Research Topics
| Y IshiuraSummaryAffiliation: Kanazawa University Country: Japan Publications
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Detail Information
Publications
Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndromeYoshihisa Ishiura
The Department of Internal Medicine, Toyama City Hospital, Toyama, Japan
Cough 6:7. 2010..However, little is known about the role of COX-2 in chronic productive cough in patients with sinobronchial syndrome known as neutrophilic bronchial inflammation...- COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthmaY Ishiura
Department of Internal Medicine, Toyama City Hospital, Toyama, Japan
J Investig Allergol Clin Immunol 19:370-4. 2009..This study was designed to investigate the role of COX-2 in cough reflex sensitivity in patients with asthma... - Effect of an orally active Th2 cytokine inhibitor, suplatast on "atopic cough" tosilateYoshihisa Ishiura
Department of Respiratory Medicine, Toyama City Hospital, Toyama, Japan
Arzneimittelforschung 58:297-302. 2008.... - In vivo PAF-induced airway eosinophil accumulation reduces bronchial responsiveness to inhaled histamineYoshihisa Ishiura
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa Graduate University School of Medicine, Kanazawa, Japan
Prostaglandins Other Lipid Mediat 75:1-12. 2005..These results suggest that in vivo airway eosinophils may reduce nonspecific bronchial responsiveness through production of inhibitory or bronchoprotective prostanoids, but not through histaminase production... - Th2 cytokine inhibition and cough in asthmatic and bronchitic patientsYoshihisa Ishiura
The Department of Internal Medicine, Toyama City Hospital, Toyama, Japan
Ann Med 36:623-9. 2004.... - Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstrictionYoshihisa Ishiura
Kanazawa Graduate University School of Medicine, Kanazawa, Japan
J Investig Allergol Clin Immunol 13:79-86. 2003.... - Effect of carbocysteine on cough reflex to capsaicin in asthmatic patientsYoshihisa Ishiura
Division of Pulmonary Medicine, Wajima Municipal Hospital, Wajima, Japan
Br J Clin Pharmacol 55:504-10. 2003..This study was designed to investigate the clinical effect of carbocysteine for cough sensitivity in patients with bronchial asthma... - Thromboxane antagonism and cough in chronic bronchitisYoshihisa Ishiura
The Division of Pulmonary Medicine, Wajima Municipal Hospital, Wajima, Japan
Ann Med 35:135-9. 2003..The increased eicosanoid synthesis has been suggested as the underlying mechanism of chronic productive cough in patients with chronic bronchitis... - Lack of adrenomedullin on antigen-induced bronchoconstriction in guinea pigs in vivoYoshihisa Ishiura
Pulmonary Medicine, Cellular Transplantation Biology, Kanazawa, Graduate University School of Medicine, Japan
Life Sci 72:1963-72. 2003..We conclude that an intravenous administration of adrenomedullin does not influence antigen-induced bronchoconstriction or bronchial responsiveness to inhaled methacholine or histamine in vivo... - Effects of suplatast tosilate, a new type of anti-allergic agent, on airway cough hypersensitivity induced by airway allergy in guinea-pigsS Myou
Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
Clin Exp Allergy 31:1939-44. 2001..Suplatast tosilate, an anti-allergic agent, is a T helper (Th)2 cytokine inhibitor that inhibits the synthesis of interleukin (IL)-4, IL-5, immunoglobulin (Ig)E production, and local eosinophil accumulation... - Bronchodilator effect of inhaled olprinone, a phosphodiesterase 3 inhibitor, in asthmatic patientsS Myou
Third Department of Internal Medicine and Laboratory of Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
Am J Respir Crit Care Med 160:817-20. 1999..The bronchodilator effect of olprinone was greater than that of salbutamol in four of the nine patients. These results suggest that the inhaled PDE3 inhibitor has a bronchodilator effect in asthmatic patients... - In vivo airway eosinophil accumulation induced by polymyxin-B reduces bronchial responsiveness in guinea pigsY Ishiura
Third Department of Internal Medicine, Kanazawa University School of Medicine, Takara machi, Kanazawa, Japan
Clin Exp Allergy 31:644-51. 2001..However, it has not been studied whether airway eosinophils enhance or inhibit bronchial responsiveness in vivo... - Effect of losartan, a type 1 angiotensin II receptor antagonist, on bronchial hyperresponsiveness to methacholine in patients with bronchial asthmaS Myou
Third Department of Internal Medicine and Department of Laboratory Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
Am J Respir Crit Care Med 162:40-4. 2000..456 (GSEM, 0.186) mg/ml with losartan. We conclude that AT1 receptors are involved in bronchial hyperresponsiveness in asthmatic patients. This is the first report demonstrating the involvement of AT1 receptors in bronchial asthma... - Potentiation of allergic bronchoconstriction by repeated exposure to formaldehyde in guinea-pigs in vivoT Kita
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Postgraduate School of Medicine, Kanazawa 920 8640, Japan
Clin Exp Allergy 33:1747-53. 2003..Indoor formaldehyde (FA) might worsen allergies and be an underlying factor for the increasing incidence and severity of asthma; the exact mechanism, however, remains unclear... - Inhaled lysophosphatidylcholine provokes bronchoconstriction in guinea pigs in vivoKouichi Nobata
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
Eur J Pharmacol 520:150-5. 2005.... - Central muscarinic mechanisms regulating voiding in ratsY Ishiura
Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
J Pharmacol Exp Ther 297:933-9. 2001..t.) indicate that muscarinic excitatory mechanisms are tonically active. These findings raise the possibility that voiding function is regulated by both inhibitory and excitatory cholinergic mechanisms in the central nervous system... - Longitudinal changes of pulmonary function and bronchial responsiveness in cough-variant asthma treated with bronchodilators aloneKouichi Nobata
Department of Internal Medicine, Kurobe City Hospital, Kurobe, Japan
Allergy Asthma Proc 27:479-85. 2006..Because bronchial hyperresponsiveness has been shown to be a risk factor for typical asthma onset from CVA, the effect of inhaled corticosteroids on the longitudinal changes in bronchial responsiveness should be examined... - Effect of intranasal administration of CV-11974, a type 1 angiotensin II receptor antagonist, on airway hyperresponsiveness and airway inflammation induced by antigen inhalation in guinea pigsShigeharu Myou
Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
Int Arch Allergy Immunol 129:86-92. 2002..Angiotensin II is a putative mediator in asthma, but the effect of topical administration of type 1 angiotensin II (AT1) receptor antagonists on allergic airway reactions is not known... - Ambroxol for the prevention of acute upper respiratory diseaseK Nobata
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
Clin Exp Med 6:79-83. 2006..Treatment with ambroxol also significantly reduced the median number of AURD episodes in this assessment (P=0.0028 vs. rebamipide in the second half-year). In conclusion, ambroxol may be useful for preventing AURD... - Antitussive effects of the leukotriene receptor antagonist montelukast in patients with cough variant asthma and atopic coughToshiyuki Kita
Department of Respiratory Medicine, National Hospital Organization Kanazawa Medical Center, Toyama, Japan
Allergol Int 59:185-92. 2010..To evaluate the antitussive effect of montelukast, a leukotriene receptor antagonist, in CVA and AC... - Bronchodilator effects of intravenous olprinone, a phosphodiesterase 3 inhibitor, with and without aminophylline in asthmatic patientsShigeharu Myou
Third Department of Internal Medicine, Kanazawa University School of Medicine, Kanazawa, Japan
Br J Clin Pharmacol 55:341-6. 2003..We compared the bronchodilator effects of intravenously administered olprinone, a selective PDE3 inhibitor, and aminophylline, a nonselective PDE inhibitor, both alone and concomitantly... - Single ectopic vaginal ureter diagnosed by computed tomographyK Komatsu
Department of Urology, Kanazawa University School of Medicine, Kanazawa, Japan
Urol Int 63:147-50. 1999..Excretory urography and renal sonography failed to visualize the dysplastic kidney, but enhanced computed tomography clearly demonstrated a poorly functioning hypoplastic kidney, ectopic ureter and vagina filled with contrast medium... - Bronchial asthma showing reduction in FEV1 after inhalation of QvarKouichi Nobata
Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Kanazawa, Japan
J Asthma 43:427-8. 2006..These findings would be noteworthy when using Qvar for Japanese patients with asthma known to have a relatively high frequency of the complication of alcohol-induced asthma... - Dehydroepiandrosterone alleviates copulatory disorder induced by social stress in male ratsTsuyoshi Mizuno
Department of Urology, Kanazawa University School of Medicine, Kanazawa, Japan
J Sex Med 3:612-8; discussion 618. 2006..We suggest that the decreased endogenous DHEA is involved in copulatory disorders induced by social stress in rats... - Asthma severity is associated with an increase in both blood CXCR3+ and CCR4+ T cellsKazuyoshi Kurashima
Respiratory Medicine, Cellular Transplantation Biology, Kanazawa Graduate University, School of Medicine, Kanazawa, Japan
Respirology 11:152-7. 2006..However, the relationship between peripheral blood Th2 cells and asthma severity has not been thoroughly investigated... - Pulmonary sarcoidosis with usual interstitial pneumonia distributed predominantly in the lower lung fieldsKouichi Nobata
Department of Internal Medicine, Ishikawa Prefectural Central Hospital, Kanazawa
Intern Med 45:359-62. 2006..These findings may enlighten the assist in understanding of the process of development of pulmonary sarcoidosis... - Effect of ozagrel hydrochloride, a thromboxane synthetase inhibitor, on alcoholic beverage-induced bronchoconstriction in asthmatic patientsShigeharu Myou
The Third Department of Internal Medicine, Kanazawa University School of Medicine, Japan
Prostaglandins Leukot Essent Fatty Acids 66:397-401. 2002..We conclude that TXA(2) is not involved in alcoholic beverage-induced bronchoconstriction... - Alpha(1L)-, but not alpha(1H)-, adrenoceptor antagonist prevents allergic bronchoconstriction in guinea pigs in vivoKouichi Nobata
The Third Department of Internal Medicine, Kanazawa University School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
Eur J Pharmacol 452:97-104. 2002..These results indicate that prevention of antigen-induced bronchoconstriction by blockade of alpha-adrenoceptors is due to the inhibition of mediator release via alpha(1L)-adrenoceptor antagonism... - Effect of candesartan, a type 1 angiotensin II receptor antagonist, on bronchial hyper-responsiveness to methacholine in patients with bronchial asthmaShigeharu Myou
The Third Department of Internal Medicine, Kanazawa University School of Medicine, 13 1 Takara machi, Kanazawa 920 8641, Japan
Br J Clin Pharmacol 54:622-6. 2002..We examined the effect of candesartan cilexetil, a specific angiotensin II type 1 (AT1) receptor antagonist, on bronchial responsiveness to inhaled methacholine in patients with asthma...