Research Topics
Species | Y AokiSummaryAffiliation: Japan Tobacco Inc Country: Japan Publications
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Detail Information
Publications
Stimulation of G-CSF gene expression in the macrophage cell line by contact with extracellular matrix proteins and a pre-B leukaemia cell lineY Aoki
Laboratory of Life Science and Biomolecular Engineering, Japan Tobacco, Inc, Kanagawa, Japan
Cytokine 10:596-602. 1998..These results indicate that there are several pathways via the cell-to-ECM and cell-to-cell interactions triggering the induction of G-CSF in the macrophages...- Functional coupling of adenosine A2a receptor to inhibition of the mitogen-activated protein kinase cascade in Chinese hamster ovary cellsD Hirano
Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
Biochem J 316:81-6. 1996..These results suggest that cyclic AMP production through Ado A2a receptor inhibits thrombin-elicited MAPK activation by a Ca(2+)-independent/wortmannin-sensitive pathway in CHO cells... - Cloning and functional expression of a cDNA encoding a mouse type 2 neuropeptide Y receptorM Nakamura
Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
Biochim Biophys Acta 1284:134-7. 1996.... - Efficient screening for catalytic antibodies using a short transition-state analog and detailed characterization of selected antibodiesN Takahashi
Laboratory of Life Science and Biomolecular Engineering, Japan Tobacco, Inc, Yokohama, Kanagawa, Japan
Eur J Biochem 261:108-14. 1999..The detailed analysis of kinetic and binding parameters for these antibodies gives us further insight into catalytic antibodies... - Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptorsM Nakamura
Life Science Research Laboratory, Japan Tobacco Inc, Kanagawa, Japan
J Biol Chem 270:30102-10. 1995..These results suggest that the Y1 beta receptor is an embryonic and a bone marrow form of the NPY-Y1 receptor, which decreases in the expression during development and differentiation... - Effects of renal sorbitol accumulation on urinary excretion of enzymes in hyperglycaemic ratsN Ishii
Department of Clinical Chemistry, Kitasato University School of Allied Health Sciences, Sagamihara, Kanagawa, Japan
Ann Clin Biochem 38:391-8. 2001..These results suggest that accumulation of intracellular sorbitol leads to proximal tubular cell dysfunction and abnormal enzymuria... - Depletion of the squalene synthase (ERG9) gene does not impair growth of Candida glabrata in miceH Nakayama
Department of Mycology, Nippon Roche K K Research Center, Kanagawa, Japan
Antimicrob Agents Chemother 44:2411-8. 2000..These results showed that squalene synthase could not be a suitable target of antifungals for the treatment of C. glabrata infection... - Isolation and characterization of mutations in the human holocarboxylase synthetase cDNAY Suzuki
Department of Biomedical Genetics, Tohoku University School of Medicine, Sendai, Japan
Nat Genet 8:122-8. 1994..coli, suggesting a functional relationship between the two proteins. The human HCS gene maps to chromosome 21q22.1... - Structure and expression of the glycine cleavage system in rat central nervous systemY Sakata
Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, 980 8574, Sendai, Japan
Brain Res Mol Brain Res 94:119-30. 2001..Our results suggest that the GCS plays a major role in the forebrain and cerebellum rather than in the spinal cord, and that N-methyl-D-aspartate receptor may participate in neuropathogenesis of NKH... - RNA interference may be more potent than antisense RNA in human cancer cell linesY Aoki
The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
Clin Exp Pharmacol Physiol 30:96-102. 2003..With further studies on the RNAi phenomenon in cancer cells, RNAi could provide a novel approach for cancer gene therapy... - Chemotactic response of Brugia pahangi infective larvae to jird serum in vitroN K Gunawardena
Department of Parasitology, Institute of Tropical Medicine, Nagasaki University, Sakamoto, 852 8523 Nagasaki, Japan
Parasitol Res 90:337-42. 2003..pahangi larvae to host serum. We conclude that B. pahangi larvae show a chemotaxic response to host serum, and that cAMP and cAMP dependent protein kinase are involved in the signal transduction... - Structure of human holocarboxylase synthetase gene and mutation spectrum of holocarboxylase synthetase deficiencyX Yang
Department of Medical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
Hum Genet 109:526-34. 2001.... - Chromosomal localization, structure, single-nucleotide polymorphisms, and expression of the human H-protein gene of the glycine cleavage system (GCSH), a candidate gene for nonketotic hyperglycinemiaS Kure
Department of Medical Genetics, Tohoku University School of Medicine, Sendai, Japan
J Hum Genet 46:378-84. 2001..In contrast, the P-protein gene was expressed in a limited number of tissues, such as liver, kidney, brain, pituitary gland, and thyroid gland, suggesting distinct transcriptional regulation of each GCS constituent... - Effects of loperamide and other opioid-related substances on the transcriptional regulation of the rat pro-opiomelanocortin gene in AtT20 cellsA Nomura
First Department of Internal Medicine, Nagoya University School of Medicine and Hospital, Nagoya, Japan
Neuroendocrinology 74:87-94. 2001..This effect does not seem to be mediated through the classical mu-opioid receptor but rather in part through a calcium/calmodulin-related mechanism... - Characterization of the bi-directional transcriptional control region between the human UFD1L and CDC45L genesH Igaki
Division of Molecular Genetics, National Institute of Infectious Diseases, 1-23-1, Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan
Biochem Biophys Res Commun 283:569-76. 2001..The deletion analyses revealed the basal activities of the three core promoters, which were enhanced by approximately twofold by the respective regulatory promoters, on the transfected DNA templates... - Isolation and cloning of rat poly(ADP-ribose) glycohydrolase: presence of a potential nuclear export signal conserved in mammalian orthologsT Shimokawa
Biochemistry Division, National Cancer Center Research Institute, Chuo Ku, Tokyo, 104 0045, Japan
J Biochem 126:748-55. 1999..Northern blot analysis showed the ubiquitous expression of a single 4.0 kb Parg mRNA in various rat tissues. The findings suggest that the 60 kDa Parg is produced by post-transcriptional processing... - Functional expression of human leukocyte elastase (HLE)/medullasin in eukaryotic cellsK Okano
Basic Research Laboratories, Toray Industries Inc, Kamakura, Japan
Biochem Biophys Res Commun 167:1326-32. 1990..As the fusion protein was designed to be connected through lysine residue, elastase activity was generated after digestion of the fusion protein with lysyl-endopeptidase... - Identification of holocarboxylase synthetase (HCS) proteins in human placentaM Hiratsuka
Department of Biochemical Genetics, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 77, Japan
Biochim Biophys Acta 1385:165-71. 1998..These results suggest that our human HCS cDNA encodes the cytosolic forms of the enzyme. These results also suggest that mRNA encoding cytosolic HCS can be translated from all three translation initiation codons, Met1, Met7 and Met58... - Two CPT2 mutations in three Japanese patients with carnitine palmitoyltransferase II deficiency: functional analysis and association with polymorphic haplotypes and two clinical phenotypesK Wataya
Department of Biochemical Genetics, Tohoku University School of Medicine, Sendai, Japan
Hum Mutat 11:377-86. 1998..In all three families with CPT II deficiency, the E174K mutation resided only on the F1V1M1 allele, whereas the F383Y mutation was observed on the F2V2M1 allele, suggesting a single origin for each mutation... - Molecular analysis of holocarboxylase synthetase deficiency: a missense mutation and a single base deletion are predominant in Japanese patientsY Aoki
Department of Biochemical Genetics, Tohoku University School of Medicine, Sendai, Japan
Biochim Biophys Acta 1272:168-74. 1995..This PCR-based technique may therefore be useful for detecting mutations among Japanese patients... - Phylogenetic relationships among vertebrate visual pigmentsO Hisatomi
Department of Biology, Faculty of Science, Osaka University, Toyonaka, Japan
Vision Res 34:3097-102. 1994..The results suggest that vertebrate visual pigments have evolved along at least five lines, and that these lines diverged from an ancestral gene before the bony fishes diverged from the rest of the higher vertebrates... - Molecular cloning of complementary DNA for human medullasin: an inflammatory serine protease in bone marrow cellsK Okano
Basic Research Laboratories, Toray Industries, Inc, Kanagawa
J Biochem 102:13-6. 1987..The deduced amino acid sequence of medullasin shows a typical serine protease structure, with 41% homology with pig elastase 1... - Associations between hyperglycaemia and somatic transversion mutations in mitochondrial DNA of people with diabetes mellitusJ Kamiya
The Second Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto City, Nagano Prefecture, Japan
Diabetologia 46:1559-66. 2003..We also studied the relations between those mutations and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) which is known to increase considerably in people with diabetes...