Research Topics
Genomes and Genes
| Hiroshi TokumitsuSummaryAffiliation: Kagawa University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Generation of autonomous activity of Ca(2+)/calmodulin-dependent protein kinase kinase ? by autophosphorylationHiroshi Tokumitsu
Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
Biochemistry 50:8193-201. 2011....- Identification and characterization of PRG-1 as a neuronal calmodulin-binding proteinHiroshi Tokumitsu
Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
Biochem J 431:81-91. 2010..The combined observations suggest that PRG-1 may be involved in postsynaptic functions regulated by intracellular Ca2+-signalling... - Phosphorylation of Numb regulates its interaction with the clathrin-associated adaptor AP-2Hiroshi Tokumitsu
Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
FEBS Lett 580:5797-801. 2006..These findings suggest a novel mechanism for the regulation of Numb-mediated endocytosis, namely through direct phosphorylation... - Phosphorylation of Numb family proteins. Possible involvement of Ca2+/calmodulin-dependent protein kinasesHiroshi Tokumitsu
Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
J Biol Chem 280:35108-18. 2005..Taken together, these results indicate that the Numb family proteins may be intracellular targets for CaM-Ks, and they may also be regulated by phosphorylation-dependent interaction with 14-3-3 protein... - Mechanism of the generation of autonomous activity of Ca2+/calmodulin-dependent protein kinase IVHiroshi Tokumitsu
Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
J Biol Chem 279:40296-302. 2004..Taken together, these results indicated that the Thr196 phosphorylation of CaM-KIV by CaM-KK reduced the interaction of the catalytic core with the autoinhibitory region, resulting in generation of the autonomous activity... - Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cellsYumi Ishikawa
Department of Signal Transduction Sciences, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
FEBS Lett 550:57-63. 2003..This sustained activation of CaM-KIdelta was completely abolished by Thr180Ala mutation and inhibited by CaM-KK inhibitor, STO-609, indicating a functional CaM-KK/CaM-KIdelta cascade in HeLa cells... - Identification and characterization of wolframin, the product of the wolfram syndrome gene (WFS1), as a novel calmodulin-binding proteinSaki Yurimoto
Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
Biochemistry 48:3946-55. 2009..This observation may indicate that CaM binding is important for wolframin function and that impairment of this interaction by mutation contributes to the pathology seen in Wolfram syndrome... - S100A1 is a novel molecular chaperone and a member of the Hsp70/Hsp90 multichaperone complexMiki Okada
Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
J Biol Chem 279:4221-33. 2004..The results demonstrate a novel physiological function for S100A1 and bring us closer to a comprehensive understanding of the molecular mechanisms of the Hsp70/Hsp90 multichaperone complex... - Identification of a novel CaMKK substrateTomohito Fujimoto
Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
Biochem Biophys Res Commun 410:45-51. 2011..This is the first report that CaMKK is capable of phosphorylating a non-kinase substrate suggesting the possibility of CaMKK-mediated novel Ca(2+)-signaling pathways that are independent of downstream protein kinases... - Activation of SAD kinase by Ca2+/calmodulin-dependent protein kinase kinaseTomohito Fujimoto
Department of Signal Transduction Sciences, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
Biochemistry 47:4151-9. 2008.... - Role of calcium-calmodulin-dependent protein kinase cascade in thyrotropin (TSH)-releasing hormone induction of TSH and prolactin gene expressionKoji Murao
First Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
Endocrinology 145:4846-52. 2004..These results indicate that the CaM-KK-CaM-KIV cascade probably plays an important role in TRH induction of TSH and PRL transcriptional activity in pituitary cells... - Exendin-4 regulates GLUT2 expression via the CaMKK/CaMKIV pathway in a pancreatic ?-cell lineKe Chen
Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe Miki cho, Kagawa 761 0793, Japan
Metabolism 60:579-85. 2011..In summary, activation of the CaMKK/CaMKIV cascade might be required for exendin-4-induced GLUT2 gene transcription, indicating that exendin-4 plays an important role in insulin secretion in pancreatic ?-cells... - Regulation of nuclear localization signal-importin ? interaction by Ca2+/S100A6Maki Takata
Department of Signal Transduction Sciences, Kagawa University, Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa 761 0793, Japan
FEBS Lett 584:4517-23. 2010..These results indicate S100A6 may regulate the nuclear transport of NLS-cargos in response to increasing concentrations of intracellular Ca(2+)... - Exendin-4 regulates pancreatic ABCA1 transcription via CaMKK/CaMKIV pathwayJunhua Li
Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe Miki cho, Kita gun, Kagawa, Japan
J Cell Mol Med 14:1083-7. 2010..Activation of the CaMKK/CaMKIV cascade by exendin-4 stimulated ABCA1 gene transcription, indicating that exendin-4 plays an important role in insulin secretion and cholesterol ester content in pancreatic beta cells... - A single amino acid difference between alpha and beta Ca2+/calmodulin-dependent protein kinase kinase dictates sensitivity to the specific inhibitor, STO-609Hiroshi Tokumitsu
Department of Signal Transduction Sciences, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
J Biol Chem 278:10908-13. 2003.... - S100 proteins regulate the interaction of Hsp90 with Cyclophilin 40 and FKBP52 through their tetratricopeptide repeatsSeiko Shimamoto
Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, Kita gun, Kagawa, Japan
FEBS Lett 584:1119-25. 2010..These findings have suggested that the Ca(2+)/S100 proteins are TPR-targeting regulators of the immunophilins-Hsp90 complex formations... - Regulatory mechanism of Dictyostelium myosin light chain kinase AHiroshi Tokumitsu
Department of Signal Transduction Sciences, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
J Biol Chem 279:42-50. 2004.... - Transcriptional regulation of nuclear orphan receptor, NOR-1, by Ca(2+)/calmodulin-dependent protein kinase cascadeHiroyuki Inuzuka
Department of Chemistry, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Japan
FEBS Lett 522:88-92. 2002..7 kb NOR-1 promoter containing triple cAMP response elements. Disruption of each element significantly reduced the promoter activity, indicating the direct transcriptional regulation of NOR-1 by CaM-KIV cascade... - The role of calcium/calmodulin-dependent protein kinase cascade on MIP-1alpha gene expression of ATL cellsKensuke Matsumoto
Division of Endocrinology, Metabolism and Hematology, Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
Exp Hematol 36:390-400. 2008..In this study, we investigated the effect of extracellular calcium on MIP-1alpha secretion in ATL cells and the role of Ca(2+)/calmodulin (CaM)-dependent protein kinase (CaM-K) cascade in transcriptional activation of MIP-1alpha... - STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinaseHiroshi Tokumitsu
Department of Chemistry, Kagawa Medical University, 1750 1 Miki cho, Kita gun, Kagawa 761 0793, Japan
J Biol Chem 277:15813-8. 2002.... - Neuronal calcium sensor proteins are direct targets of the insulinotropic agent repaglinideMiki Okada
Department of Signal Transduction Sciences, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
Biochem J 375:87-97. 2003..In addition, since repaglinide selectively targets NCS proteins among the EF-hand Ca2+-binding proteins, it is a potential lead compound for the development of more potent NCS antagonists... - Calcium/calmodulin-dependent protein kinase I inhibits neuronal nitric-oxide synthase activity through serine 741 phosphorylationTao Song
Department of Cell Physiology, Kagawa University, Faculty of Medicine, 1750 1 Ikenobe, Miki cho, Kida gun, Kagawa 761 0793, Japan
FEBS Lett 570:133-7. 2004..These results raise the possibility of a novel cross-talk between nNOS and CaM-K I through the phosphorylation of Ser741 on nNOS... - The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expressionXiao Yu
First Department of Internal Medicine, Kagawa Medical University, 1750 1, Miki cho, Kita gun, Kagawa, 761 0793, Japan
Diabetes 53:1475-81. 2004..Taken together, these results indicated that the CaM-KK/CaM-KIV cascade might play an important role in glucose-upregulated transcriptional activation of the insulin gene... - Interactions of S100A2 and S100A6 with the tetratricopeptide repeat proteins, Hsp90/Hsp70-organizing protein and kinesin light chainSeiko Shimamoto
Department of Signal Transduction Sciences, Kagawa University Faculty of Medicine, 1750 1 Ikenobe, Kita gun, Kagawa 761 0793, Japan
J Biol Chem 283:28246-58. 2008..Thus, our findings suggest a new intracellular Ca2+-signaling pathway via S100 proteins-TPR motif interactions... - Hsp90 is a direct target of the anti-allergic drugs disodium cromoglycate and amlexanoxMiki Okada
Department of Signal Transduction Sciences, Kagawa Medical University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa 761-0793, Japan
Biochem J 374:433-41. 2003..DSCG and amlexanox may serve as useful tools for evaluating the physiological significance of Hsp90... - Knockdown of nuclear Ca2+/calmodulin-dependent protein kinase phosphatase causes developmental abnormalities in zebrafishTakaki Nimura
Department of Life Sciences, Faculty of Agriculture, Kagawa University, Kagawa 761 0795, Japan
Arch Biochem Biophys 457:205-16. 2007..A number of apoptotic cells were observed in brain and spinal cord of the abnormal embryos. These results suggest that zCaMKP-N plays a crucial role in the early development of zebrafish... - A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegansYoshishige Kimura
Department of Functional Genomics, Medical Research Institute, Tokyo Medical and Dental University, Japan
EMBO Rep 3:962-6. 2002..Utilizing a transgenic approach to visualize CREB-dependent transcription in vivo, we show that this CaMK cascade regulates CRE-mediated transcription in a subset of head neurons in living nematodes... - Regulation of axonal extension and growth cone motility by calmodulin-dependent protein kinase IGary A Wayman
Vollum Institute, Oregon Health and Science University, Portland, Oregon 97239 3011, USA
J Neurosci 24:3786-94. 2004..These results identify CaMKI as a positive transducer of growth cone motility and axon outgrowth and provide a new physiological role for the CaMKK-CaMKI pathway... - 14-3-3 Proteins directly regulate Ca(2+)/calmodulin-dependent protein kinase kinase alpha through phosphorylation-dependent multisite bindingTohru Ichimura
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, Tokyo, Japan
FEBS Lett 582:661-5. 2008..The mode of regulation described herein differs the recently described mode of 14-3-3 regulation of CaMKKalpha... - Interaction of S100 proteins with the antiallergic drugs, olopatadine, amlexanox, and cromolyn: identification of putative drug binding sites on S100A1 proteinMiki Okada
Department of Chemistry, Department of Dermatology, Kagawa Medical University, 1750-1, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan
Biochem Biophys Res Commun 292:1023-30. 2002..Therefore, these drugs may serve as useful tools for evaluating the physiological significance of S100 protein family... - Post-synaptic density-95 promotes calcium/calmodulin-dependent protein kinase II-mediated Ser847 phosphorylation of neuronal nitric oxide synthaseYasuo Watanabe
Department of Cell Physiology, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kida gun, Japan
Biochem J 372:465-71. 2003..Thus PSD-95 mediates cellular trafficking of nNOS, and may be required for the efficient phosphorylation of nNOS at Ser(847) by CaM-K II in neuronal cells... - Characterization of Ca2+/calmodulin-dependent protein kinase I as a myosin II regulatory light chain kinase in vitro and in vivoFutoshi Suizu
Department of Biological Science, Graduate School of Science, Hiroshima University, Higashi Hiroshima 739 8526, Japan
Biochem J 367:335-45. 2002..This is the first demonstration that the activation of the CaM-KI cascade induces myosin II phosphorylation, resulting in regulation of actin filament organization in mammalian cells... - Distinct developmental expression of two isoforms of Ca2+/calmodulin-dependent protein kinase kinases and their involvement in hippocampal dendritic formationAkifumi Kamata
Division of Histology, Department of Cell Biology, Graduate School of Medicine, Tohoku University, Sendai 980 8575, Japan
Neurosci Lett 423:143-8. 2007..Our present findings provide the detailed anatomical information on the developmental expression of CaMKKs and the functional involvement of CaMKK in the formation of primary dendrites... - Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growthAkifumi Kamata
Division of Histology, Department of Cell Biology, Graduate School of Medicine, Japan
Neurosci Res 57:86-97. 2007....