Research Topics
Genomes and Genes | Akira SawakiSummaryAffiliation: Aichi Cancer Center Country: Japan Publications
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Publications
Clinical impact of radiotherapy for locally advanced pancreatic cancerAkira Sawaki
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan
J Gastroenterol 44:1209-14. 2009..The aim of this study was to compare the survival benefits associated with gemcitabine and concurrent chemoradiotherapy in locally advanced unresectable PC...- Imatinib mesylate acts in metastatic or unresectable gastrointestinal stromal tumor by targeting KIT receptors--a reviewAkira Sawaki
Department of Gastroenterology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, 464 0021 Nagoya, Japan
Cancer Chemother Pharmacol 54:S44-9. 2004..While several issues remain, they should be clarified by the current clinical trials and associated laboratory studies... - Practical prognostic index for patients with metastatic pancreatic cancer treated with gemcitabineAkira Sawaki
Department of Gastroenterology, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
J Gastroenterol Hepatol 23:1292-7. 2008..The aim of this study was to identify factors that predict treatment outcome in patients with metastatic pancreatic cancer treated with gemcitabine, and then to use these factors to develop a practical prognostic index... - Phase II study of motesanib in Japanese patients with advanced gastrointestinal stromal tumors with prior exposure to imatinib mesylateAkira Sawaki
Department of Gastroenterology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
Cancer Chemother Pharmacol 65:961-7. 2010..The aim of this single-arm phase II clinical study was to assess the efficacy and safety of single-agent motesanib in Japanese patients with advanced gastrointestinal stromal tumors with prior exposure to imatinib mesylate... - Improvement of oral intake following chemotherapy in gastric cancer patients with an inability to eatKohei Shitara
Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
Oncology 79:211-8. 2010..However, these studies included patients able to maintain sufficient oral intake, and the effectiveness of chemotherapy for patients unable to eat remained unclear... - Impact of alcohol consumption with polymorphisms in alcohol-metabolizing enzymes on pancreatic cancer risk in JapaneseJunya Kanda
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
Cancer Sci 100:296-302. 2009..09 (1.30–12.85)]. These results indicate that alcohol has an impact on PC risk when the effects of alcohol consumption and metabolism are combined. Acetaldehyde may be involved in the mechanisms underlying PC development... - Prospective clinical study of EUS-guided choledochoduodenostomy for malignant lower biliary tract obstructionKazuo Hara
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Am J Gastroenterol 106:1239-45. 2011..However, prospective studies of EUS-CDS have not yet been performed. We conducted a prospective study to evaluate the safety, feasibility, and efficacy of EUS-CDS in patients with malignant lower biliary tract obstruction... - Folate intake along with genetic polymorphisms in methylenetetrahydrofolate reductase and thymidylate synthase in patients with advanced gastric cancerKohei Shitara
Department of Clinical Oncology, Aichi Cancer Center Hospital, and Department of Epidemiology, Nagoya University Graduate School of Medicine, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Aichi, Japan
Cancer Epidemiol Biomarkers Prev 19:1311-9. 2010..However, to our knowledge, there are no reports that evaluate simultaneously the effects of folate intake and genetic polymorphisms on clinical outcome of gastric cancer patients... - Effects of genetic polymorphisms in the ABCB1 gene on clinical outcomes in patients with gastric cancer treated by second-line chemotherapyKohei Shitara
Department of Clinical Oncology, Aichi Cancer Center Hospital, Japan
Asian Pac J Cancer Prev 11:447-52. 2010..The purpose of this analysis was to evaluate the impact of genetic polymorphisms of the ABCB1 gene on clinical outcomes in patients with advanced gastric cancer (AGC) treated with second-line chemotherapy... - Clinical efficacy and safety of sunitinib after imatinib failure in Japanese patients with gastrointestinal stromal tumorKazuya Matsumoto
Department of Gastroenterology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
Jpn J Clin Oncol 41:57-62. 2011..However, early clinical reports have shown that sunitinib has substantial anticancer activity in patients with advanced gastrointestinal stromal tumor after failure of imatinib... - Diagnosis of autoimmune pancreatitis using endoscopic ultrasonographyNoriyuki Hoki
Department of Gastroenterology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
J Gastroenterol 44:154-9. 2009..These criteria require distinguishing AIP from neoplastic lesions. However, this can be difficult, and patients often undergo surgery on the basis of suspected pancreatic cancer (PC)... - Interventional endoscopic ultrasonographyKenji Yamao
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
J Gastroenterol Hepatol 24:509-19. 2009..In this review, we particularly focus on the present and future roles of interventional EUS, including EUS-FNA and therapeutic EUS... - A pilot study of imatinib mesylate (STI571) on gastrointestinal stromal tumors in Japanese patientsAkira Sawaki
Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-0021, Japan
J Gastroenterol 39:329-33. 2004..Early clinical reports have shown that imatinib mesylate (STI571) produces substantial anticancer activity in patients with metastatic or unresectable GIST... - Endoscopic ultrasound-guided ethanol injection in the pancreas in a porcine model: a preliminary studyKakuya Matsumoto
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
J Gastroenterol Hepatol 23:e1-6. 2008..Local progression is problematic, and minimally invasive procedures allowing locoregional control are needed. In this study, we attempted endoscopic ultrasound (EUS)-guided injection of ethanol into the pancreas... - Acute portal vein thrombosis after EUS-guided FNA of pancreatic cancer: case reportKakuya Matsumoto
Department of Gastroenterology, Aichi Cancer Center, Nagoya, Japan
Gastrointest Endosc 57:269-71. 2003 - Pancreatic endocrine neoplasm can mimic serous cystadenomaHiroshi Imaoka
Department of Gastroenterology, Aichi Cancer Center Hospital, 1 1 Kanokoden Chikusa ku, Nagoya, Japan
Int J Gastrointest Cancer 35:217-20. 2005..This case suggests that it is very difficult to distinguish PENs from SCAs based solely on imaging methods. EUS-FNAB is essential for determining the appropriate therapeutic strategy, as it provides the histopathological diagnosis... - Distinct profiles of epigenetic evolution between colorectal cancers with and without metastasisHai xing Ju
Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
Am J Pathol 178:1835-46. 2011..In addition, most methylation status in stage IV CRCs seems to be established before metastasis... - Association of fluoropyrimidines, platinum agents, taxanes, and irinotecan in any line of chemotherapy with survival in patients with advanced gastric cancerKohei Shitara
Department of Clinical Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 8681, Japan
Gastric Cancer 14:155-60. 2011.... - Association between insulin-like growth factor-1 polymorphisms and stomach cancer risk in a Japanese populationDaisuke Ennishi
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Cancer Sci 102:2231-5. 2011..In conclusion, we observed a significant association between IGF1 polymorphisms and stomach cancer risk among a Japanese population. Examination of the biological significance of IGF1 is warranted... - Is (18)F-fluorodeoxyglucose positron emission tomography meaningful for estimating the efficacy of corticosteroid therapy in patients with autoimmune pancreatitis?Minoru Shigekawa
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
J Hepatobiliary Pancreat Sci 17:269-74. 2010..This study aimed to evaluate the pattern of FDG accumulation, and the change in FDG uptake after steroid treatment in AIP and PC... - Serum tumor antigen REG4 as a diagnostic biomarker in pancreatic ductal adenocarcinomaReiko Takayama
Department of Gastroenterology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Aichi 464 0021, Japan
J Gastroenterol 45:52-9. 2010..Serum biomarkers for the early detection of pancreatic cancer are not currently available. We evaluated the usefulness of a novel serum marker, REG4, in the diagnosis of pancreatic cancer, as compared to carbohydrate antigen (CA) 19-9... - Serum tumor antigen REG4 as a useful diagnostic biomarker in gastric cancerYuji Kobayashi
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Hepatogastroenterology 57:1631-4. 2010..We evaluated the usefulness of a novel serum marker, REG4, as compared to that of CA19-9, CEA, and pepsinogen... - Endoscopic diagnosis and staging of mucinous cystic neoplasms and intraductal papillary-mucinous tumorsKenji Yamao
Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-0021, Japan
J Hepatobiliary Pancreat Surg 10:142-6. 2003..They are effective for differential diagnosis, for assessing the degree of malignancy, and for deciding upon an appropriate treatment in patients with IPMTs... - Endoscopic ultrasound-guided fine-needle aspiration biopsy for the diagnosis of gastrointestinal stromal tumors in the stomachKenji Okubo
Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, 464-8681 Nagoya, Japan
J Gastroenterol 39:747-53. 2004..When used with MIB-1 staining, the procedure may indicate GIST prognosis and influence decisions regarding therapeutic strategies... - Aberrant DNA methylation associated with aggressiveness of gastrointestinal stromal tumourYasuyuki Okamoto
Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
Gut 61:392-401. 2012..Our aim was to establish epigenetic profiles associated with the malignant transformation of GISTs... - A case of colonic morule with colitis cystica profundaMasahiro Tajika
Department of Endoscopy, Gastroenterology, and Gastroenterological Surgery, Division of Pathology and Molecular Diagnosis, Aichi Cancer Center Hospital, Nagoya City, Japan
Gastrointest Endosc 65:162-3; discussion 163. 2007 - Histological diagnosis of autoimmune pancreatitis using EUS-guided trucut biopsy: a comparison study with EUS-FNANobumasa Mizuno
Department of Gastroenterology, Aichi Cancer Center Hospital, and Nagoya University Graduate School of Medicine, 1 1 Kanokoden, Chikusa ku, Nagoya, 464 8681, Japan
J Gastroenterol 44:742-50. 2009..The aim of this study was to evaluate the feasibility and safety of endoscopic ultrasonography (EUS)-guided trucut biopsy (TCB) for diagnosis of autoimmune pancreatitis (AIP)... - Usefulness of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for undiagnosed intra-abdominal lymphadenopathyOsamu Nakahara
Department of Gastroenterology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
J Gastroenterol 44:562-7. 2009..The aim of this study was to evaluate the yield of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in patients with undiagnosed intra-abdominal lymphadenopathy... - Effect of a tyrosine kinase inhibitor STI571 in a patient with hepatic metastases from a duodenal gastrointestinal stromal tumorAkira Sawaki
Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, Nagoya 464-0021, Japan
J Gastroenterol 38:690-4. 2003..This case report describes a highly effective use of STI571 in a 54-year-old woman with multiple liver metastases from a GIST originating in the duodenum... - Clinical impact of K-ras mutation analysis in EUS-guided FNA specimens from pancreatic massesTakeshi Ogura
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Gastrointest Endosc 75:769-74. 2012..EUS-guided FNA (EUS-FNA) is considered optimal for differentially diagnosing pancreatic masses. However, the sensitivity of EUS-FNA ranges from 65% to 95%, respectively, which requires improvement... - ABO genotype and the risk of gastric cancer, atrophic gastritis, and Helicobacter pylori infectionMakoto Nakao
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya, Japan
Cancer Epidemiol Biomarkers Prev 20:1665-72. 2011.... - Gemcitabine sensitivity-related mRNA expression in endoscopic ultrasound-guided fine-needle aspiration biopsy of unresectable pancreatic cancerReiko Ashida
Department of Gastroenterology, Osaka City University Graduate School of Medicine, Osaka, Japan
J Exp Clin Cancer Res 28:83. 2009..The aim of this study was to determine a predictive indicator of gemcitabine (GEM) efficacy in unresectable pancreatic cancer using tissue obtained by endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNA)... - Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis?Susumu Hijioka
Department of Gastroenterology, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, Japan
Gastrointest Endosc 72:622-7. 2010..EUS-guided FNA (EUS-FNA) is a useful modality for sampling various targets, but its applicability to gallbladder (GB) mass lesions is limited... - Diagnostic utility of EUS-guided FNA in patients with gastric submucosal tumorsMohamed A Mekky
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Gastrointest Endosc 71:913-9. 2010..The addition of EUS-guided FNA (EUS-FNA) has the potential to improve this distinction, but published series are limited... - Risk factors for vitamin D deficiency in patients with Crohn's diseaseMasahiro Tajika
Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Chikusa-ku, 464-8681, Nagoya, Japan
J Gastroenterol 39:527-33. 2004..25-OHD levels should be assessed in patients who have had Crohn's disease for a long time (>15 years) and who have been in the active stage of the disease for long periods... - EUS-Guided Biliary DrainageKenji Yamao
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Gut Liver 4:S67-75. 2010.... - Interventional endoscopic ultrasonography for pancreatic cancerKazuo Hara
Kazuo Hara, Kenji Yamao, Nobumasa Mizuno, Susumu Hijioka, Akira Sawaki, Masahiro Tajika, Hiroki Kawai, Shinya Kondo, Yasumasa Niwa, Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya 464 8681, Japan
World J Clin Oncol 2:108-14. 2011..This review focuses on interventional EUS, including EUS-FNA and therapeutic EUS for pancreatic cancer... - [A case of anaplastic ductal carcinoma (giant cell carcinoma of osteoclastoid type) with portal vein and main pancreatic ductal invasion]Toshifumi Isaka
Department of Gastroenterology, Aichi Cancer Center Hospital
Nippon Shokakibyo Gakkai Zasshi 102:736-40. 2005 - Alcohol drinking and one-carbon metabolism-related gene polymorphisms on pancreatic cancer riskTakeshi Suzuki
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
Cancer Epidemiol Biomarkers Prev 17:2742-7. 2008..17-6.00) in the MTR 2756 AA genotype, and 3.35 (1.34-8.36) in the MTRR 66 G allele carriers. These results suggest that the folate-related enzyme polymorphism modifies the association between drinking habit and pancreatic cancer risk... - Short-term development of esophageal pyogenic granuloma observed on endoscopyMasahiro Tajika
Department of Endoscopy, Aichi Cancer Center Hospital, Nagoya City, Japan
Gastrointest Endosc 64:269-70. 2006 - EUS-guided choledochoduodenostomy for palliative biliary drainage in case of papillary obstruction: report of 2 casesKenji Yamao
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Gastrointest Endosc 64:663-7. 2006 - Recurrent autoimmune hemolytic anemia induced by XELOX chemotherapy for colon cancerTakeshi Ogura
Department of Gastroenterology, Aichi Cancer Center Hospital
Nihon Shokakibyo Gakkai Zasshi 108:1712-9. 2011..We treated her with hemodialysis, plasmapheresis and immune suppression with prednisolone, which improved the anemia and renal failure... - Metastasis of uterine leiomyosarcoma to the pancreas -Usefulness and limitations of EUS-FNA-Takeshi Ogura
Department of Gastroenterology, Aichi Cancer Center Hospital
Nihon Shokakibyo Gakkai Zasshi 108:987-96. 2011..Therefore, the final diagnosis was extremely rare metastatic leiomyosarcoma of the pancreas. Herein, we report metastasis of uterine leiomyosarcoma to the pancreas and discuss the usefulness and limitations of EUS-FNA... - Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB): past, present, and futureKenji Yamao
Department of Gastroenterology, Aichi Cancer Center Hospital, 1-1 Kanokoden, Nagoya 464-8681, Japan
J Gastroenterol 40:1013-23. 2005.... - Phase II study of combination chemotherapy with irinotecan and cetuximab for pretreated metastatic colorectal cancer harboring wild-type KRASKohei Shitara
Department of Clinical Oncology, Aichi Cancer Center Hospital, Chikusa ku, Nagoya, 464 8681, Aichi, Japan
Invest New Drugs 29:688-93. 2011..1 months. Grade 2 skin toxicity was observed in 23 patients, while no grade 3 skin toxicity was observed. Combined irinotecan and cetuximab is effective for pretreated metastatic wild-type KRAS colorectal cancer... - Differential diagnosis of pancreatic cancer and focal pancreatitis by using EUS-guided FNAKuniyuki Takahashi
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Gastrointest Endosc 61:76-9. 2005..Analysis for the K-ras point mutation in specimens obtained by EUS-guided FNA may enhance diagnostic accuracy in indeterminate cases... - Pancreaticobiliary maljunction in monozygotic twins--a case reportKenji Yamao
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Hepatogastroenterology 51:675-8. 2004..This case is not only of academic interest for familial occurrence, but also of clinical interest in the early detection of pancreaticobiliary maljunction... - Laparoscopic wedge resection for gastrointestinal stromal tumors of the stomach: initial experienceYoshinari Mochizuki
Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
Surg Today 36:341-7. 2006..CONCLUSION: Laparoscopic wedge resection is a feasible treatment option for GISTs of the stomach if the lesion is <5 cm in diameter... - [Cytologic diagnosis of pancreatic cancer]Hiroyuki Inoue
Department of Gastroenterology, Aichi Cancer Center Hospital
Nippon Rinsho 64:135-9. 2006 - Endoscopic ultrasound-guided choledochoduodenostomyKazuo Hara
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan
Dig Endosc 22:147-50. 2010..We think transduodenal direct access is the best treatment in patients with jaundice caused by inoperable malignant obstruction of the lower extrahepatic bile duct when EBD fails... - A two-step method for marking polypectomy sites in the colon and rectumAkira Sawaki
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Gastrointest Endosc 57:735-7. 2003..At surgery, all lesions were immediately visualized. CONCLUSION: The two-step tattooing method proved to be easy, safe, and accurate for marking polypectomy sites... - Characteristic methylation profile in CpG island methylator phenotype-negative distal colorectal cancersByonggu An
Division of Molecular Oncology, Aichi Cancer Center Research Institute, Chikusa ku, Nagoya 464 8681, Japan
Int J Cancer 127:2095-105. 2010.... - Efficacy of peroral pancreatoscopy in the diagnosis of pancreatic diseasesKenji Yamao
Department of Gastroenterology, Aichi Cancer Center Hospital, Nagoya, Japan
Gastrointest Endosc 57:205-9. 2003..Peroral pancreatoscopy with a thin fiberscope can provide a definitive diagnosis of intraductal papillary-mucinous tumor including the degree of malignancy... - Chemotherapy for gastric cancer that recurs after adjuvant chemotherapy with S-1Kohei Shitara
Department of Clinical Oncology, Aichi Cancer Center Hospital, Nagoya, Aichi, Japan
Jpn J Clin Oncol 38:786-9. 2008..3 versus 2.3 months, P = 0.02). S-1-containing chemotherapy does not appear to be effective in patients whose gastric cancer recurs after adjuvant S-1 chemotherapy. Other chemotherapeutic agents should be evaluated in this setting... - Risk factors for pancreatic cancer and early diagnosis of pancreatic cancerKenji Yamao
Department of Gastroenterology, Aichi Cancer Center Hospital
Nippon Shokakibyo Gakkai Zasshi 105:8-16. 2008 - Smoking increases the treatment failure for Helicobacter pylori eradicationTakeshi Suzuki
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Am J Med 119:217-24. 2006..CONCLUSIONS: Our meta-analysis demonstrated that smoking increases the treatment failure rate for H. pylori eradication... - Association of prostate stem cell antigen gene polymorphisms with the risk of stomach cancer in JapaneseKeitaro Matsuo
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
Int J Cancer 125:1961-4. 2009..No association was seen between PSCA polymorphisms and H. pylori infection. In conclusion, PSCA polymorphisms are associated with stomach cancer risk in Japanese. A possible interaction with family history warrants further evaluation... - [A case of Crohn's disease with osteomalacia detected by bone fracture]Masahiro Tajika
Department of Gastroenterology, Aichi Cancer Center Hospital
Nippon Shokakibyo Gakkai Zasshi 99:1481-6. 2002 - Long-term effects of donepezil on P300 auditory event-related potentials in patients with Alzheimer's diseaseEiichi Katada
Department of Internal Medicine, Nagoya City Johoku Hospital, Nagoya, Japan
J Geriatr Psychiatry Neurol 16:39-43. 2003..P300 latency gives very useful information on the progression of AD, especially in the longitudinal follow-up of patients with AD during treatment with DPZ acting on cholinergic pathways... - Efficacy and safety profile of imatinib mesylate (ST1571) in Japanese patients with advanced gastrointestinal stromal tumors: a phase II study (STI571B1202)Toshirou Nishida
Department of Surgery, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Osaka 565 0871, Japan
Int J Clin Oncol 13:244-51. 2008..The aim of this study was to assess the efficacy and safety of imatinib mesylate in Japanese patients with advanced GIST...