R Vigneri

Summary

Affiliation: University of Catania
Country: Italy

Publications

  1. ncbi Insulin and its analogs: actions via insulin and IGF receptors
    R Vigneri
    Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Nesima Hospital, Italy
    Acta Diabetol 47:271-8. 2010
  2. ncbi Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
    L Frittitta
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Garibaldi Hospital, Italy
    Diabetes 47:1095-100. 1998
  3. ncbi Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation
    D Spampinato
    Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Hospital, Italy
    Metabolism 52:1092-5. 2003
  4. ncbi Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
    L Sciacca
    Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Nesima Hospital, Via Palermo 636, 95122 Catania, Italy
    Diabetologia 53:1743-53. 2010
  5. ncbi The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
    B V Costanzo
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Ospedale Garibaldi, Italy
    Diabetes 50:831-6. 2001
  6. ncbi Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms
    R Baratta
    Department of Internal and Specialist Medicine, University of Catania, Garibaldi Hospital, P zza S M di Gesù, 95123 Catania, Italy
    J Mol Med (Berl) 81:718-23. 2003
  7. ncbi Acute changes in clinical parameters and thyroid function peripheral markers following L-T4 withdrawal in patients totally thyroidectomized for thyroid cancer
    C Regalbuto
    Division of Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Italy
    J Endocrinol Invest 29:32-40. 2006
  8. ncbi Aggressive fibromatosis of the neck initiated after thyroidectomy
    S Arena
    Division of Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Catania, Italy
    J Endocrinol Invest 29:78-81. 2006
  9. ncbi Healing of chronic necrobiosis lipoidica lesions in a type 1 diabetic patient after pancreas-kidney transplantation: a case report
    D Gullo
    University of Catania, Catania, Italy
    J Endocrinol Invest 30:259-62. 2007
  10. ncbi A ten-year (1989-1998) perspective study of the incidence of Type 1 diabetes in the district of Catania (Sicily) in a 0-14 year age group
    M L Arpi
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Ospedale Garibaldi, Italy
    J Endocrinol Invest 25:414-9. 2002

Collaborators

Detail Information

Publications20

  1. ncbi Insulin and its analogs: actions via insulin and IGF receptors
    R Vigneri
    Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Nesima Hospital, Italy
    Acta Diabetol 47:271-8. 2010
    ..Prospective clinical studies, however, may add further useful information on the issue of the insulin analogs' possible differences with respect to native insulin...
  2. ncbi Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling
    L Frittitta
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Garibaldi Hospital, Italy
    Diabetes 47:1095-100. 1998
    ..These studies indicate, therefore, that the elevation of PC-1 content may be a primary factor in the cause of insulin resistance...
  3. ncbi Rats that are made insulin resistant by glucosamine treatment have impaired skeletal muscle insulin receptor phosphorylation
    D Spampinato
    Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Hospital, Italy
    Metabolism 52:1092-5. 2003
    ..8 +/- 10.7 v 55.7 +/- 5.8 nmol x mg(-1) x min(-1)) was not different in the 2 groups. Our data show that GlcN-induced insulin resistance is mediated, at least in part, by impaired skeletal muscle IR autophosphorylation...
  4. ncbi Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
    L Sciacca
    Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Garibaldi Nesima Hospital, Via Palermo 636, 95122 Catania, Italy
    Diabetologia 53:1743-53. 2010
    ..The characterisation of these effects was the aim of the present study...
  5. ncbi The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121)
    B V Costanzo
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Ospedale Garibaldi, Italy
    Diabetes 50:831-6. 2001
    ....
  6. ncbi Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARgamma2 (P12A) polymorphisms
    R Baratta
    Department of Internal and Specialist Medicine, University of Catania, Garibaldi Hospital, P zza S M di Gesù, 95123 Catania, Italy
    J Mol Med (Berl) 81:718-23. 2003
    ..e., insulin sensitivity index and M value) and insulin secretion (i.e., HOMA-B%) indexes...
  7. ncbi Acute changes in clinical parameters and thyroid function peripheral markers following L-T4 withdrawal in patients totally thyroidectomized for thyroid cancer
    C Regalbuto
    Division of Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Italy
    J Endocrinol Invest 29:32-40. 2006
    ..Alternative procedures, such as the use of recombinant human TSH, should be used whenever possible...
  8. ncbi Aggressive fibromatosis of the neck initiated after thyroidectomy
    S Arena
    Division of Endocrinology, Department of Internal and Specialistic Medicine, University of Catania, Catania, Italy
    J Endocrinol Invest 29:78-81. 2006
    ..Therefore, the patient received external radiation therapy (total dose 60 Gy) with clinical benefit. The patient is without symptoms 1 yr after surgery...
  9. ncbi Healing of chronic necrobiosis lipoidica lesions in a type 1 diabetic patient after pancreas-kidney transplantation: a case report
    D Gullo
    University of Catania, Catania, Italy
    J Endocrinol Invest 30:259-62. 2007
    ....
  10. ncbi A ten-year (1989-1998) perspective study of the incidence of Type 1 diabetes in the district of Catania (Sicily) in a 0-14 year age group
    M L Arpi
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Ospedale Garibaldi, Italy
    J Endocrinol Invest 25:414-9. 2002
    ..The study revealed a non-random spatial distribution of T1DM incidence in children not accounted for by known demographic factors. A significant seasonal pattern and temporal trend of incidence were also detected...
  11. ncbi Usefulness of recombinant human thyrotropin in the radiometabolic treatment of selected patients with thyroid cancer
    G Pellegriti
    Istituto di Medicina Interna e Malattie Endocrine e del Metabolismo, University of Catania Medical School, Ospedale Garibaldi, Catania, Italy
    Thyroid 11:1025-30. 2001
    ..Its efficacy to treat advanced metastatic disease should be further investigated...
  12. ncbi The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance
    L Frittitta
    Istituto di Medicina Interna, Endocrinologia e Malattie del Metabolismo, Ospedale Garibaldi, Universita di Catania, 95123 Catania, Italy
    J Clin Endocrinol Metab 86:5888-91. 2001
    ..05) of BMI, gender, age, and waist circumference. In conclusion, the Q121 PC-1 variant and obesity have independent and additive effects in causing insulin resistance...
  13. ncbi Chronic exposure to high leucine impairs glucose-induced insulin release by lowering the ATP-to-ADP ratio
    M Anello
    Institute of Internal Medicine, Endocrinology, and Metabolism and S Signorelli Diabetes Center, Ospedale Garibaldi, Italy
    Am J Physiol Endocrinol Metab 281:E1082-7. 2001
    ..The abnormal plasma amino acid levels often present in obesity and diabetes may, therefore, affect pancreatic islet insulin secretion in these patients...
  14. ncbi Immunostaining for Met/HGF receptor may be useful to identify malignancies in thyroid lesions classified suspicious at fine-needle aspiration biopsy
    A Ippolito
    Istituto di Medicina Interna e di Malattie Endocrine e del Metabolismo, University of Catania, Italy
    Thyroid 11:783-7. 2001
    ..These data suggest that Met immunostaining of suspicious cytological smears are useful for identifying malignant lesions, especially those with a papillary histotype...
  15. ncbi Tyrosine kinase inhibitor STI571 enhances thyroid cancer cell motile response to Hepatocyte Growth Factor
    F Frasca
    Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, Universita di Catania, Ospedale Garibaldi, Piazza S Maria di Gesù, 95123 Catania, Italy
    Oncogene 20:3845-56. 2001
    ..These data suggests that c-Abl and/or STI571-inhibited tyrosine kinases can negatively regulate the Met receptor to restrain the motile response in thyroid cancer cells...
  16. ncbi A soluble PC-1 circulates in human plasma: relationship with insulin resistance and associated abnormalities
    L Frittitta
    Istituto di Medicina Interna, Malattie Endocrine e Metaboliche, Universita di Catania, Ospedale Garibaldi
    J Clin Endocrinol Metab 84:3620-5. 1999
    ..In conclusion, PC-1 circulates in human plasma, and its concentration is related to insulin sensitivity. This may help to plan studies aimed at understanding the role of PC-1 in insulin resistance...
  17. ncbi High insulin levels do not influence PC-1 gene expression and protein content in human muscle tissue and hepatoma cells
    L Frittitta
    Institute of Internal Medicine, Endocrine and Metabolic Diseases, University of Catania, Garibaldi Hospital, Catania, Italy
    Diabetes Metab Res Rev 16:26-32. 2000
    ..Data were compared with those obtained in matched insulin sensitive or resistant healthy subjects. In addition, the effect of high insulin concentration on PC-1 protein content was studied in HepG2 cells...
  18. ncbi Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases
    A Belfiore
    Cattedra di Endocrinologia, University of Catania, Italy
    J Clin Endocrinol Metab 82:2322-8. 1997
    ..99; P = 0.0099), and vascular invasion (hazard ratio = 3.19; P = 0.0358). These findings suggest a role for Met/HGF-R in papillary thyroid cancer and its clinical use to select patients with a high risk of distant metastases...
  19. ncbi BRAF(V600E) mutation and the biology of papillary thyroid cancer
    F Frasca
    Endocrinologia, Dipartimento di Medicina Interna e Medicina Specialistica, University of Catania, PO Garibaldi Nesima, Via Palermo 636, Catania, Italy
    Endocr Relat Cancer 15:191-205. 2008
    ..These results indicate that BRAF((V600E)) mutation is a marker of aggressive disease in both micro- and macro-PTCs. Moreover, for the first time, a possible link between BRAF((V600E)) mutation and environmental carcinogens is suggested...
  20. ncbi The IGF system in thyroid cancer: new concepts
    V Vella
    Cattedra di Endocrinologia, Istituto di Medicina Interna, Malattie Endocrine e del Metabolismo, University of Catania, Ospedale Garibaldi, Catania, Italy
    Mol Pathol 54:121-4. 2001
    ..These data indicate that both IR/IGF-I-R hybrids and IR-A play an important role in the overactivation of the IGF system in thyroid cancer and in IGF-I mitogenic signalling in these tumours. J Clin PATHOL: Mol Pathol..