusion compounds of auraptene and 4'-geranyloxyferulic acid
    Takuji Tanaka
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 126:830-40. 2010
    ....
  19. ncbi Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats
    Takuji Tanaka
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Chem Biol Interact 177:128-36. 2009
    ..These results may indicate the beneficial effects of MEL on colitis-related colon carcinogenesis and a potential application for inhibiting colorectal cancer development in the inflamed colon...
  20. ncbi Protein expression analysis of inflammation-related colon carcinogenesis
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    J Carcinog 8:10. 2009
    ..These findings may provide new insights into the mechanisms of inflammation-related colon carcinogenesis and the establishment of novel therapies and preventative strategies to treat carcinogenesis in the inflamed colon...
  21. ncbi Colorectal carcinogenesis: Review of human and experimental animal studies
    Takuji Tanaka
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    J Carcinog 8:5. 2009
    ..The knowledge described herein will help to reduce and prevent this malignancy, which is one of the most frequent neoplasms in some Western and developed countries...
  22. ncbi Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by citrus auraptene in rats
    T Tanaka
    First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Carcinogenesis 19:425-31. 1998
    ....
  23. ncbi Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes
    T Tanaka
    First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Cancer Res 58:2550-6. 1998
    ....
  24. ncbi Diet supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions and fatty liver in male db/db mice
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Int J Cancer 120:252-8. 2007
    ....
  25. ncbi 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Nutr Cancer 59:82-91. 2007
    ..Our findings thus provide some novel insight into the chemopreventive effect of 9t,11t-CLA against preinitiation as well as postinitiation stages of colorectal carcinogenesis...
  26. ncbi Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
    Oncol Rep 16:989-96. 2006
    ..These findings suggest the possible chemopreventive activity of CPO in the early phase of colon carcinogenesis...
  27. ncbi Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 11:4962-7. 2005
    ..Here, we investigated the modifying effects of dietary feeding with a naturally occurring polyphenolic antioxidant flavonoid silymarin on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced prostatic carcinogenesis in male F344 rats...
  28. ncbi A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, 920-0293, Ishikawa, Japan
    Cancer Lett 183:131-9. 2002
    ....
  29. ncbi Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice
    Kei Hayashi
    Department of Surgical Oncology, Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Oshikawaa 020 0903, Japan
    Nutr Cancer 58:75-84. 2007
    ....
  30. ncbi Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms
    Takuji Tanaka
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:25-34. 2006
    ..The findings also suggest that strong oxidative/nitrosative stress caused by DSS-induced inflammation may contribute to the colonic neoplasms development...
  31. ncbi Dietary beta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    Katsuhito Miyazawa
    Department of Urogenital Surgery, Kanazawa Medical University, Ishikawa 920 0293, Japan
    Oncol Rep 17:297-304. 2007
    ..These findings suggest that beta-cryptoxanthin is able to prevent OH-BBN-induced bladder carcinogenesis in mice...
  32. ncbi Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:159-69. 2004
    ..These findings might suggest possible chemopreventive ability of EGb or bilobalide, through alterations in cryptal cell proliferation activity and drug metabolizing enzymes' activities, in colon tumorigenesis...
  33. ncbi A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 121:506-13. 2007
    ..Our findings may suggest that ONO-1714 could therefore serve as an effective agent for suppression of colitis-related colon cancer development in the Apc(Min/+) mice...
  34. ncbi Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    BMC Cancer 5:46. 2005
    ....
  35. ncbi Dietary supplementation of the citrus antioxidant auraptene inhibits N,N-diethylnitrosamine-induced rat hepatocarcinogenesis
    Keiko Sakata
    Department of Pathology, Gifu University School of Medicine, Gifu, Japan
    Oncology 66:244-52. 2004
    ....
  36. ncbi Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:300-5. 2004
    ..These results might suggest that dietary feeding of the estrogenic compounds tOP and BBP did not modulate DMAB-induced prostatic carcinogenesis in rats...
  37. ncbi Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 96:69-76. 2005
    ....
  38. ncbi Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition
    Hiroyuki Kohno
    First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 110:896-901. 2004
    ....
  39. ncbi Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Biofactors 22:111-4. 2004
    ..These findings might suggest that citrus nobiletin has chemopreventive ability against AOM-induced rat colon carcinogenesis...
  40. ncbi Dietary tricin suppresses inflammation-related colon carcinogenesis in male Crj: CD-1 mice
    Takeru Oyama
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa 920 0293, Japan
    Cancer Prev Res (Phila) 2:1031-8. 2009
    ....
  41. ncbi Troglitazone, a ligand for peroxisome proliferator-activated receptor gamma, inhibits chemically-induced aberrant crypt foci in rats
    H Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
    Jpn J Cancer Res 92:396-403. 2001
    ..Our results suggest that troglitazone, a synthetic PPARgamma ligand, can inhibit the early stage of colon tumorigenesis with or without colitis...
  42. ncbi Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    BMC Cancer 7:84. 2007
    ....
  43. ncbi A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 121:2331-9. 2007
    ..Our findings thus show that pitavastatin is effective in inhibiting colitis-related colon carcinogenesis through modulation of mucosal inflammation, oxidative/nitrosative stress, and cell proliferation...
  44. ncbi An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan
    Carcinogenesis 27:619-30. 2006
    ....
  45. ncbi Zerumbone, a tropical ginger sesquiterpene, inhibits colon and lung carcinogenesis in mice
    Mihye Kim
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 124:264-71. 2009
    ....
  46. ncbi Silymarin, a naturally occurring polyphenolic antioxidant flavonoid, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats
    Hiroyuki Kohno
    First Department of Pathology, Kanazawa Medical University, Ishikawa, Japan
    Int J Cancer 101:461-8. 2002
    ....
  47. ncbi Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:2936-42. 2006
    ..Our findings may suggest that certain prenyloxycoumarins, such as auraptene and collinin, could serve as an effective agent against colitis-related colon cancer development in rodents...
  48. ncbi Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 27:162-9. 2006
    ..These differences may have been directly influenced by the response to nitrosation stress due to the inflammation caused by DSS...
  49. ncbi Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 121:1659-64. 2007
    ..These findings indicate that APNH has an initiating activity in inflamed mouse colon and the APNH-DNA adduct formation correlates with its tumorigenic potential...
  50. ncbi Chemopreventive effects of melatonin on diethylnitrosamine and phenobarbital-induced hepatocarcinogenesis in male F344 rats
    K M Wahidur Rahman
    First Department of Pathology, Gifu University School of Medicine, Gifu City 500 8705, Japan
    Nutr Cancer 47:148-55. 2003
    ..These results suggest that melatonin has an antitumor-promoting ability in DEN-initiated and PB-promoted hepatocarcinogenesis in rats...
  51. ncbi A tobacco-specific carcinogen, NNK, enhances AOM/DSS-induced colon carcinogenesis in male A/J mice
    Mihye Kim
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    In Vivo 22:557-63. 2008
    ..2 +/- 1.7). The differences in incidence and multiplicity of lung tumors were insignificant between these two groups. Our findings may suggest that smoking increases the risk of inflammation-related colon cancer development...
  52. ncbi Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    Shigeyuki Sugie
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 117:524-30. 2005
    ..These results suggest that dietary DITC could be a preventive agent against BBN-induced bladder carcinogenesis in mice when fed during the initiation phase...
  53. ncbi Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:481-6. 2004
    ....
  54. ncbi Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 13:2519-25. 2007
    ..Inflammation influences carcinogenesis. In the current study, we investigated whether ursodeoxycholic acid (UDCA) can inhibit colitis-related mouse colon carcinogenesis and compared it with the effects of sulfasalazine...
  55. ncbi Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats
    Shigeyuki Sugie
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 115:346-50. 2005
    ..These results imply that the isothiocyanate compound ANIT shows potent inhibitory effects on mammary carcinogenesis induced by PhIP in female SD rats when administered during the initiation stage...
  56. ncbi Aqueous and ethanolic extract fractions from the Brazilian propolis suppress azoxymethane-induced aberrant crypt foci in rats
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Oncol Rep 20:493-9. 2008
    ..Our findings suggest that AEP and EEP possess a chemopreventive ability in the early phase of colon carcinogenesis through the modulation of cell proliferation...
  57. ncbi Lack of modifying effects of 4-n-octylphenol on 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan
    Ecotoxicol Environ Saf 51:210-5. 2002
    ..These results might suggest that dietary feeding of the weak estrogenic compound 4-n-octylphenol did not have modulating effects on DMAB-induced rat prostatic carcinogenesis...
  58. ncbi Dietary protocatechuic acid during the progression phase exerts chemopreventive effects on chemically induced rat tongue carcinogenesis
    Rikako Suzuki
    The First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Asian Pac J Cancer Prev 4:319-26. 2003
    ..001) during progression phase. Our results suggest that dietary PCA inhibits progression of 4-NQO-induced oral carcinogenesis, and such inhibition might be related to suppression of cell proliferation by PCA...
  59. ncbi Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of beta-carotene
    T Tanaka
    First Department of Pathology, Gifu University School of Medicine, Japan
    Cancer Res 54:4653-9. 1994
    ..05). In addition, polyamine levels in the oral mucosa were lowered in rats treated with 4-NQO and three test compounds when compared to those give 4-NQO alone (P < 0.05).(ABSTRACT TRUNCATED AT 400 WORDS)..
  60. ncbi Inhibitory effect of mandarin juice rich in beta-cryptoxanthin and hesperidin on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced pulmonary tumorigenesis in mice
    H Kohno
    Department of Pathology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan
    Cancer Lett 174:141-50. 2001
    ..These findings might suggest that MJ5, which contain 3.9 mg beta-cryptoxanthin and 100 mg hesperidin in 100 g sample), has chemopreventive ability against NNK-induced mouse lung tumorigenesis...
  61. ncbi Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Jpn J Cancer Res 93:133-42. 2002
    ..These findings might suggest possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis...
  62. ncbi Modifying effects of a flavonoid morin on azoxymethane-induced large bowel tumorigenesis in rats
    T Tanaka
    First Department of Pathology and Department of Otolaryngology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 20:1477-84. 1999
    ..These results indicate that morin could exert a weak chemopreventive effect on large bowel tumorigenesis induced by AOM when fed during the post-initiation phase...
  63. ncbi Dietary administration of citrus nobiletin inhibits azoxymethane-induced colonic aberrant crypt foci in rats
    H Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Life Sci 69:901-13. 2001
    ..These findings might suggest possible chemopreventive ability of nobiletin, through suppression of cell proliferating activity of ACF, in the development of ACF...
  64. ncbi Dietary indole-3-carbinol promotes endometrial adenocarcinoma development in rats initiated with N-ethyl-N'-nitro-N-nitrosoguanidine, with induction of cytochrome P450s in the liver and consequent modulation of estrogen metabolism
    Midori Yoshida
    Department of Pathology, Sasaki Institute, Tokyo, Japan
    Carcinogenesis 25:2257-64. 2004
    ....
  65. ncbi Chemoprevention of azoxymethane-induced rat colon carcinogenesis by dietary capsaicin and rotenone
    S I Yoshitani
    Department of General and Gastrointestinal Surgery, Kanazawa Medical University, Ishikawa 920-0293, Japan
    Int J Oncol 19:929-39. 2001
    ..19%, 68% reduction, P=0.0226). Our results suggest that two natural compounds, capsaicin and rotenone, might be useful for the prevention of human colon cancers...
  66. ncbi A COX-2 inhibitor, nimesulide, inhibits chemically-induced rat tongue carcinogenesis through suppression of cell proliferation activity and COX-2 and iNOS expression
    K Yoshida
    Department of Pathology, Gifu University School of Medicine, Gifu, Japan
    Histol Histopathol 18:39-48. 2003
    ....
  67. ncbi Microadenomatous lesions involving loss of Apc heterozygosity in the colon of adult Apc(Min/+) mice
    Yasuhiro Yamada
    Department of Pathology, Gifu University School of Medicine, Gifu 500 8705, Japan
    Cancer Res 62:6367-70. 2002
    ..Our results may give an account for the low incidence of colonic tumors in Apc(Min/+) mice...
  68. ncbi Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats
    Shingo Miyamoto
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Oncol Rep 15:1169-73. 2006
    ..These findings might suggest a possible chemopreventive activity of chrysin in the early step of colon tumorigenesis through modulation of cryptal cell proliferation activity and apoptosis...
  69. ncbi Intranuclear localization of proliferating cell nuclear antigen during the cell cycle in renal cell carcinoma
    K Kawamura
    Department of Urology, Kanazawa Medical University, Ishikawa, Japan
    Anal Quant Cytol Histol 22:107-13. 2000
    ..To investigate, with laser scanning cytometry (LSC), proliferating cell nuclear antigen (PCNA) expression during the cell cycle in renal cell carcinoma...
  70. ncbi Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane
    R Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Histol Histopathol 20:483-92. 2005
    ..Thus, our findings indicate that a tumor-promoting effect of DSS was dose-dependent (1% or more) and the effect might occur under the condition of inflammation and nitrosation stress...
  71. ncbi A case of giant extramammary Paget's disease of the genital area with squamous-cell carcinoma
    H Tanabe
    Department of Dermatology, Tenri Hospital, Tenri City, Japan
    Dermatology 202:249-51. 2001
    ..A skin biopsy specimen showed the coexistence of typical Paget's disease and highly differentiated SCC invading the dermis. Immunohistochemical staining of both cell types was completely different...
  72. ncbi Modifying effect of tuna orbital oil rich in docosahexaenoic acid and vitamin D3 on azoxymethane-induced colonic aberrant crypt foci in rats
    H Kohno
    Department of Serology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Oncol Rep 7:1069-74. 2000
    ....
  73. ncbi DNA ploidy analysis of urinary tract epithelial tumors by laser scanning cytometry
    K Kawamura
    Department of Urology, Kanazawa Medical University, Ishikawa, Japan
    Anal Quant Cytol Histol 22:26-30. 2000
    ..To evaluate a rapid and simple method for DNA content analysis of urinary tract epithelial tumors with laser scanning cytometry (LSC)...
  74. ncbi Gene expression of prothrombin in human and rat kidneys: basic and clinical approach
    K Suzuki
    Department of Urology, Kanazawa Medical University, Ishikawa, Japan
    J Am Soc Nephrol 10:S408-11. 1999
    ..Serum concentration measurements can be considered useful for assessment of recovery from acute tubular necrosis after renal transplantation and for diagnosis of acute rejection...
  75. ncbi Centrosome hyperamplification and chromosomal instability in bladder cancer
    K Kawamura
    Department of Urology, Kanazawa Medical University, 1 1 Daigaku Uchinada, 920 0293, Ishikawa, Japan
    Eur Urol 43:505-15. 2003
    ..Centrosome hyperamplification (CH) occurs frequently in human cancers, and may be a contributing factor in CIN. In this study, we investigated the relationship between CH and CIN in bladder cancer...
  76. ncbi Induction of HITS, a newly identified family with sequence similarity 107 protein (FAM107B), in cancer cells by heat shock stimulation
    Hideo Nakajima
    Department of Medical Oncology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku, Ishikawa 920 0293, Japan
    Int J Oncol 37:583-93. 2010
    ..Thus HITS would be a potential tumor suppressor gene similar to TU3A containing heat responding elements, which contrasts with previously described oncogenic activities of other heat shock proteins such as HSP70 and HSP90...
  77. ncbi Proliferative activity of renal cell carcinoma associated with acquired cystic disease of the kidney: comparison with typical renal cell carcinoma
    Ryosuke Ikeda
    Department of Urology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Hum Pathol 33:230-5. 2002
    ..01% +/- 13.4%; P <.05) than in tRCCs (42.27% +/- 26.1%). These results indicate that the RCC-As are less proliferative than tRCC and are consistent with the observation that RCC-As are less aggressive neoplasms...
  78. ncbi PPAR Ligands for Cancer Chemoprevention
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    PPAR Res 2008:548919. 2008
    ..This short review summarizes currently available data on the role of PPAR ligands in carcinogenesis...
  79. ncbi Decrease of metastatic ability after selection for intravasating ability in Lewis lung carcinoma (3LL) cell line
    T Ota
    1st Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Cancer Lett 139:105-8. 1999
    ..Such a cell line has never been reported so far. The matched pair of cell lines described in this report provides a useful system for investigating the primary steps of metastasis...
  80. ncbi The diagnostic significance of lactate dehydrogenase isoenzymes in urinary cytology
    A Nishikawa
    Department of Pathology, Gifu University School of Medicine, Japan
    Br J Cancer 63:819-21. 1991
    ....
  81. ncbi Hepatocarcinogenic activities of hydroxymethyl derivatives of 4-(N,N-dimethylamino)azobenzene in ACI/N rats
    H Mori
    Department of Pathology, Gifu University School of Medicine, Japan
    J Natl Cancer Inst 79:1159-61. 1987
    ..These data suggest that 3'-CH2OH-DAB is the most potent hepatocarcinogen in the series of azo dyes. Possible reasons for the potency of the chemical are discussed...
  82. ncbi Effects of a synthetic polyprenoic acid (E-5166) on the gap junction of rat hepatocytes treated with liver tumor promoters, phenobarbital, and p,p'-dichlorodiphenyltrichloroethane
    S Sugie
    Department of Pathology, Gifu University School of Medicine, Japan
    Toxicol Pathol 22:398-403. 1994
    ..However, the unit area of gap junctions in DDT and E-5166-treated rats did not differ from in controls.(ABSTRACT TRUNCATED AT 250 WORDS)..
  83. ncbi Nodal T/NK-cell lymphoma of nasal type: a clinicopathological study of six cases
    E Takahashi
    Department of Pathology, Aichi Medical University Hospital, Nagakute, Japan
    Histopathology 52:585-96. 2008
    ....
  84. ncbi Localization of Bax and Bcl-2 proteins, regulators of programmed cell death, in the human central nervous system
    A Hara
    Department of Pathology, Gifu, University School of Medicine, Japan
    Virchows Arch 429:249-53. 1996
    ..A possible relationship between the localization of Bax or Bcl-2 proteins and the cell vulnerability in central nervous system is discussed...
  85. ncbi Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells
    Yumiko Yasui
    Graduate School of Fisheries Sciences, Hokkaido University, 3-1-1 Minato, Hakodate, Hokkaido 041-8611, Japan
    Prostaglandins Leukot Essent Fatty Acids 73:113-9. 2005
    ..These results suggest that BGO-FFA rich in 9c,11t,13t-CLN may induce apoptosis in Caco-2 cells through up-regulation of GADD45, p53 and PPARgamma...
  86. ncbi A novel rasH2 mouse carcinogenesis model that is highly susceptible to 4-NQO-induced tongue and esophageal carcinogenesis is useful for preclinical chemoprevention studies
    Shingo Miyamoto
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Carcinogenesis 29:418-26. 2008
    ....
  87. ncbi Expression of retinoid X receptor alpha is decreased in 3'-methyl-4-dimethylaminoazobenzene-induced hepatocellular carcinoma in rats
    Nobuhiro Ando
    Department of Medicine, Gifu University School of Medicine, Gifu 501 1194, Japan
    Oncol Rep 18:879-84. 2007
    ....
  88. ncbi Chemopreventive effects of a flavonoid antioxidant silymarin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    Pham Quang Vinh
    Department of Urology, Gifu University School of Medicine, Gifu 500 8705, Japan
    Jpn J Cancer Res 93:42-9. 2002
    ..These findings suggest that silymarin is effective in preventing OH-BBN-induced bladder carcinogenesis in mice...
  89. ncbi Mouse strain differences in inflammatory responses of colonic mucosa induced by dextran sulfate sodium cause differential susceptibility to PhIP-induced large bowel carcinogenesis
    Masako Nakanishi
    Biochemistry Division, National Cancer Center Research Institute, 5 1 1 Tsukiji, Tokyo 104 0045, Japan
    Cancer Sci 98:1157-63. 2007
    ..The present results provide strong evidence that prolonged chronic inflammatory responses induced by DSS are directly responsible for the observed enhancement of PhIP-induced large bowel carcinogenicity...
  90. ncbi Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice
    Shingo Miyamoto
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Carcinogenesis 29:1057-63. 2008
    ..Taken together, our results suggest that higher levels of leptin in serum promote colon carcinogenesis in mice, whereas NOB has chemopreventive effects against colon carcinogenesis, partly through regulation of leptin levels...
  91. ncbi Effects of extract of Ginkgo biloba leaves and its constituents on carcinogen-metabolizing enzyme activities and glutathione levels in mouse liver
    Keiko Sasaki
    Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari Tobetsu, Japan
    Life Sci 70:1657-67. 2002
    ....
  92. ncbi Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells
    Tetsuro Sano
    Pharmaceutical Research Laboratories, Nikken Chemicals Co, Saitama, Japan
    Nutr Cancer 51:197-206. 2005
    ..These results suggest that NIK-333 is a promising drug for the chemoprevention of HCC by uniquely suppressing the early events of hepatocarcinogenesis, that is, development of both oval-like cells and fibrogenesis...
  93. ncbi Dietary rutin, but not its aglycone quercetin, ameliorates dextran sulfate sodium-induced experimental colitis in mice: attenuation of pro-inflammatory gene expression
    Ki Han Kwon
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606-8502, Japan
    Biochem Pharmacol 69:395-406. 2005
    ..Our results suggest that rutin may be useful for the prevention and treatment of IBD and colorectal carcinogenesis via attenuation of pro-inflammatory cytokine production...
  94. ncbi Fucoxanthin induces apoptosis and enhances the antiproliferative effect of the PPARgamma ligand, troglitazone, on colon cancer cells
    Masashi Hosokawa
    Graduate School of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate, Hakodate, Hokkaido 041 8611, Japan
    Biochim Biophys Acta 1675:113-9. 2004
    ..These findings indicate that fucoxanthin may act as a chemopreventive and/or chemotherapeutic carotenoid in colon cancer cells by modulating cell viability in combination with troglitazone...
  95. ncbi Suppression of beta-catenin mutation by dietary exposure of auraptene, a citrus antioxidant, in N,N-diethylnitrosamine-induced hepatocellular carcinomas in rats
    Akira Hara
    Department of Tumor Pathology, Graduate School of Medicine, Gifu University, 1 1 Yanagido, Gifu 501 1194, Japan
    Oncol Rep 14:345-51. 2005
    ..These results demonstrate that AUR exposure in post-initiation period suppresses the occurrence of HCCs with beta-catenin mutation, presumably by negative selection for neoplastic cells harboring the mutation...
  96. ncbi Lack of enhancing effects of degraded lambda-carrageenan on the development of beta-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethane
    Kazuya Hata
    BMR Laboratories, Sunplanet Co, Ltd, 4388 Hagiwara, Kamiishidu, Yoro-gun, Gifu 503-1602, Japan
    Cancer Lett 238:69-75. 2006
    ..Our results may indicate no enhancing or promoting effects of degraded lambda-carrageenan on colon carcinogenesis in mice initiated with AOM...
  97. ncbi Extract of Kurosu, a vinegar from unpolished rice, inhibits azoxymethane-induced colon carcinogenesis in male F344 rats
    Yumi Shimoji
    Research Center, Tamanoi Vinegar, CO, Ltd, Nara, Japan
    Nutr Cancer 49:170-3. 2004
    ..05), compared with those in the AOM alone group. These findings suggest that EK may be effective for inhibiting colon carcinogenesis...
  98. ncbi Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate
    Rikako Suzuki
    Research Fellow of the Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo 102-8471, Japan
    Cancer Sci 95:721-7. 2004
    ..Our results suggest that combined treatment of mice with AOM and DSS generates neoplasms in the colonic mucosa via dysplastic lesions induced by nitrosative stress...
  99. ncbi beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice
    Kazuya Hata
    BMR Laboratories, Sunplanet Co, Ltd, 4388 Hagiwara, Kamiishidu, Yourou, Gifu 503 1602, Japan
    Cancer Lett 239:123-8. 2006
    ..Also, a few microadenomas were detected in Apc(Min/+) mice of 5-week old. Our results may indicate need of further investigation of the colorectal mucosa of Apc(Min/+) mice for examining colorectal carcinogenesis using Apc(Min/+) mice...
  100. ncbi Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis
    Masumi Suzui
    Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Int J Oncol 27:1391-9. 2005
    ..Therefore, the present study may provide further evidence for the ambivalent modulatory activity of I3C and this information may be useful when including I3C in cancer chemoprevention and/or extensive clinical therapy trials...
  101. ncbi Sphingosine kinase 1 is up-regulated in colon carcinogenesis
    Toshihiko Kawamori
    Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    FASEB J 20:386-8. 2006
    ..These results suggest that the SK1/S1P pathway may play an important role in colon carcinogenesis, in part, by regulating COX-2 expression and PGE2 production...