Research Topics
Genomes and Genes | Yuji AraiSummaryCountry: Japan Publications
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Publications
A displaced stress fracture of the femoral neck in an adolescent female distance runner with female athlete triad: A case reportShinichi Okamoto
Dept of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
Sports Med Arthrosc Rehabil Ther Technol 2:6. 2010..Athletes as well as their coaches or parents therefore need to understand female athlete triad...- A new arthroscopic-assisted drilling method through the radius in a distal-to-proximal direction for osteochondritis dissecans of the elbowYuji Arai
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Arthroscopy 24:237.e1-4. 2008..With this technique, the entire OCD lesion can be vertically drilled under arthroscopic guidance. This method is minimally invasive, and an early return to sports could be possible... - Evaluation of the vascular status of autogenous hamstring tendon grafts after anterior cruciate ligament reconstruction in humans using magnetic resonance angiographyYuji Arai
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajiicho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Knee Surg Sports Traumatol Arthrosc 16:342-7. 2008..The revascularisation of the bone tunnels could play an important role in the healing of the ligament-bone tunnel junction... - MDR1a/1b gene silencing enhances drug sensitivity in rat fibroblast-like synoviocytesKuniaki Honjo
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
J Gene Med 12:219-27. 2010..We also attempted the electroporation-mediated transfer of siRNA against multidrug resistance (MDR) genes into rat knee joints... - Influence of extracellular matrix on the expression of inflammatory cytokines, proteases, and apoptosis-related genes induced by hydrostatic pressure in three-dimensionally cultured chondrocytesTaisuke Kunitomo
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
J Orthop Sci 14:776-83. 2009.... - Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-kappaB ligand in cells derived from osteoarthritic subchondral boneKei Sakao
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
J Orthop Sci 13:202-10. 2008.... - Sonoporation mediated transduction of pDNA/siRNA into joint synovium in vivoMasazumi Saito
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
J Orthop Res 25:1308-16. 2007..In this study, we showed that pDNA/siRNA can be transduced specifically into the joint synovium using sonoporation. The present method may be useful in nucleic acid therapy for joint disorders... - N-acetylcysteine prevents nitric oxide-induced chondrocyte apoptosis and cartilage degeneration in an experimental model of osteoarthritisShuji Nakagawa
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kamigyo ku, Kyoto 602 8566, Japan
J Orthop Res 28:156-63. 2010..These results indicate that NAC inhibits NO-induced apoptosis of chondrocytes through glutathione in vitro, and inhibits chondrocyte apoptosis and articular cartilage degeneration in vivo... - Comparison of anti-rheumatic effects of local RNAi-based therapy in collagen induced arthritis rats using various cytokine genes as molecular targetsAtsuo Inoue
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Mod Rheumatol 19:125-33. 2009..The in vivo siRNA transfection method may be useful for selection of target molecules to be silenced for treatment of joint diseases... - Vitamin E prevents steroid-induced osteonecrosis in rabbitsMasaaki Kuribayashi
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Acta Orthop 81:154-60. 2010..Prevention of osteonecrosis after corticosteroid administration would be important. We examined the potential of vitamin E (alpha-tocopherol) to reduce the incidence of corticosteroid-induced osteonecrosis in an animal model... - In vivo effects of ovarian steroid hormones on the expressions of estrogen receptors and the composition of extracellular matrix in the anterior cruciate ligament in ratsAtsuhiko Yoshida
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Connect Tissue Res 50:121-31. 2009..These findings suggest that ACL is ER-dependent and that ovarian hormones alter ligament tissue composition, especially at the proximal portion. Female hormonal influences are partly involved in the biological properties of ACL... - Combination analysis of three polymorphisms for predicting the risk for steroid-induced osteonecrosis of the femoral headMasaaki Kuribayashi
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
J Orthop Sci 13:297-303. 2008..In the present study, we examined whether combined information regarding these three single nucleotide polymorphisms (SNPs) in the ABCB1, ApoB, and CBP genes is useful for predicting ONF development... - Combined microwave irradiation and intraarticular glutamine administration-induced HSP70 expression therapy prevents cartilage degradation in a rat osteoarthritis modelShinya Fujita
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
J Orthop Res 30:401-7. 2012..In the rat OA model, the severity of OA was significantly milder in a group receiving MW and Gln than in the control group. HSP70, stimulated by the combination of MW heat and Gln, may be involved in the suppression of OA progression... - Asporin and transforming growth factor-beta gene expression in osteoblasts from subchondral bone and osteophytes in osteoarthritisKei Sakao
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
J Orthop Sci 14:738-47. 2009.... - Platelet-rich plasma enhances the initial mobilization of circulation-derived cells for tendon healingYoshiteru Kajikawa
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
J Cell Physiol 215:837-45. 2008..These findings suggest that locally injected PRP is useful as an activator of circulation-derived cells for enhancement of the initial tendon healing process... - Vitamin E prevents steroid-induced osteonecrosis in rabbitsMasaaki Kuribayashi
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Acta Orthop 81:154-60. 2010..Prevention of osteonecrosis after corticosteroid administration would be important. We examined the potential of vitamin E (alpha-tocopherol) to reduce the incidence of corticosteroid-induced osteonecrosis in an animal model... - Degree of corticosteroid treatment within the first 2 months of renal transplantation has a strong influence on the incidence of osteonecrosis of the femoral headMasahiko Shibatani
Department of Orthopedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Acta Orthop 79:631-6. 2008..It has been suggested that avascular osteonecrosis (AVN) of the femoral head develops early after renal transplantation. We evaluated the relationship between risk of AVN and dose of steroids administered in different time periods... - Osteoblasts derived from osteophytes produce interleukin-6, interleukin-8, and matrix metalloproteinase-13 in osteoarthritisKei Sakao
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
J Bone Miner Metab 27:412-23. 2009..By controlling the expression of these genes in the osteophytes, the progression of cartilage degeneration in OA may be reduced, suggesting a new treatment strategy for OA... - Hyperthermia for the treatment of articular cartilage with osteoarthritisKenji A Takahashi
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Int J Hyperthermia 25:661-7. 2009..These findings suggest that hyperthermia can be positively applied to the treatment of OA. Hyperthermia is therefore expected to be an inexpensive and less-invasive conservative therapy for OA... - Intra-articular injection of hyaluronan restores the aberrant expression of matrix metalloproteinase-13 in osteoarthritic subchondral boneNobuyuki Hiraoka
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
J Orthop Res 29:354-60. 2011..These findings indicate that regulation of MMP-13 in subchondral bone may be a critical mechanism during IAI-HA... - Electromagnetic fields: a novel prophylaxis for steroid-induced osteonecrosisMasashi Ishida
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Clin Orthop Relat Res 466:1068-73. 2008..Exposure to pulsed electromagnetic field stimulation before corticosteroid administration could be an effective means to reduce the risk of osteonecrosis... - Effects of heat stimulation via microwave applicator on cartilage matrix gene and HSP70 expression in the rabbit knee jointHitoshi Tonomura
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
J Orthop Res 26:34-41. 2008..External MW application stimulated HSP70 expression in the articular cartilage in vivo. The expression of extracellular matrix genes was increased by appropriate heat stimulation... - A new double-bundle anterior cruciate ligament reconstruction using the posteromedial portal technique with hamstringsKunio Hara
Department of Orthopaedics, The Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
Arthroscopy 21:1274. 2005..Our technique does not need another tibial tunnel for the PLB; the 1 tibial tunnel enables double-bundle reconstruction and prevents tibial tunnel expansion... - [Genetic analysis for prevention of steroid-induced osteonecrosis of the femoral head]Mikihiro Fujioka
Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Department of Orthopaedics
Clin Calcium 17:894-900. 2007..For the prediction of ION, it is useful to analyze ABCB1 C3435T, ApoB C7623T and CBP (rs3751845) before the administration of steroids... - Hydrostatic pressure induces apoptosis of chondrocytes cultured in alginate beadsShu Nakamura
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
J Orthop Res 24:733-9. 2006..HSP70 expression was related to occurrence of apoptosis that resulted from HP. These findings suggest a mechanism for the pathogenesis of cartilage degeneration in osteoarthritis... - p300 plays a critical role in maintaining cardiac mitochondrial function and cell survival in postnatal heartsYasuaki Nakagawa
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, 54 Shogoin Kawara cho, Kyoto, Japan
Circ Res 105:746-54. 2009..However, the physiological function of p300 in the postnatal hearts remains to be characterized... - Absence of osteonecrosis of the femoral head following bilateral femoral neck fracture with a high degree of displacementShinya Fujita
Department of Orthopedic Surgery, Kyoto Prefectural Yosanoumi Hospital, and Department of Orthopedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Japan
J Orthop Sci 11:628-31. 2006 - Small interfering RNA targeting CD81 ameliorated arthritis in ratsShuji Nakagawa
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Biochem Biophys Res Commun 388:467-72. 2009..Expression of synoviolin, a rheumatoid regulator, was suppressed by siCD81. Thus, therapeutic intervention by targeting CD81 may be used in the treatment of rheumatoid arthritis... - An analysis of the medial patellofemoral ligament length change pattern using open-MRITetsuo Higuchi
Department of Orthopaedics, The Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii chou, Kawaramachi Hirokoji, Kyoto, Japan
Knee Surg Sports Traumatol Arthrosc 18:1470-5. 2010..However, more studies are needed to obtain a better understanding of cases with a history of patellar dislocation... - The effect of apoptosis signal-regulating kinase 1 gene transfer on rat collagen induced arthritisRyu Terauchi
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
J Rheumatol 32:2373-80. 2005..Degeneration of the synovial membrane was not evident. CONCLUSION: Adenoviral transduction of ASK1DeltaN induced apoptosis in RA synoviocytes in vitro, but not in CIA synovium in vivo... - Slipped capital femoral epiphysis first occurring in early childhood with subsequent development on the other side in later childhoodKenji A Takahashi
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kyoto, Japan
J Orthop Sci 12:395-7. 2007 - Relationship between acetabular labrum evaluation by using radial magnetic resonance imaging and progressive joint space narrowing in mild hip dysplasiaKeiichiro Ueshima
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
Magn Reson Imaging 24:645-50. 2006..41, 95% CI: 1.51-86.24, P=.018). CONCLUSION: Our findings showed that in patients whose acetabular dysplasia has 5-25 degrees CE angle, MRI staging based on radial MRI is a better factor for prediction of progression of JSN than CE angle... - Maximum intensity projection as a tool to diagnose early rheumatoid arthritisGen Mori
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii cho, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, Japan
Mod Rheumatol 18:247-51. 2008..Thus, MIP is a useful tool for making early diagnosis of RA because it yields clear visualization even with just one image... - The therapeutic effects of basic fibroblast growth factor contained in gelatin hydrogel microspheres on experimental osteoarthritis in the rabbit kneeAtsuo Inoue
Dept. of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
Arthritis Rheum 54:264-70. 2006..CONCLUSION: Our findings demonstrated that sustained release of bFGF into the joint had therapeutic effects on OA development in a rabbit model. Our results suggest the potential feasibility of a new conservative treatment for OA... - ApoB C7623T polymorphism predicts risk for steroid-induced osteonecrosis of the femoral head after renal transplantationTetsurou Hirata
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii chou, Kawaramachi Hirokoji, Kyoto 602 8566, Japan
J Orthop Sci 12:199-206. 2007.... - Electro-transfer of small interfering RNA ameliorated arthritis in ratsAtsuo Inoue
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
Biochem Biophys Res Commun 336:903-8. 2005..Our results suggest the potential feasibility of therapeutic intervention with RNA medicines for treatment of rheumatoid and other locomotor diseases... - Podocyte-specific expression of tamoxifen-inducible Cre recombinase in miceHideki Yokoi
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Kyoto, Japan
Nephrol Dial Transplant 25:2120-4. 2010..However, it may be difficult to examine the role of genes in certain pathologic conditions using conventional podocyte-specific knockout mice because they may be embryonically lethal or exhibit congenital renal abnormality... - Behavior of host and graft cells in the early remodeling process of rotator cuff defects in a transgenic animal modelYoshio Iwata
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan
J Shoulder Elbow Surg 17:101S-107S. 2008..The number of graft-derived cells decreased with time. Our result clearly demonstrated that host cells, rather than graft cells, were essential for rotator cuff remodeling after tendon grafting for rotator cuff defect... - Evaluation of the hemodynamics of the femoral head compared with the ilium, femoral neck and femoral intertrochanteric region in healthy adults: measurement with positron emission tomography (PET)Fuminori Nakamura
Department of *Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachihirokoji, Kamigyo-ku, Kyoto 602-8566, Japan
Ann Nucl Med 19:549-55. 2005.... - T-type Ca2+ channel blockade prevents sudden death in mice with heart failureHideyuki Kinoshita
Department of Medicine and Clinical Science, Kyoto University Graduated School of Medicine, Kyoto, Japan
Circulation 120:743-52. 2009..The ability of T-type Ca(2+) channel blockade to prevent lethal arrhythmias associated with heart failure has never been tested, however... - Arthroscopic treatment for septic arthritis of the shoulder in an infantToru Morihara
Department of Orthopaedics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto, 602-8566, Japan
J Orthop Sci 10:95-8. 2005..This early treatment was one of the factors that contributed to a successful result. Arthroscopic surgery, including irrigation and debridement, may be one of the options for treating septic arthritis of an infant's shoulder...