Research Topics
| Kenji AdachiSummaryAffiliation: Chugai Pharmaceutical Co Country: Japan Publications
| Collaborators
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Detail Information
Publications
Effects of granulocyte colony-stimulating factor on the kinetics of inflammatory cells in the peripheral blood and pulmonary lesions during the development of bleomycin-induced lung injury in ratsKenji Adachi
Department of Safety Assessment, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
Exp Toxicol Pathol 55:21-32. 2003..The exacerbating effect of G-CSF on the severe BLM-induced lung injury seems to be related not only to the pulmonary accumulation of activated neutrophils but also to the severity of lung injury caused by the direct effects of BLM...- Effects of granulocyte colony-stimulating factor (G-CSF) on bleomycin-induced lung injury of varying severityKenji Adachi
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
Toxicol Pathol 31:665-73. 2003..The exacerbating effects of G-CSF seem to be associated not only with the marked infiltration of activated neutrophils but also with the severity of underlying lung injury... - Effects of erlotinib on lung injury induced by intratracheal administration of bleomycin (BLM) in ratsKenji Adachi
Safety Assessment Department, Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
J Toxicol Sci 35:503-14. 2010..These results suggest that erlotinib does not have any exacerbating effects on lung injuries induced by BLM in rats... - Granulocyte colony-stimulating factor has no adverse effects on atherosclerotic lesions in high cholesterol-fed miniature SwineHirotake Takai
Department of Safety Assessment, Fuji Gotemba Research Laboratory, Chugai Pharmaceutical Co, Ltd, Shizuoka, Japan
J Vet Med Sci 70:943-50. 2008.... - Emphysematous cystitis in a chemically-induced diabetic dogSaori Matsuo
Fuji Gotemba Research Laboratories, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba shi, Shizuoka 412 8513, Japan
J Toxicol Pathol 22:289-92. 2009..Multinucleated giant cells were observed around the cysts, and gram-negative short bacilli were observed in the lumen of the urinary bladder. From these findings, this case was diagnosed as emphysematous cystitis... - Segmentation of the Pathophysiological Stages of Diabetic Changes in the db/db MouseMasaki Yamazaki
Safety Assessment Department, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba, Shizuoka 412 8513, Japan
J Toxicol Pathol 22:133-7. 2009..The pathophysiological stages of diabetes mellitus in this animal model were similar to the stages in humans... - Effects of lysine-induced acute renal failure in dogsKentaro Asanuma
Safety Assessment Department, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba shi, Shizouka 412 8513, Japan
J Toxicol Sci 31:87-98. 2006..From these findings, it can be concluded that lysine is nephrotoxic in dogs. Nephrotoxicity of lysine may relate to direct tubular toxicity and to tubular obstruction... - Establishment and characterization of in vivo human tumor models in the NOD/SCID/gamma(c)(null) mouseEtsuko Fujii
PharmaLogicals Research Pte Ltd, Singapore
Pathol Int 58:559-67. 2008..Investigators in the field of tumor research will benefit from the availability of tissue lines that allow the establishment of more relevant in vivo human tissue models... - Application of an indwelling vascular access port for intravenous administration in a repeated and intermittent dose toxicity study in ratsJunko Taketoh
Safety Assessment Department, Chugai Pharmaceutical Co, Ltd, 1 135 Komakado, Gotemba shi, Shizuoka 412 8513, Japan
J Toxicol Sci 34:39-52. 2009..The results suggested that an animal model with implanted VAP is useful for intermittent intravenous dosing of drugs. Moreover, VAP implantation in animals is expected to be extrapolated to use VAP in humans in clinical studies... - Combination of fixation using PLP fixative and embedding in paraffin by the AMeX method is useful for histochemical studies in assessment of immunotoxicityMasami Suzuki
Toxicology Laboratory, Chugai Pharmaceutical Co, Ltd, 1-135 Komakado, Gotemba-shi, Shizuoka 412-8513, Japan
J Toxicol Sci 27:165-72. 2002..These findings suggest that the PLP-AMeX method is a powerful tool for assessment of immunotoxicity... - Differences in bone responses to recombinant human granulocyte colony-stimulating factor between mice and ratsMasami Suzuki
J Toxicol Sci 33:245-9. 2008..These results suggest that there is a species-related difference between mice and rats in the response of the bone to rhG-CSF treatment, and that the reactivity in mice is lower than in rats... - Close association between activated platelets and neutrophils in the active phase of ulcerative colitis in humansSoichiro Kayo
Department of Pathology, Osaka City University Graduate School of Medicine, Osaka, Japan
Inflamm Bowel Dis 12:727-35. 2006..This suggests that platelet-neutrophil association may play an important role in the progression of inflammatory processes in UC... - Preparation of chiral 4-benzyloxymethyldihydrofuran-2-one using lipase-catalyzed kinetic resolution: synthesis of (-)-virginiae butanolide C (VB C)Kunihiko Takabe
Department of Molecular Science, Faculty of Engineering, Shizuoka University, Hamamatsu, Japan
Bioorg Med Chem Lett 12:2295-7. 2002..The butanamide 10 smoothly cyclized to give chiral 4-benzyloxymethyldihydrofuran-2-one 9 without racemization, which was effectively transformed into highly stereocontrolled virginiae butanolide C (VB C)...