Research Topics
Genomes and GenesSpecies | Susumu HiguchiSummaryCountry: Japan Publications
| Collaborators
|
Detail Information
Publications
No evidence of association between apolipoprotein E gene regulatory region polymorphism and Alzheimer's disease in JapaneseM Kimura
Division of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
J Neural Transm 107:1449-56. 2000..These results suggest that -491 polymorphism does not independently confer susceptibility to AD, but that this polymorphism is in partial linkage disequilibrium with the APOE epsilon2/3/4 polymorphism...- Influence of genetic variations of ethanol-metabolizing enzymes on phenotypes of alcohol-related disordersSusumu Higuchi
Institute of Clinical Research, National Alcoholism Center Kurihama Hospital, Yokosuka, Kanagawa, 239 0841, Japan
Ann N Y Acad Sci 1025:472-80. 2004..Possible mechanisms of altered risk for these disorders are discussed... - Co-occurrence of obsessive-compulsive personality traits in young and middle-aged Japanese alcohol-dependent menKenji Suzuki
National Institute on Alcoholism, Kurihama National Hospital, 5 3 1 Nobi Yokosuka, Kanagawa 239 0841, Japan
Alcohol Clin Exp Res 26:1223-7. 2002..Although many studies have examined the characteristics of young alcoholics compared with middle-aged alcoholics, none has compared the prevalence of obsessive-compulsive traits in young and middle-aged alcoholics... - New findings on the genetic influences on alcohol use and dependenceSusumu Higuchi
National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
Curr Opin Psychiatry 19:253-65. 2006..Alcohol dependence is a complex disorder with a well documented highly hereditary nature. This article reviews the recent advances in our understanding of the direct and indirect genetic influences on alcohol use and dependence... - Japan: alcohol todaySusumu Higuchi
National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
Addiction 102:1849-62. 2007..The purpose of this paper is to outline alcohol availability, alcohol consumption and related harm, alcohol control policy and prevention programmes in Japan, few of which have been discussed in either the Japanese or English literature... - Certain background factors exhibit an association with an increased risk for pancreatic calcification among Japanese male alcoholicsYuji Nakamura
Department of Clinical Research, National Hospital Organization Kurihama Alcoholism Center, Kanagawa, Japan
Pancreas 31:225-31. 2005..This was a cross-sectional study conducted from April 2003 through March 2004 to investigate the background factors related to pancreatic calcification (PC) in male Japanese alcoholics... - Risk of squamous cell carcinoma of the upper aerodigestive tract in cancer-free alcoholic Japanese men: an endoscopic follow-up studyAkira Yokoyama
National Hospital Organization Kurihama Alcoholism Center, 5 3 1 Nobi, Yokosuka, Kanagawa 239 0841, Japan
Cancer Epidemiol Biomarkers Prev 15:2209-15. 2006..09-0.85) in those with body mass index >or= 23.2 (highest quartile) compared with those with body mass index < 19.0 (lowest quartile). These predictors are useful for selecting appropriately patients for careful follow-up examinations... - Esophageal melanosis, an endoscopic finding associated with squamous cell neoplasms of the upper aerodigestive tract, and inactive aldehyde dehydrogenase-2 in alcoholic Japanese menAkira Yokoyama
National Hospital Organization Kurihama Alcoholism Center, 5 3 1 Nobi, Yokosuka, 239 0841, Japan
J Gastroenterol 40:676-84. 2005..This study evaluated the associations of esophageal melanosis with these neoplasms, and the factors contributing to the development of esophageal melanosis in this population... - p53 Protein accumulation, cancer multiplicity, and aldehyde dehydrogenase-2 genotype in Japanese alcoholic men with early esophageal squamous cell carcinomaAkira Yokoyama
National Hospital Organization Kurihama Alcoholism Center, 5 3 1 Nobi, Yokosuka, Kanagawa 239 0841, Japan
Cancer Lett 247:243-52. 2007..22) among the risk factors investigated, which also included smoking, less-active alcohol dehydrogenase-1B, and macrocytosis, enhancing the validity of the link between acetaldehyde exposure and cancer multiplicity... - Helicobacter pylori, chronic atrophic gastritis, inactive aldehyde dehydrogenase-2, macrocytosis and multiple upper aerodigestive tract cancers and the risk for gastric cancer in alcoholic Japanese menAkira Yokoyama
National Hospital Organization Kurihama Alcoholism Center, Kanagawa, Japan
J Gastroenterol Hepatol 22:210-7. 2007..Whether alcoholism affects Helicobacter pylori-induced chronic atrophic gastritis (CAG) is unknown... - Association of aldehyde dehydrogenase-2 polymorphism with alcoholic polyneuropathy in humansToshihiro Masaki
Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, 5 3 1 Nobi, Yokosuka, Kanagawa 239 0841, Japan
Neurosci Lett 363:288-90. 2004.... - Melanosis and squamous cell neoplasms of the upper aerodigestive tract in Japanese alcoholic menAkira Yokoyama
National Hospital Organization Kurihama Alcoholism Center, 5 3 1, Nobi, Kanagawa 239 0841, Japan
Cancer Sci 97:905-11. 2006..The presence of melanosis indicates a high risk for neoplasms in the upper aerodigestive tract of Japanese alcoholic men. Melanosis and neoplasms have the same causes, including older age, heavy smoking, and high acetaldehyde exposure... - ALDH2 promoter polymorphism has no effect on the risk for alcoholismMitsuru Kimura
National Hospital Organization, Kurihama Alcoholism Center, 5 3 1 Nobi, Yokosuka, Kanagawa 2390841, Japan
Alcohol Alcohol 41:368-71. 2006..To test for the possible association between mitochondrial aldehyde dehydrogenase (ALDH2) promoter polymorphism and alcoholism... - Severe chronic pancreatitis and severe liver cirrhosis have different frequencies and are independent risk factors in male Japanese alcoholicsYuji Nakamura
National Alcoholism Center, Kurihama National Hospital, 5-3-1 Nobi, 239-0841 Yokosuka, Japan
J Gastroenterol 39:879-87. 2004..CONCLUSIONS: Different risk factors may confer susceptibility to ACP versus ALC, which may explain the nonparallel relationship between the severities of the two diseases in Japanese alcoholics... - Homozygous (TG)11 allele in intron 8 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene has a protective role against bicarbonate decrease in pure pancreatic juice among Japanese male alcoholicsYuji Nakamura
National Hospital Organization, Kurihama Alcoholism Center, Nobi, Yokosuka, Kanagawa 239 0841
Intern Med 43:1131-7. 2004..Exocrine pancreatic insufficiency exists in about 90% of the patients with cystic fibrosis (CF), which results from an abnormal cystic fibrosis transmembrane conductance regulator gene (CFTR)... - Prolonged central sensory conduction time in alcoholics with hypoactive aldehyde dehydrogenase-2Hitoshi Mochizuki
Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
Neurosci Res 50:233-6. 2004..The present result indicates that an elevated blood concentration of acetaldehyde must cause the central sensory tract involvement and that acetaldehyde is one of factors producing brain damage in alcoholics... - Gender differences in the effects of ADH1B and ALDH2 polymorphisms on alcoholismMitsuru Kimura
National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
Alcohol Clin Exp Res 35:1923-7. 2011..This study aimed to clarify gender differences in the effects of ADH1B and ALDH2 polymorphism on the development of alcohol dependence... - Elevated cerebrospinal fluid tau protein levels in Wernicke's encephalopathySachio Matsushita
National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
Alcohol Clin Exp Res 32:1091-5. 2008..We also examined CSF total tau in nonalcohol dependent patients with Alzheimer's disease (AD) as a disease control... - Association study of brain-derived neurotrophic factor gene polymorphism and alcoholismSachio Matsushita
National Hospital Organization, Kurihama Alcoholism Center, 5 3 1 Nobi, Yokosuka, Kanagawa 239 0841, Japan
Alcohol Clin Exp Res 28:1609-12. 2004..These lines of evidence suggested that BDNF might play some role in the development of or vulnerability to alcoholism and/or clinical characteristics of alcoholic individuals... - Association between personality traits and ALDH2 polymorphism in Japanese male alcoholicsMitsuru Kimura
National Hospital Organization, Kurihama Alcoholism Center Yokosuka, 5 3 1 Nobi, Kanagawa, Japan
Alcohol Clin Exp Res 33:799-803. 2009..This study aimed to compare personality profiles and clinical characteristics between alcoholics with active and inactive ALDH2... - Serotonin transporter regulatory region polymorphism is associated with anorexia nervosaSachio Matsushita
National Institute on Alcoholism, Kurihama National Hospital, 5 3 1 Nobi Yokosuka, Kanagawa 239 0841, Japan
Am J Med Genet B Neuropsychiatr Genet 128:114-7. 2004..The 5-HTTLPR S allele might play some role in the development of AN with persistent disease... - Functional polymorphisms in the sigma1 receptor gene associated with alcoholismRyosuke Miyatake
Institute of Clinical Research, National Alcoholism Center Kurihama Hospital, Kanagawa, Japan
Biol Psychiatry 55:85-90. 2004..To investigate the role of SIGMAR1 in conveying susceptibility to alcoholism, we performed a functional analysis of polymorphisms in the SIGMAR1 and a case-control study... - [A cohort study of Japanese adolescent alcohol use and misuse (1): Observation for 2 years]Kenji Suzuki
Kurihama National Hospital, 5-3-1, Nobi, Yokosuka, Kanagawa, 239-0841, Japan
Nihon Arukoru Yakubutsu Igakkai Zasshi 37:577-85. 2002..We will continue the longitudinal cohort study to determine if these three factors promote adolescent drinking in the future... - Benign type of central pontine myelinolysis in alcoholism--clinical, neuroradiological and electrophysiological findingsHitoshi Mochizuki
Dept. of Neurology, National Institute on Alcoholism, Kurihama National Hospital, 5-3-1 Nobi, Yokosuka, Kanagawa 239-0841, Japan
J Neurol 250:1077-83. 2003..These clinical, radiological and electrophysiological findings should be of use in diagnosing CPM... - Acute axonal polyneuropathy associated with alcoholismHitoshi Mochizuki
Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Japan
Eur Neurol 50:183-4. 2003 - Effect of a comprehensive lifestyle modification program on the bone density of male heavy drinkersToshifumi Matsui
National Hospital Organization Kurihama Alcoholism Center, Kanagawa, Japan
Alcohol Clin Exp Res 34:869-75. 2010..Although abstinence is rapidly followed by a restoration of osteoblastic activity, little is known about the contributions of alcohol-related factors or the effectiveness of a lifestyle modification program (LMP) on bone density... - Role of GABRA2 in Moderating Subjective Responses to AlcoholSungwon Roh
From the Division of Clinical Research SR, S Hara, Department of Psychiatry SM, hm, gs, T Miyakawa, S Higuchi, and Department of Internal Medicine T Matsui, National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan Laboratory of Clinical and Translational Studies VAR and Office of the Director TKL, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
Alcohol Clin Exp Res 35:400-7. 2011.... - Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese alcoholic menAkira Yokoyama
National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa 239-0841, Japan
Carcinogenesis 24:1773-8. 2003..24, 4.71 and 27.01, respectively). In conclusion, MCV measurement, alone or in combination with the markers of alcohol sensitivity, provides a new means of predicting risk for esophageal squamous cell carcinoma in Japanese alcoholic men... - [The treatment cost at different stages of alcohol dependence in Japan]Tomohiro Miyakawa
National Hospital Organization, Kurihama Alcoholism Center, 5-3-1, Nobi, Yokosuka, Kanagawa 239 0841, Japan
Nihon Arukoru Yakubutsu Igakkai Zasshi 40:181-90. 2005..Placing stress on prevention, providing proper treatment for patients and reducing relapses will reduce the burden including social expenses... - Genetics of alcohol dependenceMitsuru Kimura
National Hospital Organization, Kurihama Alcoholism Center, Kanagawa, Japan
Psychiatry Clin Neurosci 65:213-25. 2011..Knowledge of the genetic basis of alcohol dependence is growing and leads to a better understanding of the biological mechanisms of addiction, which can help with strategies to prevent and treat this disease... - The Japanese society of alcohol-related problemsKatsuya Maruyama
National Alcoholism Center Kurihama Hospital, Yokosuka, Kanagawa, Japan
Addiction 99:419-24. 2004.... - Association of dystroglycan and laminin-2 coexpression with myelinogenesis in peripheral nervesToshihiro Masaki
Department of Neurology, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa 239-0841, Japan
Med Electron Microsc 36:221-39. 2003..Beta-dystroglycan and laminin-2 were also coexpressed in satellite cells in dorsal root ganglia, suggesting that interaction of these two proteins plays some role in physiological functions of these cells... - Pancreatic volume associated with endocrine and exocrine function of the pancreas among Japanese alcoholicsYuji Nakamura
National Hospital Organization, Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
Pancreatology 5:422-31. 2005.... - Investigation of quantitative trait loci in the CCKAR gene with susceptibility to alcoholismTakehito Okubo
Institute of Community Medicine, University of Tsukuba, Japan
Alcohol Clin Exp Res 26:2S-5S. 2002..In this study, association analyses were re-examined between the polymorphisms of the promoter region of the CCKAR gene and patients with alcohol withdrawal symptoms, in addition to patients with alcoholic liver injury... - Association analyses between polymorphisms of the phase II detoxification enzymes (GSTM1, NQO1, NQO2) and alcohol withdrawal symptomsTakehito Okubo
Department of Psychiatry, Bungosou Hospital, Yasato, Ibaraki, Japan
Alcohol Clin Exp Res 27:68S-71S. 2003..In this study, we investigated a possible association between polymorphisms of the GSTM1, NQO1, and NQO2 genes and alcohol withdrawal symptoms such as delirium tremens, hallucination, and seizure... - Spirits and gastrectomy increase risk for chronic pancreatitis in Japanese male alcoholicsYuji Nakamura
Institute of Clinical Research, National Alcoholism Center, Kurihama Hospital, Yokosuka shi, Kanagawa, Japan
Pancreas 26:e27-31. 2003..Most cases of chronic pancreatitis are alcohol-related, but not all alcoholics develop pancreatitis... - [Alcohol-related disorders and suicide]Sachio Matsushita
National Hospital Organization, Kurihama Alcoholism Center
Seishin Shinkeigaku Zasshi 111:1191-202. 2009..3) Heavy drinking is a risk factor for suicide. Consequently, we reviewed the literature concerning the association between alcohol dependence and suicide... - Assessing multidimensional cognitions of drinking among alcohol-dependent patients: development and validation of a drinking-related cognitions scale (DRCS)Toru Sawayama
Department of Psychiatry, Kitasato University School of Medicine, Kanagawa, Japan
Addict Behav 34:82-5. 2009..It was suggested that the DRCS would be useful for the easy measurement of multidimensional cognitions of drinking in alcohol-dependent patients... - [A review of the neuroimaging studies of alcoholism]Sachio Matsushita
National Hospital Organization, Kurihama Alcoholism Center, 5 3 1 Nobi, Yokosuka, Kanagawa 239 0841, Japan
Nihon Arukoru Yakubutsu Igakkai Zasshi 42:615-21. 2007.... - Clinical and biomarker investigation of a patient with a novel presenilin-1 mutation (A431V) in the mild cognitive impairment stage of Alzheimer's diseaseSachio Matsushita
Division of Clinical Research, National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa, Japan
Biol Psychiatry 52:907-10. 2002..We suggest that functional neuroimaging and CSF biomarkers can serve as useful predictors of development of AD. Accumulation of pathologic tau isoforms and neuron death occur even in the mildest clinical stages of AD... - Association of cholecystokinin-A receptor gene polymorphism with alcohol dependence in a Japanese populationKyoko Miyasaka
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Alcohol Alcohol 39:25-8. 2004..The aims of the present study were to determine the prevalence of the -81A/G and -128G/T polymorphism of the CCK-AR gene between alcoholics and normal control subjects and the occurrences of the polymorphisms in subtypes of alcoholics... - [Present status and future prospects in therapy for alcoholism]Susumu Higuchi
Seishin Shinkeigaku Zasshi 109:534-5. 2007 - [Drug therapy for alcoholism]Takefumi Akanashi
Seishin Shinkeigaku Zasshi 109:547-50. 2007 - Carboxylester lipase gene polymorphism as a risk of alcohol-induced pancreatitisKyoko Miyasaka
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Pancreas 30:e87-91. 2005..Nonoxidative metabolites of ethanol, fatty acid ethyl esters (FAEEs), might play an important role in pancreatic damage. Carboxylester lipase (CEL) has been known to catalyze FAEE synthesis from fatty acids and ethanol... - Diabetic vasculopathy and alcohol tolerance trait in type 2 diabetesYoshihiko Suzuki
Diabetes Care 26:246-7. 2003 - Association study between alcoholism and endocannabinoid metabolic enzyme genes encoding fatty acid amide hydrolase and monoglyceride lipase in a Japanese populationShinya Iwasaki
Department of Medical Genetics, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
Psychiatr Genet 17:215-20. 2007..Owing to the importance of endocannabinoid system in addiction, the Pro129Thr polymorphism in the FAAH gene has reportedly been associated with substance abuse and dependence in a Caucasian population... - Association analysis of the dopamine receptor D2 (DRD2) SNP rs1076560 in alcoholic patientsToshikazu Sasabe
Department of Life Sciences, Graduate School of Arts and Sciences, University of Tokyo, 3 8 1 Komaba, Meguro ku, Tokyo 153 8902, Japan
Neurosci Lett 412:139-42. 2007..1%) than in the healthy controls (34.0%) (P=0.034, odds ratio=1.300, 95% confidence interval=1.020-1.657). These data identify SNP rs1076560 as a potentially important variable in the development of alcoholism... - Association between the brain-derived neurotrophic factor 196G/A polymorphism and eating disordersHiroki Koizumi
Department of Psychiatry, Chiba University Graduate School of Medicine, Inohana, Chiba, Japan
Am J Med Genet B Neuropsychiatr Genet 127:125-7. 2004..This study suggests that the BDNF 196G/A gene polymorphism might be associated with a susceptibility to eating disorders... - Association of cholecystokinin-A receptor gene polymorphisms and panic disorder in JapaneseKyoko Miyasaka
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
Am J Med Genet B Neuropsychiatr Genet 127:78-80. 2004..The CCK-AR gene polymorphism may be involved in the neurobiology of PD... - [Nationwide survey of alcohol drinking and alcoholism among Japanese adults]Yoneatsu Osaki
Division of Environmental and Preventive Medicine, Tottori University, 86 Nishimachi, Yonago, Tottori 683-8503, Japan
Nihon Arukoru Yakubutsu Igakkai Zasshi 40:455-70. 2005..The problem of females drinking may be growing. The government should emphasize the prevention of alcohol drinking problems in adults and continue the conduct of nationwide prevalence surveys to monitor the problem... - ALDH2/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetesYoshihiko Suzuki
Saiseikai Central Hospital, Tokyo, Japan
Alcohol Clin Exp Res 28:111S-116S. 2004.... - Dynamin-binding protein gene on chromosome 10q is associated with late-onset Alzheimer's diseaseRyozo Kuwano
Genome Science Branch, Center for Bioresource based Researches, Brain Research Institute, Niigata University, Niigata, Japan
Hum Mol Genet 15:2170-82. 2006..0169). Thus, we confirmed the association of DNMBP with AD individuals with the APOE-epsilon3*3 genotype or lacking the epsilon4 allele, and DNMBP may be one of the susceptibility genes for AD... - Recent developments in the genetics of alcohol-related phenotypesVictor Hesselbrock
Department of Psychiatry, University of Connecticut School of Medicine, Farmington, 06030-2103, USA
Alcohol Clin Exp Res 29:1321-4. 2005 - [Introduction of cognitive-behavioral therapy for alcoholic inpatients at Kurihama National Hospital]Toru Sawayama
Department of Psychiatry, Kitasato University School of Medicine
Seishin Shinkeigaku Zasshi 106:161-74. 2004..However, the relationship between change in cognitions and prognosis needs to be studied in the future... - Plasma homocysteine and risk of coexisting silent brain infarction in Alzheimer's diseaseToshifumi Matsui
Department of Geriatric and Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan
Neurodegener Dis 2:299-304. 2005..Homocysteine-lowering therapy rather than antihypertensive medication might be an appropriate strategy to prevent stroke associated with AD... - Association between a polymorphism of brain-derived neurotrophic factor gene and sporadic Parkinson's diseaseToshihiro Masaki
Ann Neurol 54:276-7. 2003 - A clinical and neuropathological study of an unusual case of sporadic tauopathy. A variant of corticobasal degeneration?Shinji Ohara
Department of Neurology, National Chushin Matsumoto Hospital, 811 Kotobuki, Matsumoto 399 0021, Japan
Neurosci Lett 330:84-8. 2002..Our findings, taken together with those in previous similar case reports, indicate that the case represents an atypical form of corticobasal degeneration or a new variant of sporadic tauopathy... - [Diagnosing the mild cognitive impairment stage of Alzheimer's disease]Masahiro Maruyama
Department of Gerontology and Respiratory Medicine, Tohoku University Hospital
Seishin Shinkeigaku Zasshi 106:269-80. 2004..We speculate that stable MCI is due to ischemic change with in the white matter lesion, while progressive MCI may represent a previous stage of AD... - [A proposal for diagnostic and clinical assessment criteria for Alzheimer's disease]Mikio Shoji
Department of Neurology, Neuroscience, Biophysiological Science, Okayama University Graduate School of Medicine and Dentistry
Rinsho Shinkeigaku 45:128-37. 2005.... - Plasma phosphatidylcholine hydroperoxide as a new marker of oxidative stress in alcoholic patientsJunko Adachi
Department of Legal Medicine, Kobe University Graduate School of Medicine, 7 Kusunoki cho Chuo ku, Kobe, 650 0017 Japan
J Lipid Res 45:967-71. 2004..These results suggest the involvement of lipid peroxidation in alcohol-induced liver damage and confirm that the PCOOH plasma concentration is a new marker of alcohol consumption as well as oxidative stress in alcoholic patients... - [Status of adolescent drinking habits in Japan: results of the 1996, 2000 and 2004 surveys]Yoneatsu Ozaki
Nihon Arukoru Yakubutsu Igakkai Zasshi 42:590-4. 2007 - A transient increase in cerebrospinal fluid tau level after epileptic seizure in an elderly patientToshifumi Matsui
J Am Geriatr Soc 55:2096-7. 2007 - [Application of cognitive behavioral therapy for treatment of alcoholism]Tomohiro Miyakawa
Seishin Shinkeigaku Zasshi 109:555-9. 2007 - [Investigation on psychosocial support system for successful temperance and utilization of alcoholic rehabilitation centers]Yukio Matsushita
Seishin Shinkeigaku Zasshi 109:551-4. 2007 - [Physiopathology of alcoholism and present status of the therapy in Japan--result of the questionnaires sent to all psychiatric care facilities]Yoshiro Kochi
Seishin Shinkeigaku Zasshi 109:541-6. 2007 - Acetaldehyde accumulation suppresses Kupffer cell release of TNF-Alpha and modifies acute hepatic inflammation in ratsYuji Nakamura
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
J Gastroenterol 39:140-7. 2004..05), but acetate treatment did not. CONCLUSIONS: Acetaldehyde accumulation suppresses macrophage function, at least suppressing TNF-Alpha release, which plays a role in modifying acute hepatic inflammation in rats... - Two-month stability of hyperbolic discount rates for delayed monetary gains in abstinent inpatient alcoholicsTaiki Takahashi
Department of Cognitive and Behavioral Science, Graduate School of Arts and Sciences, University of Tokyo, Tokyo, Japan
Neuro Endocrinol Lett 28:131-6. 2007.... - Genetic association of CTNNA3 with late-onset Alzheimer's disease in femalesAkinori Miyashita
Center for Bioresources, Brain Research Institute, Niigata University, Niigata, Japan
Hum Mol Genet 16:2854-69. 2007..Furthermore, we found that this SNP exhibited no interaction with the APOE-epsilon4 allele. Our data suggest that CTNNA3 may affect LOAD through a female-specific mechanism independent of the APOE-epsilon4 allele...