Research Topics
| P ZanoliSummaryAffiliation: University of Modena and Reggio Emilia Country: Italy Publications
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Publications
Role of ferutinin in the impairment of female sexual function induced by Ferula hermonisManuela Zavatti
Department of Biomedical Sciences, Section of Pharmacology, and National InterUniversity Consortium for the Study of Natural Active Principles (CINSPAN, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
Physiol Behav 89:656-61. 2006..These results suggest a primary role of ferutinin in the impairment of sexual behaviour elicited by F. hermonis extract in hormone primed-female rats...- Pharmacognostic and pharmacological profile of Humulus lupulus LPaola Zanoli
Department of Biomedical Sciences, National InterUniversity Consortium for the Study of Natural Active Principles, University of Modena, Reggio Emilia, 41100 Modena, Italy
J Ethnopharmacol 116:383-96. 2008..Nevertheless much additional work is needed to open up new biomedical application of these compounds... - Experimental evidence of the anaphrodisiac activity of Humulus lupulus L. in naïve male ratsP Zanoli
Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, 41100 Modena, Italy
J Ethnopharmacol 125:36-40. 2009..hops) is mainly recommended as a mild sedative with antispasmodic and digestive properties. It is also reputed to exert an anaphrodisiac effect but it is still lacking the experimental evidence of this activity... - The phytoestrogen ferutinin affects female sexual behavior modulating ERalpha expression in the hypothalamusPaola Zanoli
Department of Biomedical Sciences, Section of Pharmacology, and National InterUniversity Consortium for the Study of Natural Active Principles CINSPAN, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
Behav Brain Res 199:283-7. 2009..These results suggest that ferutinin displays estrogenic or antiestrogenic activity through ERalpha in the hypothalamus, depending on the absence or the presence of estrogen priming... - Improved sexual behavior in male rats treated with a Chinese herbal extract: hormonal and neuronal implicationsPaola Zanoli
Department of Biomedical Sciences, University of Modena and Reggio Emilia, via G Campi 287, Modena 41100, Italy
Asian J Androl 10:937-45. 2008..To investigate the influence of an extract obtained from five Chinese medicinal plants on sexual behavior of adult male rats... - Evidence that the beta-acids fraction of hops reduces central GABAergic neurotransmissionP Zanoli
Department of Biomedical Sciences, Section of Pharmacology, National InterUniversity Consortium for the Study of Natural Active Principles CINSPAN, University of Modena and Reggio Emilia, 41100 Modena, Italy
J Ethnopharmacol 109:87-92. 2007..In conclusion, the behavioral effects of beta-acids fraction could be explained by a reduction in the GABAergic activity although we cannot rule out the involvement of other neurotransmitter systems... - Ferula hermonis impairs sexual behavior in hormone-primed female ratsPaola Zanoli
Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Italy
Physiol Behav 86:69-74. 2005..hermonis specifically impairs the receptive and proceptive components of female sexual behavior. The effect could be the consequence of an antiestrogenic action of the extract in hormone-primed female rats... - New insight in the neuropharmacological activity of Humulus lupulus LP Zanoli
Department of Pharmaceutical Science and National Inter University Consortium for the Study of Natural Active Principles, University of Modena and Reggio Emilia, Modena, Italy
J Ethnopharmacol 102:102-6. 2005..The same effects were elicited by the administration of the Humulus lupulus fraction containing alpha-acids, which can be considered as the major responsible for the enhanced pentobarbital effect and for the antidepressant property... - Activity of single components of Ferula hermonis on male rat sexual behaviorP Zanoli
Department of Pharmaceutical Sciences and National InterUniversity Consortium for the Study of Natural Active Principles CINSPAN, University of Modena and Reggio Emilia, Modena, Italy
Int J Impot Res 17:513-8. 2005.... - Role of hyperforin in the pharmacological activities of St. John's WortPaola Zanoli
Department of Pharmaceutical Sciences, University of Moderna Reggio Emilia, 41100 Modena, Italy
CNS Drug Rev 10:203-18. 2004..Taking into account the chemical instability of hyperforin, current efforts are directed to the synthesis of new neuroactive derivatives... - Influence of Eurycoma longifolia on the copulatory activity of sexually sluggish and impotent male ratsP Zanoli
Department of Biomedical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, 41100 Modena, Italy
J Ethnopharmacol 126:308-13. 2009..In the study we evaluated the influence of Eurycoma longifolia Jack on sexual behavior (including both motivation and copulatory performance) of sexually sluggish and impotent male rats... - Pharmacological activity of hyperforin acetate in ratsP Zanoli
Dipartimento di Scienze Farmaceutiche, Via Campi 183, I 41100 Modena, Italy
Behav Pharmacol 13:645-51. 2002..Taken together, the present results show that hyperforin acetate is a pharmacologically active derivative of hyperforin and may be a starting point from which to develop new compounds for therapeutic purposes... - Opposite effect of acute and subchronic treatments with Ferula hermonis on copulatory behavior of male ratsP Zanoli
Department of Pharmaceutical Sciences, Section of Pharmacology, University of Modena and Reggio Emilia, Modena, Italy
Int J Impot Res 15:450-5. 2003..The present results discourage a repeated assumption of F. hermonis, while suggesting its acute administration to improve the performance in sexual dysfunctions... - Influence of Griffonia simplicifolia on male sexual behavior in rats: behavioral and neurochemical studyG Carnevale
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, I 41100 Modena, Italy
Phytomedicine 18:947-52. 2011..The daily administration of the extract dosed at 50 and 100 mg/kg for 9 days significantly reduced food intake and body weight. Finally in the microdialysis experiments we found a dramatic increase in 5-HT and its metabolite 5-HIAA... - Experimental study on Satureja montana as a treatment for premature ejaculationM Zavatti
Department of Anatomy and Histology, University of Modena and Reggio Emilia, Via del Pozzo 71, 41100 Modena, Italy
J Ethnopharmacol 133:629-33. 2011..In this study we evaluated the effect of Satureja montana hydroalcoholic extract on copulatory behavior of sexually potent male rats... - Behavioral characterisation of the flavonoids apigenin and chrysinP Zanoli
Department of Pharmaceutical Sciences, Modena and Reggio Emilia University, Modena, Italy
Fitoterapia 71:S117-23. 2000..To the contrary, the anxiolytic effect of chrysin, which was blocked by the injection of Flumazenil, could be linked to an activation of the GABA(A) receptor unit... - The phytoestrogen ferutinin improves sexual behavior in ovariectomized ratsM Zavatti
Department of Biomedical Sciences, Section of Pharmacology and National InterUniversity Consortium for the Study of Natural Active Principles CINSPAN, University of Modena and Reggio Emilia, Via Campi 287, I 41100 Modena, Italy
Phytomedicine 16:547-54. 2009..Moreover, ferutinin restored a normal paced mating behavior, which had been suppressed by ovariectomy. These results show that ferutinin exerts an estrogenic activity in ovariectomized non-estrogen-primed female rats... - Anxiolytic-like effect of Griffonia simplicifolia Baill. seed extract in ratsG Carnevale
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, Modena, Italy
Phytomedicine 18:848-51. 2011..01). In conclusion these findings indicate that Griffonia simplicifolia seed extract exerts anxiolytic-like effect in rats and suggest its potential usefulness for the treatment of anxiety in humans... - Influence of ferutinin on bone metabolism in ovariectomized rats. I: role in preventing osteoporosisCarla Palumbo
Section of Human Anatomy, Department of Anatomy and Histology, University of Modena and Reggio Emilia, Via del Pozzo 71 Area policlinico, 41100, Modena, Italy
J Bone Miner Metab 27:538-45. 2009..The possibility of using ferutinin as an alternative to the commonly employed hormonal replacing therapy in post-menopausal women is discussed... - Griffonia simplicifolia negatively affects sexual behavior in female ratsG Carnevale
Department of Biomedical Sciences, University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
Phytomedicine 17:987-91. 2010..Taken together the present results, possibly ascribed to increased levels of 5-hydroxytryptamine (5-HT) in the brain, suggest a cautious administration of the plant extract owing to its negative influence on female sexual behavior... - Effects of the cannabinoid antagonist SR 141716 on sexual and motor behaviour in receptive female ratsM Zavatti
Department of Laboratories, Pathological Anatomy and Forensic Medicine, Section of Pharmacology, University of Modena and Reggio Emilia, Italy
Clin Exp Pharmacol Physiol 38:771-5. 2011..5. The results demonstrate the ability of SR to reduce female sexual receptivity, but not sexual motivation. The reduction does not seem strictly related to the motor alterations induced by the cannabinoid antagonist... - Prenatal exposure to methyl mercury in rats: focus on changes in kynurenine pathwayP Zanoli
Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Modena, Italy
Brain Res Bull 55:235-8. 2001..These results suggest that an imbalance in the kynurenine pathway could be involved in the toxic effects induced by MMC on brain development... - Evidence that bremazocine prevents urine retention induced by intraspinal cord injection of colchicine in ratsP Zanoli
Department of Pharmaceutical Sciences, School of Pharmacy, Modena University, Italy
J Auton Nerv Syst 30:S191-3. 1990..The selective kappa-receptors agonist, U-69593, had little effect, while eledoisin or naloxone administration worsened rather than counteracted urine retention... - Anti-ulcer activity of IAC, a novel free-radical scavenger, in ratsManuela Zavatti
National InterUniversity Consortium for the Study of Natural Active Principles CINSPAN, Department of Biomedical Sciences, University of Modena and Reggio Emilia, Modena, Italy
J Pharm Pharmacol 61:395-7. 2009..We investigated the ability of a novel low-molecular-weight free-radical scavenger, bis(1-hydroxy-2,2,6,6-tetramethyl-4-piperidinyl)-decandioate (IAC), to protect the gastric mucosa from indometacin-induced ulceration... - Cognitive deficits and changes in gene expression of NMDA receptors after prenatal methylmercury exposureMario Baraldi
Department of Pharmaceutical Sciences, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy
Environ Health Perspect 110:855-8. 2002..The data suggest that the behavioral abnormalities of MMC-exposed rats might be ascribed to a neurotoxic effect of the metal that alters the gene expression of a specific NMDA receptor subunit in the hippocampus...