Research Topics
Species | Makoto HiraiSummaryAffiliation: Jichi Medical School Country: Japan Publications
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Detail Information
Publications
Characterization and identification of exflagellation-inducing factor in the salivary gland of Anopheles stephensi (Diptera: Culicidae)M Hirai
Department of Medical Zoology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
Biochem Biophys Res Commun 287:859-64. 2001..The exflagellation-inducing activity in the salivary gland declined immediately after a blood meal, implying that GAF was in the saliva, and was delivered into the midgut together with the blood and induced exflagellation in the midgut...- Fertilization is a novel attacking site for the transmission blocking of malaria parasitesMakoto Hirai
Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, School of Medicine, Shimotsuke City, Tochigi, Japan
Acta Trop 114:157-61. 2010..We discuss the possibility of whether malaria GCS1 is a novel type of transmission blocking vaccine, by which anti-malaria GCS1 antibody may halt parasite fertilization and subsequent developments in the mosquitoes... - Male fertility of malaria parasites is determined by GCS1, a plant-type reproduction factorMakoto Hirai
Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University School of Medicine, Shimotsuke City, Tochigi 329 0498, Japan
Curr Biol 18:607-13. 2008..Our present findings provide a new viewpoint for understanding the parasitic fertilization system and important clues for novel strategies to attack life-threatening parasites... - cDNA cloning, functional expression and characterization of kynurenine 3-hydroxylase of Anopheles stephensi (Diptera: Culicidae)M Hirai
Department of Medical Zoology, Jichi Medical School, Minamikawachi, Tochigi, Japan
Insect Mol Biol 11:497-504. 2002..9 +/- 6.2 and 865.6 +/- 10.5 nmol/min/mg protein, respectively. The optimum pH of AsK3H was 7.0. Analysis of AsK3H gene expression using RT-PCR revealed that AsK3H was constitutively expressed in egg, larva, pupa and adult... - PbGCbeta is essential for Plasmodium ookinete motility to invade midgut cell and for successful completion of parasite life cycle in mosquitoesMakoto Hirai
Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Tochigi, 329 0498
J Biochem 140:747-57. 2006..These results demonstrate that PbGCbeta is essential for ookinete motility when passing through the midgut cells, but not for further development of the parasites... - Glucose-6-phosphate dehydrogenase (G6PD) mutations in Cambodia: G6PD Viangchan (871G>A) is the most common variant in the Cambodian populationHiroyuki Matsuoka
Department of Medical Zoology, Jichi Medical School, 3311 1 Yakushij, Minami Kawachi, Tochigi 329 0498, Japan
J Hum Genet 50:468-72. 2005..All G6PD Viangchan cases were linked to two other mutations of 1311C>T and IVS-11 nt93T>C in the G6PD gene... - Seven different glucose-6-phosphate dehydrogenase variants including a new variant distributed in Lam Dong Province in southern VietnamHiroyuki Matsuoka
Division of Medical Zoology, Department of Infection and Immunity, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
Acta Med Okayama 61:213-9. 2007..It is interesting that G6PD Mahidol (487G>A), another common variant in continental Southeast Asian populations in Myanmar, Thailand, and Malaysia, has not been detected from the Vietnamese... - Production of a transgenic mosquito expressing circumsporozoite protein, a malarial protein, in the salivary gland of Anopheles stephensi (Diptera: Culicidae)Hiroyuki Matsuoka
Division of Medical Zoology, Jichi Medical University, Shimotsuke, Tochigi 329 0498, Japan
Acta Med Okayama 64:233-41. 2010..We consider that CSP in the SG was not secreted properly into the saliva. Further techniques and trials are required in order to realize vaccine-delivering mosquitoes... - Glucose-6-phosphate dehydrogenase (G6PD) mutations in Myanmar: G6PD Mahidol (487G>A) is the most common variant in the Myanmar populationHiroyuki Matsuoka
Department of Medical Zoology, Jichi Medical School, 3311 1 Yakushiji, Minami Kawachi, Tochigi, 329 0498, Japan
J Hum Genet 49:544-7. 2004..3% (73/80) of G6PD variants were G6PD Mahidol. This finding suggests that the Myanmar population is derived from homogeneous ancestries and are different from Thai, Malaysian, and Indonesian populations... - Two cases of glucose-6-phosphate dehydrogenase-deficient Nepalese belonging to the G6PD Mediterranean-type, not India-Pakistan sub-type but Mediterranean-Middle East sub-typeHiroyuki Matsuoka
Department of Medical Zoology, Jichi Medical School, 3311 1 Yakushiji, Minamikawachi, Tochigi 329 0498, Japan
J Hum Genet 48:275-7. 2003..Thus, these two subjects in Kathmandu, Nepal, would be closer to people in Middle East countries than people in India. This is the first study of molecular analysis for G6PD deficiency in Nepal... - A rodent malaria, Plasmodium berghei, is experimentally transmitted to mice by merely probing of infective mosquito, Anopheles stephensiHiroyuki Matsuoka
Department of Medical Zoology, Jichi Medical School, Minami Kawachi, Tochigi 329 0498, Japan
Parasitol Int 51:17-23. 2002..At present, the mechanism is not clear, although we propose here the existence of the skin stage of malaria parasites before the liver stage and the blood stage... - Cross-reactivity in rapid diagnostic tests between human malaria and zoonotic simian malaria parasite Plasmodium knowlesi infectionsSatoru Kawai
Center for Tropical Medicine and Parasitology, Dokkyo Medical University, Tochigi, 321 0293, Japan
Parasitol Int 58:300-2. 2009..falciparum and higher than P. vivax. Thus, commercial RDTs based on detection of pLDH should be used with great caution, and should not replace conventional microscopy in the diagnosis of suspected cases of P. knowlesi malaria... - Cloning, expression and phylogenetic analysis of Hemolin, from the Chinese oak silkmoth, Antheraea pernyiWenli Li
Department of Genetics, Microbiology and Toxicology, Stockholm University, Svante Arrheniuse v. 16E, SE-106 91 Stockholm, Sweden
Dev Comp Immunol 29:853-64. 2005..The comparisons also show variable regions of specific interest for future studies of hemolin and its interaction with microbial entities... - Bombyx mori orphan receptor, BmHR78: cDNA cloning, testis abundant expression and putative dimerization partner for Bombyx ultraspiracleMakoto Hirai
Department of Development and Differentiation, National Institute of Agrobiological Science, 1 2 Owashi, Tsukuba, 305 8634, Ibaraki, Japan
Mol Cell Endocrinol 189:201-11. 2002..Thus, BmHR78 is a third dimerization partner for USP and may modulate the molecular action of USP, including the ecdysone signal cascades... - Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouseKyosuke Takeshita
First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai, Showa, Nagoya 466 8550, Japan
Semin Thromb Hemost 28:545-54. 2002..These observations suggest that in the process of aging the PAI-1 gene expression is increased, contributing to the development of thrombosis... - Phylogeny and evolution of the SERA multigene family in the genus PlasmodiumNobuko Arisue
Department of Molecular Protozoology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamadaoka Suita, Osaka 565 0871, Japan
J Mol Evol 65:82-91. 2007..Here, we reveal an evolutionary trail of SERA gene cluster in the genus Plasmodium and discuss a phylogeny of Plasmodium species from the viewpoint of the evolution of a multigene family... - Prevalence and severity of left atrial edema detected by electron beam tomography early after pulmonary vein ablationTaro Okada
Division of Cardiology, Aichi Prefectural Cardiovascular and Respiratory Center, Ichinomiya, Japan
J Am Coll Cardiol 49:1436-42. 2007..The aim of this study was to investigate the prevalence and severity of left atrial (LA) edema after pulmonary vein (PV) ablation and its effect on the cardiac function... - Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarctionKyosuke Takeshita
Department of Cardiology, Nagoya University Graduate School of Medicine, Showa, Japan
Am J Pathol 164:449-56. 2004.... - Sinoatrial node dysfunction and early unexpected death of mice with a defect of klotho gene expressionKyosuke Takeshita
Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Circulation 109:1776-82. 2004..Homozygous mutant mice with a defect of klotho gene expression (kl/kl) show multiple age-related disorders and premature death from unknown causes... - Biochemical and biological responses induced by coupling of Gab1 to phosphatidylinositol 3-kinase in RET-expressing cellsKengo Maeda
Department of Pathology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
Biochem Biophys Res Commun 323:345-54. 2004..These findings demonstrated that coupling of Gab1 to PI3K is important for biological responses in RET-expressing cells...