Toshiaki Iba

Summary

Country: Japan

Publications

  1. ncbi Enoxaparin and fondaparinux attenuates endothelial damage in endotoxemic rats
    Toshiaki Iba
    Department of Emergency and Disaster Medicine Juntendo University, Bunkyo ku, Tokyo, Japan
    J Trauma Acute Care Surg 72:177-82. 2012
  2. ncbi Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University, Tokyo, Japan, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Crit Care 12:R86. 2008
  3. ncbi Enoxaparin attenuates endothelial damage with less bleeding compared with unfractionated heparin in endotoxemic rats
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Shock 32:530-4. 2009
  4. ncbi Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University, Hongo Bunkyo ku, Tokyo, 113 8421, Japan
    Crit Care 13:R203. 2009
  5. ncbi Antithrombin ameliorates endotoxin-induced organ dysfunction more efficiently when combined with danaparoid sodium than with unfractionated heparin
    Toshiaki Iba
    Department of Surgery, Juntendo University School of Medicine, Juntendo Urayasu Hospital, 2 1 1 Tomioka, 279 0021 Urayasu, Chiba, Japan
    Intensive Care Med 31:1101-8. 2005
  6. ncbi Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Urayasu, Chiba, Japan
    Crit Care Med 33:368-72. 2005
  7. ncbi Effect of hemoperfusion using polymyxin B-immobilized fibers on non-shock rat sepsis model
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University, Hongo, Bunkyo ku, Japan
    J Surg Res 171:755-61. 2011
  8. ncbi Laparoscopy-assisted low anterior resection with a prolapsing technique for low rectal cancer
    Masaki Fukunaga
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University, 2-1-1 Tomioka, Urayasu 279-0021, Japan
    Surg Today 35:598-602. 2005
  9. ncbi Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Urayasu, Chiba 279 0021, Japan
    Shock 23:25-9. 2005
  10. ncbi Antithrombin modulates the leukocyte-endothelial cell interaction in the staphylococcal enterotoxin B-challenged mouse
    Toshiaki Iba
    Department of Surgery, Juntendo University Urayasu Hospital, Juntendo University, School of Medicine, Tomioka, Japan
    J Trauma 55:546-50. 2003

Collaborators

  • Youichi Yanagawa
  • Yoichi Ohno
  • Masaki Fukunaga
  • Kunihiko Nagakari
  • Akio Kidokoro
  • Masaru Suda
  • Kazuyoshi Sugiyama
  • Tetu Fukunaga
  • Seiichiro Yoshikawa
  • Tetsu Fukunaga
  • Seiichirou Yosikawa

Detail Information

Publications16

  1. ncbi Enoxaparin and fondaparinux attenuates endothelial damage in endotoxemic rats
    Toshiaki Iba
    Department of Emergency and Disaster Medicine Juntendo University, Bunkyo ku, Tokyo, Japan
    J Trauma Acute Care Surg 72:177-82. 2012
    ..Therefore, we examined the anti-inflammatory effects and bleeding events when these agents are applied in a lipopolysaccharide challenge model...
  2. ncbi Danaparoid sodium attenuates the increase in inflammatory cytokines and preserves organ function in endotoxemic rats
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University, Tokyo, Japan, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
    Crit Care 12:R86. 2008
    ..The purpose of this study was to examine whether danaparoid sodium (DA) is effective for the treatment of organ dysfunction in sepsis...
  3. ncbi Enoxaparin attenuates endothelial damage with less bleeding compared with unfractionated heparin in endotoxemic rats
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University School of Medicine, Bunkyo ku, Tokyo, Japan
    Shock 32:530-4. 2009
    ..However, UFH significantly increases the bleeding area, whereas enoxaparin does not increase bleeding, and thus, it can reduce organ damages in the endotoxemic rat...
  4. ncbi Combination effect of antithrombin and recombinant human soluble thrombomodulin in a lipopolysaccharide induced rat sepsis model
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University, Hongo Bunkyo ku, Tokyo, 113 8421, Japan
    Crit Care 13:R203. 2009
    ..Recombinant human soluble thrombomodulin (rhsTM) is newly developed for the treatment of DIC. The purpose of this study was to evaluate the efficacy of the concomitant administration of rhsTM and antithrombin (AT)...
  5. ncbi Antithrombin ameliorates endotoxin-induced organ dysfunction more efficiently when combined with danaparoid sodium than with unfractionated heparin
    Toshiaki Iba
    Department of Surgery, Juntendo University School of Medicine, Juntendo Urayasu Hospital, 2 1 1 Tomioka, 279 0021 Urayasu, Chiba, Japan
    Intensive Care Med 31:1101-8. 2005
    ..This study investigated the potential benefits of combination therapy using antithrombin (AT) with danaparoid sodium (DA) compared with the use of AT with unfractionated heparin (UFH) in the treatment of sepsis...
  6. ncbi Activated protein C improves the visceral microcirculation by attenuating the leukocyte-endothelial interaction in a rat lipopolysaccharide model
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Urayasu, Chiba, Japan
    Crit Care Med 33:368-72. 2005
    ..05) CONCLUSIONS: Recombinant human activated protein C demonstrated a protective effect on microcirculation through the inhibition of leukocyte-endothelial interaction and suppression of inflammatory cytokine production...
  7. ncbi Effect of hemoperfusion using polymyxin B-immobilized fibers on non-shock rat sepsis model
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University, Hongo, Bunkyo ku, Japan
    J Surg Res 171:755-61. 2011
    ..However, it is still unknown whether the efficacy is limited to cardiovascular dysfunction. Therefore, the purpose of this study was to examine the effects of PMX-DHP on a non-hypotensive sepsis model...
  8. ncbi Laparoscopy-assisted low anterior resection with a prolapsing technique for low rectal cancer
    Masaki Fukunaga
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University, 2-1-1 Tomioka, Urayasu 279-0021, Japan
    Surg Today 35:598-602. 2005
    ..Our limited experience suggests that the prolapsing technique helps to prevent problems with laparoscopy-assisted LAR in selected patients with low rectal cancer...
  9. ncbi Association between the severity of sepsis and the changes in hemostatic molecular markers and vascular endothelial damage markers
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Urayasu, Chiba 279 0021, Japan
    Shock 23:25-9. 2005
    ..Thus, the changes in the hemostatic molecular markers were associated with organ dysfunction from an early stage of sepsis, and antithrombin and protein C activities were found to be the most reliable markers...
  10. ncbi Antithrombin modulates the leukocyte-endothelial cell interaction in the staphylococcal enterotoxin B-challenged mouse
    Toshiaki Iba
    Department of Surgery, Juntendo University Urayasu Hospital, Juntendo University, School of Medicine, Tomioka, Japan
    J Trauma 55:546-50. 2003
    ..The beneficial effects of antithrombin on endotoxemia are well known. The purpose of this study was to examine the effects of antithrombin in a supertoxin-induced sepsis...
  11. ncbi Factor Xa-inhibitor (DX-9065a) modulates the leukocyte-endothelial cell interaction in endotoxemic rat
    Toshiaki Iba
    Department of Surgery, Juntendo University School of Medicine, Urayasu Hospital, Chiba, Japan
    Shock 17:159-62. 2002
    ..Although the mechanism for this effect could not be fully elucidated, suppression of both excessive coagulation and cytokine production appear to play a role...
  12. ncbi Comparison of the protective effects of type III phosphodiesterase (PDE3) inhibitor (cilostazol) and acetylsalicylic acid on intestinal microcirculation after ischemia reperfusion injury in mice
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, 2 1 1 Tomioka, Uruyasu, Chiba 279 0021, Japan
    Shock 26:522-6. 2006
    ..05). The villus height was best preserved in the CZ-treated mice. Cilostazol inhibited not only the platelet aggregation but also the leukocyte adhesion to the endothelium, thereby inducing organ protection...
  13. ncbi Pretreatment of sivelestat sodium hydrate improves the lung microcirculation and alveolar damage in lipopolysaccharide-induced acute lung inflammation in hamsters
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Urayasu, Chiba, Japan
    Shock 26:95-8. 2006
    ..05). Pretreatment of sivelestat demonstrated a protective effect on both intravascular and extravascular damage in the lung, whereas posttreatment only suppressed the latter damage...
  14. ncbi What can we learn from the three megatrials using anticoagulants in severe sepsis?
    Toshiaki Iba
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University School of Medicine, Chiba 279-0021, Japan
    Shock 22:508-12. 2004
  15. ncbi Laparoscopic surgery for left paraduodenal hernia
    Masaki Fukunaga
    Department of Surgery, Juntendo Urayasu Hospital, Juntendo University, Urayasu, Japan
    J Laparoendosc Adv Surg Tech A 14:111-5. 2004
    ....
  16. ncbi Formation of the venous thrombus after venous occlusion in the experimental mouse model of metabolic syndrome
    Toshiaki Iba
    Department of Emergency and Disaster Medicine, Juntendo University, Tokyo, Japan
    Thromb Res 129:e246-50. 2012
    ..Furthermore the mechanism of venous thrombosis initiation still remains elusive...