Research Topics
Genomes and Genes | Takeshi KawarabayashiSummaryAffiliation: Hirosaki University School of Medicine Country: Japan Publications
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Detail Information
Publications
Reversible memory loss in a mouse transgenic model of Alzheimer's diseaseLinda A Kotilinek
Department of Neurology, University of Minnesota, Minneapolis 55455, USA
J Neurosci 22:6331-5. 2002..If these Abeta assemblies contribute significantly to memory loss in AD, then successfully targeting them might improve memory in some AD patients...- Extracellular and intraneuronal HMW-AbetaOs represent a molecular basis of memory loss in Alzheimer's disease model mouseAyumi Takamura
Department of Alzheimer s Disease Research, Research Institute, National Center for Geriatrics and Gerontology, Aichi, Japan
Mol Neurodegener 6:20. 2011..abstract:.. - Plasma biomarkers of Alzheimer's diseaseTakeshi Kawarabayashi
Department of Neurology, Hirosaki University Graduate School of Medicine, Institute of Brain Science, 5 Zaifu cho, Hirosaki, Japan
Curr Opin Psychiatry 21:260-7. 2008..The importance of biomarkers of Alzheimer's disease is increasing. The present review aims to offer a general view of plasma biomarkers of Alzheimer's disease and to discuss their relevance and limitations... - Motor impairment and aberrant production of neurochemicals in human alpha-synuclein A30P+A53T transgenic mice with alpha-synuclein pathologyMasaki Ikeda
Department of Neurology, Gunma University Graduate School of Medicine, Maebashi, Japan
Brain Res 1250:232-41. 2009..Motor impairment was revealed in a rotarod test. Thus, TgalphaSYN is a useful model for analyzing the pathological cascade from aggregated alphaSYN to motor disturbance, and may be useful for drug trials... - Plasma antibodies to Abeta40 and Abeta42 in patients with Alzheimer's disease and normal controlsWuhua Xu
Department of Neurology, Neuroscience, Biophysiological Science, Okayama University Graduate School of Medicine, Dentistry and Pharmacy, 2 5 1 Shikatacho, Okayama 700 8558, Japan
Brain Res 1219:169-79. 2008..Clarification of the mechanism of the immune response to Abeta42 is necessary for realization of an immunotherapy for AD... - Enhanced accumulation of tau in doubly transgenic mice expressing mutant betaAPP and presenilin-1Eriko Samura
Department of Neurology, Division of Neuroscience, Biophysical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama 700 8558, Japan
Brain Res 1094:192-9. 2006..These findings suggest that mutant presenilin-1 accelerated Abeta-induced tauopathy and further promoted fibril formation of tau... - A Japanese ALS6 family with mutation R521C in the FUS/TLS gene: a clinical, pathological and genetic reportYukiko Yamamoto-Watanabe
Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036 8562, Japan
J Neurol Sci 296:59-63. 2010..While atrophy and weakness of the sternocleidomastoideus muscle is not emphasized in previous reports, this symptom may be a clinical hallmark of ALS6... - Accumulation of filamentous tau in the cerebral cortex of human tau R406W transgenic miceMasaki Ikeda
Department of Neurology, Gunma University Graduate School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
Am J Pathol 166:521-31. 2005..These findings suggested that TgTauR406W mice would be a useful model in the study of frontotemporal dementia and other tauopathies such as Alzheimer's disease (AD)... - Differentiation of PA from early PSP with different patterns of symptoms and CBF reductionTomoko Kurata
Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Neurol Res 30:860-7. 2008..To clarify the features of pure akinesia (PA) and progressive supranuclear palsy (PSP) in the early stage of disease... - Quantification of cystatin C in cerebrospinal fluid from various neurological disorders and correlation with G73A polymorphism in CST3Yukiko Yamamoto-Watanabe
Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036 8562, Japan
Brain Res 1361:140-5. 2010..The present data demonstrate that the level of CC in CSF should not be considered as a biomarker of ALS, but there is a correlation between CC levels and the CST3 genotype... - Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathyYasuhito Wakasaya
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
J Neurosci Res 89:576-84. 2011..Thus, many biological pathways and novel molecules are associated with NFT formation and neuronal cell losses in tauopathy brains... - Dimeric amyloid beta protein rapidly accumulates in lipid rafts followed by apolipoprotein E and phosphorylated tau accumulation in the Tg2576 mouse model of Alzheimer's diseaseTakeshi Kawarabayashi
Department of Neurology, Okayama University Graduate School of Medicine, Okayama, 700-8558, Japan
J Neurosci 24:3801-9. 2004..A similar increase in ApoE and a large increase in phosphorylated tau was observed in lipid rafts from AD brain. These findings suggest that lipid rafts may be an important site for interaction between dimeric Abeta, ApoE, and tau... - Enhanced accumulation of phosphorylated alpha-synuclein in double transgenic mice expressing mutant beta-amyloid precursor protein and presenilin-1Tomoko Kurata
Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
J Neurosci Res 85:2246-52. 2007..Additional overexpression of mutant PS-1 accelerated Abeta-induced alpha-synucleinopathy and further facilitated the phosphorylation of alpha-syn, suggesting a direct association between mutant PS-1 and phosphorylation of alpha-syn... - Prevalence of autosomal dominant cerebellar ataxia in Aomori, the northernmost prefecture of Honshu, JapanYukiko Yamamoto-Watanabe
Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
Intern Med 49:2409-14. 2010..The frequency of autosomal dominant cerebellar ataxia (ADCA) varies between different regions of Japan. This is the first report on the prevalence of ADCA subtypes in Aomori, Japan... - An unusual case of elderly-onset cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) with multiple cerebrovascular risk factorsMitsunori Watanabe
Department of Neurology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
J Stroke Cerebrovasc Dis 21:143-5. 2012..This case strongly indicates that CADASIL should be considered when typical findings are observed on MRI even in cases of elderly onset with multiple cerebrovascular risk factors... - A small trinucleotide expansion in the TBP gene gives rise to a sporadic case of SCA17 with abnormal putaminal findings on MRIMitsunori Watanabe
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine
Intern Med 47:2179-82. 2008..We identified a heterozygously expanded CAG/CAA repeat (45/36) within the TATA-binding protein gene, leading to a diagnosis of SCA17. These results show that a 45 CAG/CAA repeat is pathological, giving rise to early-onset SCA17... - Soluble Abeta homeostasis in AD and DS: impairment of anti-amyloidogenic protection by lipoproteinsEtsuro Matsubara
Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Schikata cho, Okayama, Okayama 700 8558, Japan
Neurobiol Aging 25:833-41. 2004.... - [Biomarker and imaging of Alzheimer's disease]Takeshi Kawarabayashi
Department of Neurology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan
No To Shinkei 57:839-52. 2005 - Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's diseaseYasumasa Ohyagi
Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
FASEB J 19:255-7. 2005.... - Cerebrospinal fluid tau in dementia disorders: a large scale multicenter study by a Japanese study groupMikio Shoji
Department of Neurology, Division of Neuroscience Biophysical Science, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan
Neurobiol Aging 23:363-70. 2002..Measurement of CSF tau was useful as a biomarker for early and differential diagnosis of AD... - Pael-R is accumulated in Lewy bodies of Parkinson's diseaseTetsuro Murakami
Department of Neurology, Okayama University Graduate School of Medicine and Dentistry, 2 5 1 Shikata cho, Okayama 700 8558, Japan
Ann Neurol 55:439-42. 2004..The absence of Pael-R and Parkin in glial cytoplasmic inclusions (GCIs) in MSA implies a distinct pathway involved in the formation of LBs and GCIs... - Reuptake of L-DOPA-derived extracellular DA in the striatum of a rodent model of Parkinson's disease via norepinephrine transporterAkira Arai
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki 036 8562, Japan
Synapse 62:632-5. 2008..This result suggests that the norepinephrine transporter could be a promising target in the treatment for Parkinson's disease... - An unusual case of chronic relapsing tetanus associated with mandibular osteomyelitisYasuhito Wakasaya
Department of Neurology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki
Intern Med 48:1311-3. 2009.... - Generation of amyloid beta protein from a presenilin-1 and betaAPP complexMasami Shizuka-Ikeda
Department of Neurology, Gunma University School of Medicine, Maebashi, Gunma, Japan
Biochem Biophys Res Commun 292:571-8. 2002..This findings suggest that the direct generation of Abeta from the complex may play an important role in the pathogenesis of Alzheimer's disease... - The relationship between Abeta and memory in the Tg2576 mouse model of Alzheimer's diseaseMarcus A Westerman
Department of Neurology, Center for Clinical and Molecular Neurobiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Neurosci 22:1858-67. 2002..These studies also provide a methodological framework within which to investigate these Abeta assemblies in vivo... - Amyloid cored plaques in Tg2576 transgenic mice are characterized by giant plaques, slightly activated microglia, and the lack of paired helical filament-typed, dystrophic neuritesAtsushi Sasaki
Department of Pathology, Gunma University School of Medicine, 3 39 22 Showa machi, Maebashi, Gunma 371 8511, Japan
Virchows Arch 441:358-67. 2002.... - [A case of corticobasal degeneration that progressed from primary progressive aphasia]Takeshi Kawarabayashi
Department of Neurology, Division of Neuroscience, Biophysical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Nippon Ronen Igakkai Zasshi 42:702-7. 2005..SPECT is useful examination to predict the progress of the disease because the decrease of blood flow was recognized before the progression to CBD... - Type-specific evolution of amyloid plaque and angiopathy in APPsw miceYasuo Harigaya
Neurology Service, Maebashi Red Cross Hospital, 3 21 36 Asahi cho, Maebashi, Gunma 371 0014, Japan
Neurosci Lett 395:37-41. 2006.... - Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomainsSuzanne Wahrle
Department of Neuroscience and Pharmacology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida 32224, USA
Neurobiol Dis 9:11-23. 2002..Thus, altering cholesterol levels may influence the development of Alzheimer's disease (AD) by influencing production and deposition of Abeta within cholesterol rich membrane microdomains...