Research Topics
| Antonio del SolSummaryAffiliation: Fujirebio Inc Country: Japan Publications
| Collaborators
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Detail Information
Publications
The origin of allosteric functional modulation: multiple pre-existing pathwaysAntonio del Sol
Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Hachioji shi, Tokyo, Japan
Structure 17:1042-50. 2009....- Modular architecture of protein structures and allosteric communications: potential implications for signaling proteins and regulatory linkagesAntonio del Sol
Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
Genome Biol 8:R92. 2007..Allosteric communications are vital for cellular signaling. Here we explore a relationship between protein architectural organization and shortcuts in signaling pathways... - Small-world network approach to identify key residues in protein-protein interactionAntonio del Sol
Bioinformatics Research Project, Frontier Research Division, Fujirebio Inc, 51 Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
Proteins 58:672-82. 2005.... - Topology of small-world networks of protein-protein complex structuresAntonio del Sol
Bioinformatics Research Project, Research and Development Division, Fujirebio Inc, 51 Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
Bioinformatics 21:1311-5. 2005..CONTACT: ao-mesa@fujirebio.co.jp SUPPLEMENTARY INFORMATION: http://www.fujirebio.co.jp/support/index.php (under construction)... - The modular organization of domain structures: insights into protein-protein bindingAntonio del Sol
Bioinformatics Research Unit, Research and Development Division, Fujirebio, Tokyo, Japan
PLoS Comput Biol 3:e239. 2007..A modular organization of binding sites confers robustness and flexibility to the performance of the functional activity, and facilitates the evolution of protein interactions... - Residues crucial for maintaining short paths in network communication mediate signaling in proteinsAntonio del Sol
Bioinformatics Research Unit, Research and Development Division, Fujirebio Inc, Hachioji shi, Tokyo, Japan
Mol Syst Biol 2:2006.0019. 2006..Thus, here we propose that centrally conserved residues, whose removal increases the characteristic path length in protein networks, may relate to the system fragility... - Residue centrality, functionally important residues, and active site shape: analysis of enzyme and non-enzyme familiesAntonio del Sol
Bioinformatics Research Unit, Research and Development Division, Tokyo, Japan
Protein Sci 15:2120-8. 2006..Residue centrality is more conserved than the protein sequence, emphasizing the robustness of protein structures... - Energetic determinants of protein binding specificity: insights into protein interaction networksPablo Carbonell
Bioinformatics Research Unit, Research and Development Division, Fujirebio, Inc, Komiya cho, Hachioji shi, Tokyo, Japan
Proteomics 9:1744-53. 2009..Knowledge of those factors playing a role in protein specificity is important for understanding how proteins acquire additional partners during evolution. It should also be useful in drug design... - Methyl side-chain dynamics prediction based on protein structurePablo Carbonell
Fujirebio Inc, Bioinformatics Research Unit, Research and Development Division, Komiya cho, Hachioji shi, Tokyo 192 0031, Japan
Bioinformatics 25:2552-8. 2009..In particular, quantitative description of side-chain dynamics would allow us to understand the role of side-chain flexibility in different functional processes, such as protein-ligand and protein-protein interactions... - TreeDet: a web server to explore sequence spaceAngel Carro
Protein Design Group, CNB-CSIC C/Darwin n.3, 28049, Madrid, Spain
Nucleic Acids Res 34:W110-5. 2006..An additional method is provided to highlight the reliability of the position in the alignments. The server is available at http://www.pdg.cnb.uam.es/servers/treedet... - Ligand binding and circular permutation modify residue interaction network in DHFRZengjian Hu
Department of Biochemistry and Molecular Biology, Howard University College of Medicine, Washington, District of Columbia, United States of America
PLoS Comput Biol 3:e117. 2007..Ligand binding at the active site has profound effects on the network centrality, especially the closeness... - A framework for computational and experimental methods: identifying dimerization residues in CCR chemokine receptorsDavid de Juan
Protein Design Group, National Center of Biotechnology (CNB-CSIC) Cantoblanco, Madrid, Spain
Bioinformatics 21:ii13-8. 2005..The experimental validation of computational procedures demonstrated here provides a wealth of valuable information not obtainable by any of the individual approaches alone... - Allostery: absence of a change in shape does not imply that allostery is not at playChung Jung Tsai
Basic Research Program, SAIC Frederick, Inc, Center for Cancer Research Nanobiology Program, NCI Frederick, Frederick, MD 21702, USA
J Mol Biol 378:1-11. 2008..Assuming that the enthalpy change does not reverse the free-energy change due to the change in entropy, entropy is mainly responsible for binding... - Identification of amino acid residues crucial for chemokine receptor dimerizationPatricia Hernanz-Falcón
Department of Immunology and Oncology, National Center of Biotechnology, Campus Universitario de Cantoblanco, E 28049 Madrid, Spain
Nat Immunol 5:216-23. 2004..This is the first description of the residues involved in chemokine receptor dimerization, and indicates a potential target for the modification of chemokine responses...