Tsutomu Ohtsuka

Summary

Affiliation: Dokkyo University School of Medicine
Country: Japan

Publications

  1. ncbi Elevated expression of epidermal ornithine decarboxylase mRNA in scleroderma
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan
    Br J Dermatol 139:1047-8. 1998
  2. ncbi Serum interleukin-6 level is reflected in elevated high-sensitivity C-reactive protein level in patients with systemic sclerosis
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    J Dermatol 37:801-6. 2010
  3. ncbi Quantitative echographic analysis of photochemotherapy on systemic sclerosis skin
    Michio Hashikabe
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
    Arch Dermatol Res 296:522-7. 2005
  4. ncbi The involvement of immunoglobulin E isotype switch in scleroderma skin tissue
    Tsutomu Ohtsuka
    Department of Dermatology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    J Dermatol Sci 39:97-104. 2005
  5. ncbi Novel mutation in ATP2C1 gene in a Japanese patient with Hailey-Hailey disease
    Tsutomu Ohtsuka
    Department of Dermatology, Koshigaya Hospital, Dokkyo University School of Medicine, 2 1 50 Minami Koshigaya, Koshigaya, Saitama 343 8555, Japan
    Dermatology 212:194-7. 2006
  6. ncbi Relation between elevated high-sensitivity C-reactive protein and anti-mitochondria antibody in patients with systemic sclerosis
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
    J Dermatol 35:70-5. 2008
  7. ncbi Palisading granuloma presenting in a patient with systemic lupus erythematosus
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    J Dermatol 35:452-5. 2008
  8. ncbi The correlation between response to oral cyclosporin therapy and systemic inflammation, metabolic abnormality in patients with psoriasis
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, 2 1 50 Mimami Koshigaya, Koshigaya, Saitama 343 8555, Japan
    Arch Dermatol Res 300:545-50. 2008
  9. ncbi Effect of gammadelta T cell supernatant on human skin fibroblast proliferation and collagen production--possible role of transforming growth factor-beta and basic fibroblast growth factor
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University, Koshigaya Hospital, Koshigaya, Saitama, Japan
    Int J Dermatol 47:1135-40. 2008
  10. ncbi Oral tacrolimus treatment for refractory eosinophilic cellulitis
    T Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Clin Exp Dermatol 34:e597-8. 2009

Collaborators

Detail Information

Publications30

  1. ncbi Elevated expression of epidermal ornithine decarboxylase mRNA in scleroderma
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan
    Br J Dermatol 139:1047-8. 1998
    ..Possibly polyamines have an important part to play in the skin changes of SSc...
  2. ncbi Serum interleukin-6 level is reflected in elevated high-sensitivity C-reactive protein level in patients with systemic sclerosis
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    J Dermatol 37:801-6. 2010
    ..53 ± 1.12 pg/mL) (P < 0.02, P < 0.01). The correlation between hs-CRP level and IL-6 level in SSc patients was 0.687 (P < 0.001). In conclusion, elevated serum IL-6 levels are reflected in elevated hs-CRP levels in SSc patients...
  3. ncbi Quantitative echographic analysis of photochemotherapy on systemic sclerosis skin
    Michio Hashikabe
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
    Arch Dermatol Res 296:522-7. 2005
    ..Quantitative echographic analysis was concluded to be a reliable method in evaluating the change of skin edema in SSc...
  4. ncbi The involvement of immunoglobulin E isotype switch in scleroderma skin tissue
    Tsutomu Ohtsuka
    Department of Dermatology, Koshigaya Hospital, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    J Dermatol Sci 39:97-104. 2005
    ..IgE is generated with isotype switch. During isotype switch, switch circles resulting from direct mu to epsilon, or from sequential mu to gamma via epsilon switching will be created...
  5. ncbi Novel mutation in ATP2C1 gene in a Japanese patient with Hailey-Hailey disease
    Tsutomu Ohtsuka
    Department of Dermatology, Koshigaya Hospital, Dokkyo University School of Medicine, 2 1 50 Minami Koshigaya, Koshigaya, Saitama 343 8555, Japan
    Dermatology 212:194-7. 2006
    ..Another patient showed no mutation of the gene. These results demonstrate that a spectrum of ATP2C1 gene mutations is present in Japanese HHD patients...
  6. ncbi Relation between elevated high-sensitivity C-reactive protein and anti-mitochondria antibody in patients with systemic sclerosis
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan
    J Dermatol 35:70-5. 2008
    ..5%) (P < 0.01). These results led us to the conclusion that elevated high-sensitivity CRP shows relation to the occurrence of anti-mitochondria antibody...
  7. ncbi Palisading granuloma presenting in a patient with systemic lupus erythematosus
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    J Dermatol 35:452-5. 2008
    ..She was diagnosed as having systemic lupus erythematosus complicated with a rheumatoid nodule. She is currently under treatment with cyclophosphamide (50 mg/day) without exaggeration of her systemic lupus erythematosus and nodule...
  8. ncbi The correlation between response to oral cyclosporin therapy and systemic inflammation, metabolic abnormality in patients with psoriasis
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, 2 1 50 Mimami Koshigaya, Koshigaya, Saitama 343 8555, Japan
    Arch Dermatol Res 300:545-50. 2008
    ..These results showed the correlation between response of oral cyclosporin therapy and systemic inflammation, metabolic abnormality in patients with psoriasis...
  9. ncbi Effect of gammadelta T cell supernatant on human skin fibroblast proliferation and collagen production--possible role of transforming growth factor-beta and basic fibroblast growth factor
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University, Koshigaya Hospital, Koshigaya, Saitama, Japan
    Int J Dermatol 47:1135-40. 2008
    ..Objective To study a role of cellular immune mechanism inducing fibroblast proliferation and collagen synthesis...
  10. ncbi Oral tacrolimus treatment for refractory eosinophilic cellulitis
    T Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Clin Exp Dermatol 34:e597-8. 2009
    ..These results led us to the diagnosis of eosinophilic cellulitis. Treatment with oral corticosteroids (prednisolone 15 mg/day) was unsuccessful. Four weeks after the start of oral tacrolimus 1 mg/day, the eruption completely resolved...
  11. ncbi Combinational effect of low-dose oral corticosteroid and mizoribine for ulcerative colitis in a patient with systemic sclerosis
    Tsutomu Ohtsuka
    Department of Dermatology, Koshigaya Hospital, Dokkyo Medical University, Saitama 343 8555, Japan
    J Dermatol 37:71-4. 2010
    ..She showed remarkable improvement for sclerodactyly and lower intestinal bleeding stopped after 6 months. She is under the same treatment without exaggeration and adverse effect of the drug until now...
  12. ncbi Response to oral cyclosporine therapy and high sensitivity-CRP level in chronic idiopathic urticaria
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo Medical University Koshigaya Hospital, Koshigaya, Saitama, Japan
    Int J Dermatol 49:579-84. 2010
    ..Chronic idiopathic urticaria (CIU) is often resistant to common treatment of uriticaria...
  13. ncbi Increased prevalence of human parvovirus B19 DNA in systemic sclerosis skin
    T Ohtsuka
    Department of Dermatology, Dokkyo Koshigaya Hospital, 2 1 50, Saitoma, 343 8555, Japan
    Br J Dermatol 150:1091-5. 2004
    ..In recent years, the possible involvement of parvovirus B19 in systemic sclerosis (SSc) has been reported...
  14. ncbi Different interaction of mast cells with human endothelial cells and fibroblasts
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, 321 0293 Tochigi, Japan
    Eur J Dermatol 10:115-21. 2000
    ..These results suggest the possibility that MC have a role in a number of chronic inflammatory diseases resulting in vascular injury and interstitial fibrosis...
  15. ncbi The polymorphism of transforming growth factor-beta1 gene in Japanese patients with systemic sclerosis
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Br J Dermatol 147:458-63. 2002
    ..Transforming growth factor (TGF)-beta has been shown to be a potent stimulator of collagen production by fibroblasts, and could play a role in the pathogenesis of systemic sclerosis (SSc)...
  16. ncbi The polymorphism of telomerase RNA component gene in patients with systemic sclerosis
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Br J Dermatol 147:250-4. 2002
    ..It can be hypothesized that abnormalities of telomerase contribute to the emergence of abnormal fibroblast clones in systemic sclerosis (SSc)...
  17. ncbi Upregulation of histidine decarboxylase mRNA expression in scleroderma skin
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Arch Dermatol Res 293:171-7. 2001
    ..The upregulation of histamine turnover appears to be involved in the formation of the skin abnormalities of SSc...
  18. ncbi The effect of extracorporeal photochemotherapy on alpha1(I) and alpha1(III) procollagen mRNA expression in systemic sclerosis skin tissue
    Tsutomu Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan
    Arch Dermatol Res 293:642-5. 2002
  19. ncbi Quantitative analysis of alpha 1(I) and alpha 1(III) procollagen mRNA expression in systemic sclerosis skin tissue--an in situ hybridization study
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan
    Arch Dermatol Res 291:575-82. 1999
    ....
  20. ncbi Quantitative analysis of microchimerism in systemic sclerosis skin tissue
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Arch Dermatol Res 293:387-91. 2001
    ..These results indicate that the elevated amount of male cell DNA in SSc skin tissue may contribute to the pathogenesis of SSc...
  21. ncbi Digital ulcers and necroses: novel manifestations of angiocentric lymphoma
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Br J Dermatol 142:1013-6. 2000
    ....
  22. ncbi Simultaneous analysis of [3H]-thymidine uptake and alpha 1(I) procollagen mRNA expression in systemic sclerosis skin fibroblasts--an in situ hybridization study
    T Ohtsuka
    Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan
    Arch Dermatol Res 292:248-55. 2000
    ..05). These results indicate that elevated DNA synthesis and elevated collagen mRNA synthesis in SSc skin fibroblasts are due to different clones with high DNA-synthesizing ability and high collagen-producing ability...
  23. ncbi Detection of mucosal human papilloma virus DNA in bowenoid papulosis, Bowen's disease and squamous cell carcinoma of the skin
    Naoto Hama
    Department of Dermatology, Dokkyo University School of Medicine, Koshigaya, Saitama, Japan
    J Dermatol 33:331-7. 2006
    ..These results showed that mucosal HPV, including HPV 31 and 16, could be detected in SSC of the skin. Mucosal HPV, not only the epidermodysplasia verruciformis type, appear to induce malignant skin tumors...
  24. ncbi Polymorphism of the vitamin D(3) receptor in patients with psoriasis
    Hiroshi Okita
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321 0293, Japan
    Arch Dermatol Res 294:159-62. 2002
    ..These results show that the VDR genotype contributes to the liver dysfunction in patients with psoriasis, although no correlation was found between VDR genotype and the skin eruptions of psoriasis...
  25. ncbi Lipodystrophia centrifugalis abdominalis infantilis-- immunohistochemical demonstration of an apoptotic process in the degenerating fatty tissue
    H Okita
    Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan
    Dermatology 201:370-2. 2000
    ..He was diagnosed as having LCAI. The present case showed the possible involvement of apoptosis in the fatty tissue degeneration in LCAI...
  26. ncbi Flow-cytometric DNA analysis in cutaneous fibrohistiocytic tumors
    Hiroshi Okita
    Department of Dermatology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    Dermatology 207:357-61. 2003
    ..CONCLUSION: Analysis of DNA ploidy using flow cytometry was concluded to be useful for the differentiation of malignant fibrohistiocytic tumors from benign ones...
  27. ncbi Squamous cell carcinoma of the penis in a man with a human papilloma virus 31 infection
    Naoto Hama
    Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan
    J Dermatol 32:581-4. 2005
    ..A polymerase chain reaction was performed to detect human papilloma virus (HPV) DNA. The result revealed the presence of HPV in the SCC. The results of sequencing analysis showed that the DNA was HPV 31...
  28. ncbi Leg ulcer presenting in a patient with congenital afibrinogenaemia
    Akira Kinebuchi
    Department of Dermatology, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi 321-0293, Japan
    Eur J Dermatol 12:70-2. 2002
    ..This is the second reported case of congenital afibrinogenaemia presented with leg ulcer...
  29. ncbi Elevated amount of human papillomavirus 31 DNA in a squamous cell carcinoma developed from bowenoid papulosis
    N Hama
    Department of Dermatology, Dokkyo University School of Medicine, Tochigi, Japan
    Dermatology 209:329-32. 2004
    ..The HPV DNA in SCC and BP was shown to be HPV-31. These observations indicated that the elevated amount of HPV-31 DNA could have led to the emergence of SCC from BP under the condition of decreased cellular immunity...
  30. ncbi Prevalence of human cytomegalovirus DNA in scleroderma skin tissue
    Tsutomu Ohtsuka
    Int J Dermatol 45:86-7. 2006