Jun ichi Kuroyanagi

Summary

Affiliation: Daiichi Sankyo Co
Country: Japan

Publications

  1. ncbi Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis
    Jun ichi Kuroyanagi
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, Edogawa ku, Tokyo 134 8630, Japan
    Bioorg Med Chem 18:5845-54. 2010
  2. ncbi 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of ?-1,6-glucan synthesis inhibitors
    Jun ichi Kuroyanagi
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, 1 16 13 Kitakasai, Edogawa ku, Tokyo 134 8630, Japan
    Bioorg Med Chem 18:7593-606. 2010
  3. ncbi Structure-activity relationships of 1,3-benzoxazole-4-carbonitriles as novel antifungal agents with potent in vivo efficacy
    Jun ichi Kuroyanagi
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 59:341-52. 2011

Detail Information

Publications3

  1. ncbi Novel antifungal agents: triazolopyridines as inhibitors of beta-1,6-glucan synthesis
    Jun ichi Kuroyanagi
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, Edogawa ku, Tokyo 134 8630, Japan
    Bioorg Med Chem 18:5845-54. 2010
    ..Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of beta-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species...
  2. ncbi 1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of ?-1,6-glucan synthesis inhibitors
    Jun ichi Kuroyanagi
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, 1 16 13 Kitakasai, Edogawa ku, Tokyo 134 8630, Japan
    Bioorg Med Chem 18:7593-606. 2010
    ..Conversion of benzene 24 into various 1,3-benzoxazole derivatives such as 2-aliphatic 34, 2-amino 35, and lactone 38 was demonstrated...
  3. ncbi Structure-activity relationships of 1,3-benzoxazole-4-carbonitriles as novel antifungal agents with potent in vivo efficacy
    Jun ichi Kuroyanagi
    Lead Discovery and Optimization Research Laboratories II, Daiichi Sankyo Co, Ltd, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 59:341-52. 2011
    ..Compound 16b showed potent in vivo efficacy against mice Candida infection models and good bioavailability in rats...