Makoto Hirotani

Summary

Affiliation: Hokkaido University
Country: Japan

Publications

  1. ncbi Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 48:373-5. 2009
  2. ncbi Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuroimmunol 221:95-100. 2010
  3. ncbi Decreased interferon-? production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Immunol 143:145-51. 2012
  4. ncbi Estrogens as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan
    Cent Nerv Syst Agents Med Chem 9:87-94. 2009
  5. ncbi Successful cyclosporine treatment in 2 patients with refractory CIDP, involving monitoring of both AUC(0-4h) and trough levels
    Akiko Takeuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 52:172-7. 2012
  6. ncbi Memory and naïve B-cell subsets in patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurosci Lett 464:74-8. 2009
  7. ncbi Abnormal brain MRI signals in the splenium of the corpus callosum, basal ganglia and internal capsule in a suspected case with tuberculous meningitis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 46:505-9. 2007

Collaborators

  • Hidenao Sasaki
  • Seiji Kikuchi
  • Masaaki Niino
  • Akiko Takeuchi
  • Takahiro Kano
  • Ikuko Takahashi
  • Kazuhiro Horiuchi
  • Masaaki Matsushima
  • Ichiro Yabe
  • Shinichi Shirai
  • Akihisa Matumoto
  • Toshiyuki Fukazawa
  • Yusei Miyazaki

Detail Information

Publications7

  1. ncbi Chronic inflammatory demyelinating polyneuropathy after treatment with interferon-alpha
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 48:373-5. 2009
    ..This case may therefore provide an important clue to understand the immune mechanism of CIDP and IFN-alpha...
  2. ncbi Decreased IL-10 production mediated by Toll-like receptor 9 in B cells in multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Neuroimmunol 221:95-100. 2010
    ..Our results indicate that TLR9-mediated IL-10 production by B cells was significantly decreased in MS, and this decrease is likely due to decreased TLR9 expression in memory B cells, suggesting a role of TLR9 in immunoregulation in MS...
  3. ncbi Decreased interferon-? production in response to CpG DNA dysregulates cytokine responses in patients with multiple sclerosis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Immunol 143:145-51. 2012
    ..These results suggest that CpG DNA-induced decreased IFN-? production causes pro-inflammatory cytokine secretion, and either IFN-? or IFN-? induces anti-inflammatory cytokine secretion in the adaptive immune system in MS...
  4. ncbi Estrogens as potential therapeutic agents in multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kitaku, Sapporo, Japan
    Cent Nerv Syst Agents Med Chem 9:87-94. 2009
    ..In this review paper, we discuss increasing evidence that points to a link between estrogen and MS. We also analyze the therapeutic potential of estrogens in MS and review current genetic studies on ER...
  5. ncbi Successful cyclosporine treatment in 2 patients with refractory CIDP, involving monitoring of both AUC(0-4h) and trough levels
    Akiko Takeuchi
    Department of Neurology, Hokkaido University Graduate School of Medicine
    Rinsho Shinkeigaku 52:172-7. 2012
    ..Monitoring both AUC(0-4 h) and trough levels of CYA seems to be a better option than monitoring the trough level alone because it leads to improved estimation of the efficacy and safety of CYA treatment in the case of CIDP patients...
  6. ncbi Memory and naïve B-cell subsets in patients with multiple sclerosis
    Masaaki Niino
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Neurosci Lett 464:74-8. 2009
    ..These results indicate that memory and naïve B-cell subsets, especially CD86(+) naïve B cells, CCR5(+) naïve B cells, and CD5(+) memory B cells, might be useful in the study of the pathogenesis of and therapy for MS...
  7. ncbi Abnormal brain MRI signals in the splenium of the corpus callosum, basal ganglia and internal capsule in a suspected case with tuberculous meningitis
    Makoto Hirotani
    Department of Neurology, Hokkaido University Graduate School of Medicine, Sapporo
    Intern Med 46:505-9. 2007
    ..This valuable case suggests that an immune mechanism contributed to the occurrence of central nervous system symptoms associated with tuberculous meningitis...