Research Topics
| Jørgen SerupSummaryAffiliation: Graduate School Country: Japan Publications
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Detail Information
Publications
[Atopic dermatitis and skin barrier function]Hachiro Tagami
Tohoku University School of Medicine
Arerugi 54:445-50. 2005- Skin conductance; validation of Skicon-200EX compared to the original model, Skicon-100Ken ichiro O'Goshi
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
Skin Res Technol 13:13-8. 2007..The aim of this study was to validate the recent model of a commonly used device for measurement of skin conductance (Skicon-200EX) vs. the original model (Skicon-100) introduced 20 years ago... - Inter-instrumental variation of skin capacitance measured with the CorneometerKen ichiro O'Goshi
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
Skin Res Technol 11:107-9. 2005..The aim of this study was to assess three inter-instrumental similar Corneometer instruments (two pieces of CM820 and one CM810) in normal skin. We named them CM-A(CM820), CM-B(CM820), and CM-C(CM810)... - Basic fibroblast growth factor treatment for various types of recalcitrant skin ulcers: reports of nine casesKen ichiro O'Goshi
Dermatology Section, Kurihara Chuo Hospital, Kurihara city, Japan
J Dermatolog Treat 18:375-81. 2007..This therapeutic modality is useful not only for chronic ulcers but also for acute extensive ulcers... - Safety of sodium fluorescein for in vivo study of skinKen ichiro O'Goshi
Department of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke 23, DK 2400 Copenhagen, Denmark
Skin Res Technol 12:155-61. 2006..The objective of this article is to systematically review the literature on fluorescein and conclude its safety in cutaneous research to support research planning and evaluations by ethics committees... - In vivo imaging of intradermal tattoos by confocal scanning laser microscopyKen ichiro O'Goshi
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
Skin Res Technol 12:94-8. 2006..In vivo confocal laser scanning microscopy (CLSM) is a new method for high-resolution imaging of intact skin in situ. Horizontal mapping of the outer skin is provided (magnification x 1000)... - [Tattoos in a dermatological perspective]Trine Høgsberg
dermatologisk afdeling D, Bispebjerg Hospital, 2400 København NV, Denmark
Ugeskr Laeger 173:34-9. 2011..The field lacks formal regulation at national and European levels and EU had to give up attempts to control the area in 2003 because of lack of knowledge in the field... - Experimental testing of skin reactions to insulin detemir in diabetes patients naïve to insulin detemirKenichiro O'goshi
Department of Dermatology, Bispebjerg Hospital, Copenhagen, Denmark
Skin Res Technol 17:411-9. 2011..The purpose of this experimental study using a provocative design was to elucidate the potential mechanisms behind such skin reactions... - Capsaicin-induced neurogenic inflammation in the skin in patients with symptoms induced by odorous chemicalsHelle Holst
Dermatology Department, The Danish Research Centre for Chemical Sensitivities, Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark
Skin Res Technol 17:82-90. 2011..Polarization spectroscopy imaging introduced recently may be used for the quantitative assessment of the temporal profile of neurogenic inflammation expressed as erythema intensity... - Establishment of an atopic dermatitis-like skin model in a hairless mouse by repeated elicitation of contact hypersensitivity that enables to conduct functional analyses of the stratum corneum with various non-invasive biophysical instrumentsKatsuo Matsumoto
POLA Laboratories, Yokohama, Japan
Skin Res Technol 10:122-9. 2004.... - The accelerating effect of histamine on the cutaneous wound-healing process through the action of basic fibroblast growth factorYukikazu Numata
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
J Invest Dermatol 126:1403-9. 2006..From these observations, it was concluded that the accelerated wound-healing activity of histamine was mediated by the activity of bFGF, which leads to angiogenesis, and macrophage recruitment in the wound-healing process... - Decreased keratinocyte motility in skin wound on mice lacking the epidermal fatty acid binding protein geneYoshiyuki Kusakari
Department of Dermatology, Tohoku University Graduate School of Medicine, Tohoku, Japan
Mol Cell Biochem 284:183-8. 2006..Our analyses suggest that the E-FABP elevation may be necessary for the activation of cell motility within regenerative epidermis during wound healing... - Altered water barrier function in epidermal-type fatty acid binding protein-deficient miceYuji Owada
Division of Histology, Division of Molecular Genetics, Department of Cell Biology, Tohoku University, Sendai, Japan
J Invest Dermatol 118:430-5. 2002..The molecular mechanism by which epidermal-type fatty acid binding protein contributes to the water barrier function of the skin remains to be elucidated... - Comparison of the effects of daily applications between topical corticosteroid and tacrolimus ointments on normal skin: evaluation with noninvasive methodsKatsuko Kikuchi
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
Dermatology 205:378-82. 2002..To evaluate the skin changes of the neck of normal individuals after repeated applications of moderate-strength corticosteroid or tracrolimus ointment for 3 weeks by use of noninvasive biophysical measurements... - Functional analyses of the eyelid skin constituting the most soft and smooth area on the face: contribution of its remarkably large superficial corneocytes to effective water-holding capacity of the stratum corneumWalaiorn Pratchyapruit
Institute of Dermatology, Bangkok, Thailand
Skin Res Technol 13:169-75. 2007..Moreover, the skin of the eyelid does not show any prominent follicular orifices or an oily appearance even in adults. Despite such uniqueness, its biophysical characteristics have remained unclear as compared with other facial skin... - Atopic xerosis: employment of noninvasive biophysical instrumentation for the functional analyses of the mildly abnormal stratum corneum and for the efficacy assessment of skin care productsHachiro Tagami
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
J Cosmet Dermatol 5:140-9. 2006.... - Alleviation of the plantar discomfort caused by pachyonychia congenita with topical applications of aluminum chloride and salicylic acid ointmentsMariko Takayama
Dermatology 211:302. 2005 - Development of a novel Ag-specific immunotherapy using CpG oligodeoxynucleotides in a new, unique mouse cutaneous eosinophilic inflammation modelTanawatt Kootiratrakarn
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
Eur J Immunol 35:3277-86. 2005..The presented results provide strong evidence for the feasibility of a novel Ag-specific immunomodulator to treat cutaneous eosinophilic inflammation such as that characteristically found in patients with severe AD... - Amicrobial pustulosis of the folds affecting a young male without any accompanying autoimmune diseasesRyuhei Okuyama
Dermatology 217:121-3. 2008 - Eosinophilic granulomatous reaction after intradermal injection of hyaluronic acidShuko Okada
Acta Derm Venereol 88:69-70. 2008 - Demonstration of characteristic skin surface contours of extramammary Paget's disease and parapsoriasis en plaque by image analysis of negative impression replicasKatsuko Kikuchi
Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan
J Dermatol Sci 30:20-8. 2002.... - Functional characteristics of the stratum corneum in photoaged skin in comparison with those found in intrinsic agingHachiro Tagami
Tohoku University, 3 27 1 Kaigamori, Aoba ku, Sendai 981 0942, Japan
Arch Dermatol Res 300:S1-6. 2008.... - Impairment of skin barrier function is not inherent in atopic dermatitis patients: a prospective study conducted in newbornsKatsuko Kikuchi
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
Pediatr Dermatol 23:109-13. 2006..Therefore, we concluded that the barrier impairment found in atopic dermatitis is not inherent but represents a phenomenon secondary to dermatitic skin changes... - Pachydermodactyly in an elderly Japanese patient showing distal involvement of the fingersRyuhei Okuyama
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
Dermatology 213:177-8. 2006 - Notch signaling: its role in epidermal homeostasis and in the pathogenesis of skin diseasesRyuhei Okuyama
Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
J Dermatol Sci 49:187-94. 2008..Future efforts to further define how Notch controls cell proliferation and differentiation may lead to the application of Notch in new therapies for various skin diseases... - Localization of IL-8 and complement components in lesional skin of psoriasis vulgaris and pustulosis palmaris et plantarisMaki Ozawa
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
Dermatology 211:249-55. 2005..Munro's microabscesses are a characteristic histopathologic feature of psoriasis vulgaris; however, the pathomechanisms underlying the migration of transepidermal leukocytes (PMNs) have not been fully elucidated yet... - Measurement of electrical current perception threshold of sensory nerves for pruritus in atopic dermatitis patients and normal individuals with various degrees of mild damage to the stratum corneumHiromi Kobayashi
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
Dermatology 206:204-11. 2003.... - Characteristics of the epidermis and stratum corneum of hairless mice with experimentally induced diabetes mellitusShingo Sakai
Basic Research Laboratory, Kanebo Ltd, Kanagawa 250-0002, Japan
J Invest Dermatol 120:79-85. 2003..Our new animal model of diabetes will be useful for the study of diabetic dermopathy as well as the mechanisms of stratum corneum moisturization... - Acute diffuse and total alopecia of the female scalp. A new subtype of diffuse alopecia areata that has a favorable prognosisMaki Sato-Kawamura
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
Dermatology 205:367-73. 2002..We suggest to name it 'acute diffuse and total alopecia of the female scalp (ADTAFS)'... - Three-dimensional analyses of individual corneocytes with atomic force microscope: morphological changes related to age, location and to the pathologic skin conditionsNobuo Kashibuchi
POLA Laboratories, Pola Chemical, Inc 27 1, Takashimadai, Kanagawa ku, Yokohama 221 0833, Japan
Skin Res Technol 8:203-11. 2002..Through analyses of the obtained data, we tried to find morphological parameters that reflect more closely the differentiation process of the corneocytes in the stratum corneum than the frequently used two-dimensional projected area... - Comparison of the distribution and numbers of antigen-presenting cells among T-lymphocyte-mediated dermatoses: CD1a+, factor XIIIa+, and CD68+ cells in eczematous dermatitis, psoriasis, lichen planus and graft-versus-host diseaseMasatoshi Deguchi
Department of Dermatology, Tohoku University Graduate School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980 8574, Japan
Arch Dermatol Res 294:297-302. 2002..The differences in the numbers of APCs in lesional skin appeared to reflect differences in the pathophysiology of these inflammatory skin diseases... - Cutaneous late phase reaction in adult atopic dermatitis patients with high serum IgE antibody to Dermatophagoides farinae: correlation with IL-5 production by allergen-stimulated peripheral blood mononuclear cellsMikiko Okada
Department of Dermatology, Tohoku University School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
J Dermatol Sci 29:73-84. 2002..e. LPR-positive and LPR-negative ones. The observation of LPR can be an important and practical way to classify AD patients into subgroups, which may enable us to regard IL-5 or eosinophils as a target for treatment... - Cholinergic urticaria, a new pathogenic concept: hypohidrosis due to interference with the delivery of sweat to the skin surfaceHiromi Kobayashi
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
Dermatology 204:173-8. 2002..CONCLUSION: We think that such a hypohidrosis due to occlusion of superficial sweat ducts may also play a role in many other patients with CU of unknown etiology that becomes exacerbated in winter when sweating is not a frequent event... - A portable device using a closed chamber system for measuring transepidermal water loss: comparison with the conventional methodHachiro Tagami
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
Skin Res Technol 8:7-12. 2002..Moreover, it is far less expensive than other devices currently available... - The "Haptic Finger"- a new device for monitoring skin conditionMami Tanaka
Department Mechatronics and Precision Engineering, Tohoku University, Sendai, Japan
Skin Res Technol 9:131-6. 2003..Use of this sensor could prove extremely valuable in cosmetic research where skin surface texture (in terms of tactile properties) is difficult to measure... - Resolution of a leg ulcer after hysterectomy for huge uterine myomaTomoyuki Ohtani
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
J Dermatol 30:530-2. 2003..Uterine myoma can become the cause of venous insufficiency of the leg, when it is big enough to disturb the blood circulation in the pelvis in individuals who have incompetent perforating veins... - Detection of various types of human papillomavirus DNA, mainly belonging to the cutaneous-group, more frequently in normal tissue than in squamous cell carcinomas of the lipMakoto Shimizu
Department of Dermatology, Nagoya University Graduate School of Medicine, Tsurumai, Showa-ku, Nagoya 466-8550, Japan
J Dermatol Sci 36:33-9. 2004..CONCLUSION: On the surface of the normal lip various types of mainly cutaneous-group HPVs may be present, but there does not appear to be any obvious association with SCCs developing in this site... - p38 Mitogen-Activated protein kinase mediates dual role of ultraviolet B radiation in induction of maturation and apoptosis of monocyte-derived dendritic cellsSatoshi Nakagawa
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
J Invest Dermatol 123:361-70. 2004..Thus, our study revealed a dual effect of UVB, to stimulate maturation or to induce apoptosis in MoDC, depending on the dosage, via p38 MAPK pathway... - Ber-EP4 antigen is a marker for a cell population related to the secondary hair germMaki Ozawa
Department of Dermatology, Division of Internal Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan
Exp Dermatol 13:401-5. 2004.... - High commitment of embryonic keratinocytes to terminal differentiation through a Notch1-caspase 3 regulatory mechanismRyuhei Okuyama
Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
Dev Cell 6:551-62. 2004..Thus, a Notch1-caspase 3 regulatory mechanism underlies the intrinsically high commitment of embryonic keratinocytes to terminal differentiation... - Acute cutaneous barrier disruption activates epidermal p44/42 and p38 mitogen-activated protein kinases in human and hairless guinea pig skinHiromi Kobayashi
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
Exp Dermatol 12:734-46. 2003..These results for strongly suggest that the activation of p44/42 and p38 MAPKs links the stimuli of barrier disruption to the subsequent homeostatic responses to repair the barrier defect... - H1 and H2 histamine receptors are absent on Langerhans cells and present on dermal dendritic cellsTomoyuki Ohtani
Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan
J Invest Dermatol 121:1073-9. 2003..These data suggest that LC do not express either H1 or H2 receptors, mainly because of the effect of TGF-beta1. This made a striking contrast with the expression of the functional H1 and H2 receptors on MoDC and dermal dendritic cells... - Ratio of immature cornified envelopes does not correlate with parakeratosis in inflammatory skin disordersTetsuji Hirao
Shiseido Life Science Research Center, 2 2 1 Hayabuchi, Tsuzuki ku Yokohama 236 8643, Japan
Exp Dermatol 12:591-601. 2003..These results obviously suggest that the maturation of CEs and disappearance of nuclei are differentially regulated in the epidermis... - Improvement of mild inflammatory changes of the facial skin induced by winter environment with daily applications of a moisturizing cream. A half-side test of biophysical skin parameters, cytokine expression pattern and the formation of cornified envelopeKatsuko Kikuchi
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
Dermatology 207:269-75. 2003.... - Cord blood CD34+ cells differentiate into dermal dendritic cells in co-culture with cutaneous fibroblasts or stromal cellsZia U A Mollah
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan
J Invest Dermatol 118:450-60. 2002....