Research Topics
Species | Shizuko TsuchiyaSummaryAffiliation: Chiba University Country: Japan Publications
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Detail Information
Publications
Effect of mitragynine, derived from Thai folk medicine, on gastric acid secretion through opioid receptor in anesthetized ratsShizuko Tsuchiya
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263 8522, Japan
Eur J Pharmacol 443:185-8. 2002..The inhibitory effect of mitragynine (30 microg) was reversed by naloxone (100 microg). These results suggest that mitragynine has a morphine-like action on gastric acid secretion in the CNS...- Stimulatory effects of centrally injected kainate and N-methyl-D-aspartate on gastric acid secretion in anesthetized ratsS Tsuchiya
Laboratory of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University, 263 8522, Chiba, Japan
Brain Res 914:115-22. 2001..v.) and vagotomy. These findings suggest that kainate and NMDA receptor mechanisms are independently involved in the central nervous system to control gastric acid secretion through vagus cholinergic activation... - Stimulatory effects of centrally injected nitric oxide donors on gastric acid secretion in anesthetized ratsShizuko Tsuchiya
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Jpn J Pharmacol 89:126-32. 2002..These results suggest that centrally injected NO donors stimulate gastric acid secretion in both conscious and anesthetized rats through vagus activation... - Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brainSachie Minowa
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 260 8675, Japan
Brain Res 1039:75-83. 2005..In conclusion, the TRPV1 system, which is activated by capsaicin and anandamide, is preferentially coupled with non-NMDA and GABA(A) receptor systems in the brain and stimulates gastric acid secretion in rats... - Involvement of glutamate and gamma-amino-butyric acid receptor systems on gastric acid secretion induced by activation of kappa-opioid receptors in the central nervous system in ratsSachie Minowa
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan
Br J Pharmacol 138:1049-58. 2003..The present findings show pharmacological evidence for kappa-opioid receptor subtypes that regulate gastric acid secretion in the rat brain... - Gastric acid secretion stimulated by centrally injected nociceptin in urethane-anesthetized ratsSatomi Ishihara
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan
Eur J Pharmacol 441:105-14. 2002..v.). In conclusion, nociceptin injected into the CNS stimulated gastric acid secretion in rats via the ORL1 receptors and through mechanisms involving the vagus nerve... - Role of neuropeptide receptor systems in vanilloid VR1 receptor-mediated gastric acid secretion in rat brainSachie Minowa
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan
Eur J Pharmacol 486:317-24. 2004..These findings suggest the involvement of tachykinin NK2, CGRP and non-NMDA receptor systems in the vanilloid VR1 receptor-mediated regulation of gastric acid secretion in the rat brain regions close to the lateral cerebroventricle... - Morphine-6-glucuronide induces contraction of the ileal circular muscle more potently than morphine in miceHiroki Iwata
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Inohana, Chiba, Japan
Eur J Pharmacol 600:130-2. 2008..Morphine-3-glucuronide induced slight contraction at high dose. These results suggest that the strong contraction induced by morphine-6-glucuronide contributed to the inhibition of small intestinal transit in mice... - Contractile effect of TRPA1 receptor agonists in the isolated mouse intestineAngelica Penuelas
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba, 260 8675, Japan
Eur J Pharmacol 576:143-50. 2007.... - Mesaconitine-induced relaxation in rat aorta: involvement of Ca2+ influx and nitric-oxide synthase in the endotheliumMana Mitamura
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba 263-8522, Japan
Eur J Pharmacol 436:217-25. 2002..These findings suggest that mesaconitine-induced Ca2+ influx and activation of nitric-oxide synthase in endothelial cells and, thus, induced vasorelaxation in rat aorta... - Morphine leads to contraction of the ileal circular muscle via inhibition of the nitrergic pathway in miceHiroki Iwata
Laboratory of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan
Eur J Pharmacol 574:66-70. 2007.... - Regionally differential effects of sennoside A on spontaneous contractions of colon in miceMichiko Kobayashi
Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
Basic Clin Pharmacol Toxicol 101:121-6. 2007.... - The structure-activity relationship between oxycoumarin derivatives showing inhibitory effects on iNOS in mouse macrophage RAW264.7 cellsTomonori Nakamura
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, 260 8675, Japan
J Nat Med 63:15-20. 2009..It is expected that these compounds will show anti-inflammatory activities via inhibition of the expressions of iNOS and COX-2... - Stimulatory effect of centrally injected capsaicin, an agonist of vanilloid receptors, on gastric acid secretion in ratsS Minowa
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, 263-8522, Chiba, Japan
Eur J Pharmacol 428:349-56. 2001.... - Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentationMasumi Sasaki
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Biol Pharm Bull 30:682-6. 2007..Genistein, a soy isoflavone that has the pro-apoptotic activity, also caused cell death with DNA fragmentation. Further evaluation of the potential of dietary flavonoids as neuroprotective reagents is needed... - Gastric acid secretion by central injection of dynorphin A-(1-17), an endogenous ligand of kappa-opioid receptor, in urethane-anesthetized ratsS Ishihara
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Chiba University, Japan
Jpn J Pharmacol 87:14-20. 2001..These findings showed that both an endogenous ligand dynorphin A-(1-17) and a synthetic kappa3-opioid receptor agonist stimulated gastric acid secretion via kappa-opioid receptors in the CNS of rats in vivo... - Stimulatory effects of centrally injected kappa-opioid receptor agonists on gastric acid secretion in urethane-anesthetized ratsS Ishihara
Laboratory of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University, 263-8522, Chiba, Japan
Eur J Pharmacol 418:187-94. 2001..D-Pen(2)-D-Pen(5)]enkephalin (10microg, delta-opioid receptor agonist) had no effect on secretion. The dual roles of the opioid system in the CNS in gastric acid secretion are discussed... - Phenolic compounds from Gastrodia rhizome and relaxant effects of related compounds on isolated smooth muscle preparationJunko Hayashi
Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, 263-8522, Chiba, Japan
Phytochemistry 59:513-9. 2002..The relaxant effects of these constituents on smooth muscle preparations isolated from guinea-pig ileum were also studied in order to reveal their characteristic pharmacological activities... - Stimulatory effect of dibutyryl cyclic GMP on acid secretion in mouse isolated stomach and on histamine release in gastric mucosal cellsS Horie
Department of Drug Evaluation and Toxicological Sciences, Faculty of Pharmaceutical Sciences, Chiba University, Japan
J Physiol Paris 94:25-9. 2000..On the other hand, in gastric parietal cells, cyclic AMP has a stimulatory effect on gastric acid secretion, whereas cyclic GMP has an inhibitory effect... - Enhancement of phenylephrine-induced contraction in the isolated rat aorta with endothelium by H2O-extract from an Oriental medicinal plant Leonuri herbaS Pang
Laboratory of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Chiba University, Japan
Jpn J Pharmacol 86:215-22. 2001..35 mg/kg). These findings suggest that there is a component(s) in Leonuri herba, which shows a vasoconstrictive activity in rat aorta in vitro and in vivo and has similar pharmacological profile to that of L-NAME... - Selectivity of isoprenoid-containing imidazole antifungal compounds for sterol 14-demethylase P450 (P450(14)DM) and 7-ethoxycoumarin O-deethylase P450 of rat liver microsomesT Ito
Faculty of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo, Japan
Biochem Pharmacol 48:1577-82. 1994..These results suggest that azole compounds interacting with the side-chain recognition site of P450(14)DM may be good candidates as antifungal agents selective for fungal P450(14)DM...