Research Topics
Genomes and Genes | Takuro KanekuraSummaryAffiliation: Kagoshima University Country: Japan Publications
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Detail Information
Publications
Ultrastructural localization of basigin in normal human epidermisX Chen
Department of Dermatology, Kagoshima University Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima, 890 8520, Japan
Histochem Cell Biol 115:465-70. 2001..Microvilli on basal and suprabasal keratinocytes might play roles in the differentiation of keratinocytes through basigin on the tips of microvilli...- Skin disorders with prominent eosinophilic infiltration treated successfully with nicotine. Report of two casesTakuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Dermatology 208:153-7. 2004..Nicotine was effective in the treatment of skin disorders attributable to neutrophils such as pyoderma gangrenosum and orogenital ulcerations due to Behçet's disease... - Improvement of adult Still's disease with granulocyte and monocyte adsorption apheresisT Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
Clin Exp Dermatol 29:410-2. 2004..Her joint pain responded dramatically to the GCAP therapy, suggesting that GCAP may be useful for treating adult Still's disease. We present a detailed description of the patient and this novel therapy... - Treatment of Behçet's disease with granulocyte and monocyte adsorption apheresisTakuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
J Am Acad Dermatol 51:S83-7. 2004..Our results demonstrate that granulocyte and monocyte adsorption apheresis may be useful for treating orogenital ulcerations of Behçet's disease... - Three dimensional structural studies of alpha-N-acetylgalactosaminidase (alpha-NAGA) in alpha-NAGA deficiency (Kanzaki disease): different gene mutations cause peculiar structural changes in alpha-NAGAs resulting in different substrate specificities and cTakuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
J Dermatol Sci 37:15-20. 2005..Although they are on the same codon, the clinical manifestation was more severe in R329W because an amino acid substitution led to protein instability resulting in structural change, which is greater in R329W than in R329Q... - Selenium deficiency: report of a caseT Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
Clin Exp Dermatol 30:346-8. 2005..The clinical similarity to zinc deficiency and the literature yielded important clues for a diagnosis of selenium deficiency in this patient... - Eruptive pruritic papular porokeratosis: a pruritic variant of porokeratosisTakuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 33:813-6. 2006..Histopathological examination revealed the characteristic cornoid lamellae. We describe this case in detail and provide a review of the published work... - Treatment of pyoderma gangrenosum with granulocyte and monocyte adsorption apheresisTakuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Ther Apher Dial 9:292-6. 2005..The turgid skin lesions containing pustules and ulcers of the other patient showed amelioration and a marked decrease in the volume of exudate. Our results suggest that GCAP is a useful treatment modality for pyoderma gangrenosum... - Immunoelectron-microscopic detection of globotriaosylceramide accumulated in the skin of patients with Fabry diseaseT Kanekura
Anatomy, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Br J Dermatol 153:544-8. 2005..The major glycolipid accumulated in tissue is globotriaosylceramide (GL-3). To date, no direct detection of GL-3 by immunoelectron microscopy has been reported... - Granulocyte and monocyte adsorption apheresis for cutaneous allergic vasculitisTakuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Ther Apher Dial 10:287-90. 2006..9 MFI (mean fluorescence intensity) to 27.0 MFI (normal controls: 10.5 +/- 1.2 MFI) by GCAP, respectively. These results suggest that GCAP is useful for skin disorders with leucocytoclastic vasculitis... - Treatment of psoriatic arthritis with granulocyte and monocyte adsorption apheresisTakuro Kanekura
Department of Dermatology, University Faculty of Medicine, Kogoshima, Japan
J Am Acad Dermatol 50:242-6. 2004..Treatment with GCAP resulted in remarkable clearing of joint pain, suggesting that GCAP is valuable for treating arthritis as well as skin disorders. We present a detailed description of these patients and this novel therapy... - Granulocyte and monocyte adsorption apheresis (GCAP) for refractory skin diseases caused by activated neutrophils and psoriatic arthritis: evidence that GCAP removes Mac-1-expressing neutrophilsTakuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Ther Apher Dial 10:247-56. 2006..GCAP was useful for treating neutrophilic dermatoses and PsA. GCAP adsorbs Mac-1-expressing neutrophils to the CA beads by the binding of complement component (iC3b) on CA beads and CD11b expressed on activated neutrophils... - Basigin (CD147) is expressed on melanoma cells and induces tumor cell invasion by stimulating production of matrix metalloproteinases by fibroblastsTakuro Kanekura
Department of Dermatology, Kagoshima University Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8530, Japan
Int J Cancer 99:520-8. 2002..Basigin is highly expressed in melanoma cells and may play an important role in their invasiveness and metastasis by stimulating surrounding fibroblasts to express MMPs... - The involvement of NF-kappaB in the constitutive overexpression of cyclooxygenase-2 in cyclooxygenase-1 null cellsTakuro Kanekura
Department of Dermatology, Kagoshima University Faculty of Medicine, Japan
Biochim Biophys Acta 1542:14-22. 2002.... - Efficacy of topical tacrolimus for treating the malar rash of systemic lupus erythematosusT Kanekura
Department of Dermatology, Kagoshima University Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Br J Dermatol 148:353-6. 2003..Although the study is preliminary, the results demonstrate that topical tacrolimus may be useful for treating the malar rash of SLE... - Beneficial effects of synthetic phospholipid polymer, poly(2-methacryloyloxyethyl phosphorylcholine-co-n-butyl methacrylate), on stratum corneum functionT Kanekura
Department of Dermatology, Kagoshima University Faculty of Medicine, Japan
Clin Exp Dermatol 27:230-4. 2002..Our results indicate that this substance may be useful clinically in the treatment of dry skin... - CD147/basigin promotes progression of malignant melanoma and other cancersTakuro Kanekura
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
J Dermatol Sci 57:149-54. 2010..These findings strongly suggest CD147 as a possible therapeutic target for overcoming metastasis and MDR, major obstacles to the effective treatment of malignant cancers... - Treatment of pustular psoriasis with granulocyte and monocyte adsorption apheresisTakuro Kanekura
Department of Dermatology, Kagoshima University, Japan
J Am Acad Dermatol 49:329-32. 2003..We present detailed descriptions of these patients and this novel therapy... - Metastatic cutaneous squamous cell carcinoma treated successfully with surgery, radiotherapy and S-1/cisplatin chemotherapyShigeto Matsushita
Department of Dermatology, Field of Sensory Organology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 37:666-70. 2010..The chemotherapeutic agent S-1/cisplatin was selected based on results of the histoculture drug response assay. The patient responded dramatically to this multidisciplinary treatment and complete remission was achieved... - ER signaling is activated to protect human HaCaT keratinocytes from ER stress induced by environmental doses of UVBKentaro Mera
Department of Dermatology, Field of Sensory Organology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Biochem Biophys Res Commun 397:350-4. 2010..This is the first report to show ER signaling in UVB-irradiated keratinocytes... - Negative feedback regulation of phosphatidylinositol 3-kinase/Akt pathway by over-expressed cyclooxygenase-2 in human epidermal cancer cellsKoichiro Takeda
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 31:516-23. 2004..COX-2 inhibitor NS398 up-regulated Akt phosphorylation. These results imply that constitutively over-expressed COX-2 down-regulates the Akt phosphorylation through a negative feedback mechanism... - Extramammary Paget's disease/carcinoma successfully treated with a combination chemotherapy: report of two casesYuji Mochitomi
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
J Dermatol 32:632-7. 2005..We describe two patients with EMPD/C whose metastatic lesions responded well to this combination of chemotherapy... - Retinoic acids exhibit anti-fibrotic activity through the inhibition of 5-lipoxygenase expression in scleroderma fibroblastsRong Xiao
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kagoshima, Japan
J Dermatol 38:345-53. 2011.... - A CD147-targeting siRNA inhibits the proliferation, invasiveness, and VEGF production of human malignant melanoma cells by down-regulating glycolysisJuan Su
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Cancer Lett 273:140-7. 2009..These results strongly suggest that highly-expressed CD147 interacts with MCT1 and 4 to promote tumor cell glycolysis, resulting in the progression of MM... - Proteome analysis of multidrug resistance of human oral squamous carcinoma cells using CD147 silencingYe Hong Kuang
Department of Dermatology, Xiang Ya Hospital, Central South University, Hunan, 410008, China, Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, 890 8520, Japan
J Proteome Res 7:4784-91. 2008..We document an abundance of molecules that interact with CD147 in the MDR of human oral squamous carcinoma cells. Additional studies are needed to investigate these novel target proteins of CD147... - Immunohistochemical comparison of beta-catenin expression by human normal epidermis and epidermal tumorsKeiko Fukumaru
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 34:746-53. 2007.... - The 3G5 antigen is expressed in dermal mast cells but not pericytesAkira Gushi
Department of Dermatology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Japan
J Cutan Pathol 35:278-84. 2008..This study was designed to determine whether the expression of the 3G5 antigen is restricted to specific stages of pericyte development, or if it is expressed in other cells rather than pericytes in capillary vessels... - Thrombomodulin exerts cytoprotective effect on low-dose UVB-irradiated HaCaT cellsMasahiro Iwata
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
Biochem Biophys Res Commun 377:642-7. 2008.... - Contact dermatitis due to orchids (Cymbidium and Oncidium)Masahiro Iwata
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Japan
J Dermatol 33:115-7. 2006..A diagnosis of contact dermatitis attributable to the cultivated orchids was made... - Evaluation of a newly-developed immunochromatography strip test for diagnosing dermatophytosisYuko Higashi
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima City Hospital, Kagoshima, Japan
Int J Dermatol 51:406-9. 2012..Traditionally, dermatophytosis, a common disease affecting millions of people world-wide, has been diagnosed by direct microscopy and fungal culture. The immunochromatography (ICG) strip test was recently developed... - Multicentric Castleman disease with cutaneous manifestations: report of 2 cases and comparison with systemic plasmacytosisYuko Higashi
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Dermatology 214:170-3. 2007..PCR disclosed clonal T-cell receptor gene rearrangement in the bone marrow cells of 1 patient. We discuss the possible relationship between multicentric Castleman disease and systemic plasmacytosis as well as plasma cell proliferation... - Primary squamous cell carcinoma of the frontal sinusNobuyo Yoshida
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 33:855-7. 2006..Herein, we present a detailed description of this patient and a review of the published work... - Beneficial effects of tissue inhibitor of metalloproteinases-2 (TIMP-2) on chronic dermatitisHayao Miyoshi
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 32:346-53. 2005..05). Our results suggest that NC/Kuj mice with Df extract-induced chronic eczema may be a useful model for investigating chronic dermatitis, and that TIMP-2 may be a good agent for treating chronic dermatitis as well as chronic ulcers... - Estrogen dermatitis: a dendritic-cell-mediated allergic conditionShinichi Yotsumoto
Department of Dermatology, Kagoshima University Faculty of Medicine, Kagoshima, Japan
Dermatology 207:265-8. 2003..Most estrogen dermatitides are induced by local or systemic contact dermatitis where dendritic cells are central, and tamoxifen has a blocking effect on dendritic cells... - Epidermodysplasia-verruciformis-like eruption associated with gamma-papillomavirus infection in a patient with adult T-cell leukemiaKazuhiro Kawai
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
Dermatology 219:274-8. 2009..This is the first documentation of an association between EV-like eruption and gamma-papillomavirus infection... - Possible role of transcriptional coactivator P/CAF and nuclear acetylation in calcium-induced keratinocyte differentiationHisashi Kawabata
Department of Dermatology and Laboratory of Molecular Medicine, Kagoshima University, Faculty of Medicine, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
J Biol Chem 277:8099-105. 2002..Our results suggest that P/CAF HAT activity and induction of ap97 are involved in calcium-dependent keratinocyte differentiation... - Role for E-cadherin as an inhibitory receptor on epidermal gammadelta T cellsYouhei Uchida
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima 890 8544, Japan
J Immunol 186:6945-54. 2011.... - Case of adult T-cell leukemia with pulmonary involvement presenting as nodular shadowsKimitaka Oyama
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima, Japan
J Dermatol 35:225-8. 2008..Our review of the published work found only two previously reported cases of ATL with pulmonary involvement manifested as nodular shadows. Herein, we present details on the third case... - Immunohistochemical studies comparing the localization of type XV collagen in normal human skin and skin tumors with that of type IV collagenTomoko Fukushige
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima, Japan
J Dermatol 32:74-83. 2005..These findings suggest that type XV collagen plays a role in the adherence of the basement membrane to surrounding connective tissue and that it may be associated with the tumorigenesis of keratinocytes and melanocytes... - Spontaneous regression of recurrent and metastatic Merkel cell carcinomaHidemichi Kubo
Department of Dermatology, Field of Sensory Organology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 34:773-7. 2007..Although she received no treatment due to her poor condition, the recurrent metastatic lesion regressed spontaneously within 2 months... - Granulomas induced by subcutaneous injection of leuprorelin acetateRyoko Sakamoto
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 33:43-5. 2006..A biopsy of the nodules disclosed epithelioid granulomatous inflammation and resulted in a diagnosis of drug-induced granulomatous reaction to leuprorelin acetate... - Syringocystadenoma papilliferum: report of the first case on the lower legNoriko Yoshii
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 31:939-42. 2004..A 26-year-old man had an asymptomatic tumor on his lower leg. Histopathological examination showed it to be a typical SCAP on organoid nevus. This is the first report of SCAP on the lower leg... - Syringoma-like eccrine sweat duct proliferation induced by radiationNoriko Yoshii
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 33:36-9. 2006..The lesions spread rapidly on her chest during radiation therapy and regressed spontaneously 3 weeks after its completion. We postulate that the lesions were induced by radiation, and promoted by anti-estrogen therapy... - CD147-targeting siRNA inhibits cell-matrix adhesion of human malignant melanoma cells by phosphorylating focal adhesion kinaseRie Nishibaba
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan
J Dermatol 39:63-7. 2012..Our results suggest that CD147/basigin regulates the adhesion of MM cells to extracellular matrices and of integrin ?1 signaling via the phosphorylation of FAK... - Genetic analysis of the ferrochelatase gene in eight Japanese patients from seven families with erythropoietic protoporphyriaHiroshi Saruwatari
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, Sakuragaoka, Kaoshima, Japan
J Dermatol 33:603-8. 2006..All patients were C/C homozygous for IVS3-48. The allelic frequency of IVS3-48C polymorphism in the healthy Japanese volunteers was 67.8% (103/152)... - Unusual anogenital apocrine tumor resembling mammary-like gland adenoma in male perineum: a case reportKazuhito Hatanaka
Department of Molecular and Cellular Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, 8 35 1 Sakuragaoka, Kagoshima 890 8544, Japan
Diagn Pathol 5:42. 2010.... - Pseudoxanthoma elasticum (PXE)-like calcification in adult dermatomyositisAkiyo Gushi
Department of Dermatology, Kagoshima University Faculty of Medicine, Japan
J Dermatol 29:423-6. 2002..The calcification clinically disappeared without any specific treatment except for prednisolone and cyclophosphamide... - A case of antiepiligrin cicatricial pemphigoid with nephrotic syndromeYuri Uchino
Department of Dermatology, Kagoshima University Faculty of Medicine, Kagoshima, Japan
J Dermatol 31:228-31. 2004..To our knowledge, the association of antiepiligrin cicatricial pemphigoid with nephrotic syndrome has not been reported previously... - Bidens pilosa suppresses interleukin-1beta-induced cyclooxygenase-2 expression through the inhibition of mitogen activated protein kinases phosphorylation in normal human dermal fibroblastsNobuyo Yoshida
Department of Dermatology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
J Dermatol 33:676-83. 2006..The physiological activities and clinical effectiveness of BP observed under diverse conditions may be partly attributable to its ability to inhibit MAPK, mainly p38, activity, COX-2 expression, and subsequent PGE(2) production... - Crusted scabies in an adult T-cell leukemia/lymphoma patient successfully treated with oral ivermectinKentaro Yonekura
Department of Hematology, Imamura Bun in Hospital, Kagoshima, Japan
J Dermatol 33:139-41. 2006..While ivermectin may be useful for treating intractable scabies, attention must be paid to the possible appearance of ivermectin-resistant mites... - Detection and sequences of human papillomavirus DNA in nongenital seborrhoeic keratosis of immunopotent individualsAkiyo Gushi
Faculty of Medicine, Department of Dermatology, Kagoshima University, 8 35 1, Sakuragaoka, 890 8520, Kagoshima, Japan
J Dermatol Sci 31:143-9. 2003..In the present study, HPVs were frequently detected from genital lesions or hair follicle in immunocompromised host... - The role of thymidine phosphorylase in the induction of early growth response protein-1 and thrombospondin-1 by 5-fluorouracil in human cancer carcinoma cellsShigeto Matsushita
Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890 8520, Japan
Int J Oncol 36:1193-200. 2010.... - Anti-NXP2 autoantibodies in adult patients with idiopathic inflammatory myopathies: possible association with malignancyYuki Ichimura
Correspondence to Manabu Fujimoto, Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
Ann Rheum Dis 71:710-3. 2012..Recent studies have shown that anti-NXP2 antibody (Ab) is a major MSA in juvenile dermatomyositis (JDM). In this study the frequencies and clinical associations of anti-NXP2 Ab were evaluated in adult patients with IIM... - A pediatric case of sclerodermatous chronic graft-versus-host diseaseKenjiro Terasaki
Department of Dermatology, Kagoshima University, Faculty of Medicine, Kagoshima, Japan
Pediatr Dermatol 20:327-31. 2003..Furthermore, treating this disease is even more difficult in children. In the future, clarification of the pathogenesis of chronic GVHD and establishment of therapy will be necessary...