Research Topics
| Akiyoshi OhtakeSummaryAffiliation: Astellas Pharma Inc Country: Japan Publications
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Detail Information
Publications
[Pharmacological and clinical profile of solifenacin succinate (Vesicare) developed as a new therapeutic agent for overactive bladder]Akiyoshi Ohtake
Nippon Yakurigaku Zasshi 128:425-32. 2006- The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overactive bladder symptoms, especially urgenAkiyoshi Ohtake
Applied Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, Tsukuba shi, Ibaraki 305 8585, Japan
J Pharmacol Sci 112:135-41. 2010..The pharmacological profile of solifenacin is therefore considered to contribute to its beneficial effects of high efficacy against OAB symptoms with good tolerability... - Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agentsAkiyoshi Ohtake
Pharmacology Research Labs, Drug Discovery Research, Astellas Pharma Inc, Tsukuba, Ibaraki, Japan
Biol Pharm Bull 30:54-8. 2007..These results support the fact that solifenacin, similarly to currently used antimuscarinic agents, is an effective agent in the treatment of overactive bladder symptoms such as urinary frequency and urge incontinence... - Effects of tamsulosin on resting urethral pressure and arterial blood pressure in anaesthetized female dogsAkiyoshi Ohtake
Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
J Pharm Pharmacol 58:345-50. 2006..These results suggest that tamsulosin will be useful in the treatment of voiding dysfunction associated with bladder outlet obstruction in women, with little hypotensive effect... - Effect of tamsulosin on spontaneous bladder contraction in conscious rats with bladder outlet obstruction: comparison with effect on intraurethral pressureAkiyoshi Ohtake
Pharmacology Research Labs, Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
Eur J Pharmacol 545:185-91. 2006..These results partly support the fact that tamsulosin has improved storage symptoms as well as voiding symptoms in patients with lower urinary tract symptoms associated with bladder outlet obstruction by blocking alpha(1)-adrenoceptors... - Pharmacological characterization of YM598, a selective endothelin-A receptor antagonistKatsumi Sudoh
Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, Tsukuba shi, Ibaraki, Japan
J Cardiovasc Pharmacol 44:S390-3. 2004..These results suggest that YM598 has a high selectivity for native human ETA receptors against ETB receptors, and that YM598 is superior to atrasentan as an ETA receptor antagonist, with regard to pharmacological bioavailability in rats... - In vitro and in vivo effects of endothelin-1 and YM598, a selective endothelin ET A receptor antagonist, on the lower urinary tractMasashi Ukai
Applied Pharmacology II, Pharmacology Research Labs, Institute for Drug Discovery Research, Astellas Pharma Inc, 21, Miyukigaoka, Tsukuba shi, Ibaraki 305 8585, Japan
Eur J Pharmacol 580:394-400. 2008.... - In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in ratsAkiyoshi Ohtake
Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
Eur J Pharmacol 492:243-50. 2004.... - Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarcted ratsMasanori Suzuki
Applied Pharmacology Research, Pharmacology Laboratories, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
Eur J Pharmacol 512:61-6. 2005..These results suggest that solifenacin may improve detrusor overactivity without causing urinary retention and may be a promising drug in the treatment of patients with overactive bladder syndrome... - Participation of endogenous endothelin and ETA receptor in premicturition contractions in rats with bladder outlet obstructionMasashi Ukai
Pharmacology Research Labs, Institute for Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
Naunyn Schmiedebergs Arch Pharmacol 373:197-203. 2006.... - In vivo study on the effects of alpha1-adrenoceptor antagonists on intraurethral pressure in the prostatic urethra and intraluminal pressure in the vas deferens in male dogsYukiko Noguchi
Pharmacology Research Labs, Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585, Japan
Eur J Pharmacol 580:256-61. 2008.... - Relationship between the functional effect of tamsulosin and its concentration in lower urinary tract tissues in dogsShuichi Sato
Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
Biol Pharm Bull 30:481-6. 2007.... - Effects of intravenously and orally administered solifenacin succinate (YM905) on carbachol-induced intravesical pressure elevation and salivary secretion in miceHiroko Okutsu
Pharmacology Research Labs, Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
Biol Pharm Bull 30:2324-7. 2007..These results provide further evidence for the clinical use of solifenacin as a promising therapeutic drug for OAB with a low incidence of dry mouth... - Effects of tamsulosin on hypogastric nerve stimulation-induced intraurethral pressure elevation in male and female dogs under anesthesiaAkiyoshi Ohtake
Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
Eur J Pharmacol 497:327-34. 2004..These results indicate that tamsulosin will be useful in the treatment of dysuria associated with lower urinary tract symptoms in women as well as men... - Superiority of YM598 over atrasentan as a selective endothelin ETA receptor antagonistHironori Yuyama
Applied Pharmacology Research, Pharmacology Laboratories, Institute for Drug Discovery Research, Yamanouchi Pharmaceutical Co, Ltd, 21 Miyukigaoka, Tsukuba, Ibaraki 305-8585, Japan
Eur J Pharmacol 498:171-7. 2004..These results suggest that YM598 has high selectivity for native human ETA against ETB receptors, and that YM598 is superior to atrasentan as an ETA receptor antagonist with regard to pharmacological bioavailability in rats... - Effects of tamsulosin on bladder blood flow and bladder function in rats with bladder outlet obstructionHiroko Okutsu
Applied Pharmacology Research Laboratories, Astellas Pharma Inc, Miyukigaoka, Tsukuba shi, Ibaraki, Japan
Urology 75:235-40. 2010.... - Effect of tamsulosin on bladder blood flow and bladder function in a rat model of bladder over distention/emptying induced bladder overactivityHiroko Okutsu
Applied Pharmacology Research Laboratories, Astellas Pharma, Inc, Tsukuba, Japan
J Urol 186:2470-7. 2011..We developed a rat model of bladder over distention/emptying induced bladder overactivity and investigated the effect of the ?(1)-adrenoceptor antagonist tamsulosin on bladder blood flow and bladder function in this model... - Tamsulosin potently and selectively antagonizes human recombinant ?(1A/1D)-Adrenoceptors: slow dissociation from the ?(1A)-adrenoceptor may account for selectivity for ?(1A)-adrenoceptor over ?(1B)-adrenoceptor subtypeShuichi Sato
Applied Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
Biol Pharm Bull 35:72-7. 2012..In conclusion, tamsulosin potently and selectively antagonized ?(1A/1D)-adrenoceptor ligand binding, and slowly dissociated from the ?(1A)-adrenoceptor subtype... - Effect of antimuscarinic drugs used for overactive bladder on learning in a rat passive avoidance response testMasanori Suzuki
Pharmacology Research Labs, Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki, 305 8585 Japan
Eur J Pharmacol 557:154-8. 2007..v.) produced no significant impairment. These results suggest that antimuscarinic drugs such as darifenacin, solifenacin and tolterodine may have less effect on cognitive function in the treatment of patients with overactive bladder... - Effects of ?1-adrenoceptor antagonists on phenylephrine-induced salivary secretion and intraurethral pressure elevation in anesthetized ratsHiroko Yanai-Inamura
Applied Pharmacology Research Laboratories, Drug Discovery Research, Astellas Pharma Inc, 21 Miyukigaoka, Tsukuba, Ibaraki 305 8585, Japan
Eur J Pharmacol 679:127-31. 2012.... - Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstructionShuji Maruyama
Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
Neurosci Lett 414:80-4. 2007.... - In vivo studies on the effects of alpha1-adrenoceptor antagonists on pupil diameter and urethral tone in rabbitsMartin C Michel
Department of Pharmacology and Pharmacotherapy, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
Naunyn Schmiedebergs Arch Pharmacol 372:346-53. 2006..Higher doses of all antagonists are required to induce miosis in the absence of an exogenous agonist, and such miosis is always reversible within hours...