Alberto Verrotti

Summary

Affiliation: University of Chieti
Country: Italy

Publications

  1. ncbi Glut1 deficiency: when to suspect and how to diagnose?
    A Verrotti
    Department of Paediatrics, University of Chieti, Ospedale Policlinico SS Annunziata, Via dei Vestini 5, 66100 Chieti, Italy
    Eur J Paediatr Neurol 16:3-9. 2012
  2. ncbi Human photosensitivity: from pathophysiology to treatment
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Chieti, Italy
    Eur J Neurol 12:828-41. 2005
  3. ncbi Color vision and macular recovery time in epileptic adolescents treated with valproate and carbamazepine
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Eur J Neurol 13:736-41. 2006
  4. ncbi Nonalcoholic fatty liver disease during valproate therapy
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, 5 66100, Chieti Italy
    Eur J Pediatr 168:1391-4. 2009
  5. ncbi Afebrile benign convulsions with mild gastroenteritis: a new entity?
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Ospedale Policlinico, Chieti, Italy
    Acta Neurol Scand 120:73-9. 2009
  6. ncbi Paroxysmal tonic upgaze of childhood and childhood absence epilepsy
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy
    Eur J Paediatr Neurol 14:93-6. 2010
  7. ncbi The metabolic syndrome in overweight epileptic patients treated with valproic acid
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Epilepsia 51:268-73. 2010
  8. ncbi A 12-month longitudinal study of calcium metabolism and bone turnover during valproate monotherapy
    A Verrotti
    Department of Pediatrics, Chieti University Hospital, Chieti, Italy
    Eur J Neurol 17:232-7. 2010
  9. ncbi Levetiracetam monotherapy for childhood occipital epilepsy of gastaut
    A Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Acta Neurol Scand 120:342-6. 2009
  10. ncbi Bone and calcium metabolism and antiepileptic drugs
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Italy
    Clin Neurol Neurosurg 112:1-10. 2010

Detail Information

Publications146 found, 100 shown here

  1. ncbi Glut1 deficiency: when to suspect and how to diagnose?
    A Verrotti
    Department of Paediatrics, University of Chieti, Ospedale Policlinico SS Annunziata, Via dei Vestini 5, 66100 Chieti, Italy
    Eur J Paediatr Neurol 16:3-9. 2012
    ..Treatment with a ketogenic diet results in marked improvement of seizures and movement disorders. This review summarizes recent advances in understanding of GLUT1-DS and highlights the diagnostic and therapeutic approach to GLUT1-DS...
  2. ncbi Human photosensitivity: from pathophysiology to treatment
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Chieti, Italy
    Eur J Neurol 12:828-41. 2005
    ....
  3. ncbi Color vision and macular recovery time in epileptic adolescents treated with valproate and carbamazepine
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Eur J Neurol 13:736-41. 2006
    ..Further investigations are required to determine the pathophysiological alteration(s) that are at the basis of color perception defects...
  4. ncbi Nonalcoholic fatty liver disease during valproate therapy
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, 5 66100, Chieti Italy
    Eur J Pediatr 168:1391-4. 2009
    ..The present case suggests that obesity, hyperinsulinemia, insulin resistance, and long-term treatment with VPA may be all associated with the development of NAFLD; this side effect is reversible after VPA withdrawal...
  5. ncbi Afebrile benign convulsions with mild gastroenteritis: a new entity?
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Ospedale Policlinico, Chieti, Italy
    Acta Neurol Scand 120:73-9. 2009
    ..In conclusion, this type of seizure seems to be a new entity, but it awaits a correct place in the large group of infantile convulsion disorders...
  6. ncbi Paroxysmal tonic upgaze of childhood and childhood absence epilepsy
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy
    Eur J Paediatr Neurol 14:93-6. 2010
    ..Our case suggests a possible association between PTU and epilepsy...
  7. ncbi The metabolic syndrome in overweight epileptic patients treated with valproic acid
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Epilepsia 51:268-73. 2010
    ..To evaluate the presence of metabolic syndrome (MS) in children and adolescents treated with valproate (VPA)...
  8. ncbi A 12-month longitudinal study of calcium metabolism and bone turnover during valproate monotherapy
    A Verrotti
    Department of Pediatrics, Chieti University Hospital, Chieti, Italy
    Eur J Neurol 17:232-7. 2010
    ....
  9. ncbi Levetiracetam monotherapy for childhood occipital epilepsy of gastaut
    A Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Acta Neurol Scand 120:342-6. 2009
    ..The aim of this open label pilot study was to evaluate the efficacy and tolerability of levetiracetam (LEV) as 'de novo' monotherapy in children and adolescents with late onset childhood occipital epilepsy-Gastaut type (COE-G)...
  10. ncbi Bone and calcium metabolism and antiepileptic drugs
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Italy
    Clin Neurol Neurosurg 112:1-10. 2010
    ..g., valproate) cannot be readily explained by vitamin D metabolism. In this article, the literature related to the effects of classic and new antiepileptic drugs on bone health and calcium metabolism is reviewed...
  11. ncbi Adolescents and epilepsy: hormonal aspects
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Minerva Pediatr 60:417-28. 2008
    ..Changes in hormone serum levels that occur during pubertal period are probably related to modifications in seizure features and are involved in some types of epilepsy that begin typically in adolescence...
  12. ncbi Increased oxidative stress in epileptic children treated with valproic acid
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Italy
    Epilepsy Res 78:171-7. 2008
    ..To determine influence of Valproic Acid (VPA) treatment on oxidative status in non-obese and overweight epileptic children...
  13. ncbi Influence of sex hormones on brain excitability and epilepsy
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    J Endocrinol Invest 30:797-803. 2007
    ..This review provides an overview of the current knowledge in this field and highlights some of the prevailing hypotheses about the effects of sexual hormones on neuronal excitability analysing data from both animal and clinical studies...
  14. ncbi Photosensitivity and epilepsy
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Chieti, Italy
    J Child Neurol 19:571-8. 2004
    ..Stimulus avoidance and stimulus modification can be an effective treatment in some patients and can sometimes be combined with antiepileptic drug treatment...
  15. ncbi The treatment of juvenile myoclonic epilepsy
    Alberto Verrotti
    University of Chieti, Alberto Verrotti Dept of Pediatrics, University of Chieti Ospedale Policlinico, Via dei Vestini 5, Italy
    Expert Rev Neurother 6:847-54. 2006
    ..Currently, administration of new antiepileptic drugs, such as levetiracetam, lamotrigine and topiramate, seems to have beneficial effects in the patients with poor response to valproate...
  16. ncbi Levetiracetam monotherapy for children and adolescents with benign rolandic seizures
    A Verrotti
    Department of Pediatrics, University of Chieti, Policlinico Universitario, Via dei Vestini 5, 66100 Chieti, Italy
    Seizure 16:271-5. 2007
    ..5%) patients. Our results support findings that LEV monotherapy is effective and well tolerated in children with BECTS. Prospective, large, long-term double-blind studies are needed to confirm these findings...
  17. ncbi Photosensitivity and epilepsy: a follow-up study
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti Ospedale Policlinico, Chieti, Italy
    Dev Med Child Neurol 46:347-51. 2004
    ..Thirty-three patients became seizure-free. Our study confirms that photosensitive epilepsy has a good prognosis for seizure control that is independent of the persistence or disappearance of photosensitivity...
  18. ncbi Intermittent oral diazepam prophylaxis in febrile convulsions: its effectiveness for febrile seizure recurrence
    Alberto Verrotti
    Section of Pediatrics, Department of Medicine, University of Chieti Ospedale Policlinico, Via dei Vestini 5, Chieti 66013, Italy
    Eur J Paediatr Neurol 8:131-4. 2004
    ..7%) went on to have one or more additional episodes. In conclusion, our study demonstrates that oral diazepam, given only when fever is present, is an effective means of reducing the risk of recurrences of FS...
  19. ncbi Topiramate in frontal lobe epilepsy
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Acta Neurol Scand 115:132-5. 2007
    ..Frontal lobe epilepsy (FLE) is a type of epilepsy that is difficult to treat and there are few studies about the use of topiramate (TPM)...
  20. ncbi Antiepileptic drugs and visual function
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Pediatr Neurol 36:353-60. 2007
    ....
  21. ncbi Update of the medical treatment of West syndrome
    A Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Minerva Pediatr 59:249-53. 2007
    ..This review outlines the usefulness of the different antiepileptic drugs for the treatment of West syndrome...
  22. ncbi Extended-release formulations in epilepsy
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Italy
    J Child Neurol 22:419-26. 2007
    ..The results of these studies are encouraging and suggest a good tolerability and efficacy of these extended-release formulations, although larger studies are needed...
  23. ncbi Epilepsy, sex hormones and antiepileptic drugs in female patients
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy
    Expert Rev Neurother 9:1803-14. 2009
    ..The aim of the present review is to critically evaluate the recently published data concerning the interactions between sex hormones, epilepsy and AEDs...
  24. ncbi Catamenial epilepsy: hormonal aspects
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Gynecol Endocrinol 26:783-90. 2010
    ..Also, variations in concentrations of antiepileptic drugs across the menstrual cycle may contribute to increased seizure susceptibility. A variety of approaches have been proposed for the treatment of catamenial epilepsy...
  25. ncbi Benign convulsions associated with mild gastroenteritis: a multicenter clinical study
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Epilepsy Res 93:107-14. 2011
    ..To assess the clinical characteristics and the outcome of benign convulsions associated with mild gastroenteritis (CwG) in Italian children...
  26. ncbi Pharmacotherapy for children and adolescents with epilepsy
    Alberto Verrotti
    University of Chieti, Department of Pediatrics, Ospedale Policlinico, Via dei Vestini 5, Chieti, Italy
    Expert Opin Pharmacother 12:175-94. 2011
    ..Despite these improvements, few AEDs are now considered to be a first-choice for the treatment of epilepsy in children...
  27. ncbi Cognitive and linguistic abnormalities in benign childhood epilepsy with centrotemporal spikes
    A Verrotti
    Department of Paediatrics, University of Chieti, Italy
    Acta Paediatr 100:768-72. 2011
    ..To assess the cognitive function and language ability in children with benign partial epilepsy with centrotemporal spikes...
  28. ncbi Weight gain following treatment with valproic acid: pathogenetic mechanisms and clinical implications
    A Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Obes Rev 12:e32-43. 2011
    ....
  29. ncbi Thyroid hormones in children with epilepsy during long-term administration of carbamazepine and valproate
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Eur J Endocrinol 160:81-6. 2009
    ..This study evaluates the effects of long-term carbamazepine (CBZ) and valproate acid (VPA) therapy on thyroid function in epileptic children...
  30. ncbi Levetiracetam in childhood epilepsy
    Alberto Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Paediatr Drugs 12:177-86. 2010
    ....
  31. ncbi Gastaut type-idiopathic childhood occipital epilepsy and childhood absence epilepsy: a clinically significant association?
    Alberto Verrotti
    Department of Paediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy
    Seizure 19:368-72. 2010
    ..We discuss the possible association between these two epileptic syndromes and its common pathophysiological mechanisms...
  32. ncbi Topiramate-induced weight loss: a review
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66013 Chieti, Italy
    Epilepsy Res 95:189-99. 2011
    ..In international literature, the reported body weight loss incidences linked to TPM therapy vary widely and, in some cases, are very conflicting...
  33. ncbi Antiepileptic drugs, sex hormones, and PCOS
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Epilepsia 52:199-211. 2011
    ..A better understanding of the effects of AEDs on sex hormones is key to selecting the appropriate AEDs and is crucial for reproductive health in female patients...
  34. ncbi Effects of irbesartan on intracellular antioxidant enzyme expression and activity in adolescents and young adults with early diabetic angiopathy
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, I 66100 Chieti, Italy
    Diabetes Care 28:1690-7. 2005
    ..The objective of this study was to evaluate the effects of irbesartan, an angiotensin II receptor antagonist, on IAP in adolescents and young adults with type 1 diabetes and early signs of retinopathy and nephropathy...
  35. ncbi Insulin resistance in epileptic girls who gain weight after therapy with valproic acid
    Alberto Verrotti
    Department of Medicine, University of Chieti, Ospedale Policlinico, Italy
    J Child Neurol 17:265-8. 2002
    ..Therefore, these obese patients could be exposed to the risks related to these metabolic abnormalities; if these data are confirmed in longer studies, these side effects may raise some concerns about the safety of valproic acid...
  36. ncbi Factors associated with poor control in partial complex epilepsy
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Chieti, Italy
    J Child Neurol 19:262-4. 2004
    ....
  37. ncbi Long term outcome in children affected by absence epilepsy with onset before the age of three years
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Epilepsy Behav 20:366-9. 2011
    ..The goal of this study was to define the long-term outcome of absence epilepsy presenting before the age of 3 years...
  38. ncbi The effect of recurrent severe hypoglycemia on cognitive performance in children with type 1 diabetes: a meta-analysis
    Annalisa Blasetti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    J Child Neurol 26:1383-91. 2011
    ..However, these results must be considered with caution taking into account factors such as small sample sizes, the different definitions of severe hypoglycemia, and the variety of neuropsychological tests used...
  39. ncbi Levetiracetam in absence epilepsy
    Alberto Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Dev Med Child Neurol 50:850-3. 2008
    ..Prospective, large, long-term double-blind studies are needed to confirm these findings...
  40. ncbi Risk factors for recurrence of epilepsy and withdrawal of antiepileptic therapy: a practical approach
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti Ospedale Policlinico, Italy
    Ann Med 35:207-15. 2003
    ..In this review we analyse data from the literature and we suggest a practical approach for safe anticonvulsant withdrawal, although the decision should always be made individually, weighing risks and benefits...
  41. ncbi Increased vascular endothelial growth factor serum concentrations may help to identify patients with onset of type 1 diabetes during childhood at risk for developing persistent microalbuminuria
    F Santilli
    Department of Medicine, Division of Pediatrics, University of Chieti, 66100 Chieti, Italy
    J Clin Endocrinol Metab 86:3871-6. 2001
    ..Persistently increased vascular endothelial growth factor serum levels may help to identify normotensive, normoalbuminuric patients with type 1 diabetes who are predisposed to develop persistent microalbuminuria later in life...
  42. ncbi Peri-ictal and inter-ictal headache in children and adolescents with idiopathic epilepsy: a multicenter cross-sectional study
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Italy
    Childs Nerv Syst 27:1419-23. 2011
    ..Headache in epileptic population ranges from 8% to 15%. The aim of this paper was to study the clinical and temporal characteristics of primary headache comorbidity in idiopathic epileptic children...
  43. ncbi Obesity and plasma concentrations of alpha-tocopherol and beta-carotene in epileptic girls treated with valproate
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Chieti, Italy
    Neuroendocrinology 79:157-62. 2004
    ..In conclusion, the data suggest that epileptic patients who gain weight after VPA therapy have reduced plasma concentrations of antioxidant vitamins and that these reductions are reversible after VPA withdrawal...
  44. ncbi Nonalcoholic fatty liver disease in adolescents receiving valproic acid
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Epilepsy Behav 20:382-5. 2011
    ..The aim of this study was to investigate the association between the metabolic derangements induced by valproic acid (VPA) and ultrasound-diagnosed nonalcoholic fatty liver disease (NAFLD) in adolescents...
  45. ncbi Valproate-induced insulin resistance and obesity in children
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Horm Res 71:125-31. 2009
    ..Among the side effects of VPA, weight gain is frequently reported, although the real incidence and magnitude of this problem is unknown. Its pathogenesis is most likely multifactorial, and is controversial...
  46. ncbi Should "migralepsy" be considered an obsolete concept? A multicenter retrospective clinical/EEG study and review of the literature
    Alberto Verrotti
    Child Neurology and Department of Pediatrics, University of Chieti, Chieti, Italy
    Epilepsy Behav 21:52-9. 2011
    ....
  47. ncbi The possible role of esRAGE and sRAGE in the natural history of diabetic nephropathy in childhood
    Cosimo Giannini
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100, Chieti, Italy
    Pediatr Nephrol 27:269-75. 2012
    ..The inverse association between esRAGE levels and early kidney alterations suggests a potential role of esRAGE in diabetic nephropathy...
  48. ncbi Diffuse onset of ictal electroencephalography in a typical case of Panayiotopoulos syndrome and review of the literature
    Paola Iannetti
    Department of Pediatrics, Division of Child Neurology, La Sapienza University of Rome, Viale Regina Elena 324, Rome, Italy
    J Child Neurol 24:472-6. 2009
    ....
  49. ncbi Hormonal and reproductive disturbances in epileptic male patients: emerging issues
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Italy
    Reprod Toxicol 31:519-27. 2011
    ..To review the relationship between epilepsy, antiepileptic drugs and reproductive function...
  50. ncbi von Willebrand factor and its propeptide in children with diabetes. Relation between endothelial dysfunction and microalbuminuria
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Oespedale Policlinico, Chieti, Italy
    Pediatr Res 53:382-6. 2003
    ....
  51. ncbi What is the significance of soluble and endogenous secretory receptor for advanced glycation end products in liver steatosis in obese prepubertal children?
    Ebe D'Adamo
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Antioxid Redox Signal 14:1167-72. 2011
    ..These findings suggest that AGE-RAGE pathway plays an independent role in the development of liver injury already present in this age group...
  52. ncbi Weight gain and insulin resistance in children treated with valproate: the influence of time
    Fabio Masuccio
    Department of Pediatrics, University of Chieti, Chieti, Italy
    J Child Neurol 25:941-7. 2010
    ..These results might be helpful to enhance the knowledge of valproic acid action on both insulin resistance and weight gain, allowing to plan appropriate approach for the prevention of the consequences of the treatment with valproic acid...
  53. ncbi Typical and atypical rolandic epilepsy in childhood: a follow-up study
    Alberto Verrotti
    Department of Pediatrics-Policlinico Colle Dell'Ara, University of Chieti, Via dei Vestini 5, I-66013 Chieti, Italy
    Pediatr Neurol 26:26-9. 2002
    ..5% vs 7.8%; P < 0.0001). In conclusion, atypical rolandic epilepsy seems to be associated with a high percentage of learning and behavioral disorders...
  54. ncbi Developmental anomalies of the medial septal area: possible implication for limbic epileptogenesis
    Paola Iannetti
    Department of Pediatrics, Child Neurology Division, Sapienza University, La Sapienza Roma, Viale Regina Elena 324, 00161, Rome, Italy
    Childs Nerv Syst 27:765-70. 2011
    ..The limbic system includes a group of interconnected gray and white matter structures; in this circuit, the fornix is an important white matter connection with the septum pellucidum...
  55. ncbi Antiepileptic drugs and thyroid function
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Chieti, Italy
    J Pediatr Endocrinol Metab 21:401-8. 2008
    ..The aim of this review is to analyse critically the principal alterations in thyroid function caused by AED therapy...
  56. ncbi Long-term outcome of epilepsy in Kabuki syndrome
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, 66100 Chieti, Italy
    Seizure 20:650-4. 2011
    ..Prognosis of this epilepsy is favourable in the majority of cases with complete disappearance of seizures and EEG abnormalities...
  57. ncbi Variables associated with severe hypoglycemia in children and adolescents with type 1 diabetes: a population-based study
    Annalisa Blasetti
    Department of Pediatrics, University of Chieti, Via dei Vestini 5, Chieti, Italy
    Pediatr Diabetes 12:4-10. 2011
    ..The aim of our study was to determine the incidence of SH and associated variables in a population of children and adolescents with T1DM...
  58. ncbi Early-onset pure absence epilepsy: a distinct epileptic syndrome
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Italy
    Acta Paediatr 100:647-50. 2011
    ....
  59. ncbi Increased bone turnover in prepubertal, pubertal, and postpubertal patients receiving carbamazepine
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Italy
    Epilepsia 43:1488-92. 2002
    ..CONCLUSIONS: CBZ induces an increase of bone formation and of bone resorption that seems to be independent of the pubertal stage...
  60. ncbi Benign focal epilepsy with onset in infancy in a patient with 18q-syndrome
    Alberto Verrotti
    Section of Pediatrics, Department of Medicine, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, 66100 Chieti, Italy
    Childs Nerv Syst 20:362-5. 2004
    ..The magnetic resonance imaging of the brain was normal. CONCLUSION: In conclusion, benign focal epilepsy with onset in infancy could be a condition associated with 18q-syndrome...
  61. ncbi Levetiracetam in juvenile myoclonic epilepsy: long-term efficacy in newly diagnosed adolescents
    Alberto Verrotti
    Department of Paediatrics, University of Chieti, Rome, Italy
    Dev Med Child Neurol 50:29-32. 2008
    ..At 12-month evaluation: 29 patients were seizure free; three patients were responders. No patients reported adverse events. These data provide preliminary evidence that LEV may be effective for treating patients with newly diagnosed JME...
  62. ncbi Preventing microvascular diabetic complications in children and adolescents: looking beyond glycaemic control
    Alberto Verrotti
    Department of Pediatrics-Policlinico Colle Dell'Ara, University G. D'Annunzio, Via dei Vestini 5, I-66013 Chieti, Italy
    Expert Opin Pharmacother 4:525-32. 2003
    ..Therapeutic interventions, particularly excellent metabolic control, may be almost effective in preventing complication onset, or significantly retarding the rate of progression...
  63. ncbi Old and new antiepileptic drugs for the treatment of idiopathic generalized epilepsies
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, 66013 Chieti, Italy
    Curr Clin Pharmacol 2:249-59. 2007
    ..Today, "new" antiepileptic drugs, such as lamotrigine, levetiracetam, topiramate and zonisamide are useful tools in the treatment of pharmacoresistant epilepsies...
  64. ncbi Diabetic neuropathy in children and adolescents
    Daniela Trotta
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Pediatr Diabetes 5:44-57. 2004
    ..Etiopathogenetic theories and diagnostic tools are also reviewed from in a pediatric perspective...
  65. ncbi Endocrine and metabolic changes in epileptic patients receiving valproic acid
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Italy
    J Pediatr Endocrinol Metab 18:423-30. 2005
    ....
  66. ncbi Effects of vitamin E supplementation on intracellular antioxidant enzyme production in adolescents with type 1 diabetes and early microangiopathy
    Francesco Chiarelli
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini, 5, I 66100 Chieti, Italy
    Pediatr Res 56:720-5. 2004
    ..Adolescents with early signs of diabetic angiopathy have defective IAP and activity, which are not modified by vitamin E...
  67. ncbi Recent advances on neural tube defects with special reference to Valproic Acid
    Alberto Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Italy
    Endocr Metab Immune Disord Drug Targets 6:25-31. 2006
    ..There is strong evidence for a protective effect of adequate folate consumption...
  68. ncbi Leptin, ghrelin, and adiponectin in epileptic patients treated with valproic acid
    R Greco
    Department of Medicine, University of Chieti, Italy
    Neurology 65:1808-9. 2005
    ..5%) had development of obesity. They showed circulating leptin and insulin levels significantly higher and ghrelin and adiponectin levels significantly lower than those of patients who did not gain weight...
  69. ncbi Retinal nerve fiber layer and macular thickness in adolescents with epilepsy treated with valproate and carbamazepine
    Lucio Lobefalo
    Department of Experimental Surgery, Section of Ophthalmology, University of Chieti, Italy
    Epilepsia 47:717-9. 2006
    ..CONCLUSIONS: The present study demonstrates that no modification of RNFL and macular thickness parameters is found after 1 year of treatment with VPA and CBZ monotherapy...
  70. ncbi Valproate-induced hyperammonemic encephalopathy
    Alberto Verrotti
    Department of Pediatrics, University of Chieti, Italy
    Metab Brain Dis 17:367-73. 2002
    ..Moreover, VHE seems to be more frequently in patients with carnitine deficiency or with congenital urea cycle enzymatic defects...
  71. ncbi Thyroid hormones in epileptic children receiving carbamazepine and valproic acid
    A Verrotti
    Department of Medicine, Section of Pediatrics, University of Chieti, Chieti, Italy
    Pediatr Neurol 25:43-6. 2001
    ..Thyroid-stimulating hormone and thyrotropin-releasing hormone levels do not seem to be affected by these drugs, suggesting that hypothalamic function is not affected in these children...
  72. ncbi New trends in the treatment of diabetic nephropathy in children
    Alberto Verrotti
    Department of Pediatrics, Ospedale Policlinico, Via dei Vestini, Chieti, Italy
    Expert Opin Pharmacother 3:1169-76. 2002
    ..In this review controversial aspects of this issue are presented and discussed...
  73. ncbi Increased concentrations of soluble CD40 ligand may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuria
    F Chiarelli
    Department of Pediatrics, University of Chieti, Chieti, Italy
    Diabetes Metab Res Rev 24:570-6. 2008
    ..Soluble CD40 ligand (sCD40L) is supposed to be one of the most likely candidates for both retinopathy and nephropathy...
  74. ncbi Discontinuation of anticonvulsant therapy in children with partial epilepsy
    A Verrotti
    Department of Medicine, University of Chieti, Ospedale Policlinico, Italy
    Neurology 55:1393-5. 2000
    ..8%; Group B, 25%). It is safe to discontinue the anticonvulsant therapy in children with cryptogenic partial epilepsy who were seizure free for only 1 year...
  75. ncbi Necrobiosis lipoidica diabeticorum in children and adolescents: a clue for underlying renal and retinal disease
    A Verrotti
    Department of Pediatrics, University of Chieti, Italy
    Pediatr Dermatol 12:220-3. 1995
    ..001) than those without NLD. Our study suggests that children as well as adult diabetics with NLD can be at high risk for nephropathy and retinopathy; NLD can be a clue for diabetic nephropathy and retinopathy...
  76. ncbi Plasma prorenin levels may predict persistent microalbuminuria in children with diabetes
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Pediatr Nephrol 16:116-20. 2001
    ....
  77. ncbi New trends in the etiopathogenesis of diabetic peripheral neuropathy
    A Verrotti
    Department of Medicine, University of Chieti, Italy
    J Child Neurol 16:389-94. 2001
    ..The role of other factors, such as possible direct neurotrophic effects of insulin and insulin-related growth factors, seems to be relevant...
  78. ncbi Serum leptin changes during weight loss in obese diabetic subjects with and without microalbuminuria
    A Verrotti
    Department of Medicine, University of Chieti, Italy
    Diabetes Nutr Metab 14:283-7. 2001
    ..The changes of leptin in diabetics seem to be similar to those observed in healthy obese subjects...
  79. ncbi Paroxysmal tonic upgaze of childhood: effect of age-of-onset on prognosis
    A Verrotti
    Department of Paediatrics, University of Chieti, Italy
    Acta Paediatr 90:1343-5. 2001
    ..CONCLUSION: From a long-term follow-up, we can confirm the good prognosis of PTU and suggest it is possible to define a distinct syndrome of childhood without any neurological abnormalities and with spontaneous resolution...
  80. ncbi Serum copper, zinc, selenium, glutathione peroxidase and superoxide dismutase levels in epileptic children before and after 1 year of sodium valproate and carbamazepine therapy
    A Verrotti
    Department of Medicine, Division of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66100 Chieti, Italy
    Epilepsy Res 48:71-5. 2002
    ..In conclusion our study demonstrates that epilepsy per se and treatment with VPA and CBZ do not affect levels of Cu, Zn, Se, GSH-PX and CuZn-SOD concentrations...
  81. ncbi Effect of anticonvulsant drugs on interleukins-1, -2 and -6 and monocyte chemoattractant protein-1
    A Verrotti
    Department of Medicine, University of Chieti, Ospedale Policlinico, Italy
    Clin Exp Med 1:133-6. 2001
    ..In conclusion, antiepileptic drugs can influence the immune system by modifying interleukin and chemokine concentrations; these changes seem to be independent of the serum concentrations of these drugs...
  82. ncbi Serum angiogenin concentrations in young patients with diabetes mellitus
    F Chiarelli
    Department of Medicine, Division of Pediatrics, University of Chieti, Italy
    Eur J Clin Invest 32:110-4. 2002
    ..Angiogenin serum levels were measured in a large group of type 1 diabetic young patients, looking at whether increased Angiogenin concentrations are associated with long-term glycemic control and microvascular complications...
  83. ncbi Screening for vascular complications in children and adolescents with type 1 diabetes mellitus
    F Chiarelli
    Department of Pediatrics, University of Chieti, Italy
    Horm Res 57:113-6. 2002
    ..Early detection of diabetic microangiopathy and timely treatment of early signs of these complications have a pivotal role in prevention of blindness and end-stage renal failure in children and adolescents with diabetes...
  84. ncbi Photoparoxysmal responses in non-epileptic children in long-term follow-up
    A Verrotti
    Department of Medicine, Division of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66100 Chieti, Italy
    Acta Neurol Scand 105:400-2. 2002
    ..To evaluate the photoparoxysmal responses (PPR) in non-epileptic children and adolescents in long-term follow-up...
  85. ncbi Increased Na+/Li+ countertransport activity may help to identify type 1 diabetic adolescents and young adults at risk for developing persistent microalbuminuria
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Diabetes Care 22:1158-64. 1999
    ....
  86. ncbi Skin reactions due to anti-epileptic drugs: several case-reports with long-term follow-up
    C Feliciani
    Department of Dermatology, University G D Annunzio, Chieti, Italy
    Int J Immunopathol Pharmacol 16:89-93. 2003
    ....
  87. ncbi Kidney involvement and disease in patients with diabetes
    F Chiarelli
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Panminerva Med 45:23-41. 2003
    ....
  88. ncbi Anticardiolipin, glutamic acid decarboxylase, and antinuclear antibodies in epileptic patients
    A Verrotti
    Department of Pediatrics, University of Chieti, Ospedale Policlinico, Via dei Vestini 5, I 66013 Chieti, Italy
    Clin Exp Med 3:32-6. 2003
    ..There was no significant difference in serum glutamic acid decarboxylase antibodies between epileptic children and controls, and between patients who were seizure free and those with uncontrolled epilepsy...
  89. ncbi Febrile convulsions after 5 years of age: long-term follow-up
    A Verrotti
    Department of Medicine, University of Chieti, Italy
    J Child Neurol 15:811-3. 2000
    ..1% vs 7.4%, P < .05). Our data suggest that children with febrile convulsions after 5 years of age probably must be considered as a group of patients at risk of developing unprovoked seizures...
  90. ncbi New antiepileptic drugs in childhood
    A Verrotti
    Department of Paediatrics, University of Chieti, Chieti, Italy
    Panminerva Med 44:221-5. 2002
    ..g. phenobarbital, valproate, etc.). We report their mechanisms of action, effectiveness, dosage and side effects; moreover, some practical advice for their use in pediatric patients is given...
  91. ncbi Vascular endothelial growth factor (VEGF) in children, adolescents and young adults with Type 1 diabetes mellitus: relation to glycaemic control and microvascular complications
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Diabet Med 17:650-6. 2000
    ....
  92. ncbi Flicker perimetry in diabetic children without retinopathy
    L Lobefalo
    Institute of Ophthalmology, G D Annunzio University, Chieti, Italy
    Can J Ophthalmol 32:324-8. 1997
    ..To determine the flicker fusion frequency in children and adolescents with insulin-dependent diabetes mellitus (IDDM) who did not have fluorescein angiographic signs of retinopathy...
  93. ncbi The importance of microalbuminuria as an indicator of incipient diabetic nephropathy: therapeutic implications
    F Chiarelli
    Department of Paediatrics, University of Chieti, Italy
    Ann Med 29:439-45. 1997
    ..Screening programmes for microalbuminuria and early intervention can substantially modify the natural history of diabetic renal involvement and disease and possibly reduce the incidence of end-stage renal failure...
  94. ncbi Confirmation of the colobomatous macrophthalmia with microcornea syndrome: report of another family
    R Pallotta
    Center for Diagnosis, Prevention and Care of Birth Defects, Department of Medicine, G D Annunzio University, Chieti, Italy
    Am J Med Genet 76:252-4. 1998
    ..The recurrence of this distinctive ocular pattern in our opinion confirms the existence of a new syndrome, with autosomal dominant inheritance...
  95. ncbi Approaches to quality of control in diabetes care
    F Chiarelli
    Department of Pediatrics, University of Chieti, Italy
    Horm Res 50:41-7. 1998
    ....
  96. ncbi Modern management of childhood diabetes: a role for computerized devices?
    F Chiarelli
    Department of Medicine, University of Chieti, Italy
    Acta Paediatr Jpn 40:299-302. 1998
    ..Nonetheless, computers cannot substitute for the pediatric diabetes team, which remains the major determinant for better care of diabetes in children and adolescents...
  97. ncbi Blue-on-yellow and achromatic perimetry in diabetic children without retinopathy
    L Lobefalo
    Institute of Ophthalmology, University G D Annunzio, Chieti, Italy
    Diabetes Care 21:2003-6. 1998
    ..We compared blue-on-yellow perimetry with achromatic perimetry to determine whether the first was more sensitive in detecting visual field defects...
  98. ncbi Neonatal suppurative parotitis: a study of five cases
    G Sabatino
    Neonatal Intensive Care Unit, University of Chieti, Italy
    Eur J Pediatr 158:312-4. 1999
    ..Antimicrobial therapy was effective in all cases; surgery was not required. CONCLUSION: Although neonatal suppurative parotitis is now uncommon in the newborn, it cannot be considered a "vanishing disease"...
  99. ncbi Epilepsy with myoclonic absences with early onset: a follow-up study
    A Verrotti
    Department of Medicine, Pediatrics Section, University of Chieti, Italy
    J Child Neurol 14:746-9. 1999
    ..Our data suggest that myoclonic absence seizures with early onset can have a good long-term prognosis. Valproate is a useful anticonvulsant drug in these patients. Mental retardation is present only in patients with poor seizure control...
  100. ncbi Visual evoked potentials in young persons with newly diagnosed diabetes: a long-term follow-up
    A Verrotti
    Department of Paediatrics Policlinico Colle Dell Ara, University of Chieti, Italy
    Dev Med Child Neurol 42:240-4. 2000
    ..These findings suggest that early functional abnormalities of the optic nerve can be detected at onset of diabetes, and that glycaemic control reverses these abnormalities...
  101. ncbi Childhood epilepsy with occipital paroxysms and benign nocturnal childhood occipital epilepsy
    A Verrotti
    Department of Paediatrics, University of Chieti, Italy
    J Child Neurol 15:218-21. 2000
    ..Therefore, although childhood epilepsy with occipital paroxysms and benign nocturnal childhood occipital epilepsy are two different types of epilepsy, the long-term prognosis seems to be similar...